SG11202104114TA - Novel urea 6,7-dihydro-4h-pyrazolo[1,5-a]pyrazines active against the hepatitis b virus (hbv) - Google Patents
Novel urea 6,7-dihydro-4h-pyrazolo[1,5-a]pyrazines active against the hepatitis b virus (hbv)Info
- Publication number
- SG11202104114TA SG11202104114TA SG11202104114TA SG11202104114TA SG11202104114TA SG 11202104114T A SG11202104114T A SG 11202104114TA SG 11202104114T A SG11202104114T A SG 11202104114TA SG 11202104114T A SG11202104114T A SG 11202104114TA SG 11202104114T A SG11202104114T A SG 11202104114TA
- Authority
- SG
- Singapore
- Prior art keywords
- pyrazines
- hbv
- pyrazolo
- hepatitis
- dihydro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18000879 | 2018-11-02 | ||
| PCT/EP2019/079970 WO2020089456A1 (en) | 2018-11-02 | 2019-11-01 | Novel urea 6,7-dihydro-4h-pyrazolo[1,5-a]pyrazines active against the hepatitis b virus (hbv) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202104114TA true SG11202104114TA (en) | 2021-05-28 |
Family
ID=64362288
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202104114TA SG11202104114TA (en) | 2018-11-02 | 2019-11-01 | Novel urea 6,7-dihydro-4h-pyrazolo[1,5-a]pyrazines active against the hepatitis b virus (hbv) |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20220009931A1 (en) |
| EP (1) | EP3873907A1 (en) |
| JP (1) | JP2022508042A (en) |
| KR (1) | KR20210098983A (en) |
| CN (1) | CN112969704A (en) |
| AR (1) | AR116948A1 (en) |
| AU (1) | AU2019373678A1 (en) |
| CA (1) | CA3118382A1 (en) |
| EA (1) | EA202191218A1 (en) |
| IL (1) | IL282648A (en) |
| SG (1) | SG11202104114TA (en) |
| TW (1) | TW202031660A (en) |
| UY (1) | UY38435A (en) |
| WO (1) | WO2020089456A1 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR117189A1 (en) * | 2018-11-02 | 2021-07-21 | Aicuris Gmbh & Co Kg | DERIVATIVES OF 6,7-DIHIDRO-4H-PIRAZOLO [1,5-A] PIRAZIN INDOL-2-CARBOXAMIDAS ACTIVE AGAINST THE VIRUS OF HEPATITIS B (HBV) |
| AR117188A1 (en) * | 2018-11-02 | 2021-07-21 | Aicuris Gmbh & Co Kg | DERIVATIVES OF UREA 6,7-DIHIDRO-4H-PIRAZOLO [1,5-A] PYRAZINES ACTIVE AGAINST THE VIRUS OF HEPATITIS B (HBV) |
Family Cites Families (51)
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| DE19817264A1 (en) | 1998-04-18 | 1999-10-21 | Bayer Ag | New dihydropyrimidine derivatives and their corresponding mesomers useful as antiviral agents |
| AU4289100A (en) | 1999-03-25 | 2000-10-16 | Bayer Aktiengesellschaft | Dihydropyrimidines and their use in the treatment of hepatitis |
| EP1189501B1 (en) | 1999-04-23 | 2007-02-28 | Extenday IP Limited | Sheet fastening and anchoring component |
| WO2001045712A1 (en) | 1999-12-22 | 2001-06-28 | Bayer Aktiengesellschaft | Combinations of medicaments for treating viral diseases |
| WO2006033995A2 (en) | 2004-09-16 | 2006-03-30 | Valeant Research And Development | Thiazolidin-4-ones having anti-hepatitis b activity |
| CA2692713A1 (en) | 2007-07-17 | 2009-01-22 | Amgen Inc. | Heterocyclic modulators of pkb |
| ES2445199T3 (en) | 2008-06-05 | 2014-02-28 | Glaxo Group Limited | Benzpyrazole derivatives as PI3-kinase inhibitors |
| WO2010024258A1 (en) * | 2008-08-29 | 2010-03-04 | 塩野義製薬株式会社 | Ring-fused azole derivative having pi3k-inhibiting activity |
| US9399619B2 (en) | 2011-07-01 | 2016-07-26 | Baruch S. Blumberg Institute | Sulfamoylbenzamide derivatives as antiviral agents against HBV infection |
| KR101699822B1 (en) | 2011-12-21 | 2017-01-25 | 노비라 테라퓨틱스, 인코포레이티드 | Hepatitis b antiviral agents |
| WO2013102655A1 (en) | 2012-01-06 | 2013-07-11 | Janssen R&D Ireland | 4,4-disubstituted-1,4-dihydropyrimidines and the use thereof as medicaments for the treatment of hepatitis b |
| ES2610758T3 (en) | 2012-08-28 | 2017-05-03 | Janssen Sciences Ireland Uc | Condensed bicyclic sulfamoyl derivatives and their use as medicines in the treatment of hepatitis B |
| AR092270A1 (en) | 2012-08-28 | 2015-04-08 | Janssen R&D Ireland | SULFAMOILARILAMIDAS AND ITS USE AS MEDICINES FOR THE TREATMENT OF HEPATITIS B |
| WO2014165128A2 (en) | 2013-03-12 | 2014-10-09 | Novira Therapeutics, Inc. | Hepatitis b antiviral agents |
| US20160039825A1 (en) | 2013-03-15 | 2016-02-11 | Biogen Ma Inc. | S1p and/or atx modulating agents |
| JP6533217B2 (en) | 2013-05-17 | 2019-06-19 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 6-Bridged Heteroaryldihydropyrimidines for the Treatment and Prevention of Hepatitis B Virus Infection |
| JP6441315B2 (en) | 2013-05-17 | 2018-12-19 | ヤンセン・サイエンシズ・アイルランド・ユーシー | Sulfamoylthiophenamide derivatives and their use as pharmaceuticals for treating hepatitis B |
| US10450270B2 (en) | 2013-07-25 | 2019-10-22 | Janssen Sciences Ireland Uc | Glyoxamide substituted pyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis B |
| ES2739435T3 (en) | 2013-10-18 | 2020-01-31 | Univ Indiana Res & Tech Corp | Hepatitis B viral assembly effectors |
| EP3068774B1 (en) | 2013-11-14 | 2019-12-25 | Novira Therapeutics Inc. | Azepane derivatives and methods of treating hepatitis b infections |
| US9169212B2 (en) | 2014-01-16 | 2015-10-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
| CA2935811C (en) | 2014-03-07 | 2018-09-18 | F. Hoffmann-La Roche Ag | 6-fused heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection |
| ES2748029T3 (en) | 2014-03-13 | 2020-03-12 | Univ Indiana Res & Tech Corp | Allosteric modulators of hepatitis B core protein |
| MY196243A (en) | 2014-03-28 | 2023-03-24 | Sunshine Lake Pharma Co Ltd | Dihydropyrimidine Compounds and Their Application In Pharmaceuticals |
| AU2015255656A1 (en) | 2014-05-09 | 2016-11-10 | Assembly Biosciences, Inc. | Methods and compositions for treating hepatitis B virus infections |
| JP6506836B2 (en) | 2014-08-14 | 2019-04-24 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Novel pyridazones and triazinones for the treatment and prevention of hepatitis B virus infection |
| GB201416754D0 (en) | 2014-09-23 | 2014-11-05 | Mission Therapeutics Ltd | Novel compounds |
| CA2969557A1 (en) | 2014-12-02 | 2016-06-09 | Novira Therapeutics, Inc. | Sulfide alkyl and pyridyl reverse sulfonamide compounds for hbv treatment |
| WO2016109684A2 (en) | 2014-12-30 | 2016-07-07 | Novira Therapeutics, Inc. | Derivatives and methods of treating hepatitis b infections |
| MA41338B1 (en) | 2015-01-16 | 2019-07-31 | Hoffmann La Roche | Pyrazine compounds for the treatment of infectious diseases |
| PT3270915T (en) | 2015-03-16 | 2020-06-17 | H Hoffnabb La Roche Ag | Combined treatment with a tlr7 agonist and an hbv capsid assembly inhibitor |
| WO2016161268A1 (en) | 2015-04-01 | 2016-10-06 | Enanta Pharmaceuticals, Inc. | Hepatitis b antviral agents |
| CN107624113B (en) | 2015-05-04 | 2020-10-23 | 豪夫迈·罗氏有限公司 | Tetrahydropyridopyrimidines and tetrahydropyridopyridines as inhibitors of HBsAg (HBV surface antigen) and HBV DNA production for the treatment of hepatitis B virus infection |
| WO2016183266A1 (en) | 2015-05-13 | 2016-11-17 | Enanta Pharmaceuticals, Inc. | Ehpatitis b antiviral agents |
| US10875876B2 (en) | 2015-07-02 | 2020-12-29 | Janssen Sciences Ireland Uc | Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B |
| US10179131B2 (en) | 2015-07-13 | 2019-01-15 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| CN107849037B (en) | 2015-07-21 | 2020-04-17 | 豪夫迈·罗氏有限公司 | Tricyclic 4-pyridone-3-carboxylic acid derivatives for the treatment and prevention of hepatitis B virus infection |
| WO2017015451A1 (en) | 2015-07-22 | 2017-01-26 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| TWI730985B (en) | 2015-09-15 | 2021-06-21 | 美商艾森伯利生物科學公司 | Hepatitis b core protein modulators |
| AU2016330964B2 (en) | 2015-09-29 | 2021-04-01 | Novira Therapeutics, Inc. | Crystalline forms of a hepatitis B antiviral agent |
| ES2794639T3 (en) | 2015-11-04 | 2020-11-18 | Qilu Pharmaceutical Co Ltd | Crystalline form, method of preparation and intermediate of compound with dihydropyrido ring |
| WO2017136403A1 (en) | 2016-02-02 | 2017-08-10 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| ES2938341T3 (en) | 2016-03-07 | 2023-04-10 | Enanta Pharm Inc | Antiviral agents against hepatitis B |
| EP3458455B1 (en) * | 2016-05-20 | 2021-06-16 | F. Hoffmann-La Roche AG | Novel pyrazine compounds with oxygen, sulfur and nitrogen linker for the treatment of infectious diseases |
| US10975077B2 (en) * | 2016-06-29 | 2021-04-13 | Novira Therapeutics, Inc. | Diazepinone derivatives and their use in the treatment of hepatitis B infections |
| CN109476668B (en) | 2016-07-14 | 2022-03-22 | 豪夫迈·罗氏有限公司 | 6, 7-dihydro-4H-pyrazolo [1,5-a ] pyrazines and 6, 7-dihydro-4H-triazolo [1,5-a ] pyrazines for the treatment of infectious diseases |
| WO2018011160A1 (en) | 2016-07-14 | 2018-01-18 | F. Hoffmann-La Roche Ag | 6,7-dihydro-4h-pyrazolo[1,5-a]pyrazine compounds for the treatment of infectious diseases |
| EP3484885B1 (en) | 2016-07-14 | 2020-03-04 | H. Hoffnabb-La Roche Ag | Carboxy 6,7-dihydro-4h-pyrazolo[1,5-a]pyrazine compounds for the treatment of infectious diseases |
| US11001564B2 (en) | 2016-09-13 | 2021-05-11 | Arbutus Biopharma Corporation | Substituted chromane-8-carboxamide compounds and analogues thereof, and methods using same |
| AU2018227811A1 (en) | 2017-03-02 | 2019-09-19 | Assembly Biosciences, Inc. | Cyclic sulfamide compounds and methods of using same |
| CA3056886A1 (en) | 2017-03-21 | 2018-09-27 | Arbutus Biopharma Corporation | Substituted dihydroindene-4-carboxamides and analogs thereof, and methods using same |
-
2019
- 2019-10-31 UY UY0001038435A patent/UY38435A/en not_active Application Discontinuation
- 2019-10-31 AR ARP190103181A patent/AR116948A1/en unknown
- 2019-11-01 US US17/290,541 patent/US20220009931A1/en not_active Abandoned
- 2019-11-01 AU AU2019373678A patent/AU2019373678A1/en not_active Abandoned
- 2019-11-01 TW TW108139832A patent/TW202031660A/en unknown
- 2019-11-01 EA EA202191218A patent/EA202191218A1/en unknown
- 2019-11-01 CA CA3118382A patent/CA3118382A1/en not_active Abandoned
- 2019-11-01 EP EP19795566.9A patent/EP3873907A1/en not_active Withdrawn
- 2019-11-01 CN CN201980072925.8A patent/CN112969704A/en active Pending
- 2019-11-01 WO PCT/EP2019/079970 patent/WO2020089456A1/en unknown
- 2019-11-01 KR KR1020217016294A patent/KR20210098983A/en not_active Application Discontinuation
- 2019-11-01 SG SG11202104114TA patent/SG11202104114TA/en unknown
- 2019-11-01 JP JP2021523650A patent/JP2022508042A/en active Pending
-
2021
- 2021-04-26 IL IL282648A patent/IL282648A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2022508042A (en) | 2022-01-19 |
| KR20210098983A (en) | 2021-08-11 |
| WO2020089456A1 (en) | 2020-05-07 |
| TW202031660A (en) | 2020-09-01 |
| EA202191218A1 (en) | 2021-07-29 |
| US20220009931A1 (en) | 2022-01-13 |
| AU2019373678A1 (en) | 2021-05-27 |
| AR116948A1 (en) | 2021-06-30 |
| EP3873907A1 (en) | 2021-09-08 |
| IL282648A (en) | 2021-06-30 |
| CA3118382A1 (en) | 2020-05-07 |
| UY38435A (en) | 2020-05-29 |
| CN112969704A (en) | 2021-06-15 |
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