SG11202108665PA - Transposon-based modifications of immune cells - Google Patents

Transposon-based modifications of immune cells

Info

Publication number
SG11202108665PA
SG11202108665PA SG11202108665PA SG11202108665PA SG11202108665PA SG 11202108665P A SG11202108665P A SG 11202108665PA SG 11202108665P A SG11202108665P A SG 11202108665PA SG 11202108665P A SG11202108665P A SG 11202108665PA SG 11202108665P A SG11202108665P A SG 11202108665PA
Authority
SG
Singapore
Prior art keywords
transposon
immune cells
based modifications
modifications
immune
Prior art date
Application number
SG11202108665PA
Inventor
Mark Cobbold
Maggie Lee
Jeremy Minshull
Feng Shi
Yifang Shui
Original Assignee
Dna Twopointo Inc
Massachusetts Gen Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dna Twopointo Inc, Massachusetts Gen Hospital filed Critical Dna Twopointo Inc
Publication of SG11202108665PA publication Critical patent/SG11202108665PA/en

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C—CHEMISTRY; METALLURGY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12N2800/90—Vectors containing a transposable element
SG11202108665PA 2019-02-08 2020-02-07 Transposon-based modifications of immune cells SG11202108665PA (en)

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US201962803142P 2019-02-08 2019-02-08
PCT/US2020/017283 WO2020163755A1 (en) 2019-02-08 2020-02-07 Transposon-based modifications of immune cells

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EP (1) EP3920941A4 (en)
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KR (1) KR20220030205A (en)
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AU (1) AU2020218546A1 (en)
CA (1) CA3129263A1 (en)
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KR20230005865A (en) * 2020-05-04 2023-01-10 살리오젠 테라퓨틱스 인코포레이티드 potential-based therapy
WO2022072932A1 (en) * 2020-10-02 2022-04-07 The Regents Of The University Of California Dna constructs for improved t cell immunotherapy of cancer
WO2023081815A1 (en) * 2021-11-04 2023-05-11 Saliogen Therapeutics, Inc. Manufacturing of stem cells
WO2023094527A1 (en) * 2021-11-25 2023-06-01 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Cd95 polypeptides
WO2023150801A2 (en) * 2022-02-07 2023-08-10 Seattle Children's Hospital D/B/A Seattle Children's Research Institute Recombinant proteins that stimulate an immune response in the presence of naturally inhibitory ligand binding
WO2023154968A2 (en) * 2022-02-14 2023-08-17 The Regents Of The University Of California Dna constructs for improved t cell immunotherapy
WO2023178358A2 (en) * 2022-03-18 2023-09-21 Dna Twopointo, Inc. Modification of t cells

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US6143291A (en) * 1995-05-04 2000-11-07 Us Navy Methods for modulating T cell survival by modulating bcl-XL protein level
FR2736931B1 (en) * 1995-07-17 1997-09-19 Univ Paris Curie REGULATORY SEQUENCES ARISING FROM THE CD4 GENE AND WITH SPECIFIC EXPRESSION IN T MATURE LYMPHOCYTES
US10233454B2 (en) * 2014-04-09 2019-03-19 Dna2.0, Inc. DNA vectors, transposons and transposases for eukaryotic genome modification
WO2017061615A1 (en) * 2015-10-08 2017-04-13 国立大学法人名古屋大学 Method for preparing genetically-modified t cells which express chimeric antigen receptor
US11311609B2 (en) * 2017-02-08 2022-04-26 Dana-Farber Cancer Institute, Inc. Regulating chimeric antigen receptors
AU2018236461A1 (en) * 2017-03-17 2019-09-19 Fred Hutchinson Cancer Center Immunomodulatory fusion proteins and uses thereof

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WO2020163755A1 (en) 2020-08-13
WO2020163755A9 (en) 2020-10-08
AU2020218546A1 (en) 2021-09-09
CA3129263A1 (en) 2020-08-13
JP2022521486A (en) 2022-04-08
EP3920941A1 (en) 2021-12-15
KR20220030205A (en) 2022-03-10
US20220170044A1 (en) 2022-06-02
IL285422A (en) 2021-09-30
EP3920941A4 (en) 2023-01-18

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