SI1819331T1 - Kombinacije, ki obsegajo epotilone in inhibitorje protein-tirozin-kimaze, in njihove farmacevtske uporabe - Google Patents

Kombinacije, ki obsegajo epotilone in inhibitorje protein-tirozin-kimaze, in njihove farmacevtske uporabe

Info

Publication number
SI1819331T1
SI1819331T1 SI200530886T SI200530886T SI1819331T1 SI 1819331 T1 SI1819331 T1 SI 1819331T1 SI 200530886 T SI200530886 T SI 200530886T SI 200530886 T SI200530886 T SI 200530886T SI 1819331 T1 SI1819331 T1 SI 1819331T1
Authority
SI
Slovenia
Prior art keywords
tyrosine kinase
protein tyrosine
epothilones
combinations
kinase inhibitors
Prior art date
Application number
SI200530886T
Other languages
English (en)
Inventor
Jerry Min-Jian Huang
Anandhi Ranganathan Johri
Ronald Richard Linnartz
Paul M J Mcsheehy
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36118322&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI1819331(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of SI1819331T1 publication Critical patent/SI1819331T1/sl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
SI200530886T 2004-11-30 2005-11-28 Kombinacije, ki obsegajo epotilone in inhibitorje protein-tirozin-kimaze, in njihove farmacevtske uporabe SI1819331T1 (sl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63183704P 2004-11-30 2004-11-30
EP05852316A EP1819331B1 (en) 2004-11-30 2005-11-28 Combinations comprising epothilones and protein tyrosine kinase inhibitors and pharmaceutical uses thereof

Publications (1)

Publication Number Publication Date
SI1819331T1 true SI1819331T1 (sl) 2010-02-26

Family

ID=36118322

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200530886T SI1819331T1 (sl) 2004-11-30 2005-11-28 Kombinacije, ki obsegajo epotilone in inhibitorje protein-tirozin-kimaze, in njihove farmacevtske uporabe

Country Status (29)

Country Link
US (2) US20080139587A1 (sl)
EP (1) EP1819331B1 (sl)
JP (1) JP2008521826A (sl)
KR (1) KR20070088653A (sl)
CN (1) CN101065127A (sl)
AT (1) ATE445398T1 (sl)
AU (1) AU2005312061B2 (sl)
BR (1) BRPI0518733A2 (sl)
CA (1) CA2584163A1 (sl)
CY (1) CY1110559T1 (sl)
DE (1) DE602005017181D1 (sl)
DK (1) DK1819331T3 (sl)
ES (1) ES2333348T3 (sl)
HK (1) HK1109059A1 (sl)
HR (1) HRP20100012T1 (sl)
IL (1) IL183138A (sl)
JO (1) JO2596B1 (sl)
MA (1) MA29032B1 (sl)
MX (1) MX2007006371A (sl)
NO (1) NO20073370L (sl)
NZ (1) NZ554552A (sl)
PL (1) PL1819331T3 (sl)
PT (1) PT1819331E (sl)
RU (1) RU2423980C2 (sl)
SI (1) SI1819331T1 (sl)
TN (1) TNSN07212A1 (sl)
TW (1) TW200630091A (sl)
WO (1) WO2006060331A1 (sl)
ZA (1) ZA200703196B (sl)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2503888A4 (en) 2009-11-23 2015-07-29 Cerulean Pharma Inc POLYMERS ON CYCLODEXTRINBASIS FOR THERAPEUTIC ADMINISTRATION
WO2011090940A1 (en) 2010-01-19 2011-07-28 Cerulean Pharma Inc. Cyclodextrin-based polymers for therapeutic delivery
AU2011255647A1 (en) 2010-05-18 2012-11-15 Cerulean Pharma Inc. Compositions and methods for treatment of autoimmune and other diseases
CN102134246A (zh) * 2011-01-06 2011-07-27 王文怡 一种埃博霉素衍生物及其制备和药物应用
US20130178520A1 (en) 2011-12-23 2013-07-11 Duke University Methods of treatment using arylcyclopropylamine compounds
EP2879675B1 (en) 2012-08-06 2019-11-13 Duke University Compounds and methods for targeting hsp90
WO2015148714A1 (en) 2014-03-25 2015-10-01 Duke University Heat shock protein 70 (hsp-70) receptor ligands
WO2017184956A1 (en) 2016-04-22 2017-10-26 Duke University Compounds and methods for targeting hsp90
US10927083B2 (en) 2016-09-29 2021-02-23 Duke University Substituted benzimidazoles as inhibitors of transforming growth factor-β kinase
US10207998B2 (en) 2016-09-29 2019-02-19 Duke University Substituted benzimidazole and substituted benzothiazole inhibitors of transforming growth factor-β kinase and methods of use thereof
EP3826988A4 (en) 2018-07-24 2023-03-22 Hygia Pharmaceuticals, LLC COMPOUNDS, DERIVATIVES AND ANALOGS AGAINST CANCER
WO2021185844A1 (en) 2020-03-16 2021-09-23 Pvac Medical Technologies Ltd Use of substance and pharmaceutical composition thereof, and medical treatments or uses thereof
WO2021233534A1 (en) 2020-05-20 2021-11-25 Pvac Medical Technologies Ltd Use of substance and pharmaceutical composition thereof, and medical treatments or uses thereof
US20230285576A1 (en) 2020-08-05 2023-09-14 Ellipses Pharma Ltd Treatment of cancer using a cyclodextrin-containing polymer-topoisomerase inhibitor conjugate and a parp inhibitor
GB2617409A (en) 2022-04-27 2023-10-11 Cancertain Ltd Method for predicting responsiveness to therapy
WO2024030441A1 (en) 2022-08-02 2024-02-08 National University Corporation Hokkaido University Methods of improving cellular therapy with organelle complexes

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2775187B1 (fr) * 1998-02-25 2003-02-21 Novartis Ag Utilisation de l'epothilone b pour la fabrication d'une preparation pharmaceutique antiproliferative et d'une composition comprenant l'epothilone b comme agent antiproliferatif in vivo
EP1339458B1 (en) * 2000-11-22 2007-08-15 Novartis AG Combination comprising an agent decreasing vegf activity and an agent decreasing egf activity
NZ527764A (en) * 2001-02-27 2006-01-27 Novartis Ag Combination comprising a signal transduction inhibitor and an epothilone derivative
GB0119249D0 (en) * 2001-08-07 2001-10-03 Novartis Ag Organic compounds
CN100506224C (zh) * 2001-10-25 2009-07-01 诺瓦提斯公司 包含选择性环加氧酶-2抑制剂的组合
DE60333754D1 (de) * 2002-06-10 2010-09-23 Novartis Ag Epothilone enthaltende kombinationen und deren pharmazeutische verwendungen
WO2004004644A2 (en) * 2002-07-05 2004-01-15 Beth Israel Deaconess Medical Center Combination of mtor inhibitor and a tyrosine kinase inhibitor for the treatment of neoplasms

Also Published As

Publication number Publication date
AU2005312061B2 (en) 2009-09-03
DK1819331T3 (da) 2010-01-04
JP2008521826A (ja) 2008-06-26
MA29032B1 (fr) 2007-11-01
CA2584163A1 (en) 2006-06-08
PT1819331E (pt) 2009-11-30
PL1819331T3 (pl) 2010-03-31
ES2333348T3 (es) 2010-02-19
US20080139587A1 (en) 2008-06-12
MX2007006371A (es) 2007-06-20
HK1109059A1 (en) 2008-05-30
RU2423980C2 (ru) 2011-07-20
HRP20100012T1 (hr) 2010-02-28
DE602005017181D1 (de) 2009-11-26
TNSN07212A1 (en) 2008-11-21
ATE445398T1 (de) 2009-10-15
EP1819331B1 (en) 2009-10-14
US20110190312A1 (en) 2011-08-04
ZA200703196B (en) 2009-08-26
RU2007124492A (ru) 2009-04-10
CY1110559T1 (el) 2015-04-29
AU2005312061A1 (en) 2006-06-08
BRPI0518733A2 (pt) 2008-12-02
EP1819331A1 (en) 2007-08-22
CN101065127A (zh) 2007-10-31
WO2006060331A1 (en) 2006-06-08
KR20070088653A (ko) 2007-08-29
IL183138A (en) 2011-03-31
IL183138A0 (en) 2008-04-13
NO20073370L (no) 2007-06-29
TW200630091A (en) 2006-09-01
JO2596B1 (en) 2011-02-27
NZ554552A (en) 2011-05-27

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