SG11202107698XA - The atr kinase inhibitor bay1895344 for use in the treatment of a hyper-proliferative disease - Google Patents

The atr kinase inhibitor bay1895344 for use in the treatment of a hyper-proliferative disease

Info

Publication number
SG11202107698XA
SG11202107698XA SG11202107698XA SG11202107698XA SG11202107698XA SG 11202107698X A SG11202107698X A SG 11202107698XA SG 11202107698X A SG11202107698X A SG 11202107698XA SG 11202107698X A SG11202107698X A SG 11202107698XA SG 11202107698X A SG11202107698X A SG 11202107698XA
Authority
SG
Singapore
Prior art keywords
bay1895344
hyper
treatment
kinase inhibitor
proliferative disease
Prior art date
Application number
SG11202107698XA
Inventor
Dennis Krickau
Eleni Lagkadinou
Antje Wengner
Michael Krause
Peter Serno
Michaela Bairlein
Gary Wilkinson
Siobhan Watters
Pardis Assi
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of SG11202107698XA publication Critical patent/SG11202107698XA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2009Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • A61K9/2018Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
SG11202107698XA 2019-02-11 2020-02-06 The atr kinase inhibitor bay1895344 for use in the treatment of a hyper-proliferative disease SG11202107698XA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19156399 2019-02-11
PCT/EP2020/052971 WO2020165015A1 (en) 2019-02-11 2020-02-06 The atr kinase inhibitor bay1895344 for use in the treatment of a hyper-proliferative disease

Publications (1)

Publication Number Publication Date
SG11202107698XA true SG11202107698XA (en) 2021-08-30

Family

ID=65408941

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202107698XA SG11202107698XA (en) 2019-02-11 2020-02-06 The atr kinase inhibitor bay1895344 for use in the treatment of a hyper-proliferative disease

Country Status (17)

Country Link
US (1) US20220117973A1 (en)
EP (1) EP3923951A1 (en)
JP (1) JP2022521683A (en)
KR (1) KR20210126589A (en)
CN (1) CN113412114A (en)
AU (1) AU2020221473A1 (en)
BR (1) BR112021013869A2 (en)
CA (1) CA3129346A1 (en)
CL (1) CL2021002098A1 (en)
EA (1) EA202192180A1 (en)
IL (1) IL285136A (en)
JO (1) JOP20210215A1 (en)
MA (1) MA54928A (en)
MX (1) MX2021009550A (en)
SG (1) SG11202107698XA (en)
TW (1) TW202045185A (en)
WO (1) WO2020165015A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI656121B (en) 2014-08-04 2019-04-11 德商拜耳製藥公司 2-(morpholin-4-yl)-1,7-naphthyridine
US11690911B2 (en) 2017-08-04 2023-07-04 Bayer Aktiengesellschaft Combination of ATR kinase inhibitors and PD-1/PD-L1 inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI656121B (en) 2014-08-04 2019-04-11 德商拜耳製藥公司 2-(morpholin-4-yl)-1,7-naphthyridine
CA3054247A1 (en) * 2017-02-24 2018-08-30 Antje Margret Wengner Combination of atr kinase inhibitors with parp inhibitors
JOP20190197A1 (en) * 2017-02-24 2019-08-22 Bayer Pharma AG An inhibitor of atr kinase for use in a method of treating a hyper-proliferative disease
TW201840319A (en) * 2017-02-24 2018-11-16 德商拜耳廠股份有限公司 Combination of atr kinase inhibitors with radium-223 salt
WO2018153970A1 (en) 2017-02-24 2018-08-30 Bayer Pharma Aktiengesellschaft Solid forms of 2-[(3r)-3-methylmorpholin-4-yl]-4-(1-methyl-1h-pyrazol-5-yl)-8-(1h-pyrazol-5-yl)-1,7-naphthyridine

Also Published As

Publication number Publication date
AU2020221473A1 (en) 2021-08-05
JOP20210215A1 (en) 2023-01-30
MX2021009550A (en) 2021-09-08
CA3129346A1 (en) 2020-08-20
KR20210126589A (en) 2021-10-20
MA54928A (en) 2021-12-22
TW202045185A (en) 2020-12-16
CN113412114A (en) 2021-09-17
BR112021013869A2 (en) 2021-09-21
CL2021002098A1 (en) 2022-02-25
JP2022521683A (en) 2022-04-12
IL285136A (en) 2021-09-30
EA202192180A1 (en) 2022-01-13
WO2020165015A1 (en) 2020-08-20
US20220117973A1 (en) 2022-04-21
EP3923951A1 (en) 2021-12-22

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