SG11202109522VA - Aromatic derivatives, preparation methods, and medical uses thereof - Google Patents
Aromatic derivatives, preparation methods, and medical uses thereofInfo
- Publication number
- SG11202109522VA SG11202109522VA SG11202109522VA SG11202109522VA SG11202109522VA SG 11202109522V A SG11202109522V A SG 11202109522VA SG 11202109522V A SG11202109522V A SG 11202109522VA SG 11202109522V A SG11202109522V A SG 11202109522VA SG 11202109522V A SG11202109522V A SG 11202109522VA
- Authority
- SG
- Singapore
- Prior art keywords
- preparation methods
- medical uses
- aromatic derivatives
- aromatic
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/CN2019/076926 WO2020177067A1 (en) | 2019-03-05 | 2019-03-05 | Aromatic derivatives, preparation methods, and medical uses thereof |
PCT/CN2020/075849 WO2020177534A1 (en) | 2019-03-05 | 2020-02-19 | Aromatic derivatives, preparation methods, and medical uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202109522VA true SG11202109522VA (en) | 2021-09-29 |
Family
ID=72337401
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202109522VA SG11202109522VA (en) | 2019-03-05 | 2020-02-19 | Aromatic derivatives, preparation methods, and medical uses thereof |
Country Status (9)
Country | Link |
---|---|
US (1) | US11976058B2 (en) |
EP (1) | EP3935048A4 (en) |
JP (1) | JP7470708B2 (en) |
KR (1) | KR20210135558A (en) |
CN (1) | CN111902400A (en) |
CA (1) | CA3132405A1 (en) |
SG (1) | SG11202109522VA (en) |
TW (1) | TW202100514A (en) |
WO (2) | WO2020177067A1 (en) |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2721156B1 (en) | 2011-06-16 | 2016-12-21 | Ionis Pharmaceuticals, Inc. | Antisense modulation of fibroblast growth factor receptor 4 expression |
KR102163776B1 (en) * | 2012-07-11 | 2020-10-12 | 블루프린트 메디신즈 코포레이션 | Inhibitors of the fibroblast growth factor receptor |
AU2014228746B2 (en) | 2013-03-15 | 2018-08-30 | Celgene Car Llc | Heteroaryl compounds and uses thereof |
JP6084292B2 (en) | 2013-07-18 | 2017-02-22 | 大鵬薬品工業株式会社 | FGFR inhibitor resistant cancer therapeutics |
AU2014337291B9 (en) | 2013-10-18 | 2020-05-07 | Eisai R&D Management Co., Ltd. | Pyrimidine FGFR4 inhibitors |
ES2682493T3 (en) | 2013-10-25 | 2018-09-20 | Novartis Ag | Compounds derived from ring-fused bicyclic pyridyl as FGFR4 inhibitors |
JP6458023B2 (en) | 2013-10-25 | 2019-01-23 | ブループリント メディシンズ コーポレイション | Inhibitors of fibroblast growth factor receptor |
WO2015108992A1 (en) | 2014-01-15 | 2015-07-23 | Blueprint Medicines Corporation | Heterobicyclic compounds and their use as fgfr4 receptor inhibitors |
EP3160935B1 (en) | 2014-06-24 | 2021-11-17 | Covestro Intellectual Property GmbH & Co. KG | Method for producing di- and polyamines of the diphenylmethane series |
WO2016064960A1 (en) | 2014-10-22 | 2016-04-28 | Incyte Corporation | Bicyclic heterocycles as fgfr4 inhibitors |
EP3029864B1 (en) | 2014-12-01 | 2020-11-18 | Harman Becker Automotive Systems GmbH | Fast representation of station information in a fm receiver using a single tuner |
WO2016134294A1 (en) * | 2015-02-20 | 2016-08-25 | Incyte Corporation | Bicyclic heterocycles as fgfr4 inhibitors |
MA41551A (en) | 2015-02-20 | 2017-12-26 | Incyte Corp | BICYCLIC HETEROCYCLES USED AS FGFR4 INHIBITORS |
CN113004278B (en) | 2015-02-20 | 2023-07-21 | 因赛特控股公司 | Bicyclic heterocycles as FGFR inhibitors |
CN105906630B (en) | 2015-04-06 | 2018-10-23 | 四川百利药业有限责任公司 | Two substitutional amine-group compounds of N- (1H- pyrazoles -5- bases) pyrimido pyrazoles -4,6- as FGFR inhibitor |
WO2016164703A1 (en) | 2015-04-09 | 2016-10-13 | Eisai R & D Management Co., Ltd. | Fgfr4 inhibitors |
CN107286130A (en) | 2016-04-13 | 2017-10-24 | 成都融科博海科技有限公司 | A kind of Kinase Selectivity inhibitor |
KR102288281B1 (en) * | 2016-12-19 | 2021-08-10 | 아비스코 테라퓨틱스 컴퍼니 리미티드 | FGFR4 inhibitors, methods for their preparation and pharmaceutical applications |
JP7346420B2 (en) * | 2017-09-05 | 2023-09-19 | バイオアーディス エルエルシー | Aromatic derivatives, their preparation methods and their medical applications |
CN109224235B (en) | 2018-10-23 | 2020-05-19 | 孙喜家 | Double-cavity tube |
CN109331654A (en) | 2018-10-26 | 2019-02-15 | 高邮高和光电器材有限公司 | A kind of organic exhaust gas photocatalytic oxidation device |
-
2019
- 2019-03-05 WO PCT/CN2019/076926 patent/WO2020177067A1/en active Application Filing
-
2020
- 2020-02-19 KR KR1020217031713A patent/KR20210135558A/en active Search and Examination
- 2020-02-19 CN CN202080000743.2A patent/CN111902400A/en active Pending
- 2020-02-19 CA CA3132405A patent/CA3132405A1/en active Pending
- 2020-02-19 WO PCT/CN2020/075849 patent/WO2020177534A1/en unknown
- 2020-02-19 EP EP20767365.8A patent/EP3935048A4/en not_active Withdrawn
- 2020-02-19 JP JP2021552591A patent/JP7470708B2/en active Active
- 2020-02-19 SG SG11202109522VA patent/SG11202109522VA/en unknown
- 2020-02-19 US US17/436,476 patent/US11976058B2/en active Active
- 2020-03-05 TW TW109107205A patent/TW202100514A/en unknown
Also Published As
Publication number | Publication date |
---|---|
KR20210135558A (en) | 2021-11-15 |
EP3935048A1 (en) | 2022-01-12 |
JP2022522890A (en) | 2022-04-20 |
US20220169634A1 (en) | 2022-06-02 |
CN111902400A (en) | 2020-11-06 |
US11976058B2 (en) | 2024-05-07 |
WO2020177534A1 (en) | 2020-09-10 |
JP7470708B2 (en) | 2024-04-18 |
CA3132405A1 (en) | 2020-09-10 |
EP3935048A4 (en) | 2022-11-09 |
TW202100514A (en) | 2021-01-01 |
WO2020177067A1 (en) | 2020-09-10 |
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