SG11202103999VA - Methods of treatment using anti-cd123 immunoconjugates - Google Patents
Methods of treatment using anti-cd123 immunoconjugatesInfo
- Publication number
- SG11202103999VA SG11202103999VA SG11202103999VA SG11202103999VA SG11202103999VA SG 11202103999V A SG11202103999V A SG 11202103999VA SG 11202103999V A SG11202103999V A SG 11202103999VA SG 11202103999V A SG11202103999V A SG 11202103999VA SG 11202103999V A SG11202103999V A SG 11202103999VA
- Authority
- SG
- Singapore
- Prior art keywords
- immunoconjugates
- treatment
- methods
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
- A61K47/6867—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from a cell of a blood cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862752832P | 2018-10-30 | 2018-10-30 | |
US201962860565P | 2019-06-12 | 2019-06-12 | |
US201962881137P | 2019-07-31 | 2019-07-31 | |
PCT/US2019/058824 WO2020092533A2 (en) | 2018-10-30 | 2019-10-30 | Methods of treatment using anti-cd123 immunoconjugates |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202103999VA true SG11202103999VA (en) | 2021-05-28 |
Family
ID=70464182
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202103999VA SG11202103999VA (en) | 2018-10-30 | 2019-10-30 | Methods of treatment using anti-cd123 immunoconjugates |
Country Status (12)
Country | Link |
---|---|
US (2) | US20200157228A1 (en) |
EP (1) | EP3873524A4 (en) |
JP (1) | JP2022513405A (en) |
KR (1) | KR20210087951A (en) |
CN (1) | CN113329768A (en) |
AU (1) | AU2019370291A1 (en) |
CA (1) | CA3117493A1 (en) |
IL (1) | IL282685A (en) |
MA (1) | MA54088A (en) |
SG (1) | SG11202103999VA (en) |
TW (1) | TW202028248A (en) |
WO (1) | WO2020092533A2 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020223351A1 (en) * | 2019-04-29 | 2020-11-05 | Immunogen, Inc. | Therapeutic combinations comprising anti-cd123 immunoconjugates |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
DK1791565T3 (en) | 2004-09-23 | 2016-08-01 | Genentech Inc | Cysteingensplejsede antibodies and conjugates |
WO2008127735A1 (en) * | 2007-04-13 | 2008-10-23 | Stemline Therapeutics, Inc. | Il3ralpha antibody conjugates and uses thereof |
ES2613963T3 (en) | 2008-01-18 | 2017-05-29 | Medimmune, Llc | Cysteine manipulated antibodies for site specific conjugation |
EP2445520A4 (en) | 2009-06-22 | 2013-03-06 | Medimmune Llc | ENGINEERED Fc REGIONS FOR SITE-SPECIFIC CONJUGATION |
WO2014092804A1 (en) * | 2012-12-13 | 2014-06-19 | Immunomedics, Inc. | Dosages of immunoconjugates of antibodies and sn-38 for improved efficacy and decreased toxicity |
BR112015028244A2 (en) * | 2013-05-14 | 2017-09-19 | Immunogen Inc | IMMUNOCONJUGATE THAT BINDS TO FOLR1 AND ITS USE |
TW201709932A (en) * | 2015-06-12 | 2017-03-16 | 西雅圖遺傳學公司 | CD123 antibodies and conjugates thereof |
CA2988806A1 (en) | 2015-06-29 | 2017-01-05 | Immunogen, Inc. | Conjugates of cysteine engineered antibodies |
KR20180021177A (en) | 2015-06-29 | 2018-02-28 | 이뮤노젠 아이엔씨 | Anti-CD123 antibodies and conjugates and derivatives thereof |
EP3544983A2 (en) * | 2016-11-23 | 2019-10-02 | Immunogen, Inc. | Selective sulfonation of benzodiazepine derivatives |
-
2019
- 2019-10-30 CN CN201980073676.4A patent/CN113329768A/en active Pending
- 2019-10-30 CA CA3117493A patent/CA3117493A1/en active Pending
- 2019-10-30 MA MA054088A patent/MA54088A/en unknown
- 2019-10-30 SG SG11202103999VA patent/SG11202103999VA/en unknown
- 2019-10-30 TW TW108139297A patent/TW202028248A/en unknown
- 2019-10-30 KR KR1020217014003A patent/KR20210087951A/en unknown
- 2019-10-30 JP JP2021548551A patent/JP2022513405A/en active Pending
- 2019-10-30 EP EP19878291.4A patent/EP3873524A4/en active Pending
- 2019-10-30 US US16/668,257 patent/US20200157228A1/en not_active Abandoned
- 2019-10-30 WO PCT/US2019/058824 patent/WO2020092533A2/en active Application Filing
- 2019-10-30 AU AU2019370291A patent/AU2019370291A1/en active Pending
-
2021
- 2021-04-27 IL IL282685A patent/IL282685A/en unknown
-
2022
- 2022-11-09 US US18/054,076 patent/US20230312735A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20200157228A1 (en) | 2020-05-21 |
CN113329768A (en) | 2021-08-31 |
AU2019370291A1 (en) | 2021-05-20 |
WO2020092533A2 (en) | 2020-05-07 |
WO2020092533A3 (en) | 2020-06-04 |
KR20210087951A (en) | 2021-07-13 |
JP2022513405A (en) | 2022-02-07 |
TW202028248A (en) | 2020-08-01 |
IL282685A (en) | 2021-06-30 |
CA3117493A1 (en) | 2020-05-07 |
US20230312735A1 (en) | 2023-10-05 |
MA54088A (en) | 2022-03-16 |
EP3873524A4 (en) | 2022-11-09 |
EP3873524A2 (en) | 2021-09-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ZA202006746B (en) | Methods of treatment | |
GB201804514D0 (en) | Treatment of pyroptosis | |
IL274865A (en) | Methods of treatment with asparaginase | |
IL269490B (en) | Surface treatment methods and compositions therefor | |
IL283948A (en) | Methods for the treatment of depression | |
IL272937A (en) | Compositions and methods for the treatment of fibrotic diseases | |
ZA201907401B (en) | Treatment of adipocytes | |
SG11202011117VA (en) | Treatment of cancer | |
IL281792A (en) | Treatment methods | |
GB201804515D0 (en) | Treatment of necroptosis | |
EP3894768C0 (en) | Methods of cryo-curing | |
IL270011B (en) | Therapeutic compounds and methods | |
GB201617820D0 (en) | Dental treatment | |
IL287446A (en) | Therapeutic combinations comprising anti-cd123 immunoconjugates | |
IL281839A (en) | Treatment methods | |
IL272147A (en) | Methods and compositions for the treatment of cancer | |
IL282685A (en) | Methods of treatment using anti-cd123 immunoconjugates | |
SG11202105877YA (en) | Method of treatment | |
SG11202005850VA (en) | Methods of treatment of hypertrigl yceridemia | |
IL290983A (en) | Methods of treatment | |
GB201801249D0 (en) | Methods of treatment | |
GB201918853D0 (en) | Methods of treatment | |
GB201900942D0 (en) | Methods of treatment | |
ZA201908255B (en) | Treatment of oral candidiasis | |
GB201820975D0 (en) | Methods of cancer treatment |