SG11202109724QA - Compositions and methods for biosynthesis of terpenoids or cannabinoids in a heterologous system - Google Patents

Compositions and methods for biosynthesis of terpenoids or cannabinoids in a heterologous system

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Publication number
SG11202109724QA
SG11202109724QA SG11202109724QA SG11202109724QA SG 11202109724Q A SG11202109724Q A SG 11202109724QA SG 11202109724Q A SG11202109724Q A SG 11202109724QA SG 11202109724Q A SG11202109724Q A SG 11202109724QA
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Singapore
Prior art keywords
cannabinoids
terpenoids
biosynthesis
compositions
methods
Prior art date
Application number
Inventor
Vikramaditya G Yadav
Protiva Roy
Sonal Ayakar
Benson Chang
Eric Hsu
Original Assignee
Inmed Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inmed Pharmaceuticals Inc filed Critical Inmed Pharmaceuticals Inc
Publication of SG11202109724QA publication Critical patent/SG11202109724QA/en

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/21—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
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    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
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    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
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    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/02—Preparation of hydrocarbons or halogenated hydrocarbons acyclic
    • C12P5/026—Unsaturated compounds, i.e. alkenes, alkynes or allenes
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    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
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    • C12Y121/00—Oxidoreductases acting on X-H and Y-H to form an X-Y bond (1.21)
    • C12Y121/03—Oxidoreductases acting on X-H and Y-H to form an X-Y bond (1.21) with oxygen as acceptor (1.21.3)
    • C12Y121/03008—Cannabidiolic acid synthase (1.21.3.8)
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    • C12Y—ENZYMES
    • C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C12Y205/01001—Dimethylallyltranstransferase (2.5.1.1)
    • C—CHEMISTRY; METALLURGY
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    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/07—Nucleotidyltransferases (2.7.7)
    • C12Y207/0706—2-C-Methyl-D-erythritol 4-phosphate cytidylyltransferase (2.7.7.60)
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    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/03—Carbon-oxygen lyases (4.2) acting on phosphates (4.2.3)
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    • C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C12Y205/01102—Geranyl-pyrophosphate—olivetolic acid geranyltransferase (2.5.1.102)

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SG11202109724Q 2019-03-06 2020-03-06 Compositions and methods for biosynthesis of terpenoids or cannabinoids in a heterologous system SG11202109724QA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962814816P 2019-03-06 2019-03-06
US201962814823P 2019-03-06 2019-03-06
PCT/CA2020/050309 WO2020176998A1 (en) 2019-03-06 2020-03-06 Compositions and methods for biosynthesis of terpenoids or cannabinoids in a heterologous system

Publications (1)

Publication Number Publication Date
SG11202109724QA true SG11202109724QA (en) 2021-10-28

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SG11202109724Q SG11202109724QA (en) 2019-03-06 2020-03-06 Compositions and methods for biosynthesis of terpenoids or cannabinoids in a heterologous system

Country Status (10)

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US (1) US20220170056A1 (en)
EP (1) EP3935178A4 (en)
JP (1) JP2022523992A (en)
KR (1) KR20220078526A (en)
CN (1) CN114096671A (en)
AU (1) AU2020230468A1 (en)
CA (1) CA3129314A1 (en)
IL (1) IL286035A (en)
SG (1) SG11202109724QA (en)
WO (1) WO2020176998A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020176547A1 (en) 2019-02-25 2020-09-03 Ginkgo Bioworks, Inc. Biosynthesis of cannabinoids and cannabinoid precursors
CA3129314A1 (en) * 2019-03-06 2020-09-10 Vikramaditya Ganapati Yadav Compositions and methods for biosynthesis of terpenoids or cannabinoids in a heterologous system
US11891640B1 (en) * 2021-01-20 2024-02-06 National Technology & Engineering Solutions Of Sandia, Llc Crop protection in algae by exogenous terpene expression
WO2023064639A1 (en) * 2021-10-15 2023-04-20 Cellibre, Inc. Optimized biosynthesis pathway for cannabinoid biosynthesis

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7422873B2 (en) * 2006-03-31 2008-09-09 E.I. Du Pont De Nemours And Company Mutant carotenoid ketolase
US9512236B2 (en) * 2006-12-19 2016-12-06 Ablynx N.V. Amino acid sequences directed against GPCRS and polypeptides comprising the same for the treatment of GPCR-related diseases and disorders
US20200385715A1 (en) * 2016-05-11 2020-12-10 The Regents Of The University Of Colorado, A Body Corporate Compositions and methods for altering bacteria fitness
CN106148263B (en) * 2016-07-08 2019-05-10 福建师范大学 Hydrogenlike silicon ion bacterial strain and its preparation method and application
WO2018098262A1 (en) * 2016-11-23 2018-05-31 The Regents Of The University Of California G-protein-coupled receptor internal sensors
CN110892075A (en) * 2017-07-12 2020-03-17 生物医学股份有限公司 Production of cannabinoids in yeast
WO2019046941A1 (en) * 2017-09-05 2019-03-14 Inmed Pharmaceuticals Inc. Metabolic engineering of e. coli for the biosynthesis of cannabinoid products
EP3684353A4 (en) * 2017-09-22 2021-06-23 Inmed Pharmaceuticals Inc. Topical formulations of cannabinoids and use thereof in the treatment of pain
US10709763B2 (en) * 2017-12-19 2020-07-14 Gpcr Therapeutics, Inc. GPCR heteromer inhibitors and uses thereof
CA3129314A1 (en) * 2019-03-06 2020-09-10 Vikramaditya Ganapati Yadav Compositions and methods for biosynthesis of terpenoids or cannabinoids in a heterologous system
WO2022241298A2 (en) * 2021-05-14 2022-11-17 Cellibre, Inc. Engineered cells, enzymes, and methods for producing cannabinoids

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Publication number Publication date
KR20220078526A (en) 2022-06-10
EP3935178A4 (en) 2023-03-29
WO2020176998A1 (en) 2020-09-10
JP2022523992A (en) 2022-04-27
CN114096671A (en) 2022-02-25
AU2020230468A1 (en) 2021-10-07
EP3935178A1 (en) 2022-01-12
US20220170056A1 (en) 2022-06-02
IL286035A (en) 2021-10-31
CA3129314A1 (en) 2020-09-10

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