SI2895198T1 - Nekovalentna samosestavljiva hidrogelna matrika za biotehnološko uporabo - Google Patents

Nekovalentna samosestavljiva hidrogelna matrika za biotehnološko uporabo

Info

Publication number
SI2895198T1
SI2895198T1 SI201331202T SI201331202T SI2895198T1 SI 2895198 T1 SI2895198 T1 SI 2895198T1 SI 201331202 T SI201331202 T SI 201331202T SI 201331202 T SI201331202 T SI 201331202T SI 2895198 T1 SI2895198 T1 SI 2895198T1
Authority
SI
Slovenia
Prior art keywords
selforganising
hydrogelmatrix
biotechnoligical
covalent
applications
Prior art date
Application number
SI201331202T
Other languages
English (en)
Inventor
Robert Wieduwild
Yixin Zhang
Carsten Werner
Mikhail Tsurkan
Uwe Freudenberg
Original Assignee
Technische Universitaet Dresden
Leibniz-Institut Fuer Polymerforschung Dresden E.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Technische Universitaet Dresden, Leibniz-Institut Fuer Polymerforschung Dresden E.V. filed Critical Technische Universitaet Dresden
Publication of SI2895198T1 publication Critical patent/SI2895198T1/sl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068General culture methods using substrates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727Heparin; Heparan
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/33Fibroblasts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6903Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being semi-solid, e.g. an ointment, a gel, a hydrogel or a solidifying gel
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4866Organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00Supports or coatings for cell culture, characterised by material
    • C12N2533/30Synthetic polymers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00Supports or coatings for cell culture, characterised by material
    • C12N2533/50Proteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00Supports or coatings for cell culture, characterised by material
    • C12N2533/70Polysaccharides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
SI201331202T 2012-09-13 2013-09-13 Nekovalentna samosestavljiva hidrogelna matrika za biotehnološko uporabo SI2895198T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102012108560.9A DE102012108560B4 (de) 2012-09-13 2012-09-13 Nichtkovalente selbstorganisierende Hydrogelmatrix für biotechnologische Anwendungen
EP13783244.0A EP2895198B1 (de) 2012-09-13 2013-09-13 Nichtkovalente selbstorganisierende hydrogelmatrix für biotechnologische anwendungen
PCT/DE2013/100327 WO2014040591A2 (de) 2012-09-13 2013-09-13 Nichtkovalente selbstorganisierende hydrogelmatrix für biotechnologische anwendungen

Publications (1)

Publication Number Publication Date
SI2895198T1 true SI2895198T1 (sl) 2019-02-28

Family

ID=49488446

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201331202T SI2895198T1 (sl) 2012-09-13 2013-09-13 Nekovalentna samosestavljiva hidrogelna matrika za biotehnološko uporabo

Country Status (10)

Country Link
US (1) US20150246132A1 (sl)
EP (1) EP2895198B1 (sl)
CN (1) CN104736182B (sl)
DE (1) DE102012108560B4 (sl)
DK (1) DK2895198T3 (sl)
ES (1) ES2690062T3 (sl)
HK (1) HK1210700A1 (sl)
LT (1) LT2895198T (sl)
SI (1) SI2895198T1 (sl)
WO (1) WO2014040591A2 (sl)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2280720B1 (en) 2008-03-27 2019-01-16 Purdue Research Foundation Collagen-binding synthetic peptidoglycans, preparation, and methods of use
MX349693B (es) 2011-05-24 2017-08-09 Symic Ip Llc Peptidoglicanos sinteticos de union a acido hialuronico, su preparacion y metodos de uso.
MX2015012608A (es) 2013-03-15 2016-07-06 Symic Biomedical Inc Peptidos sinteticos de union a matriz extracelular.
WO2015164822A1 (en) 2014-04-25 2015-10-29 Purdue Research Foundation Collagen binding synthetic peptidoglycans for treatment of endothelial dysfunction
EP3181153A1 (en) 2015-12-18 2017-06-21 BSN medical GmbH Wound care product comprising ecm-functionalized nanocellulose
EP3181152A1 (en) 2015-12-18 2017-06-21 BSN medical GmbH Multi-layered wound care product
DE102016109067B4 (de) 2016-05-17 2018-07-19 Leibniz-Institut Für Polymerforschung Dresden E.V. Verfahren zur Bildung von Nierentubuli
EP3315145B1 (en) 2016-10-28 2022-06-08 BSN medical GmbH Multi-layer wound care product with perforated collagen layer
DE102017105195A1 (de) 2017-03-10 2018-09-13 Leibniz-Institut Für Polymerforschung Dresden E.V. Verfahren zur differenzierten Sequestrierung von Stoffen verschiedener Stoffgruppen mit Hilfe von sulfatierte oder sulfonierte Komponenten enthaltenden Hydrogelen
EP3395327B1 (en) * 2017-04-28 2020-03-11 denovoMATRIX GmbH Non-covalently assembled conductive hydrogel
EP3415165A1 (en) 2017-06-16 2018-12-19 Technische Universität Dresden Non-covalently assembled biomatrix layer
AU2018298224B2 (en) 2017-07-07 2024-08-15 Symic Ip, Llc Synthetic bioconjugates
JPWO2022270482A1 (sl) * 2021-06-24 2022-12-29

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994004176A1 (en) * 1992-08-14 1994-03-03 University Of Michigan Novel peptides for heparin anticoagulation reversal
US5534619A (en) * 1993-11-12 1996-07-09 The Board Of Regents Acting On Behalf Of University Of Michigan Peptides for heparin and low molecular weight heparin anticoagulation reversal
US6958212B1 (en) * 1999-02-01 2005-10-25 Eidgenossische Technische Hochschule Zurich Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds
EP1814519A1 (en) * 2004-11-16 2007-08-08 Université de Liège Active substance delivery system comprising a hydrogel atrix and microcarriers
US8415325B2 (en) 2005-03-31 2013-04-09 University Of Delaware Cell-mediated delivery and targeted erosion of noncovalently crosslinked hydrogels
US8367639B2 (en) 2005-03-31 2013-02-05 University Of Delaware Hydrogels with covalent and noncovalent crosslinks
US20090226525A1 (en) * 2007-04-09 2009-09-10 Chimeros Inc. Self-assembling nanoparticle drug delivery system

Also Published As

Publication number Publication date
WO2014040591A2 (de) 2014-03-20
EP2895198A2 (de) 2015-07-22
EP2895198B1 (de) 2018-07-04
CN104736182B (zh) 2018-01-09
ES2690062T3 (es) 2018-11-19
WO2014040591A3 (de) 2014-05-08
DE102012108560A1 (de) 2014-03-13
CN104736182A (zh) 2015-06-24
DK2895198T3 (en) 2018-10-22
LT2895198T (lt) 2018-11-12
DE102012108560B4 (de) 2018-12-20
HK1210700A1 (en) 2016-05-06
US20150246132A1 (en) 2015-09-03

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