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Priority claimed from DE3901551Aexternal-prioritypatent/DE3901551A1/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
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Medicinal Preparation
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Adhesive Tapes
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Medicines That Contain Protein Lipid Enzymes And Other Medicines
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Abstract
The invention refers to the procedure for the production of the superficial therapeutic system which consists of an impermeable back layer, a matrix that contains the active substance and of a re-detachable protective layer. It is marked in the way that the following components of the matrix a. antineoplastic active substance, b. self-adhesive polyacrylate, c. water absorber and possibly d. non-adhesive hydrophile polyacrylate, e. softener and/or accelerator of the penetration are homogeneously mixed, possibly with dissolving in a solvent. The homogeneous mixture is applied to the impermeable back layer, the solvent is possibly removed and then the layer of the matrix is covered with the protective layer.
Claims (5)
POSTOPEK ZA IZDELAVO POVRŠINSKEGA TERAPEVTSKEGA SISTEMA Z VSEBINO ANTINEOPLASTIČNE DEJAVNE SNOVI. ZLASTI 5-FLUORURACILA PATENTNI ZAHTEVKI 1 Postopek za izdelavo površinskega terapevtskega sistema z vsebino antineoplastične dejavne snovi, zlasti 5-fluoruracila, sestavljenega iz nepropustnega hrbtnega sloja, dejavno snov vsebujoče matrike in iz ponovno snemljivega varovalnega sloja, označen s tem, da se sledeče sestavine matrike: a. 0,2 - 5 %, prednostno 0,3 - 1 %, ter zlasti prednostno 0,6 - 0,9 %, antineoplastične dejavne snovi, b. vsaj 50 %, prednostno 65 - 75 %, polarnega polimernega nosilca dejavne snovi v obliki samolepljivega poliakrilata, c. 1-15 %, prednostno 1-10 %, ter zlasti prednostno 4 - 5 %, vodnega absorberja, dodanega dejavni snovi, pri čemer vodni absorber bazira na omreženi predhodno nevtralizirani poliakrilni kislini, in, eventualno, d. 0 - 48,8 %, prednostno 10-35 %, ter zlasti prednostno 15-25 %, nelepljivega hidrofilnega poliakrilata, ki bazira na kopolimeru estra akrilne kisline in estrih metakrilne kisline, ki vsebujejo kvartarne amonijeve skupine, e. 0-20 %, prednostno 5-15 %, ter zlasti prednostno 5-10 %, mehčalca ali pospeševalca penetracije, raztope v topilu in homogeno mešajo, homogeno zmes se nanese na nepropustni sloj, da se odstrani topilo in se na matriko nanese varovalni sloj.PROCEDURE FOR THE MANUFACTURE OF SURFACE THERAPEUTIC SYSTEM WITH ANTINEOPLASTIC ACTIVE SUBSTANCE CONTENT. A method for the manufacture of a topical therapeutic system with the content of an antineoplastic active substance, in particular 5-fluorouracil consisting of a watertight back layer, an active substance-containing matrix and a removable protective layer, characterized in that the following ingredients of the matrix : a. 0.2 - 5%, preferably 0.3 - 1%, and particularly preferably 0.6 - 0.9%, antineoplastic active substances, b. at least 50%, preferably 65-75%, a polar polymeric carrier of an active substance in the form of a self-adhesive polyacrylate, c. 1-15%, preferably 1-10%, and preferably preferably 4 - 5%, a water absorber, an added active substance, wherein the water absorber is based on the network previously neutralized polyacrylic acid, and, optionally, d. 0 to 48.8%, preferably 10-35%, and particularly preferably 15-25%, non-sticky hydrophilic polyacrylate based on the copolymer of the acrylic acid ester and methacrylic acid esters containing quaternary ammonium groups, e. 0-20%, preferably 5-15%, and especially preferably 5-10%, a softener or penetration promoter, solvent dilutions and homogenously mixing, the homogeneous mixture is applied to the impermeable layer to remove the solvent and apply a protective layer to the matrix .2 Postopek po zahtevku 1, označen s tem, da je antineoplastična dejavna snov 5-fluoruracil. -2-Method according to claim 1, characterized in that the antineoplastic active substance is 5-fluorouracil. -2-3 Postopek po enem od zahtevkov 1 ali 2, označen s tem, da je mehčalec oz. pospeševalec penetriranja 1,2-propandiol.Method according to one of claims 1 or 2, characterized in that the plasticiser or penetrating promoter 1,2-propanediol.4 Postopek po enem od zahtevkov 1 ali 2, označen s tem, da se sistempo nanošenju ponovno snemljivega varovalnega sloja razreže v kose krožne oblike premera 0,5 - 3 cm, prednostno 1 - 2 cm, zlasti prednostno 1-1,2 cm.Method according to one of the claims 1 or 2, characterized in that the system is cut into circular shaped shapes with a diameter of 0.5-3 cm, preferably 1 to 2 cm, in particular preferably 1-1.2 cm in diameter, by the application of a removable protective layer.5 Postopek po enem od zahtevkov 1 ali 2, označen s tem, da se sistempo nanošenju zaščitne folije razreže v kose pravokotne oblike površine 1 - 200 cm2, prednostno 1 - 50 cm2, zlasti prednostno 2 - 20 cm2.Method according to one of the claims 1 or 2, characterized in that the systemic coating of the protective film is cut into pieces of rectangular shape of a surface of 1-200 cm2, preferably 1-50 cm2, in particular preferably 2-20 cm2.
SI9010033A1989-01-201990-01-09Process for preparing of a superficial therapeutic system containing antineoplastic agent, particularly 5-fluoro uracil
SI9010033B
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