SG43921A1 - Galanin antagonist - Google Patents

Galanin antagonist

Info

Publication number
SG43921A1
SG43921A1 SG1996005509A SG1996005509A SG43921A1 SG 43921 A1 SG43921 A1 SG 43921A1 SG 1996005509 A SG1996005509 A SG 1996005509A SG 1996005509 A SG1996005509 A SG 1996005509A SG 43921 A1 SG43921 A1 SG 43921A1
Authority
SG
Singapore
Prior art keywords
galanin
pro
antagonist
enkephalin
leu
Prior art date
Application number
SG1996005509A
Inventor
Bo Ahren
Thomas Bartfai
Silvana Consolo
Thomas Hokfelt
Tiit Land
Ulo Langel
Stefan Lindskog
Zsuzsanna Wiesenfeld-Hal-Lin
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of SG43921A1 publication Critical patent/SG43921A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/22—Tachykinins, e.g. Eledoisins, Substance P; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/70—Enkephalins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/18—Kallidins; Bradykinins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

A galanin antagonist which is a galanin receptor ligand is described. Further, new peptides Galanin(1-12)-Pro-Substance P(5-11), Galanin(1-12)-Pro-Bradykinin(2-9), Galanin(1-12)-Pro-Pro-Pro-(Leu<5>-Enkephalin(5-1)), Galanin(1-12)-Pro-Lys( epsilon -NH-)Pro-(Leu<5>-Enkephalin(5-1)) and functional analogues and functional derivates thereof which exhibit substantially the same galanin antagonistic effect as said peptides are disclosed. Use of the galanin antagonist, a pharmaceutical preparation comprising it and a method of treating a disorder in a mammal which depends on the physiological function of galanin at the galanin receptor are also included.
SG1996005509A 1991-05-15 1992-05-14 Galanin antagonist SG43921A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9101472A SE9101472D0 (en) 1991-05-15 1991-05-15 GALANIN ANTAGONIST

Publications (1)

Publication Number Publication Date
SG43921A1 true SG43921A1 (en) 1997-11-14

Family

ID=20382742

Family Applications (1)

Application Number Title Priority Date Filing Date
SG1996005509A SG43921A1 (en) 1991-05-15 1992-05-14 Galanin antagonist

Country Status (24)

Country Link
EP (2) EP0514361A1 (en)
JP (1) JPH06507629A (en)
KR (1) KR100221769B1 (en)
AT (1) ATE149525T1 (en)
AU (1) AU664180B2 (en)
CA (1) CA2109503A1 (en)
CZ (1) CZ242293A3 (en)
DE (2) DE585300T1 (en)
DK (1) DK0585300T3 (en)
EE (1) EE9400346A (en)
ES (1) ES2098510T3 (en)
FI (1) FI935010A (en)
GR (1) GR3023150T3 (en)
HU (1) HUT65810A (en)
IE (1) IE921555A1 (en)
IS (1) IS3866A (en)
NO (1) NO934098D0 (en)
PL (1) PL171497B1 (en)
SE (1) SE9101472D0 (en)
SG (1) SG43921A1 (en)
SI (1) SI9200081B (en)
SK (1) SK127793A3 (en)
WO (1) WO1992020709A1 (en)
YU (1) YU50592A (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL107400A0 (en) * 1992-11-10 1994-01-25 Cortech Inc Bradykinin antagonists
FR2716205B1 (en) * 1994-02-17 1996-04-12 Rhone Poulenc Rorer Sa Galanine receptor, nucleic acids, transformed cells and uses.
ES2112238T1 (en) 1996-01-24 1998-04-01 Synaptic Pharma Corp NUCLEIC ACID.
US5972624A (en) * 1996-01-24 1999-10-26 Synaptic Pharmaceutical Corporation Method of identifying ligands which bind recombinant galanin receptor (GALR2)
PT1342410E (en) 1996-07-24 2010-05-11 Neurotargets Ltd Use of a galanin agonist in the preparation of a medicament for improving memory and other cognitive functions
US6329197B2 (en) 1996-10-09 2001-12-11 Synaptic Pharmaceutical Corporation DNA encoding galanin GALR3 receptors and uses thereof
WO1999005302A1 (en) * 1997-07-24 1999-02-04 The Perkin-Elmer Corporation Conjugates of transporter peptides and nucleic acid analogs, and their use
AU2957099A (en) 1998-03-25 1999-10-18 Takeda Chemical Industries Ltd. Novel physiologically active peptides and utilization thereof
CA2374775A1 (en) * 1999-05-21 2000-11-30 Ortho-Mcneil Pharmaceutical, Inc. 1,4-dithiin and 1,4-dithiepin-1,1,4,4, tetroxide derivatives useful as antagonists of the human galanin receptor
US6407136B1 (en) 1999-05-21 2002-06-18 Ortho-Mcneil Pharmaceutical, Inc. 1,4-dithiin and 1,4-dithiepin-1,1,4,4, tetroxide derivatives useful as antagonists of the human galanin receptor
EP1089439A1 (en) * 1999-09-28 2001-04-04 TELEFONAKTIEBOLAGET L M ERICSSON (publ) Interleaver and method for interleaving an input data bit sequence using a coded storing of symbol and additional information
US7220775B2 (en) 2002-08-07 2007-05-22 H. Lundbeck A/S Compound useful for the treatment of neuropathic pain
WO2006047302A1 (en) 2004-10-21 2006-05-04 Transtech Pharma, Inc. Bissulfonamide compounds as agonists of galr1, compositions, and methods of use
GB0523550D0 (en) 2005-11-18 2005-12-28 Hunter Fleming Ltd Therapeutic uses of steroidal compounds
US8435940B2 (en) 2006-01-05 2013-05-07 University Of Utah Research Foundation Methods and compositions related to improving properties of pharmacological agents targeting nervous system
AU2008361604A1 (en) * 2008-09-09 2010-03-18 Mondobiotech Laboratories Ag Use of a peptide as a therapeutic agent
AU2011343822B2 (en) 2010-12-15 2017-06-29 Neuroadjuvants, Inc. Neuropeptide analogs, compositions, and methods for treating pain
WO2014147129A1 (en) 2013-03-21 2014-09-25 Sanofi-Aventis Deutschland Gmbh Synthesis of cyclic imide containing peptide products
EP2976331B1 (en) 2013-03-21 2017-03-01 Sanofi-Aventis Deutschland GmbH Synthesis of hydantoin containing peptide products
CN110055340B (en) * 2019-04-11 2021-01-01 中国农业大学 Method and kit for rapidly detecting bovine-derived components in food

Also Published As

Publication number Publication date
SE9101472D0 (en) 1991-05-15
ATE149525T1 (en) 1997-03-15
AU664180B2 (en) 1995-11-09
WO1992020709A1 (en) 1992-11-26
SI9200081A (en) 1992-12-31
DE69217937D1 (en) 1997-04-10
AU1785892A (en) 1992-12-30
SI9200081B (en) 2000-08-31
PL171497B1 (en) 1997-05-30
DK0585300T3 (en) 1997-09-01
FI935010A0 (en) 1993-11-12
KR100221769B1 (en) 1999-10-01
GR3023150T3 (en) 1997-07-30
EE9400346A (en) 1996-04-15
EP0514361A1 (en) 1992-11-19
JPH06507629A (en) 1994-09-01
IE921555A1 (en) 1992-11-18
NO934098L (en) 1993-11-12
SK127793A3 (en) 1994-04-06
YU50592A (en) 1994-09-09
NO934098D0 (en) 1993-11-12
ES2098510T3 (en) 1997-05-01
CZ242293A3 (en) 1994-07-13
EP0585300A1 (en) 1994-03-09
IS3866A (en) 1992-11-16
CA2109503A1 (en) 1992-11-16
HUT65810A (en) 1994-07-28
EP0585300B1 (en) 1997-03-05
DE69217937T2 (en) 1997-06-19
DE585300T1 (en) 1994-06-16
FI935010A (en) 1993-11-12

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