SG11202108503PA - Arginase inhibitors and methods of use thereof - Google Patents

Arginase inhibitors and methods of use thereof

Info

Publication number
SG11202108503PA
SG11202108503PA SG11202108503PA SG11202108503PA SG11202108503PA SG 11202108503P A SG11202108503P A SG 11202108503PA SG 11202108503P A SG11202108503P A SG 11202108503PA SG 11202108503P A SG11202108503P A SG 11202108503PA SG 11202108503P A SG11202108503P A SG 11202108503PA
Authority
SG
Singapore
Prior art keywords
methods
arginase inhibitors
arginase
inhibitors
Prior art date
Application number
SG11202108503PA
Inventor
Scott Nathan Mlynarski
Tyler Grebe
Sameer Kawatkar
Maurice Raymond Verschoyle Finlay
Iain Simpson
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of SG11202108503PA publication Critical patent/SG11202108503PA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02Boron compounds
    • C07F5/025Boronic and borinic acid compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/69Boron compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SG11202108503PA 2019-02-08 2020-02-07 Arginase inhibitors and methods of use thereof SG11202108503PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962802765P 2019-02-08 2019-02-08
PCT/IB2020/050982 WO2020161675A1 (en) 2019-02-08 2020-02-07 Arginase inhibitors and methods of use thereof

Publications (1)

Publication Number Publication Date
SG11202108503PA true SG11202108503PA (en) 2021-09-29

Family

ID=69770954

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202108503PA SG11202108503PA (en) 2019-02-08 2020-02-07 Arginase inhibitors and methods of use thereof

Country Status (29)

Country Link
US (1) US20220106335A1 (en)
EP (1) EP3921033B1 (en)
JP (1) JP7526734B2 (en)
KR (1) KR20210126044A (en)
CN (1) CN113395996B (en)
AU (1) AU2020218651B2 (en)
BR (1) BR112021015581A2 (en)
CA (1) CA3127755A1 (en)
CL (1) CL2021002056A1 (en)
CO (1) CO2021011039A2 (en)
CR (1) CR20210463A (en)
DK (1) DK3921033T3 (en)
DO (1) DOP2021000166A (en)
EA (1) EA202192114A1 (en)
ES (1) ES2960034T3 (en)
FI (1) FI3921033T3 (en)
HR (1) HRP20231092T1 (en)
HU (1) HUE062968T2 (en)
IL (1) IL285108B1 (en)
LT (1) LT3921033T (en)
MA (1) MA56324B1 (en)
MX (1) MX2021009499A (en)
PE (1) PE20220280A1 (en)
PL (1) PL3921033T3 (en)
PT (1) PT3921033T (en)
RS (1) RS64781B1 (en)
SG (1) SG11202108503PA (en)
SI (1) SI3921033T1 (en)
WO (1) WO2020161675A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202228720A (en) 2020-12-22 2022-08-01 波蘭商昂科艾倫迪治療法股份公司 Arginase inhibitors and methods of use thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9901572D0 (en) * 1999-05-03 1999-05-03 Astra Ab New compounds
SE0300907D0 (en) * 2003-03-31 2003-03-31 Astrazeneca Ab Novel compounds
HUE046932T2 (en) * 2009-01-26 2020-04-28 Univ Pennsylvania Arginase inhibitors and methods of use
MY162535A (en) 2010-04-22 2017-06-15 Mars Inc Inhibitors of arginase and their therapeutic applications
RS54750B1 (en) * 2010-10-26 2016-10-31 Mars Inc Boronates as arginase inhibitors
US9266908B2 (en) * 2011-10-19 2016-02-23 Mars, Incorporated Inhibitors of arginase and their therapeutic applications
MX2015007797A (en) * 2012-12-17 2015-10-05 Parion Sciences Inc 3,5-diamino-6-chloro-n-(n-(4-phenylbutyl)carbamimidoyl) pyrazine-2- carboxamide compounds.
PL410665A1 (en) * 2014-12-29 2016-07-04 Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością Arginase inhibitors and their therapeutical applications
WO2016210106A1 (en) * 2015-06-23 2016-12-29 Calithera Biosciences, Inc. Compositions and methods for inhibiting arginase activity
WO2017175185A1 (en) * 2016-04-08 2017-10-12 Novartis Ag Heteroaryl butanoic acid derivatives as lta4h inhibitors
AU2017382405B2 (en) 2016-12-22 2021-12-16 Calithera Biosciences, Inc. Compositions and methods for inhibiting arginase activity
CN108794517B (en) * 2017-04-27 2021-03-30 南京谷睿生物科技有限公司 Arginase inhibitor and preparation method and application thereof
MX2020008570A (en) * 2018-02-17 2020-09-21 Astrazeneca Ab Arginase inhibitors and methods of use thereof.
WO2019205979A1 (en) * 2018-04-27 2019-10-31 四川科伦博泰生物医药股份有限公司 Non-natural amino acid derivative, pharmaceutical composition comprising same, method for preparing same, and use of same
KR102668252B1 (en) * 2018-08-22 2024-05-21 아스트라제네카 아베 Arginase inhibitors and methods of use thereof

Also Published As

Publication number Publication date
HRP20231092T1 (en) 2023-12-22
MX2021009499A (en) 2021-09-08
CR20210463A (en) 2021-10-15
CL2021002056A1 (en) 2022-03-04
KR20210126044A (en) 2021-10-19
AU2020218651B2 (en) 2023-01-12
HUE062968T2 (en) 2023-12-28
EP3921033A1 (en) 2021-12-15
EP3921033B1 (en) 2023-07-26
CO2021011039A2 (en) 2021-09-09
BR112021015581A2 (en) 2021-10-05
EA202192114A1 (en) 2021-12-01
PT3921033T (en) 2023-10-11
DOP2021000166A (en) 2021-09-30
CA3127755A1 (en) 2020-08-13
DK3921033T3 (en) 2023-10-16
JP2022521474A (en) 2022-04-08
US20220106335A1 (en) 2022-04-07
IL285108B1 (en) 2024-06-01
FI3921033T3 (en) 2023-09-15
CN113395996B (en) 2024-05-28
SI3921033T1 (en) 2023-11-30
IL285108A (en) 2021-09-30
JP7526734B2 (en) 2024-08-01
CN113395996A (en) 2021-09-14
ES2960034T3 (en) 2024-02-29
WO2020161675A1 (en) 2020-08-13
PL3921033T3 (en) 2024-01-15
RS64781B1 (en) 2023-11-30
MA56324B1 (en) 2023-10-31
LT3921033T (en) 2023-09-25
PE20220280A1 (en) 2022-02-25
AU2020218651A1 (en) 2021-09-30

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