SI8710853A - Improved capsule - Google Patents

Abstract

The capsule of the gelatin capsule has a annular groove in part of the open end to reduce ovality.

Description

The invention ee relates to a type of capsule consisting mainly of cylindrical cylindrical bottoms and a lid which is telescopically folded onto the body, and in particular relates to the neck of hard gelatine capsules frequently used for the filling of pharaaoeut preparations ·

Hard gelatin capsules are made of two parts by dropping Selicic columns into molten gelatin solution, forming 1 are »Shading gelatin and removing formed shells from the stem ·

It is generally recognized that the gelatin film shrinks during drying · Moisture control during and after the drying operation is critical with the dlmensional stability of the capsules formed · The shrinkage of the number of factors such as the amount of water to be removed, the type of gelatin used, the drying regime and the number 1 types of additives, such as Sto au Colors 1 surfactants · Capsules lose up to $$ of moisture after stripping off the stairs, which are for

The effect of changes in drying conditions and composition of gelatin leads to changes in the diameter of formed and dry shells be round, a real oval opening «

One of the effects of this ovality is that it makes it difficult to fit two halves of the capsule. • Frequently telescopically pulling the mast into the mast, the two halves can be pulled up to some limit, with the difficulty of collapsing one or both halves of the capsule, with the current or later loss of «capsule content ·

Efforts have been made to overcome oval problems, for example. · However, it has not been possible so far to find with "sufficient problem solving and measurement" thrown on the size of a cap of capsule 6 * 9 mm in diameter that the oval position, a certain measurement "of the difference between the largest and smallest diameters, Is »Carries up to 0 * 5 mm, regardless of capsule manufacturer *

-2 Finding Predicts r®Songe Oval Problems But Changes the Capsule Formation and Quenching Yesterday ·

The present invention provides that the capsule shell has a annular groove in the portion of the open end. "Preferably, the groove is on the lid.

"Open end boo" equates to being near the open end, ie "no further than 2 mA, preferably between 0.5 mm and 1 * 5 in. From the cut end, depending on the size of the capsule.

The presence of a slotted groove allows the capsule film to dry at normal angles, with a much reduced possibility of forming an oval. it is best to place the groove at a distance of about 0.5 ®m to about 1 * 6 cm from the open end of the shell. “The groove should be continuous. However, it is possible to achieve a reduction in ovality by using a segmental groove, for example, from about 2 to about 12 segments. Segments should surround the thinnest about $ 90 shell volume «Typically, the Groove Width of about

0 * 3 mm to about 1 * 9 na, e depth from about O «ol ms to about O.o5 aa« Dimensions, cross-section profile and groove position are not critical, but the preferred dimension depends on the size of the capsule * Ovi parameters for ordinary capsule sizes they can choose from the table. Volume capsules Gutter depth (mm) Distance from the cut end (om) ^x gutter Width (®m) 00 Ο * ο25-Ο · ο35 1-1.6 0 * 51-0.55 0 O.o25-O.o35 1-1 * 6 0 * 91-0.55 1 O.o2o-O «e3o 1-1 * 6 0.46-0.50 2 O * el5 ~ © «o25 0.8-1.4 0.37-0.41 5 0 * olo-0 «o2o 0 * 7-1.3 0.32-0.36 4 G.Gle-O. © 2o 0.7-1.3 0.32-0.36 ^x Hereno to groove * e

The groove cross-section may be curved or angular and may vary in shape, eg from single to multiple diameter, Ui to be in shape V, to polygonal shapes, as square, rectangular or trapezoidal.

The invention will be better understood by the enclosed orbit, wherein FIG. 1 shows optionally a capsule lid made according to the invention, and FIG. 2 shows embodiments of the details marked A not FIG. 1. "

Fig «1 shows part of capsule cover of size X« Total length of capsule cap of size 1 is 10 mm «Groove of depth O.o2 aa and Width 0« 5o as formed ea centered at a distance of 1 * 3 ss from the closed end «The cover is formed on attubichu fits * yesterday profile »

The cross-sectional shape of the groove can be aa already adopted, and Figs. 2 bevels a series of suitable cross-sectional shapes of grooves which may be used but not finite.

The shells of the capsule of the invention may take other forms, such as e.g. clockwork, according to British patentiaa 970761, 1040859 and 1442121.

8a. On the other hand, the invention also relates to a bar having a annular groove suitable for making a Shell Capsule according to the invention.

A series of tests were conducted to make lellatin lids of discernable shape, which contained either 2 PRE-IOK formations or 4 PRS-IOK formations (see British patent 1442121). The covers are made with a groove O.o2 ma, shown in fig. 9.

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The caps of capsules of size 1 were made aa 2 PRE-LOK ^M formation and followed by a grooved groove, as previously described * Bi «the capsules of size 1 with 4 PRELOK formation were also made, but without a groove« Pattern of $ 0 per « flaps of both types were taken at a relative humidity of 15% · The circumference of each flap was determined by measuring the largest and smallest diameter and determining the difference. For standard flaps the mean oval was 0 «127 mm, while for circular groove caps the median oval was reduced to C «o89 mm.

The above test was made under special conditions and samples were taken at a relative humidity of 14.5%. the standard capsules showed a mean ovale of 0.132 mo, while the capsule with ring grooves had a median ovale of only 0 "© 79 mm.

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The size 1 capsules are made with 2 "FRS-LOK Shapes and with ring® grooves keo according to test 1. Siaul« tene caps are made of standard size 1 capsules with pub-LOK * formations and ea P06ILCK (Trademark) Formation ® »according to British patent 1442121» but the color of the ring is a "stack" of the forehead "Fifty dents pcs considered more than ever" at an incident humidity of 14.63 and the oval was oval as in test 1 while the capsules of the invention according to the invention had a mean circumference of only O.e62 mm *

Reducing the ovality of the capsules »millet invention« makes it easier to work with the son »as sorting» filling 1 joining »and improves the apa ^ sting. For the sake of improved jointing, the tolerance of crude oil in production has been mentioned »which results in a better connection of the body and the lid and a reduced accidental separation of the half caps of the filling tank.

it is often desirable that the tape be glued to the epee capsule "to avoid leakage in the case of liquid contents" or that the capsule be marked for forced opening "or resistant to the same" or for identification. This can be achieved by using known procedures and equipment "such as What is a Quali ~ Seal Machine (1'anufacturing Cheaist" Day "193?" P. 27). In these conditions, the cap of the ea groove cap has surprising advantages in connection with the coupling strip "and is especially useful when the capsule contains liquid filling" The first "mentioned® oval capability not only facilitates machine operation" i.e. rotating in a way to close the psi by placing a lanyard tape "more What is more important" makes the distance between the circumference of the cap and the body of the capsule more uniform "than in the case of a capsule conventionally ^ in the form of" When the lanyard is "such as Latin" place between the end of the lid and the drip body the distance that the strap should bridge is more uniform and allows a more accurate fitting »while allowing a thinner Selatine strap to be used» Other »evenly spaced by volume» upwards Exposed® »together with better dimension locking 1 additionally »retaining bushings which are recovered by the process of the invention» provide have additional advantages »when the capsule should contain a little viscous liquid» • 5 as oil * fats * 17 these »capsules containing liquid · need to discharge a leak of a rare oil or other gravity in the eye · by closing with a« race »or other ® techniques * If the salt prevents leakage during the 5 * 10 min filling job »at which time the augmented capsules can be sorted and» placed in the correct position for the joints »the capsule of the capsule junction spreads to the contact surface» with the risk of further leaching of the contents and a drop of sul. surprisingly, I announce that with a half-silion capsule filled with lava oil oil, I saw the wrinkling of the contents and the capsule was the result of the use of a ring with a groove "according to the invention"

Claims (14)

PATENT APPLICATIONS 1. A capsule shell characterized in that it has a annular groove in the portion of the open end. Capsule shell according to claim 1, characterized in that it is a capsule cover. Capsule shell according to claims 1 and 2, characterized in that it has a continuous groove throughout the circumference. Capsule shell according to claims 1, 2 and 3, characterized in that the groove is at a distance of 0.5 mm to 1.5 mm from the open portion. The capsule shell according to claim 4, characterized by stem, provides a groove at a distance of about 1.3 mm. 6. Capsule shell according to claims 1, 2, 3, 4 and 5, characterized in that the groove width is from 0.3 mm to 1.5 mm. 7. Capsule shell according to claim 6, characterized in that the groove width is about 0.5 mm. The capsule shell according to claims 1, 2, 3, 4, 5, 6 and 7, characterized in that the groove depth is from 0.01 mm to 0.05 mm. A capsule shell according to claim 8, characterized in that the groove depth is about 0.02 mm. The capsule shell according to claims 1, 2, 3, 4, 5, 6, 7, 8 and 9, characterized in that it is gelatin. 11. Filled gelatin capsule, characterized in that it consists of a capsule shell according to any one of claims 1 to 10. 12. The filled gelatin capsule according to claim 11, characterized in that it has a fastening strap which is mounted at the end of the cap and body of the capsule. 13. The filled capsule according to claim 12, characterized in that it is filled with liquid. 14. Ring groove pillar for the manufacture of capsules according to one of claims 1 to 10.