SG11202111401RA - Methods and compositions for editing rnas - Google Patents
Methods and compositions for editing rnasInfo
- Publication number
- SG11202111401RA SG11202111401RA SG11202111401RA SG11202111401RA SG11202111401RA SG 11202111401R A SG11202111401R A SG 11202111401RA SG 11202111401R A SG11202111401R A SG 11202111401RA SG 11202111401R A SG11202111401R A SG 11202111401RA SG 11202111401R A SG11202111401R A SG 11202111401RA
- Authority
- SG
- Singapore
- Prior art keywords
- compositions
- methods
- rnas
- editing
- editing rnas
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/16—Aptamers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3519—Fusion with another nucleic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
- C12N2310/3521—Methyl
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/531—Stem-loop; Hairpin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/533—Physical structure partially self-complementary or closed having a mismatch or nick in at least one of the strands
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Cell Biology (AREA)
- Mycology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2019082713 | 2019-04-15 | ||
| CN2019129952 | 2019-12-30 | ||
| PCT/CN2020/084922 WO2020211780A1 (en) | 2019-04-15 | 2020-04-15 | Methods and compositions for editing rnas |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202111401RA true SG11202111401RA (en) | 2021-11-29 |
Family
ID=72837012
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202111401RA SG11202111401RA (en) | 2019-04-15 | 2020-04-15 | Methods and compositions for editing rnas |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US20220307020A1 (en) |
| EP (1) | EP3956449A4 (en) |
| JP (1) | JP2022526455A (en) |
| KR (1) | KR20220004674A (en) |
| CN (1) | CN113939591A (en) |
| AU (1) | AU2020259548B2 (en) |
| BR (1) | BR112021020608A8 (en) |
| CA (1) | CA3136735A1 (en) |
| CL (1) | CL2021002695A1 (en) |
| CO (1) | CO2021015214A2 (en) |
| CR (1) | CR20210572A (en) |
| EC (1) | ECSP21080618A (en) |
| IL (1) | IL287248A (en) |
| MX (1) | MX2021012645A (en) |
| PE (1) | PE20212214A1 (en) |
| SG (1) | SG11202111401RA (en) |
| TW (1) | TW202043249A (en) |
| WO (1) | WO2020211780A1 (en) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20220307020A1 (en) | 2019-04-15 | 2022-09-29 | Edigene Inc. | Methods and compositions for editing rnas |
| CN117778385A (en) | 2019-07-12 | 2024-03-29 | 北京大学 | Targeted RNA editing with engineered RNA using endogenous ADAR |
| CN115038789A (en) | 2019-12-02 | 2022-09-09 | 塑造治疗公司 | Therapeutic editing |
| IL294260A (en) * | 2019-12-30 | 2022-08-01 | Edigene Therapeutics Beijing Inc | Method for treating usher syndrome and composition thereof |
| CA3163272A1 (en) * | 2019-12-30 | 2021-07-08 | Pengfei YUAN | Leaper technology based method for treating mps ih and composition |
| KR20220162168A (en) * | 2020-04-15 | 2022-12-07 | 에디진 테라퓨틱스 (베이징) 인크. | Treatment methods and drugs for Hurler syndrome |
| CN113528582B (en) * | 2020-04-15 | 2022-05-17 | 博雅辑因（北京）生物科技有限公司 | Method and medicine for targeted editing of RNA based on LEAPER technology |
| CN116157520A (en) * | 2020-05-26 | 2023-05-23 | 塑造治疗公司 | Compositions and methods for genome editing |
| CN117015605A (en) * | 2021-01-12 | 2023-11-07 | 北京大学 | Targeted RNA editing using engineered RNAs by utilizing endogenous ADAR |
| US20230194709A9 (en) * | 2021-06-29 | 2023-06-22 | Seagate Technology Llc | Range information detection using coherent pulse sets with selected waveform characteristics |
| WO2023020574A1 (en) * | 2021-08-18 | 2023-02-23 | Peking University | Engineered adar-recruiting rnas and methods of use thereof |
| WO2023143539A1 (en) * | 2022-01-28 | 2023-08-03 | Edigene Therapeutics (Beijing) Inc. | Engineered adar-recruiting rnas and methods of use thereof |
| WO2023152371A1 (en) | 2022-02-14 | 2023-08-17 | Proqr Therapeutics Ii B.V. | Guide oligonucleotides for nucleic acid editing in the treatment of hypercholesterolemia |
| WO2024013361A1 (en) | 2022-07-15 | 2024-01-18 | Proqr Therapeutics Ii B.V. | Oligonucleotides for adar-mediated rna editing and use thereof |
| WO2024013360A1 (en) | 2022-07-15 | 2024-01-18 | Proqr Therapeutics Ii B.V. | Chemically modified oligonucleotides for adar-mediated rna editing |
| GB202215614D0 (en) | 2022-10-21 | 2022-12-07 | Proqr Therapeutics Ii Bv | Heteroduplex rna editing oligonucleotide complexes |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK187280A (en) | 1980-04-30 | 1981-10-31 | Novo Industri As | RUIT REDUCING AGENT FOR A COMPLETE LAUNDRY |
| US5773244A (en) | 1993-05-19 | 1998-06-30 | Regents Of The University Of California | Methods of making circular RNA |
| CN103180445B (en) | 2010-10-22 | 2018-02-16 | 库尔纳公司 | IDUA relevant diseases are treated by suppressing the natural antisense transcript of α L iduronases (IDUA) |
| US9650627B1 (en) | 2012-07-19 | 2017-05-16 | University Of Puerto Rico | Site-directed RNA editing |
| WO2015134812A1 (en) | 2014-03-05 | 2015-09-11 | Editas Medicine, Inc. | Crispr/cas-related methods and compositions for treating usher syndrome and retinitis pigmentosa |
| EP3230445B1 (en) | 2014-12-12 | 2024-01-24 | Tod M. Woolf | Compositions and methods for editing nucleic acids in cells utilizing oligonucleotides |
| EP3712269A1 (en) | 2014-12-17 | 2020-09-23 | ProQR Therapeutics II B.V. | Targeted rna editing |
| JP6624743B2 (en) | 2015-07-14 | 2019-12-25 | 学校法人福岡大学 | Site-specific RNA mutagenesis method, target editing guide RNA used therefor, and target RNA-target editing guide RNA complex |
| DE102015012522B3 (en) * | 2015-09-26 | 2016-06-02 | Eberhard Karls Universität Tübingen | Methods and substances for directed RNA editing |
| US10617707B2 (en) | 2016-04-25 | 2020-04-14 | Proqr Therapeutics Ii B.V. | Oligonucleotides to treat eye disease |
| JP7074345B2 (en) * | 2016-06-22 | 2022-05-24 | プロキューアール セラピューティクス ツー ベスローテン フェンノートシャップ | Single-stranded RNA editing oligonucleotide |
| WO2018041873A1 (en) | 2016-09-01 | 2018-03-08 | F. Hoffmann-La Roche Ag | Process for the preparation of (6s)-6-isopropyl-10-methoxy-9-(3-methoxypropoxy)-2-oxo-6,7-dihydrobenzo[a]quinolizine-3-carboxylic acid |
| EP3507366B1 (en) | 2016-09-01 | 2020-10-07 | ProQR Therapeutics II B.V. | Chemically modified single-stranded rna-editing oligonucleotides |
| GB201616202D0 (en) | 2016-09-23 | 2016-11-09 | Proqr Therapeutics Ii Bv | Antisense oligonucleotides for the treatment of eye deisease |
| EP3571300A1 (en) | 2017-01-19 | 2019-11-27 | ProQR Therapeutics II B.V. | Oligonucleotide complexes for use in rna editing |
| JP2020508685A (en) | 2017-03-03 | 2020-03-26 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | RNA targeting of mutations by suppressor tRNA and deaminase |
| CA3062595A1 (en) | 2017-05-10 | 2018-11-15 | The Regents Of The University Of California | Directed editing of cellular rna via nuclear delivery of crispr/cas9 |
| WO2019005886A1 (en) | 2017-06-26 | 2019-01-03 | The Broad Institute, Inc. | Crispr/cas-cytidine deaminase based compositions, systems, and methods for targeted nucleic acid editing |
| CN111511388A (en) | 2017-09-21 | 2020-08-07 | 博德研究所 | Systems, methods, and compositions for targeted nucleic acid editing |
| CN111373041A (en) | 2017-09-26 | 2020-07-03 | 伊利诺伊大学理事会 | CRISPR/CAS systems and methods for genome editing and regulation of transcription |
| WO2019071048A1 (en) | 2017-10-04 | 2019-04-11 | The Broad Institute, Inc. | Systems, methods, and compositions for targeted nucleic acid editing |
| CA3084632A1 (en) | 2017-12-21 | 2019-06-27 | Crispr Therapeutics Ag | Materials and methods for treatment of usher syndrome type 2a |
| US20210079393A1 (en) | 2018-02-14 | 2021-03-18 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for rna editing |
| BR112020019079A2 (en) | 2018-03-23 | 2020-12-29 | Massachusetts Eye And Ear Infirmary | CRISPR / CAS9 MEDIUM JUMP APPROACH FOR USHER SYNDROME ASSOCIATED WITH USH2A |
| US20220073915A1 (en) * | 2018-06-29 | 2022-03-10 | Eberhard-Karls-Universität-Tübingen | Artificial nucleic acids for rna editing |
| CA3110998A1 (en) | 2018-09-06 | 2020-03-12 | The Regents Of The University Of California | Rna and dna base editing via engneered adar recruitment |
| CN113631708B (en) | 2018-10-12 | 2022-05-24 | 北京大学 | Methods and compositions for editing RNA |
| JP7144618B2 (en) | 2018-12-20 | 2022-09-29 | 北京大学 | Compositions and methods for efficient genetic screening using barcoded guide RNA constructs |
| EP3924484A1 (en) | 2019-02-13 | 2021-12-22 | Beam Therapeutics, Inc. | Methods of editing a disease-associated gene using adenosine deaminase base editors, including for the treatment of genetic disease |
| CN109943586B (en) | 2019-03-15 | 2021-02-26 | 上海交通大学 | Plant circRNA overexpression vector and construction method thereof |
| US20220307020A1 (en) | 2019-04-15 | 2022-09-29 | Edigene Inc. | Methods and compositions for editing rnas |
| AU2020265060A1 (en) | 2019-04-30 | 2021-12-16 | Edigene (Guangzhou) Inc. | Method for predicting effectiveness of treatment of hemoglobinopathy |
| CN117778385A (en) | 2019-07-12 | 2024-03-29 | 北京大学 | Targeted RNA editing with engineered RNA using endogenous ADAR |
| AU2020342207A1 (en) | 2019-09-04 | 2022-04-21 | Edigene (Guangzhou) Inc. | Method for evaluating gene editing therapy based on off-target assessment |
| KR20220116508A (en) | 2019-12-16 | 2022-08-23 | 에디진 (광저우) 인크. | Low molecular weight compounds and combinations thereof for amplification of hematopoietic stem cells |
| CA3163272A1 (en) | 2019-12-30 | 2021-07-08 | Pengfei YUAN | Leaper technology based method for treating mps ih and composition |
| IL294260A (en) | 2019-12-30 | 2022-08-01 | Edigene Therapeutics Beijing Inc | Method for treating usher syndrome and composition thereof |
| AU2020417930A1 (en) | 2019-12-31 | 2022-08-18 | Edigene Therapeutics (Beijing) Inc. | New method for targeted editing of RNA |
| DE102020126779A1 (en) | 2020-10-13 | 2022-04-14 | Fritsch Bakery Technologies GmbH & Co. KG | Dough processing machine for processing products |
| CN117015605A (en) | 2021-01-12 | 2023-11-07 | 北京大学 | Targeted RNA editing using engineered RNAs by utilizing endogenous ADAR |
-
2020
- 2020-04-15 US US17/603,918 patent/US20220307020A1/en active Pending
- 2020-04-15 JP JP2021561885A patent/JP2022526455A/en active Pending
- 2020-04-15 TW TW109112632A patent/TW202043249A/en unknown
- 2020-04-15 CN CN202080029167.4A patent/CN113939591A/en active Pending
- 2020-04-15 AU AU2020259548A patent/AU2020259548B2/en active Active
- 2020-04-15 KR KR1020217037218A patent/KR20220004674A/en not_active Application Discontinuation
- 2020-04-15 BR BR112021020608A patent/BR112021020608A8/en unknown
- 2020-04-15 PE PE2021001716A patent/PE20212214A1/en unknown
- 2020-04-15 SG SG11202111401RA patent/SG11202111401RA/en unknown
- 2020-04-15 WO PCT/CN2020/084922 patent/WO2020211780A1/en unknown
- 2020-04-15 CA CA3136735A patent/CA3136735A1/en active Pending
- 2020-04-15 EP EP20792124.8A patent/EP3956449A4/en active Pending
- 2020-04-15 CR CR20210572A patent/CR20210572A/en unknown
- 2020-04-15 MX MX2021012645A patent/MX2021012645A/en unknown
-
2021
- 2021-10-13 IL IL287248A patent/IL287248A/en unknown
- 2021-10-14 US US17/501,954 patent/US11702658B2/en active Active
- 2021-10-14 CL CL2021002695A patent/CL2021002695A1/en unknown
- 2021-11-11 CO CONC2021/0015214A patent/CO2021015214A2/en unknown
- 2021-11-15 EC ECSENADI202180618A patent/ECSP21080618A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2021012645A (en) | 2021-11-12 |
| CR20210572A (en) | 2022-04-07 |
| ECSP21080618A (en) | 2021-12-30 |
| US20220307020A1 (en) | 2022-09-29 |
| CO2021015214A2 (en) | 2022-02-07 |
| AU2020259548A1 (en) | 2021-12-09 |
| KR20220004674A (en) | 2022-01-11 |
| IL287248A (en) | 2021-12-01 |
| US20220098587A1 (en) | 2022-03-31 |
| CA3136735A1 (en) | 2020-10-22 |
| BR112021020608A2 (en) | 2022-02-22 |
| EP3956449A1 (en) | 2022-02-23 |
| EP3956449A4 (en) | 2023-03-29 |
| AU2020259548B2 (en) | 2023-10-12 |
| CL2021002695A1 (en) | 2022-07-01 |
| PE20212214A1 (en) | 2021-11-19 |
| TW202043249A (en) | 2020-12-01 |
| US11702658B2 (en) | 2023-07-18 |
| WO2020211780A1 (en) | 2020-10-22 |
| BR112021020608A8 (en) | 2023-03-21 |
| CN113939591A (en) | 2022-01-14 |
| JP2022526455A (en) | 2022-05-24 |
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