SI2387563T2 - Malatna sol N-(4-((6,7-bis(metiloksi)kinolin-4-il)oksi)fenil-N'-(4-lurofenil)-ciklo- propan-1,1-dikarboksamida in njene kristalinične oblike za zdravljenje raka - Google Patents

Malatna sol N-(4-((6,7-bis(metiloksi)kinolin-4-il)oksi)fenil-N'-(4-lurofenil)-ciklo- propan-1,1-dikarboksamida in njene kristalinične oblike za zdravljenje raka

Info

Publication number
SI2387563T2
SI2387563T2 SI201030193T SI201030193T SI2387563T2 SI 2387563 T2 SI2387563 T2 SI 2387563T2 SI 201030193 T SI201030193 T SI 201030193T SI 201030193 T SI201030193 T SI 201030193T SI 2387563 T2 SI2387563 T2 SI 2387563T2
Authority
SI
Slovenia
Prior art keywords
ylćoxyćphenyl
dicarboxamide
methyloxy
quinolin
cyclopropane
Prior art date
Application number
SI201030193T
Other languages
English (en)
Other versions
SI2387563T1 (sl
Inventor
Adrian St. Clair Brown
Peter Lamb
William P. Gallagher
Original Assignee
Exelixis, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exelixis, Inc. filed Critical Exelixis, Inc.
Priority claimed from EP10701175.1A external-priority patent/EP2387563B2/en
Publication of SI2387563T1 publication Critical patent/SI2387563T1/sl
Publication of SI2387563T2 publication Critical patent/SI2387563T2/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
SI201030193T 2009-01-16 2010-01-15 Malatna sol N-(4-((6,7-bis(metiloksi)kinolin-4-il)oksi)fenil-N'-(4-lurofenil)-ciklo- propan-1,1-dikarboksamida in njene kristalinične oblike za zdravljenje raka SI2387563T2 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14542109A 2009-01-16 2009-01-16
EP10701175.1A EP2387563B2 (en) 2009-01-16 2010-01-15 Malate salt of n- (4- { [ 6, 7-bis (methyloxy) quinolin-4-yl]oxy}phenyl-n' - (4 -fluorophenyl) cyclopropane-1,1-dicarboxamide, and crystalline forms thereof for the treatment of cancer
PCT/US2010/021194 WO2010083414A1 (en) 2009-01-16 2010-01-15 Malate salt of n- (4- { [ 6, 7-bis (methyloxy) quin0lin-4-yl] oxy}phenyl-n' - (4 -fluorophenyl) cyclopropane-1-dicarboxamide, and crystalline forms therof for the treatment of cancer

Publications (2)

Publication Number Publication Date
SI2387563T1 SI2387563T1 (sl) 2013-06-28
SI2387563T2 true SI2387563T2 (sl) 2022-08-31

Family

ID=58449012

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201030193T SI2387563T2 (sl) 2009-01-16 2010-01-15 Malatna sol N-(4-((6,7-bis(metiloksi)kinolin-4-il)oksi)fenil-N'-(4-lurofenil)-ciklo- propan-1,1-dikarboksamida in njene kristalinične oblike za zdravljenje raka

Country Status (2)

Country Link
CY (1) CY1114007T1 (sl)
SI (1) SI2387563T2 (sl)

Also Published As

Publication number Publication date
CY1114007T1 (el) 2016-07-27
SI2387563T1 (sl) 2013-06-28

Similar Documents

Publication Publication Date Title
IL234097A0 (en) Malate salt of n-(4-{[-7,6-bis(methyloxy)quinolin-4-yl]oxy}phenyl}-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, and crystalline forms thereof for treatment in cancer
IL220129A (en) History of benzamide, preparations containing them and their use in the treatment of cancer
IL201309A0 (en) Novel n - (8 - heteroaryltetrahydronaphtalene - 2yl) or n - (5 - heteroarylchromane - 3 - yl) carboxamide derivatives for the treatment of pain
IL217768A (en) Coinimod for the treatment of Crohn's disease
IL223783B (en) Compound 1-converted indole for use in the treatment of a disease or condition, a pharmaceutical preparation containing the compound and use of the compound to prepare a medicine
IL216967B (en) The history of 17-hydroxy-17-pentafluoroethyl-astra-9,4 (10)-diene-11-aryl and their use for the treatment of diseases
IL231495B (en) N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide compounds or a pharmaceutically acceptable salt thereof in the preparation of a medicament for the treatment of osteoporosis
EP1985302A4 (en) DRUGS FOR TUMOR THERAPY AND ITS USE
IL187235A0 (en) 2,6 quinolinyl derivatives, processes for preparing them and their use as medicament
IL230487B (en) 6-(n-(7-chloro-1-hydroxy-3,1-dihydrobenzo[c][1,2]oxaborole-5-yl)methylsulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-n- Methylbenzofuran-3-carboxamide, their salts and pharmaceutical preparations containing them
IL230484A (en) "6- (n- (7-Chloro-1-Hydroxy-1, 3-Dihydrobenzo [c] [1,2] Oxaborol-5-Yl) - Methylbenzoforan-3 - Carbamamide and a Pharmaceutical Preparation
EP2328877A4 (en) 1,4-BENZOXAZINE COMPOUNDS AND DERIVATIVES THEREOF AS THERAPEUTIC MEDICINES FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS
EP1881974A4 (en) PHOSPHONE FLUOROQUINOLONES, THEIR ANTIBACTERIAL ANALOGUES, AND METHODS FOR PREVENTING AND TREATING BONE AND JOINT INFECTIONS
HK1164862A1 (en) 3-benzofuranyl-indol-2-one derivatives substituted at the 3 position, preparation thereof, and therapeutic use thereof
SI2387563T2 (sl) Malatna sol N-(4-((6,7-bis(metiloksi)kinolin-4-il)oksi)fenil-N'-(4-lurofenil)-ciklo- propan-1,1-dikarboksamida in njene kristalinične oblike za zdravljenje raka
EP2425829A4 (en) SOLUBLE PHARMACEUTICAL FORMS OF N, N'-DIAMINODIPHENYLSULPHONE FOR OPTIMAL USE IN THE TREATMENT OF VARIOUS ILLNESSES
ZA201000582B (en) 1-oxo-isoindoline-4-carboxamide and 1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamide derivatives,preparation and therapeutic use thereof
HK1188565A1 (en) Diarylpyridazinone derivatives, preparation thereof, and use thereof for the treatment of humans
EP2629767A4 (en) BENZENE-SULFONANILIDE AMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND METHOD OF TREATING CANCER USING SAME
EP2119700A4 (en) BENZYLAMINE DERIVATIVE OR PHARMACEUTICALLY SUBSTANTIAL ACIDIC ACID SALT AND THE USE THEREOF FOR MEDICAL PURPOSES
PL2521727T3 (pl) Nowe benzoesowe pochodne pirolopirydyny i ich zastosowanie w leczeniu choroby parkinsona
IL214487A0 (en) N-[(6-azabicyclo[3.2.1]oct-1-yl)-aryl-methyl]-benzamide derivatives, preparation thereof, and therapeutic use thereof