SK798A3 - Process for producing active substances from unused or discarded devices for the transdermal administration of active substances and/or from their production waste - Google Patents
Process for producing active substances from unused or discarded devices for the transdermal administration of active substances and/or from their production waste Download PDFInfo
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- SK798A3 SK798A3 SK7-98A SK798A SK798A3 SK 798 A3 SK798 A3 SK 798A3 SK 798 A SK798 A SK 798A SK 798 A3 SK798 A3 SK 798A3
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- active
- active substance
- substances
- process according
- unused
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- 239000013543 active substance Substances 0.000 title claims abstract description 54
- 238000000034 method Methods 0.000 title claims abstract description 40
- 239000002699 waste material Substances 0.000 title claims abstract description 13
- 238000004519 manufacturing process Methods 0.000 title claims description 5
- 239000002904 solvent Substances 0.000 claims abstract description 21
- 239000000126 substance Substances 0.000 claims abstract description 21
- 238000011084 recovery Methods 0.000 claims abstract description 9
- 238000004806 packaging method and process Methods 0.000 claims abstract description 8
- 238000004064 recycling Methods 0.000 claims abstract description 8
- 239000011159 matrix material Substances 0.000 claims abstract description 5
- 239000003094 microcapsule Substances 0.000 claims abstract description 3
- 239000013078 crystal Substances 0.000 claims abstract 2
- 239000008240 homogeneous mixture Substances 0.000 claims abstract 2
- 239000006193 liquid solution Substances 0.000 claims abstract 2
- 239000004480 active ingredient Substances 0.000 claims description 11
- 239000000853 adhesive Substances 0.000 claims description 11
- 238000000605 extraction Methods 0.000 claims description 11
- 239000007788 liquid Substances 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 239000010408 film Substances 0.000 claims description 9
- 230000001070 adhesive effect Effects 0.000 claims description 8
- 230000002378 acidificating effect Effects 0.000 claims description 6
- 238000004821 distillation Methods 0.000 claims description 5
- 238000000926 separation method Methods 0.000 claims description 5
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 4
- 239000007789 gas Substances 0.000 claims description 4
- 230000007935 neutral effect Effects 0.000 claims description 4
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- 230000001681 protective effect Effects 0.000 claims description 3
- 239000002994 raw material Substances 0.000 claims description 3
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- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 2
- 239000001569 carbon dioxide Substances 0.000 claims description 2
- 238000001704 evaporation Methods 0.000 claims description 2
- 230000008020 evaporation Effects 0.000 claims description 2
- 239000011888 foil Substances 0.000 claims description 2
- 238000002803 maceration Methods 0.000 claims description 2
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- 238000001556 precipitation Methods 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims 1
- 238000005325 percolation Methods 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 238000002203 pretreatment Methods 0.000 claims 1
- 238000003756 stirring Methods 0.000 claims 1
- 239000000463 material Substances 0.000 abstract description 12
- 239000004820 Pressure-sensitive adhesive Substances 0.000 abstract 1
- 238000009792 diffusion process Methods 0.000 description 3
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
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- 239000012876 carrier material Substances 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
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- ASUTZQLVASHGKV-JDFRZJQESA-N galanthamine Chemical compound O1C(=C23)C(OC)=CC=C2CN(C)CC[C@]23[C@@H]1C[C@@H](O)C=C2 ASUTZQLVASHGKV-JDFRZJQESA-N 0.000 description 2
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- 239000000583 progesterone congener Chemical class 0.000 description 2
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- 231100000027 toxicology Toxicity 0.000 description 2
- WHBHBVVOGNECLV-OBQKJFGGSA-N 11-deoxycortisol Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 WHBHBVVOGNECLV-OBQKJFGGSA-N 0.000 description 1
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical class OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 1
- HPOIPOPJGBKXIR-UHFFFAOYSA-N 3,6-dimethoxy-10-methyl-galantham-1-ene Natural products O1C(C(=CC=2)OC)=C3C=2CN(C)CCC23C1CC(OC)C=C2 HPOIPOPJGBKXIR-UHFFFAOYSA-N 0.000 description 1
- 229930000680 A04AD01 - Scopolamine Natural products 0.000 description 1
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- 229920002799 BoPET Polymers 0.000 description 1
- LPCKPBWOSNVCEL-UHFFFAOYSA-N Chlidanthine Natural products O1C(C(=CC=2)O)=C3C=2CN(C)CCC23C1CC(OC)C=C2 LPCKPBWOSNVCEL-UHFFFAOYSA-N 0.000 description 1
- 229920001634 Copolyester Polymers 0.000 description 1
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- STECJAGHUSJQJN-GAUPFVANSA-N Hyoscine Natural products C1([C@H](CO)C(=O)OC2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-GAUPFVANSA-N 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- STECJAGHUSJQJN-UHFFFAOYSA-N N-Methyl-scopolamin Natural products C1C(C2C3O2)N(C)C3CC1OC(=O)C(CO)C1=CC=CC=C1 STECJAGHUSJQJN-UHFFFAOYSA-N 0.000 description 1
- PIJVFDBKTWXHHD-UHFFFAOYSA-N Physostigmine Natural products C12=CC(OC(=O)NC)=CC=C2N(C)C2C1(C)CCN2C PIJVFDBKTWXHHD-UHFFFAOYSA-N 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
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- 206010039966 Senile dementia Diseases 0.000 description 1
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- 206010003119 arrhythmia Diseases 0.000 description 1
- 230000006793 arrhythmia Effects 0.000 description 1
- HKVRHMQPCDDBJY-UHFFFAOYSA-N benzene-1,3-dicarboxylic acid;3,6-dioxabicyclo[6.2.2]dodeca-1(10),8,11-triene-2,7-dione Chemical compound OC(=O)C1=CC=CC(C(O)=O)=C1.O=C1OCCOC(=O)C2=CC=C1C=C2 HKVRHMQPCDDBJY-UHFFFAOYSA-N 0.000 description 1
- 238000003339 best practice Methods 0.000 description 1
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- RMRJXGBAOAMLHD-IHFGGWKQSA-N buprenorphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]11CC[C@]3([C@H](C1)[C@](C)(O)C(C)(C)C)OC)CN2CC1CC1 RMRJXGBAOAMLHD-IHFGGWKQSA-N 0.000 description 1
- 229960001736 buprenorphine Drugs 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
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- 235000014632 disordered eating Nutrition 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
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- 229930182833 estradiol Natural products 0.000 description 1
- 150000002159 estradiols Chemical class 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 229960003980 galantamine Drugs 0.000 description 1
- BGLNUNCBNALFOZ-WMLDXEAASA-N galanthamine Natural products COc1ccc2CCCC[C@@]34C=CCC[C@@H]3Oc1c24 BGLNUNCBNALFOZ-WMLDXEAASA-N 0.000 description 1
- ASUTZQLVASHGKV-UHFFFAOYSA-N galanthamine hydrochloride Natural products O1C(=C23)C(OC)=CC=C2CN(C)CCC23C1CC(O)C=C2 ASUTZQLVASHGKV-UHFFFAOYSA-N 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
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- 230000003054 hormonal effect Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
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- IYVSXSLYJLAZAT-NOLJZWGESA-N lycoramine Natural products CN1CC[C@@]23CC[C@H](O)C[C@@H]2Oc4cccc(C1)c34 IYVSXSLYJLAZAT-NOLJZWGESA-N 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 229960005181 morphine Drugs 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000037368 penetrate the skin Effects 0.000 description 1
- 230000004526 pharmaceutical effect Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- PIJVFDBKTWXHHD-HIFRSBDPSA-N physostigmine Chemical compound C12=CC(OC(=O)NC)=CC=C2N(C)[C@@H]2[C@@]1(C)CCN2C PIJVFDBKTWXHHD-HIFRSBDPSA-N 0.000 description 1
- 229960001697 physostigmine Drugs 0.000 description 1
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B09—DISPOSAL OF SOLID WASTE; RECLAMATION OF CONTAMINATED SOIL
- B09B—DISPOSAL OF SOLID WASTE NOT OTHERWISE PROVIDED FOR
- B09B3/00—Destroying solid waste or transforming solid waste into something useful or harmless
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B09—DISPOSAL OF SOLID WASTE; RECLAMATION OF CONTAMINATED SOIL
- B09B—DISPOSAL OF SOLID WASTE NOT OTHERWISE PROVIDED FOR
- B09B3/00—Destroying solid waste or transforming solid waste into something useful or harmless
- B09B3/0075—Disposal of medical waste
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B09—DISPOSAL OF SOLID WASTE; RECLAMATION OF CONTAMINATED SOIL
- B09B—DISPOSAL OF SOLID WASTE NOT OTHERWISE PROVIDED FOR
- B09B2101/00—Type of solid waste
- B09B2101/65—Medical waste
- B09B2101/68—Transdermal patches
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Environmental & Geological Engineering (AREA)
- General Health & Medical Sciences (AREA)
- Dermatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Extraction Or Liquid Replacement (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Processing Of Solid Wastes (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
Oblasť technikyTechnical field
Vynález sa nepoužitých, transkutánnu týka postupu na získavanie účinných látok z prípadne odložených účinných látok na aplikáciu účinných látok a/alebo z odpadu z ich výroby, pričom sa účinné látky v prostriedkoch vyskytujú v spojení s polymérovými filmami a polymérovými fóliami.The invention relates to unused transcutaneous processes for obtaining active substances from optionally discarded active substances for the application of the active substances and / or from the production waste thereof, wherein the active substances are present in the compositions in conjunction with polymer films and polymer films.
Súčasný stav technikyThe state of the art
Prostriedky na transkutánnu aplikáciu je možné rozdeliť do dvoch kategórií:Devices for transcutaneous administration can be divided into two categories:
a) na systémy, ktoré účinnú látku odovzdávajú pokožke, eventuálne organizmu prostredníctvom pasívnej difúzie a(a) to systems which pass on the active substance to the skin or to the body through passive diffusion; and
b) na systémy, ktoré účinnú látku odovzdávajú pokožke, resp. organizmu pôsobením, eventuálne s podporou elektrických prúdov.(b) to systems which deliver the active substance to the skin or skin. organism, possibly with the support of electric currents.
Systémy, ktoré spočívajú na pasívnej difúzii, sú tzv. transkutánne terapeutické systémy (TTS). Môžu sa d’alej rozdelovať na tzv. matricové a zásobníkové (rezervoárové) systémy.Systems that rely on passive diffusion are so-called. transcutaneous therapeutic systems (TTS). They can be further subdivided into so-called. matrix and reservoir systems.
V matricových systémoch je účinná látka rozpustená v polymérových filmoch alebo do určitej miery prídavné suspendovaná kryštalický alebo vo forme mikrokapsulí. Takéto systémy sa preto v najjednoduchšom prípade skladajú z rubovej vrstvy, ktorá je pre účinnú látku v podstate nerozpustná, z matrice obsahujúcou účinnú látku, ktorá je výhodne samolepiacou a z ochrannej fólie, ktorá sa pred použitím musí odstrániť.In matrix systems, the active ingredient is dissolved in polymer films or, to some extent, additionally suspended, crystalline or in the form of microcapsules. Such systems therefore, in the simplest case, consist of a backing layer which is substantially insoluble for the active substance, an active substance-containing matrix which is preferably self-adhesive and a protective film which must be removed before use.
Zásobníkové systémy obsahujú účinnú látku v kvapalnom zásobníku. Ten môže byť k dispozícii ako celkom alebo len čiastočne rozpustený. V najjednoduchšom prípade sú tvorené takéto systémy z rubovej vrstvy, ktorá je nepriepustná pre substanciu, ktorá sa nachádza v zásobníku a z membrány, ktorá je prinajmenšom priepustná pre účinnú látku a ktorá je výhodne vybavená ešte lepivým filmom na upevnenie systému na pokožke.Container systems contain the active ingredient in a liquid container. This may be available in total or only partially dissolved. In the simplest case, such systems are formed of a backing layer which is impermeable to the substance contained in the reservoir and of a membrane which is at least permeable to the active substance and which is preferably provided with an adhesive film for attaching the system to the skin.
Systémy, ktoré odovzdávajú účinnú látku pokožke s pomocou elektrického prúdu, môžu byť konštruované veľmi rozmanito. Sú používané hlavne pre účinné látky, ktoré na základe svojich chemicko-fyzikálnych vlastností nemôžu v dostatočnom množstve pasívnou difúziou preniknúť pokožkou.Systems which deliver the active substance to the skin by means of electric current can be designed in a very diverse range. They are mainly used for active substances which, due to their chemical-physical properties, cannot penetrate the skin in sufficient quantity by passive diffusion.
Zo známych dôvodov zostáva v každom nosenom TTS nespotrebovaná časť účinnej látky. Takéto odpadky s obsahom účinnej látky vyvolávajú toxikologické, resp. ekologické riziko a preto sú odstrániteľné ako zvláštne odpadky len pri osobitne vysokých nákladoch. Na druhej strane, tieto odpadky, pochádzajúce z lekárskych prípravkov, ešte obsahujú veľmi drahé a hodnotné obsiahnuté látky, resp. účinné látky, ktorých spätné získavanie by sa od prípadu k prípadu mohlo ukázať ako ekonomicky účelné.For known reasons, an unused portion of the active ingredient remains in each TTS worn. Such garbage containing the active substance causes toxicological resp. ecological risk and are therefore removable as special garbage only at particularly high costs. On the other hand, these wastes, which come from medical preparations, still contain very expensive and valuable substances, respectively. active substances whose recovery could prove economically useful on a case-by-case basis.
Ekonomické vychádzajú úvahy, ku v prospech ktorým je tu potrebné prihliadnúť, spätného získavania účinných látok aj preto, že nosný materiál, ktorý je do značnej miery zbavený účinnej látky, už nepatrí medzi zvláštne odpadky a tým sú náklady na jeho odstraňovanie priaznivejšie.The economic considerations to be taken into account here are the recovery of the active substances, also because the carrier material, which is largely deprived of the active substance, is no longer a special garbage and thus the cost of its disposal is more favorable.
To isté platí aj pre nepoužité TTS a pre výrobný odpad, ktorý pri určitých výrobných postupoch nevyhnutne vzniká, eventuálne pre chybné šarže, ktoré je nie možné celkom vylúčiť.The same applies to unused TTSs and to the production waste which is inevitably produced in certain production processes, possibly to faulty batches which cannot be totally excluded.
Zo súčasného stavu techniky je známy rad recyklačných postupov, najmä také pre odpadky s fóliovým materiálom s vrstvou lepidla. Tak popisuje DE 42 09 676 recyklačný postup pre samolepivý materiál, citlivý na tlak, s vypuklo realizovaným zlupovacím filmom, najmä z fóliového materiálu PET, laminovaného etylén-terftalát-izoftalátkopolyesterom.A number of recycling processes are known from the state of the art, particularly for garbage with a film material with an adhesive layer. Thus, DE 42 09 676 describes a recycling process for a pressure-sensitive self-adhesive material with a peeling film, in particular made of PET film, laminated with ethylene terephthalate-isophthalate copolyester.
DE 42 21 681 opisuje recyklačný postup pre polyetylénové, polypropylénové, alebo polystyrénové lepidlá z etiketového odpadu.DE 42 21 681 describes a recycling process for polyethylene, polypropylene or polystyrene adhesives from label waste.
DE 40 37 562 opisuje recyklačný postup pre plastové filmy s vrstvou lepidla, spočívajúci v opakovanom miesení v rozpúšťadle, odkvapkanie v závitovkovom dopravníku a viacnásobnom priechode ostávajúceho materiálu rovnakou procedúrou.DE 40 37 562 discloses a recycling process for plastic films with an adhesive layer consisting of repeated mixing in a solvent, dripping in a screw conveyor and multiple passage of the remaining material through the same procedure.
jeis a
Pri známy postup povlakom tom sa pohybuje pre : lepidla v prvom fóliovými recykláciu oddelením i stupni po odrezkamiIn the known coating process, this ranges for: adhesives in the first foil recycling by separation and step by section
Z dokumentu DE 40 37 562 odrezkov z plastových fólií plastového materiálu a lepidla, určitú dobu pri mechanickom pôsobení v rozpúšťadle, aby sa v rozpúšťadle degradovalo lepidlo, ktoré prilnieva na fóliových odrezkoch.Potom pôsobením mechanickej sily nasleduje oddelenie v rozpúšťadle dispergovaného lepidla od fóliových odrezkov. K fóliovým odrezkom, stupni, sa privedie v rovnakom druhom stupni čerstvé a disperzia rozpúšťadlo-lepidlo z druhého stupňa stupňa prvého.From DE 40 37 562 plastic film shavings of plastic material and an adhesive, for some time under mechanical action in a solvent, in order to degrade the adhesive adhering to the film shavings in the solvent. Thereafter, mechanical action results in separation of the solvent dispersed adhesive from the film shavings. Fresh film and the solvent-adhesive dispersion from the second step of the first step are fed to the film cuts, step, in the same second step.
vyneseným v prvom rozpúšťadlo zavedie do sain the first solvent introduced into
Podstata vynálezu vynálezu je ukázať postup, ktorým spôsobom podarí spracovať odpadky a najmä nepoužitých, prípadne po transkutánnu saSUMMARY OF THE INVENTION It is an object of the present invention to show a process by which waste and especially unused, possibly after transcutaneous
Účelom prijateľným prípravkov prostriedkov na na znovuzískavanie v nich likvidáciu odpadkov z nosného po odtiahnutí obsahu účinnej ekonomicky lekárskych odložených , tzv. TTS, súčasne na z nosení aplikáciu účinných látok obsiahnutých látok a materiálu pri priaznivých nákladoch látky.The purpose of acceptable formulations of means for recovery therein is to dispose of the garbage from the carrier after withdrawing the content of effective economically deferred, so-called. TTS, at the same time on wearing the application of the active substances contained in the material and the material at a favorable cost of the substance.
Riešenie tejto úlohy sa postupu predtým menovaného obsahom účinnej látky uvedie znovuzíska účinná látka.To solve this task, the active substance content will be reintroduced to the process previously mentioned.
podarí podlá tohto vynálezu využitím spôsobu tak, že sa substancia s v rozpúšťadle do roztoku a z toho saaccording to the present invention using a process by adding a substance s in a solvent to a solution and therefrom
Navrhnutý postup šetrí životné prostredie, je realizovatelný hospodárnymi prostriedkami a poskytuje na jednej strane získavanie cennej suroviny a na druhej strane frakciu pevných látok, resp. nosičov, ktorá je do značnej miery zbavená obsiahnutých látok, je ekologicky neutrálna a preto bezproblémovo likvidovatelná.The proposed procedure saves the environment, is feasible by economic means and provides, on the one hand, valuable raw material and, on the other hand, a solids fraction, resp. The carrier, which is largely free of constituents, is environmentally neutral and therefore can be disposed of without any problems.
Nosičové materiály, resp. iné zvyšky z tohto podlá metód, známych zo súčasného stavu recyklovať.Carrier materials, respectively. other residues from this according to methods known from the current state of recycle.
postupu, sa môžu techniky, ďalejof the process, the techniques can be further
Jedna realizácia tohto postupu predpokladá, že materiály, ktoré sa majú spracovať, sa podrobia predspracovaniu a pri tom, vo vzťahu k účinnej látky, sa rozdelia na druhovo čisté frakcie, vytriedené od cudzích látok, nosičových a/alebo ochranných fólii, obalového materiálu, atď., a substancia s obsahom účinnej látky sa skoncentruje.One realization of this procedure assumes that the materials to be treated are subjected to pretreatment and, in relation to the active substance, are separated into species-pure fractions, sorted from foreign substances, carrier and / or protective films, packaging material, etc. and the substance containing the active substance is concentrated.
Ďalšia realizácia vynálezu predpokladá, že materiály, ktoré sú zavádzané do znovuspracovávania (tiež označené ako odpadky), sú dodávané zabalené v obaloch, resp. obalových pomôckach a že obaly, resp. obalové pomôcky majú označenie, ktoré je zretelne orientované na obsah, napríklad vo forme farebného vzoru alebo pre automatické triedenie vhodného kódovacieho póla. S pomocou takéhoto kódovacieho póla sa môže, podlá vzoru triedenia poštových zásielok, uskutočňovať plnoautomatické triedenie kódovaného balenia na druhovo čisté obsiahnuté látky. Tým odpadá drahá ručná práca a triedenie je bezchybne uskutočnitelné. Toto je pre postup dôležité. Na podporu rozpustenia substancie s obsahom účinnej látky v rozpúšťadle môže byť výhodné nechať, od prípadu k prípadu, odpadky chladom skrehnúť. Hlboké zmrazenie kvapalným dusíkom má tú ďalšiu výhodu, že zo zmrazených odpadkov pri rozomielaní nedochádza k úniku škodlivých látok do prostredia. Pri takto získatelnom rozomletí na velkosť čiastočiek napríklad pod mm je možné rozomletý zväčšenia jeho aktívneho povrchu lahšie rozpustiť v rozpúšťadlovom kúpeli, resp.A further embodiment of the invention assumes that the materials that are introduced into the reprocessing (also referred to as garbage) are delivered packaged in packages, respectively. packaging aids and that the packaging, respectively. the packaging devices have a marking which is clearly oriented towards the contents, for example in the form of a color pattern or for automatic sorting of a suitable coding pole. With the aid of such a coding pole, a fully automatic sorting of the coded package into generically pure substances can be carried out, according to the pattern of mailing sorting. This eliminates the need for expensive manual labor and sorting is feasible. This is important for the procedure. In order to promote the dissolution of the active substance-containing substance in the solvent, it may be advantageous to allow the garbage to be quenched on a case-by-case basis. Deep freezing with liquid nitrogen has the further advantage that the frozen refuse does not escape pollutants into the environment when ground. With the grinding thus obtained to a particle size of, for example, below mm, the milled enlargement of its active surface can be more easily dissolved in a solvent bath or in a solvent bath.
materiál následkom a tiež úplnejšie získať účinnú látku maceráciou, vyluhovaním alebo extrakciou vo fluidnej vrstve.material as a result and also more fully obtain the active ingredient by maceration, leaching or fluidized-bed extraction.
Ďalej opatrenie, podstatné pre vynález, pamätá na to, že na rozpustenie substancie s obsahom účinnej látky sa používa rozpúšťadlo, resp. zmes rozpúšťadiel, majúce pomerne malý rozpúšťači potenciál pre lepidlo a výhodný rozpúšťači potenciál pre účinnú látku. Ďalšia izolácia účinnej látky z roztoku je potom možná napr. extrakciou kvapaliny kvapalinou, protiprúdovou extrakciou alebo iným vhodným postupom.Furthermore, a measure essential to the invention is to remember that a solvent or a solvent is used to dissolve the active substance-containing substance. a solvent mixture having a relatively low solubility potential for the adhesive and a preferred solubility potential for the active ingredient. Further isolation of the active ingredient from the solution is then possible e.g. liquid extraction by liquid, countercurrent extraction or other suitable method.
Na získanie účinnej látky z roztoku pamätané na to, že získavanie je možné alebo cestou chemického medziproduktu alebo zlúčenín odparovaním, destiláciou postupmi.In order to recover the active substance from the solution, remember that recovery is possible or via a chemical intermediate or compounds by evaporation, distillation by processes.
Pri extrakcii účinných rozpúšťadiel, sa pre zásaditú kyslým pH, resp. na kyslé opačne, pre kyslé účinné látky môže byť v ďalšom uskutočňovať zrážaním separáciou cudzích alebo inými vhodnými deliacimi látok rozpúšťadlom, resp. zmesou účinnú látku ponúka použiť vodu s pH nastavenú zmes voda/alkohol a nastaviť zásaditú hodnotu pH.In the extraction of active solvents, the basic acidic pH, respectively. on the acidic counterpart, for the acidic active substances, it may further be effected by precipitation by separation of the foreign or other suitable separating agents with a solvent, respectively. The active ingredient mixture offers to use water with a pH adjusted water / alcohol mixture and to adjust the basic pH.
Pre účinné látky bez kyslej alebo zásaditej funkčnej skupiny sa ponúka použiť neutrálne zmesi voda/alkohol. Z týchto zmesí sa môžu potom účinné látky odstrániť zmenou hodnoty pH alebo prídavkom vody, resp. extrakciou kvapaliny kvapalinou. Značné použitie vodných rozpúšťadiel má ďalej tú výhodu, že značné lipofílne pomocné látky sa spoločne extrahujú len v nepatrnej miere. Na extrakciu účinnej látky sa môžu použiť ako rozpúšťadla tiež nadkritické plyny. Ich zvláštnou výhodou je to, že teplota a tlak ich rozpúšťacieho potenciálu môžu byť v určitých hraniciach ovplyvnené primiešaním prídavných rozpúšťadiel a extrahované podiely môžu byť velmi lahko od rozpúšťadla oddelené. Pretože nadkritické plyny majú velmi nepatrnú viskozitu a preto môžu do extrahovaného materiálu velmi rýchlo prodifundovať, sú zvlášť vhodné na extrakciu účinných látok z polymérových materiálov. Pre dobrú znášanlivosť zo životným prostredím, nízku cenu a dobrú manipulovatelnosť sa na tento účel hodí najmä nadkritický oxid uhličitý. Pretože po odtiahnutí účinných látok sú pevné látky ďalekosiahlo zbavené toxikologický a ekologicky rizikových látok, môžu byť tieto, takto oddelené pevné látky, ako pre životné prostredie neutrálne látky, likvidované bezproblémovo napríklad spalovaním alebo ukladaním na skládkach. Náklady, ktoré sa týmto ušetria v porovnaní prekračujú náklady vynálezu. V tom s nákladmi na ukladanie zvláštneho odpadu, na postup znovuzískavania podlá tohto spočíva ekonomická šanca na postup znovuzískavania účinných látok. Tieto, do rozpúšťadla prejdené účinné a obsažné látky, je možné z roztoku, resp. zo zmesí rozpúšťadiel získať znovu, s pomerne nepatrným vynaložením nákladov a energie, známymi tepelnými čistiacimi postupmi ako je destilácia, resp. rektifikácia, ktoré ako také sú známe a osvedčené postupy.For active substances without an acidic or basic functional group, it is advisable to use neutral water / alcohol mixtures. The active compounds can then be removed from these mixtures by changing the pH value or by adding water or water. liquid extraction by liquid. Furthermore, the considerable use of aqueous solvents has the advantage that considerable lipophilic excipients are only co-extracted to a minor extent. Supercritical gases can also be used as solvents for the extraction of the active ingredient. Their particular advantage is that the temperature and pressure of their dissolution potential can be influenced by admixture of additional solvents within certain limits and the extracted fractions can be separated very easily from the solvent. Since the supercritical gases have a very low viscosity and can therefore diffuse very rapidly into the extracted material, they are particularly suitable for the extraction of active substances from polymeric materials. For good environmental compatibility, low cost and good manageability, supercritical carbon dioxide is particularly suitable for this purpose. Since, after the active substances have been withdrawn, the solids are largely freed from toxicological and ecologically hazardous substances, these solids thus separated, such as environmentally neutral substances, can be disposed of, for example, by incineration or landfill. The costs which are thereby saved in comparison with the costs of the invention. Therein, with the cost of storing special waste, the recovery process according to this, there is an economic chance of the recovery process of the active substances. These active substances and substances which are introduced into the solvent are possible from the solution or from the solution. recovered from the solvent mixtures, with a relatively low cost and energy expense, by known thermal cleaning processes such as distillation and resp. rectification as such are known and best practices.
Ďalej sa vo finálnom pracovnom kroku pamätá na spracovanie suroviny, získanej z roztoku, na farmaceutický čistú účinnú látku.Furthermore, in the final process step, the raw material obtained from the solution is processed into a pharmaceutically pure active ingredient.
Vhodné postupy na to sú odborníkom známe, napríklad, či už spomenutá rekryštalizácia, alebo preparatívna vysokotlaká alebo strednotlaká chromátografia.Suitable procedures for this are known to those skilled in the art, for example, whether the aforementioned recrystallization or preparative high-pressure or medium-pressure chromatography.
Postup je účelný a ekonomicky výhodný a optimálne spĺňa úlohu zadanú v úvode.The procedure is expedient and economically advantageous and optimally fulfills the task set out in the introduction.
Najmä účinné látky s hormonálnym účinkom, estradiol, estradiolové deriváty, gestagén, gestagénové deriváty alebo ich zmesi, morfín alebo morfínové deriváty, buprenorfín, fysostigmín, skopolamín, galanthamín, môžu byť znovuzískané voíbou parametrov postupu. Znovuzískané látky sa potom môžu opäť použiť v, závislosti od farmaceutického účinku, ako bolesť utišujúce prostriedky, ako aj na liečenie senilnej demencie, vysokého krvného tlaku, arytmie, cievnych ochorení, chorôb zo závislosti, zvýšenej hladiny tuku v krvi, duševných porúch, na ovplyvnenie zrážanlivosti krvi, porúch prijímania potravy alebo porúch výmeny cukrov.In particular, the active substances having a hormonal action, estradiol, estradiol derivatives, gestagen, gestagen derivatives or mixtures thereof, morphine or morphine derivatives, buprenorphine, physostigmine, scopolamine, galanthamine can be recovered by selecting process parameters. The recovered substances can then be used again, depending on the pharmaceutical effect, as painkillers, as well as for the treatment of senile dementia, high blood pressure, arrhythmia, vascular diseases, addiction diseases, increased blood fat levels, mental disorders, affecting blood clotting, eating disorders or sugar exchange disorders.
Claims (13)
Applications Claiming Priority (2)
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| DE19524083A DE19524083C2 (en) | 1995-07-01 | 1995-07-01 | Process for the disposal of transdermal application hazardous waste |
| PCT/EP1996/002734 WO1997002100A1 (en) | 1995-07-01 | 1996-06-24 | Process for producing active substances from unused or discarded devices for the transdermal administration of active substances and/or from their production waste |
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| JP (1) | JP3213006B2 (en) |
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| DE19736520A1 (en) * | 1997-08-22 | 1999-02-25 | Lohmann Therapie Syst Lts | New adhesive plaster containing electronic information |
| DE19800277B4 (en) * | 1998-01-07 | 2004-09-02 | Lts Lohmann Therapie-Systeme Ag | Process for the recovery of drugs from preparations, their precursors or waste |
| FR2790851B1 (en) | 1999-03-12 | 2001-06-08 | Ge Medical Syst Sa | METHOD FOR IMPROVING THE DETECTION OF ELEMENTS OF INTEREST IN A DIGITAL RADIOGRAPHIC IMAGE |
| DE10348046A1 (en) * | 2003-10-16 | 2005-05-19 | Beiersdorf Ag | Production of transdermal or topical matrix, used in skin and wound care, involves reacting polymer matrix containing added liquid fatty ester, paraffin or silicone oil on carrier, extracting additive and applying active agent and adjuvent |
| EA011308B1 (en) * | 2004-03-05 | 2009-02-27 | Н. Калеб Эйвери | Method and system for optimal pricing and allocation |
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| US4543364A (en) * | 1984-12-13 | 1985-09-24 | The Dow Chemical Company | Recovery of polyethylene terephthalate (PET) |
| DE4037562C1 (en) * | 1990-11-26 | 1992-08-27 | Wnc-Nitrochemie Gmbh, 8261 Aschau, De | |
| DE4221681C2 (en) * | 1992-07-02 | 1995-01-26 | Pago Etikettiersysteme Gmbh | Process for recycling film waste |
| US5288408A (en) * | 1992-10-26 | 1994-02-22 | Chemical Industry Consultants, Inc. | Method of gelatin recovery and purification from encapsulation processes |
| US5461147A (en) * | 1993-09-27 | 1995-10-24 | Schering Corporation | Process for preparing benzazepine intermediates for the synthesis of D1 antagonists |
| DE4340093A1 (en) * | 1993-11-24 | 1995-06-01 | Cognis Bio Umwelt | Process for the simplified separation of multi-component mixtures of at least a proportion of organic origin |
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1996
- 1996-06-24 CZ CZ19974208A patent/CZ289134B6/en not_active IP Right Cessation
- 1996-06-24 AT AT96922023T patent/ATE184519T1/en active
- 1996-06-24 NZ NZ311681A patent/NZ311681A/en not_active IP Right Cessation
- 1996-06-24 ES ES96922023T patent/ES2139365T3/en not_active Expired - Lifetime
- 1996-06-24 DK DK96922023T patent/DK0836538T3/en active
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- 1996-06-24 CA CA002226153A patent/CA2226153C/en not_active Expired - Fee Related
- 1996-06-24 AU AU63047/96A patent/AU714549B2/en not_active Ceased
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- 1996-06-24 KR KR1019970709835A patent/KR100411690B1/en not_active IP Right Cessation
- 1996-06-24 WO PCT/EP1996/002734 patent/WO1997002100A1/en active IP Right Grant
- 1996-06-24 HU HU9900336A patent/HUP9900336A3/en unknown
- 1996-06-24 EP EP96922023A patent/EP0836538B1/en not_active Expired - Lifetime
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| JPH11508815A (en) | 1999-08-03 |
| KR19990028517A (en) | 1999-04-15 |
| WO1997002100A1 (en) | 1997-01-23 |
| DE19524083A1 (en) | 1997-01-09 |
| NO975923D0 (en) | 1997-12-16 |
| AU714549B2 (en) | 2000-01-06 |
| HUP9900336A2 (en) | 1999-05-28 |
| US5869652A (en) | 1999-02-09 |
| EP0836538B1 (en) | 1999-09-15 |
| GR3032071T3 (en) | 2000-03-31 |
| NO309707B1 (en) | 2001-03-19 |
| DE19524083C2 (en) | 2000-07-06 |
| DE59603092D1 (en) | 1999-10-21 |
| ZA965495B (en) | 1997-01-30 |
| NO975923L (en) | 1997-12-16 |
| CA2226153C (en) | 2004-05-11 |
| EP0836538A1 (en) | 1998-04-22 |
| ES2139365T3 (en) | 2000-02-01 |
| CA2226153A1 (en) | 1997-01-23 |
| HUP9900336A3 (en) | 2001-01-29 |
| AU6304796A (en) | 1997-02-05 |
| JP3213006B2 (en) | 2001-09-25 |
| DK0836538T3 (en) | 2000-04-03 |
| PL324406A1 (en) | 1998-05-25 |
| CZ289134B6 (en) | 2001-11-14 |
| CN1189788A (en) | 1998-08-05 |
| MX9800243A (en) | 1998-03-31 |
| ATE184519T1 (en) | 1999-10-15 |
| NZ311681A (en) | 1999-01-28 |
| CZ420897A3 (en) | 1998-06-17 |
| CN1094801C (en) | 2002-11-27 |
| SK282659B6 (en) | 2002-11-06 |
| MY132204A (en) | 2007-09-28 |
| KR100411690B1 (en) | 2004-03-30 |
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