SG11202108568YA - Dna-binding domain transactivators and uses thereof - Google Patents

Dna-binding domain transactivators and uses thereof

Info

Publication number
SG11202108568YA
SG11202108568YA SG11202108568YA SG11202108568YA SG11202108568YA SG 11202108568Y A SG11202108568Y A SG 11202108568YA SG 11202108568Y A SG11202108568Y A SG 11202108568YA SG 11202108568Y A SG11202108568Y A SG 11202108568YA SG 11202108568Y A SG11202108568Y A SG 11202108568YA
Authority
SG
Singapore
Prior art keywords
transactivators
dna
binding domain
domain
binding
Prior art date
Application number
SG11202108568YA
Inventor
Miguel Esteves
Scot Wolfe
Original Assignee
Univ Massachusetts
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Massachusetts filed Critical Univ Massachusetts
Publication of SG11202108568YA publication Critical patent/SG11202108568YA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases RNAses, DNAses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/71—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
    • C07K2319/81—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor containing a Zn-finger domain for DNA binding
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
SG11202108568YA 2019-02-25 2020-02-24 Dna-binding domain transactivators and uses thereof SG11202108568YA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962810005P 2019-02-25 2019-02-25
PCT/US2020/019546 WO2020176426A1 (en) 2019-02-25 2020-02-24 Dna-binding domain transactivators and uses thereof

Publications (1)

Publication Number Publication Date
SG11202108568YA true SG11202108568YA (en) 2021-09-29

Family

ID=72238705

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202108568YA SG11202108568YA (en) 2019-02-25 2020-02-24 Dna-binding domain transactivators and uses thereof

Country Status (14)

Country Link
US (1) US20220185862A1 (en)
EP (1) EP3931213A4 (en)
JP (1) JP2022521432A (en)
KR (1) KR20210132109A (en)
CN (1) CN113710693A (en)
AU (1) AU2020228028A1 (en)
BR (1) BR112021016294A2 (en)
CA (1) CA3129757A1 (en)
CL (1) CL2021002226A1 (en)
CO (1) CO2021011722A2 (en)
IL (1) IL285687A (en)
MX (1) MX2021010169A (en)
SG (1) SG11202108568YA (en)
WO (1) WO2020176426A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023042104A1 (en) * 2021-09-16 2023-03-23 Novartis Ag Novel transcription factors
WO2023129940A1 (en) * 2021-12-30 2023-07-06 Regel Therapeutics, Inc. Compositions for modulating expression of sodium voltage-gated channel alpha subunit 1 and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030082561A1 (en) * 2000-07-21 2003-05-01 Takashi Sera Zinc finger domain recognition code and uses thereof
EP1631676A4 (en) * 2003-06-10 2006-12-20 Toolgen Inc Transducible dna-binding proteins
CA2796600C (en) * 2010-04-26 2019-08-13 Sangamo Biosciences, Inc. Genome editing of a rosa locus using zinc-finger nucleases
GB201517227D0 (en) * 2015-09-29 2015-11-11 Univ Edinburgh Genetically-edited swine
EP3443081A4 (en) * 2016-04-13 2019-10-30 Duke University Crispr/cas9-based repressors for silencing gene targets in vivo and methods of use
US11730828B2 (en) * 2017-02-07 2023-08-22 The Regents Of The University Of California Gene therapy for haploinsufficiency
TW202315946A (en) * 2017-04-03 2023-04-16 美商編碼製藥公司 Tissue selective transgene expression

Also Published As

Publication number Publication date
BR112021016294A2 (en) 2021-10-13
JP2022521432A (en) 2022-04-07
EP3931213A4 (en) 2022-12-14
CA3129757A1 (en) 2020-09-03
US20220185862A1 (en) 2022-06-16
WO2020176426A1 (en) 2020-09-03
IL285687A (en) 2021-10-31
CL2021002226A1 (en) 2022-04-29
EP3931213A1 (en) 2022-01-05
CN113710693A (en) 2021-11-26
AU2020228028A1 (en) 2021-09-30
MX2021010169A (en) 2021-12-10
CO2021011722A2 (en) 2021-12-10
KR20210132109A (en) 2021-11-03

Similar Documents

Publication Publication Date Title
EP3694187A4 (en) Domain name access method and device
SG11202101675UA (en) Anti-bcma single domain antibodies and application thereof
IL277794A (en) Atf6 inhibitors and uses thereof
EP4036116A4 (en) Anti-vhh domain antibodies and use thereof
SG11202009787VA (en) Modified mitochondria and use thereof
EP4076448A4 (en) Fluoroalkyl-oxadiazoles and uses thereof
PT3621694T (en) Lrrc33 inhibitors and use thereof
SG11202104010PA (en) Rgmc-selective inhibitors and use thereof
PT3712147T (en) Sglts inhibitor and application thereof
ZA202105752B (en) Haloallylamine compounds and application thereof
IL285687A (en) Dna-binding domain transactivators and uses thereof
ZA202102192B (en) Fgfr4 inhibitor and use thereof
EP4063489A4 (en) Composition and use thereof
IL279483A (en) Cyanotriazole compounds and uses thereof
IL277502A (en) Compounds and uses thereof
IL281114A (en) Novel nuclease domain and use thereof
IL277749A (en) Pladienolide compounds and their use
PT3601450T (en) Coating composition and use thereof
GB201803363D0 (en) New materials and uses thereof
EP4006048A4 (en) Novel micropeptide hmmw and application thereof
EP4051270A4 (en) 4-amino-imidazoquinoline compounds and use thereof
GB201906914D0 (en) Substituted naphtahlene diimdes and their use
GB201919187D0 (en) Kits and devices
IL287503A (en) Thiosemicarbazates and uses thereof
GB201815215D0 (en) Composition and use