SG11202110607WA - Adeno-associated virus with engineered capsid - Google Patents
Adeno-associated virus with engineered capsidInfo
- Publication number
- SG11202110607WA SG11202110607WA SG11202110607WA SG11202110607WA SG11202110607WA SG 11202110607W A SG11202110607W A SG 11202110607WA SG 11202110607W A SG11202110607W A SG 11202110607WA SG 11202110607W A SG11202110607W A SG 11202110607WA SG 11202110607W A SG11202110607W A SG 11202110607WA
- Authority
- SG
- Singapore
- Prior art keywords
- adeno
- associated virus
- engineered capsid
- capsid
- engineered
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1055—Protein x Protein interaction, e.g. two hybrid selection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0657—Cardiomyocytes; Heart cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14145—Special targeting system for viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14171—Demonstrated in vivo effect
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Cell Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962827576P | 2019-04-01 | 2019-04-01 | |
US202062984197P | 2020-03-02 | 2020-03-02 | |
PCT/US2020/026009 WO2020205889A1 (en) | 2019-04-01 | 2020-03-31 | Adeno-associated virus with engineered capsid |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202110607WA true SG11202110607WA (en) | 2021-10-28 |
Family
ID=72666396
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202110607WA SG11202110607WA (en) | 2019-04-01 | 2020-03-31 | Adeno-associated virus with engineered capsid |
Country Status (10)
Country | Link |
---|---|
US (2) | US20220154217A1 (de) |
EP (1) | EP3947700A4 (de) |
JP (1) | JP2022527199A (de) |
KR (1) | KR20210148232A (de) |
CN (1) | CN114450411A (de) |
AU (1) | AU2020253435A1 (de) |
CA (1) | CA3135609A1 (de) |
IL (1) | IL286831A (de) |
SG (1) | SG11202110607WA (de) |
WO (1) | WO2020205889A1 (de) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2751592C2 (ru) * | 2019-08-22 | 2021-07-15 | Общество С Ограниченной Ответственностью "Анабион" | Выделенный модифицированный белок VP1 капсида аденоассоциированного вируса 5 серотипа (AAV5), капсид и вектор на его основе |
PE20230767A1 (es) | 2020-05-13 | 2023-05-09 | Voyager Therapeutics Inc | Redireccion del tropismo de las capsides de aav |
US11781156B2 (en) | 2020-10-09 | 2023-10-10 | Tenaya Therapeutics, Inc. | Plakophillin-2 gene therapy methods and compositions |
AU2021358069A1 (en) * | 2020-10-09 | 2023-06-08 | Tenaya Therapeutics, Inc. | Plakophillin-2 gene therapy methods and compositions |
AU2022401548A1 (en) * | 2021-12-01 | 2024-07-04 | Shape Therapeutics Inc. | Functional aav capsids for systemic administration |
CA3240616A1 (en) * | 2021-12-10 | 2023-06-15 | Christopher Dean HERZOG | Troponin c (tnnc1) gene therapy using aav vector |
WO2023230464A2 (en) * | 2022-05-23 | 2023-11-30 | New York University | A murine model to test the effect of pkp2 mutations on living adult hearts and uses thereof |
TW202417467A (zh) * | 2022-06-28 | 2024-05-01 | 美商航海家醫療公司 | Aav蛋白殼變異體及其用途 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999061601A2 (en) * | 1998-05-28 | 1999-12-02 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Aav5 vector and uses thereof |
EP3445773B1 (de) * | 2016-05-13 | 2022-12-28 | 4D Molecular Therapeutics Inc. | Adeno-assoziierte virus-kapsidvarianten und verfahren zu deren verwendung |
WO2017201121A1 (en) * | 2016-05-17 | 2017-11-23 | University Of Florida Research Foundation, Inc. | Recombinant aav for gene therapy in lungs |
CA3031071A1 (en) * | 2016-07-18 | 2018-01-25 | Jaan Biotherapeutics, Llc | Compositions and methods for treatment of cardiac diseases |
WO2018222503A1 (en) * | 2017-05-31 | 2018-12-06 | The Regents Of The University Of California | Adeno-associated virus with variant capsid and methods of use thereof |
WO2019060454A2 (en) * | 2017-09-20 | 2019-03-28 | 4D Molecular Therapeutics Inc. | CAPSID VARIANT ADENO-ASSOCIATED VIRUSES AND METHODS OF USE |
-
2020
- 2020-03-31 CN CN202080036330.XA patent/CN114450411A/zh active Pending
- 2020-03-31 CA CA3135609A patent/CA3135609A1/en active Pending
- 2020-03-31 EP EP20782986.2A patent/EP3947700A4/de active Pending
- 2020-03-31 JP JP2021558819A patent/JP2022527199A/ja active Pending
- 2020-03-31 WO PCT/US2020/026009 patent/WO2020205889A1/en active Application Filing
- 2020-03-31 US US17/599,750 patent/US20220154217A1/en active Pending
- 2020-03-31 KR KR1020217035010A patent/KR20210148232A/ko unknown
- 2020-03-31 AU AU2020253435A patent/AU2020253435A1/en not_active Abandoned
- 2020-03-31 SG SG11202110607WA patent/SG11202110607WA/en unknown
-
2021
- 2021-09-30 IL IL286831A patent/IL286831A/en unknown
-
2023
- 2023-10-24 US US18/493,663 patent/US20240084327A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2020205889A1 (en) | 2020-10-08 |
US20240084327A1 (en) | 2024-03-14 |
EP3947700A4 (de) | 2023-01-04 |
AU2020253435A1 (en) | 2021-11-18 |
EP3947700A1 (de) | 2022-02-09 |
US20220154217A1 (en) | 2022-05-19 |
KR20210148232A (ko) | 2021-12-07 |
CN114450411A (zh) | 2022-05-06 |
JP2022527199A (ja) | 2022-05-31 |
CA3135609A1 (en) | 2020-10-08 |
IL286831A (en) | 2021-12-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL286831A (en) | An adeno-associated virus with an engineered capsid | |
IL263801B1 (en) | Novel adeno-associated virus capsid proteins | |
IL286911A (en) | Recombinant adeno-associated viruses and their uses | |
HK1257480A1 (zh) | 工程病毒 | |
EP4139443A4 (de) | Adeno-assoziiertes virus mit manipuliertem kapsid | |
EP3368054A4 (de) | Regulierbare expression unter verwendung des adeno-assoziierten virus (aav) | |
GB2583614B (en) | Hepatitis B capsid assembly modulators | |
EP3262162A4 (de) | Regulierbare expression unter verwendung des adeno-assoziierten virus (aav) | |
BR112019017762A2 (de) | ||
BR112021017339A2 (de) | ||
IL289489A (en) | A chemically modified adeno-associated virus | |
BR112019016141A2 (de) | ||
IL292625A (en) | Viruses with adapted capsid proteins | |
BR112021017782A2 (de) | ||
AU2020104490A5 (de) | ||
BR112021008711A2 (de) | ||
BR112019016142A2 (de) | ||
BR112019016138A2 (de) | ||
BR112021017728A2 (de) | ||
BR112021017637A2 (de) | ||
BR112021017234A2 (de) | ||
BR112021017355A2 (de) | ||
BR112021017703A2 (de) | ||
BR112021017173A2 (de) | ||
IL290924A (en) | Vaccines for hepatitis b virus |