SG11202108922WA - Piezo type mechanosensitive ion channel component 1 (piezo1) variants and uses thereof - Google Patents

Piezo type mechanosensitive ion channel component 1 (piezo1) variants and uses thereof

Info

Publication number
SG11202108922WA
SG11202108922WA SG11202108922WA SG11202108922WA SG11202108922WA SG 11202108922W A SG11202108922W A SG 11202108922WA SG 11202108922W A SG11202108922W A SG 11202108922WA SG 11202108922W A SG11202108922W A SG 11202108922WA SG 11202108922W A SG11202108922W A SG 11202108922WA
Authority
SG
Singapore
Prior art keywords
piezo1
variants
ion channel
channel component
piezo type
Prior art date
Application number
SG11202108922WA
Inventor
Joshua Backman
Aris Baras
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of SG11202108922WA publication Critical patent/SG11202108922WA/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/192Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/60Salicylic acid; Derivatives thereof
    • A61K31/612Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/14Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1096Processes for the isolation, preparation or purification of DNA or RNA cDNA Synthesis; Subtracted cDNA library construction, e.g. RT, RT-PCR
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6827Hybridisation assays for detection of mutation or polymorphism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Vascular Medicine (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
SG11202108922WA 2019-02-18 2020-02-07 Piezo type mechanosensitive ion channel component 1 (piezo1) variants and uses thereof SG11202108922WA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962806932P 2019-02-18 2019-02-18
US201962862847P 2019-06-18 2019-06-18
PCT/US2020/017267 WO2020171982A1 (en) 2019-02-18 2020-02-07 Piezo type mechanosensitive ion channel component 1 (piezo1) variants and uses thereof

Publications (1)

Publication Number Publication Date
SG11202108922WA true SG11202108922WA (en) 2021-09-29

Family

ID=69771182

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202108922WA SG11202108922WA (en) 2019-02-18 2020-02-07 Piezo type mechanosensitive ion channel component 1 (piezo1) variants and uses thereof

Country Status (13)

Country Link
US (2) US11584966B2 (en)
EP (2) EP3927844B1 (en)
JP (1) JP2022520659A (en)
KR (1) KR20210136038A (en)
CN (1) CN113661252A (en)
AU (1) AU2020225197A1 (en)
CA (1) CA3130320A1 (en)
DK (1) DK3927844T3 (en)
FI (1) FI3927844T3 (en)
IL (1) IL285644A (en)
MX (1) MX2021009983A (en)
SG (1) SG11202108922WA (en)
WO (1) WO2020171982A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3130320A1 (en) 2019-02-18 2020-08-27 Regeneron Pharmaceuticals, Inc. Piezo type mechanosensitive ion channel component 1 (piezo1) variants and uses thereof
US20230041060A1 (en) * 2021-07-08 2023-02-09 Regeneron Pharmaceuticals, Inc. Treatment of Varicose Veins With Piezo Type Mechanosensitive Ion Channel Component 1 (PIEZO1) Agonists
CN115120723B (en) * 2022-05-09 2023-05-26 浙江大学 Application of macrophage Piezo1 knockout in promoting ischemic tissue angiogenesis

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3130320A1 (en) 2019-02-18 2020-08-27 Regeneron Pharmaceuticals, Inc. Piezo type mechanosensitive ion channel component 1 (piezo1) variants and uses thereof

Also Published As

Publication number Publication date
EP4317456A3 (en) 2024-04-24
US20200263252A1 (en) 2020-08-20
AU2020225197A1 (en) 2021-09-16
KR20210136038A (en) 2021-11-16
IL285644A (en) 2021-09-30
EP3927844A1 (en) 2021-12-29
US11584966B2 (en) 2023-02-21
EP3927844B1 (en) 2024-03-27
US20230287502A1 (en) 2023-09-14
CA3130320A1 (en) 2020-08-27
EP4317456A2 (en) 2024-02-07
WO2020171982A1 (en) 2020-08-27
CN113661252A (en) 2021-11-16
MX2021009983A (en) 2021-12-10
DK3927844T3 (en) 2024-06-10
JP2022520659A (en) 2022-03-31
FI3927844T3 (en) 2024-05-27
AU2020225197A8 (en) 2021-10-07

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