SI2046716T1 - Substituted 1,3-diphenylpropane derivatives, preparations and uses thereof - Google Patents

Substituted 1,3-diphenylpropane derivatives, preparations and uses thereof

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Publication number
SI2046716T1
SI2046716T1 SI200731347T SI200731347T SI2046716T1 SI 2046716 T1 SI2046716 T1 SI 2046716T1 SI 200731347 T SI200731347 T SI 200731347T SI 200731347 T SI200731347 T SI 200731347T SI 2046716 T1 SI2046716 T1 SI 2046716T1
Authority
SI
Slovenia
Prior art keywords
preparations
substituted
diphenylpropane derivatives
diphenylpropane
derivatives
Prior art date
Application number
SI200731347T
Other languages
Slovenian (sl)
Inventor
Jean-Francois Delhomel
Remy Hanf
Karine Caumont-Bertrand
Original Assignee
Genfit Parck Eurosante - Lille Metropole
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genfit Parck Eurosante - Lille Metropole filed Critical Genfit Parck Eurosante - Lille Metropole
Publication of SI2046716T1 publication Critical patent/SI2046716T1/en

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    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/84—Unsaturated compounds containing keto groups containing six membered aromatic rings
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    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
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    • C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/48—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
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    • C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
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    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/45—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms doubly-bound to the carbon skeleton
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    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
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    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
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    • C07C59/40—Unsaturated compounds
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    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers
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    • C07C69/734—Ethers
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
SI200731347T 2006-06-21 2007-06-21 Substituted 1,3-diphenylpropane derivatives, preparations and uses thereof SI2046716T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0605540A FR2902789A1 (en) 2006-06-21 2006-06-21 SUBSTITUTED 1,3-DIPHENYLPROPANE DERIVATIVES, PREPARATIONS AND USES
EP07786798.4A EP2046716B1 (en) 2006-06-21 2007-06-21 Substituted 1,3-diphenylpropane derivatives, preparations and uses thereof
PCT/EP2007/056225 WO2007147880A1 (en) 2006-06-21 2007-06-21 Substituted 1,3-diphenylpropane derivatives, preparations and uses thereof

Publications (1)

Publication Number Publication Date
SI2046716T1 true SI2046716T1 (en) 2014-02-28

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Family Applications (2)

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SI200731347T SI2046716T1 (en) 2006-06-21 2007-06-21 Substituted 1,3-diphenylpropane derivatives, preparations and uses thereof
SI200731453T SI2046715T1 (en) 2006-06-21 2007-06-21 Substituted 1,3-diphenylpropane derivatives, preparations and uses thereof

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SI200731453T SI2046715T1 (en) 2006-06-21 2007-06-21 Substituted 1,3-diphenylpropane derivatives, preparations and uses thereof

Country Status (22)

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US (2) US8258182B2 (en)
EP (2) EP2046715B1 (en)
JP (2) JP5350230B2 (en)
KR (2) KR101416262B1 (en)
CN (3) CN104193660B (en)
AU (2) AU2007262938B2 (en)
BR (1) BRPI0713600B1 (en)
CA (2) CA2655744C (en)
CY (2) CY1115082T1 (en)
DK (2) DK2046715T5 (en)
EA (1) EA018437B1 (en)
ES (2) ES2434071T3 (en)
FR (1) FR2902789A1 (en)
IL (2) IL196071A0 (en)
MX (1) MX2008016239A (en)
NO (1) NO341866B1 (en)
NZ (1) NZ573674A (en)
PL (2) PL2046716T3 (en)
PT (2) PT2046716E (en)
SI (2) SI2046716T1 (en)
WO (2) WO2007147880A1 (en)
ZA (1) ZA200810709B (en)

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FR2902789A1 (en) * 2006-06-21 2007-12-28 Genfit Sa SUBSTITUTED 1,3-DIPHENYLPROPANE DERIVATIVES, PREPARATIONS AND USES
FR2917084B1 (en) * 2007-06-05 2009-07-17 Galderma Res & Dev NOVEL 3-PHENYL PROPANOIC ACID DERIVATIVES OF PPAR-TYPE RECEPTORS, THEIR METHOD OF PREPARATION AND THEIR USE IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS
US9221751B2 (en) 2009-11-26 2015-12-29 Genfit Use of 1,3-diphenylprop-2-en-1-one derivatives for treating liver disorders
CN102647982B (en) * 2009-11-26 2014-10-15 基恩菲特公司 Use of 1,3-diphenylprop-2-en-1-one derivatives for treating liver disorders
US10722575B2 (en) 2009-11-26 2020-07-28 Genfit Use of 1,3-diphenylprop-2-en-1-one derivatives for treating liver disorders
WO2011080276A1 (en) 2009-12-29 2011-07-07 Genfit Pharmaceutical combinations comprising a dpp-4 inhibitor and a 1,3-diphenylprop-2-en-1-one derivative
NZ603371A (en) 2010-05-17 2013-12-20 Genfit Improved preparation of chalcone derivatives
EP2593426B1 (en) * 2010-07-12 2014-08-20 F.Hoffmann-La Roche Ag 1-hydroxyimino-3-phenyl-propanes
EP2780330B1 (en) * 2011-11-14 2016-01-06 F.Hoffmann-La Roche Ag 1-pyridazinyl-hydroxyimino- 3- phenyl- propanes as gpbar1 agonists
KR102023667B1 (en) * 2011-12-28 2019-09-23 장피트 1,3-diphenylpropane derivatives, preparations and uses thereof
EP3416629A4 (en) * 2016-02-16 2019-08-07 CoNCERT Pharmaceuticals, Inc. Deuterated gft-505
IT201600098338A1 (en) * 2016-09-30 2018-03-30 Univ Degli Studi Padova COMPOUNDS 1-PHENYLPROPANONE AND THEIR USE
RU186145U1 (en) * 2018-08-08 2019-01-11 Общество с ограниченной ответственностью "Научно-производственное объединение "Центротех" (ООО "НПО "Центротех") Vibrating frame vibrating screen
US11634387B2 (en) 2019-09-26 2023-04-25 Abionyx Pharma Sa Compounds useful for treating liver diseases
BR112022015800A2 (en) 2020-02-10 2022-10-11 Genfit TREATMENT OF PRIMARY BILIARY CHOLANGITIS WITH ELAFIBRANOR
CN114901641A (en) * 2020-02-28 2022-08-12 四川科伦博泰生物医药股份有限公司 Aromatic compound and pharmaceutical composition and application thereof
MX2022014364A (en) 2020-05-18 2022-12-15 Genfit Elafibranor for the treatment of primary sclerosing cholangitis.
MX2023002159A (en) 2020-08-26 2023-03-01 Genfit Compositions and methods for the treatment of primary biliary cholangitis.
WO2022238450A1 (en) 2021-05-11 2022-11-17 Genfit Ppar-agonists for use in the treatment of liver failure
WO2022238448A1 (en) 2021-05-11 2022-11-17 Genfit Elafibranor derivatives agonists of ppar for use in the treatment of sepsis

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