SG128403A1 - Tnf-receptors, tnf binding proteins and dnas coding for them - Google Patents

Tnf-receptors, tnf binding proteins and dnas coding for them

Info

Publication number
SG128403A1
SG128403A1 SG1996007006A SG1996007006A SG128403A1 SG 128403 A1 SG128403 A1 SG 128403A1 SG 1996007006 A SG1996007006 A SG 1996007006A SG 1996007006 A SG1996007006 A SG 1996007006A SG 128403 A1 SG128403 A1 SG 128403A1
Authority
SG
Singapore
Prior art keywords
tnf
tnf receptor
binding protein
receptors
binding proteins
Prior art date
Application number
SG1996007006A
Inventor
Rudolf Hauptmann
Adolf Himmler
Ingrid Maurer-Fogy
Christian Stratowa
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of SG128403A1 publication Critical patent/SG128403A1/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

DNA sequences coding for a TNF binding protein and for the TNF receptor of which this protein represents the soluble domain. The DNA sequences can be used for the preparation of recombinant DNA molecules for the production of TNF binding protein and TNF receptor. Recombinant TNF-binding protein is used in pharmaceutical preparations for treating indications in the case of which a detrimental effect of TNF is observed. With the aid of the TNF receptor or fragments thereof, or with the aid of suitable host organisms transformed with' recombinant DNA molecules containing the DNA coding for the TNF receptor, or fragments or modifications thereof, substances can be assayed for their interaction with the TNF receptor and/or their impact on the biological activity of TNF. No suitable figure
SG1996007006A 1989-04-21 1990-04-06 Tnf-receptors, tnf binding proteins and dnas coding for them SG128403A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3913101A DE3913101A1 (en) 1989-04-21 1989-04-21 DNA encoding TNF binding protein and TNF- receptor

Publications (1)

Publication Number Publication Date
SG128403A1 true SG128403A1 (en) 2007-01-30

Family

ID=6379124

Family Applications (1)

Application Number Title Priority Date Filing Date
SG1996007006A SG128403A1 (en) 1989-04-21 1990-04-06 Tnf-receptors, tnf binding proteins and dnas coding for them

Country Status (2)

Country Link
DE (1) DE3913101A1 (en)
SG (1) SG128403A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7264944B1 (en) 1989-04-21 2007-09-04 Amgen Inc. TNF receptors, TNF binding proteins and DNAs coding for them
US6221675B1 (en) 1989-04-21 2001-04-24 Amgen, Inc. TNF receptors, TNF binding proteins and DNAs coding for them
ES2238070T3 (en) * 1989-04-21 2005-08-16 Amgen Inc. TNF RECEPTOR, TNF BINDING PROTEIN AND CODANT DNA FOR THESE.
US6143866A (en) * 1989-07-18 2000-11-07 Amgen, Inc. Tumor necrosis factor (TNF) inhibitor and method for obtaining the same
IL95031A (en) 1989-07-18 2007-03-08 Amgen Inc Method for the production of a human recombinant tumor necrosis factor inhibitor

Also Published As

Publication number Publication date
DE3913101A1 (en) 1990-10-31

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