SI2124933T1 - Tosylate salt of a therapeutic compound and pharmaceutical compositions thereof - Google Patents

Tosylate salt of a therapeutic compound and pharmaceutical compositions thereof

Info

Publication number
SI2124933T1
SI2124933T1 SI200830802T SI200830802T SI2124933T1 SI 2124933 T1 SI2124933 T1 SI 2124933T1 SI 200830802 T SI200830802 T SI 200830802T SI 200830802 T SI200830802 T SI 200830802T SI 2124933 T1 SI2124933 T1 SI 2124933T1
Authority
SI
Slovenia
Prior art keywords
pharmaceutical compositions
therapeutic compound
tosylate salt
tosylate
salt
Prior art date
Application number
SI200830802T
Other languages
Slovenian (sl)
Inventor
Travis T. Wager
Todd William Butler
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of SI2124933T1 publication Critical patent/SI2124933T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Otolaryngology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Psychology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SI200830802T 2007-01-22 2008-01-10 Tosylate salt of a therapeutic compound and pharmaceutical compositions thereof SI2124933T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US88593107P 2007-01-22 2007-01-22
PCT/IB2008/000088 WO2008090429A1 (en) 2007-01-22 2008-01-10 Tosylate salt of a therapeutic compound and pharmaceutical compositions thereof
EP08702250A EP2124933B1 (en) 2007-01-22 2008-01-10 Tosylate salt of a therapeutic compound and pharmaceutical compositions thereof

Publications (1)

Publication Number Publication Date
SI2124933T1 true SI2124933T1 (en) 2012-12-31

Family

ID=39277093

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200830802T SI2124933T1 (en) 2007-01-22 2008-01-10 Tosylate salt of a therapeutic compound and pharmaceutical compositions thereof

Country Status (25)

Country Link
US (1) US8314139B2 (en)
EP (1) EP2124933B1 (en)
JP (1) JP4585610B2 (en)
KR (1) KR101108109B1 (en)
CN (1) CN101631545B (en)
AR (1) AR064963A1 (en)
AU (1) AU2008208653B2 (en)
BR (1) BRPI0806473A2 (en)
CA (1) CA2676456C (en)
CL (1) CL2008000180A1 (en)
DK (1) DK2124933T3 (en)
ES (1) ES2395744T3 (en)
HK (1) HK1137660A1 (en)
IL (1) IL199587A (en)
MX (1) MX2009007782A (en)
NZ (1) NZ577951A (en)
PE (1) PE20081690A1 (en)
PL (1) PL2124933T3 (en)
PT (1) PT2124933E (en)
RU (1) RU2430099C2 (en)
SI (1) SI2124933T1 (en)
TW (1) TWI358294B (en)
UY (1) UY30878A1 (en)
WO (1) WO2008090429A1 (en)
ZA (1) ZA200905827B (en)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8158673B2 (en) * 2005-10-27 2012-04-17 Pfizer Inc. Histamine-3 receptor antagonists
NZ611323A (en) * 2006-06-23 2014-10-31 Abbvie Bahamas Ltd Cyclopropyl amine derivatives as histamin h3 receptor modulators
US9108948B2 (en) * 2006-06-23 2015-08-18 Abbvie Inc. Cyclopropyl amine derivatives
KR20100075679A (en) 2007-12-07 2010-07-02 화이자 인코포레이티드 Tosylate salt of trans-n-isobutyl-3-fluoro-3-[3-fluoro-4-(pyrrolidin-1-yl-methyl)-phenyl] cyclobutanecarboxamide
US20090221648A1 (en) * 2007-12-21 2009-09-03 Abbott Laboratories Compositions for treatment of cognitive disorders
US8383657B2 (en) * 2007-12-21 2013-02-26 Abbott Laboratories Thiazolylidine urea and amide derivatives and methods of use thereof
US9186353B2 (en) * 2009-04-27 2015-11-17 Abbvie Inc. Treatment of osteoarthritis pain
WO2012037258A1 (en) 2010-09-16 2012-03-22 Abbott Laboratories Processes for preparing 1,2-substituted cyclopropyl derivatives
ES2602794T3 (en) 2011-03-31 2017-02-22 Pfizer Inc Novel bicyclic pyridinones
WO2012172449A1 (en) 2011-06-13 2012-12-20 Pfizer Inc. Lactams as beta secretase inhibitors
WO2013030713A1 (en) 2011-08-31 2013-03-07 Pfizer Inc. Hexahydropyrano [3,4-d][1,3] thiazin-2-amine compounds
ES2426539B1 (en) * 2012-04-18 2014-09-09 Dr Healthcare España, S. L. USE OF DIAMINOOXIDASE FOR THE TREATMENT OR PREVENTION OF THE DISORDER FOR DEFICIT OF CARE WITH HYPERACTIVITY (ADHD)
JP6110937B2 (en) 2012-05-04 2017-04-05 ファイザー・インク Heterocyclic substituted hexahydropyrano [3,4-d] [1,3] thiazin-2-amine compounds as inhibitors of APP, BACE1, and BACE2
AP3902A (en) 2012-06-29 2016-11-17 Pfizer Novel 4-(substituted-amino)-7H-pyrrolo[2,3-d]pyrimidines as LRRK2 inhibitors
US9260455B2 (en) 2012-09-20 2016-02-16 Pfizer Inc. Alkyl-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
UA110688C2 (en) 2012-09-21 2016-01-25 Пфайзер Інк. Bicyclic pirydynony
CN103113405B (en) * 2012-10-17 2016-03-02 上海日馨生物科技有限公司 Benfotiamine polymorphs body, preparation method and application thereof
CA2891122C (en) 2012-11-14 2021-07-20 The Johns Hopkins University Methods and compositions for treating schizophrenia
JP2016502978A (en) 2012-12-11 2016-02-01 ファイザー・インク Hexahydropyrano [3,4-d] [1,3] thiazin-2-amine compounds as inhibitors of BACE1
JP6162820B2 (en) 2012-12-19 2017-07-12 ファイザー・インク Carbocyclic and heterocyclic substituted hexahydropyrano [3,4-d] [1,3] thiazin-2-amine compounds
CA2897678A1 (en) 2013-02-13 2014-08-21 Pfizer Inc. Heteroaryl-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
US9233981B1 (en) 2013-02-15 2016-01-12 Pfizer Inc. Substituted phenyl hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
CN105121439A (en) 2013-02-19 2015-12-02 辉瑞公司 Azabenzimidazole compounds as inhibitors of pde4 isozymes for the treatment of cns and other disorders
EP3052495B1 (en) 2013-10-04 2019-06-26 Pfizer Inc Novel bicyclic pyridinones as gamma-secretase modulators
EP3083618B1 (en) 2013-12-17 2018-02-21 Pfizer Inc Novel 3,4-disubstituted-1h-pyrrolo[2,3-b]pyridines and 4,5-disubstituted-7h-pyrrolo[2,3-c]pyridazines as lrrk2 inhibitors
JP6643247B2 (en) 2014-04-01 2020-02-12 ファイザー・インク Chromene and 1,1a, 2,7B-tetrahydrocyclopropa [C] chromenpyridopyrazinedione as gamma secretase modulator
CN106459088A (en) 2014-04-10 2017-02-22 辉瑞公司 2-amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8h)-yl-1,3-thiazol-4-yl amides
WO2016012896A1 (en) 2014-07-24 2016-01-28 Pfizer Inc. Pyrazolopyrimidine compounds
HUE044040T2 (en) 2014-08-06 2019-09-30 Pfizer Imidazopyridazine compounds
MX368391B (en) 2015-02-03 2019-09-30 Pfizer Novel cyclopropabenzofuranyl pyridopyrazinediones.
US11472805B2 (en) 2015-06-17 2022-10-18 Pfizer, Inc. Tricyclic compounds and their use as phosphodiesterase inhibitors
JP6873980B2 (en) 2015-09-14 2021-05-19 ファイザー・インク Novel imidazole [4,5-c] quinoline and imidazole [4,5-c] [1,5] naphthylidine derivatives as LRRK2 inhibitors
WO2017051294A1 (en) 2015-09-24 2017-03-30 Pfizer Inc. N-[2-(3-amino-2,5-dimethyl-1,1-dioxido-5,6-dihydro-2h-1,2,4-thiadiazin-5-yl)-1,3-thiazol-4-yl] amides useful as bace inhibitors
EP3353183A1 (en) 2015-09-24 2018-08-01 Pfizer Inc N-[2-(2-amino-6,6-disubstituted-4, 4a, 5, 6-tetrahydropyrano [3,4-d][1,3]thiazin-8a (8h)-yl) -1, 3-thiazol-4-yl]amides
EP3353182A1 (en) 2015-09-24 2018-08-01 Pfizer Inc Tetrahydropyrano[3,4-d][1,3]oxazin derivatives and their use as bace inhibitors
ES2775674T3 (en) 2016-02-23 2020-07-27 Pfizer 6,7-Dihydro-5H-Pyrazolo [5,1-b] [1,3] Oxazine-2-Carboxamide Compounds
JP7046018B2 (en) 2016-07-01 2022-04-01 ファイザー・インク 5,7-Dihydropyrrolopyridine derivative for treating neurological and neurodegenerative diseases
JP2020514343A (en) 2017-03-10 2020-05-21 ファイザー・インク Cyclic substituted imidazo [4,5-c] quinoline derivative
SG10202110112TA (en) 2017-03-10 2021-10-28 Pfizer Novel imidazo[4,5-c]quinoline derivatives as lrrk2 inhibitors
US20230137562A1 (en) 2017-06-07 2023-05-04 Adrx, Inc. Tau aggregation inhibitors
FI3642202T3 (en) 2017-06-22 2023-03-01 Dihydro-pyrrolo-pyridine derivatives
AU2018318319A1 (en) 2017-08-18 2020-02-20 Adrx, Inc. Tau aggregation peptide inhibitors
DK3768669T3 (en) 2018-03-23 2023-04-24 Pfizer Piperazinazaspiro derivatives

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6559140B2 (en) 2000-03-09 2003-05-06 Abbott Laboratories Cyclic and bicyclic diamino histamine-3 receptor antagonists
CA2555071A1 (en) * 2004-02-02 2005-09-01 Pfizer Products Inc. Histamine-3 receptor modulators
US8158673B2 (en) 2005-10-27 2012-04-17 Pfizer Inc. Histamine-3 receptor antagonists
KR20100075679A (en) 2007-12-07 2010-07-02 화이자 인코포레이티드 Tosylate salt of trans-n-isobutyl-3-fluoro-3-[3-fluoro-4-(pyrrolidin-1-yl-methyl)-phenyl] cyclobutanecarboxamide

Also Published As

Publication number Publication date
TW200838499A (en) 2008-10-01
MX2009007782A (en) 2009-07-31
EP2124933A1 (en) 2009-12-02
NZ577951A (en) 2012-02-24
KR20090101948A (en) 2009-09-29
JP2010516749A (en) 2010-05-20
US8314139B2 (en) 2012-11-20
UY30878A1 (en) 2009-08-31
PT2124933E (en) 2013-01-07
JP4585610B2 (en) 2010-11-24
PE20081690A1 (en) 2008-11-28
RU2430099C2 (en) 2011-09-27
KR101108109B1 (en) 2012-02-06
CL2008000180A1 (en) 2008-08-01
BRPI0806473A2 (en) 2011-09-27
IL199587A (en) 2014-06-30
RU2009124541A (en) 2011-02-27
CA2676456A1 (en) 2008-07-31
ZA200905827B (en) 2010-05-26
AR064963A1 (en) 2009-05-06
ES2395744T3 (en) 2013-02-14
PL2124933T3 (en) 2013-02-28
IL199587A0 (en) 2010-03-28
US20080176925A1 (en) 2008-07-24
WO2008090429A1 (en) 2008-07-31
EP2124933B1 (en) 2012-10-17
CN101631545B (en) 2013-03-13
CA2676456C (en) 2012-03-27
DK2124933T3 (en) 2012-11-19
AU2008208653B2 (en) 2012-11-22
HK1137660A1 (en) 2010-08-06
TWI358294B (en) 2012-02-21
CN101631545A (en) 2010-01-20
AU2008208653A1 (en) 2008-07-31

Similar Documents

Publication Publication Date Title
HK1137660A1 (en) Tosylate salt of a therapeutic compound and pharmaceutical compositions thereof
ZA200900347B (en) Preparation of pharmaceutical compositions
IL199853A (en) Substituted derivatives of 5-hydroxy-adamantyl-2-yl and pharmaceutical compositions comprising them
EP2150109A4 (en) Pharmaceutical use of substituted amides
IL195237A0 (en) Conjugates of aziridinyl-epothilone analogs and pharmaceutical compositions comprising same
EP2291157A4 (en) Compositions and methods for the transdermal delivery of pharmaceutical compounds
ZA201002547B (en) Heterocyclic compound and pharmaceutical composition thereof
EP2168944A4 (en) Amine compound and pharmaceutical use thereof
AP2627A (en) New form of administration of racecadotril
AP2920A (en) Anti-malarial pharmaceutical composition
HK1181389A1 (en) Pharmaceutical composition comprising amide derivative or pharmaceutically acceptable salt thereof
PL2121025T3 (en) Methods and compositions for the delivery of a therapeutic agent
EP2114374A4 (en) Pharmaceutical compositions of entacapone
GB0716907D0 (en) Pharmaceutical powder compositions
GB0623897D0 (en) Pharmaceutical composition of memantine
IL202766A0 (en) Pharmaceutical combination of opioid and prostaglandin compound
PL2195006T3 (en) Use of a biphaline analog as an analgesic pharmaceutical agent
GB0619891D0 (en) Pharmaceutical composition of risedronate
HUP0700096A2 (en) Homeopathic pharmaceutical compositions