SG11202109857UA - Muscarinic acetylcholine receptor subtype 4 antagonists in the treatment of anemia - Google Patents

Muscarinic acetylcholine receptor subtype 4 antagonists in the treatment of anemia

Info

Publication number
SG11202109857UA
SG11202109857UA SG11202109857UA SG11202109857UA SG 11202109857U A SG11202109857U A SG 11202109857UA SG 11202109857U A SG11202109857U A SG 11202109857UA SG 11202109857U A SG11202109857U A SG 11202109857UA
Authority
SG
Singapore
Prior art keywords
anemia
antagonists
treatment
acetylcholine receptor
receptor subtype
Prior art date
Application number
Inventor
Abed Yousef Al
Lingbo Zhang
Original Assignee
Cold Spring Harbor Laboratory
Feinstein Institutes For Medical Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cold Spring Harbor Laboratory, Feinstein Institutes For Medical Research filed Critical Cold Spring Harbor Laboratory
Publication of SG11202109857UA publication Critical patent/SG11202109857UA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/472Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
SG11202109857U 2019-03-25 2020-03-20 Muscarinic acetylcholine receptor subtype 4 antagonists in the treatment of anemia SG11202109857UA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962823214P 2019-03-25 2019-03-25
PCT/US2020/023989 WO2020198054A1 (en) 2019-03-25 2020-03-20 Muscarinic acetylcholine receptor subtype 4 antagonists in the treatment of anemia

Publications (1)

Publication Number Publication Date
SG11202109857UA true SG11202109857UA (en) 2021-10-28

Family

ID=72608578

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202109857U SG11202109857UA (en) 2019-03-25 2020-03-20 Muscarinic acetylcholine receptor subtype 4 antagonists in the treatment of anemia

Country Status (12)

Country Link
US (1) US20220185821A1 (en)
EP (1) EP3946321A4 (en)
JP (1) JP2022525293A (en)
KR (1) KR20210144697A (en)
CN (1) CN113613650A (en)
AU (1) AU2020247812A1 (en)
BR (1) BR112021019189A2 (en)
CA (1) CA3132381A1 (en)
IL (1) IL286617A (en)
MX (1) MX2021011588A (en)
SG (1) SG11202109857UA (en)
WO (1) WO2020198054A1 (en)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6500837B2 (en) * 2000-09-22 2002-12-31 Warner-Lambert Company Fused ring system containing indole as M4 selective aza-anthracene muscarinic receptor antagonists
EP2036889A4 (en) * 2006-05-23 2009-11-04 Alla Chem Llc Substituted indoles and a method for the production and use thereof
WO2011113036A2 (en) * 2010-03-12 2011-09-15 Whitehead Institute For Biomedical Research Compositions and methods for expanding bfu-e cells
WO2019010491A1 (en) * 2017-07-07 2019-01-10 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Drug combinations for protecting against neuronal cell death

Also Published As

Publication number Publication date
IL286617A (en) 2021-10-31
KR20210144697A (en) 2021-11-30
WO2020198054A1 (en) 2020-10-01
JP2022525293A (en) 2022-05-12
MX2021011588A (en) 2021-12-15
EP3946321A1 (en) 2022-02-09
EP3946321A4 (en) 2023-03-08
AU2020247812A1 (en) 2021-09-30
CN113613650A (en) 2021-11-05
BR112021019189A2 (en) 2021-11-30
US20220185821A1 (en) 2022-06-16
CA3132381A1 (en) 2020-10-01

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