SG11202103667QA - Pyrrolo[2,3-d]pyrimidine tosylate salt, crystalline form thereof and manufacturing process and intermediates thereto - Google Patents
Pyrrolo[2,3-d]pyrimidine tosylate salt, crystalline form thereof and manufacturing process and intermediates theretoInfo
- Publication number
- SG11202103667QA SG11202103667QA SG11202103667QA SG11202103667QA SG11202103667QA SG 11202103667Q A SG11202103667Q A SG 11202103667QA SG 11202103667Q A SG11202103667Q A SG 11202103667QA SG 11202103667Q A SG11202103667Q A SG 11202103667QA SG 11202103667Q A SG11202103667Q A SG 11202103667QA
- Authority
- SG
- Singapore
- Prior art keywords
- pyrrolo
- intermediates
- manufacturing process
- crystalline form
- tosylate salt
- Prior art date
Links
- SDCVTUZMZOCTNV-UHFFFAOYSA-N 4-methylbenzenesulfonic acid 7H-pyrrolo[2,3-d]pyrimidine Chemical compound S(=O)(=O)(O)C1=CC=C(C)C=C1.N1C=NC=C2C1=NC=C2 SDCVTUZMZOCTNV-UHFFFAOYSA-N 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862748628P | 2018-10-22 | 2018-10-22 | |
| PCT/IB2019/058940 WO2020084435A1 (en) | 2018-10-22 | 2019-10-21 | Pyrrolo[2,3-d]pyrimidine tosylate salt, crystalline form thereof and manufacturing process and intermediates thereto |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202103667QA true SG11202103667QA (en) | 2021-05-28 |
Family
ID=68343187
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202103667QA SG11202103667QA (en) | 2018-10-22 | 2019-10-21 | Pyrrolo[2,3-d]pyrimidine tosylate salt, crystalline form thereof and manufacturing process and intermediates thereto |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20210387989A1 (en) |
| EP (1) | EP3870584A1 (en) |
| JP (1) | JP6944496B2 (en) |
| KR (1) | KR102629132B1 (en) |
| CN (1) | CN112888691B (en) |
| AR (1) | AR116797A1 (en) |
| AU (1) | AU2019363840B2 (en) |
| BR (1) | BR112021007568A2 (en) |
| CA (1) | CA3059000A1 (en) |
| IL (1) | IL282446B1 (en) |
| MX (1) | MX2021003241A (en) |
| SG (1) | SG11202103667QA (en) |
| TW (1) | TWI729530B (en) |
| WO (1) | WO2020084435A1 (en) |
| ZA (1) | ZA202101735B (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4021452B1 (en) * | 2019-08-26 | 2023-12-20 | Chemwerth Inc | Substituted (7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino compounds useful as jak1 inhibitors |
| CN113121539A (en) * | 2019-12-31 | 2021-07-16 | 江苏艾立康医药科技有限公司 | Preparation method of PF06651600 |
| IL292929A (en) * | 2019-12-31 | 2022-07-01 | Pfizer R& D Uk Ltd | Stable immediate release tablet and capsule formulations of 1-((2s,5r)-5-((7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one |
| CN111732591B (en) * | 2020-06-15 | 2022-06-10 | 江苏艾立康医药科技有限公司 | PF-06651600L-tartrate, crystal form and preparation method thereof |
| CN114835715B (en) * | 2020-06-15 | 2024-04-05 | 江苏艾立康医药科技有限公司 | PF-06651600 maleate and preparation method thereof |
| CN111620880B (en) * | 2020-06-15 | 2022-06-10 | 江苏艾立康医药科技有限公司 | PF-06651600 DL-tartrate, crystal form and preparation method thereof |
| WO2022012587A1 (en) * | 2020-07-14 | 2022-01-20 | 苏州晶云药物科技股份有限公司 | Malonate crystal form of propenone compound, and preparation method therefor |
| KR102473645B1 (en) * | 2020-08-28 | 2022-12-05 | (주)부흥산업사 | Manufacturing method of (2S, 5R)-benzyl 5-(tert-butoxycarbonylamino)-2-methylpiperidine-1-carboxylate |
| CN112877379B (en) * | 2021-01-18 | 2023-09-01 | 华南理工大学 | Method for synthesizing N- [ (3R, 6R) -6-methylpiperidine-3-yl ] tert-butyl carbamate by chemical enzyme method |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3318565T3 (en) * | 2013-12-05 | 2021-05-25 | Pfizer | Pyrrolo [2,3-D] pyrimidinyl-, pyrrolo [2,3-B] pyrazinyl- and pyrrolo [2,3-D] pyridinylacrylamides |
| MA41350A (en) * | 2015-01-14 | 2017-11-21 | Janssen Pharmaceutica Nv | SUMMARY OF A BRUTON TYROSINE KINASE INHIBITOR |
| CN105859721B (en) * | 2015-01-22 | 2018-04-17 | 浙江京新药业股份有限公司 | A kind of Yi Bulu replaces the preparation method of Buddhist nun |
-
2019
- 2019-10-16 JP JP2019189151A patent/JP6944496B2/en active Active
- 2019-10-17 CA CA3059000A patent/CA3059000A1/en active Pending
- 2019-10-17 TW TW108137470A patent/TWI729530B/en active
- 2019-10-21 WO PCT/IB2019/058940 patent/WO2020084435A1/en active Application Filing
- 2019-10-21 SG SG11202103667QA patent/SG11202103667QA/en unknown
- 2019-10-21 MX MX2021003241A patent/MX2021003241A/en unknown
- 2019-10-21 US US17/286,018 patent/US20210387989A1/en active Pending
- 2019-10-21 KR KR1020217015125A patent/KR102629132B1/en active IP Right Grant
- 2019-10-21 CN CN201980069164.0A patent/CN112888691B/en active Active
- 2019-10-21 BR BR112021007568-2A patent/BR112021007568A2/en unknown
- 2019-10-21 IL IL282446A patent/IL282446B1/en unknown
- 2019-10-21 AU AU2019363840A patent/AU2019363840B2/en active Active
- 2019-10-21 EP EP19794259.2A patent/EP3870584A1/en active Pending
- 2019-10-22 AR ARP190103015A patent/AR116797A1/en unknown
-
2021
- 2021-03-15 ZA ZA2021/01735A patent/ZA202101735B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2019363840A1 (en) | 2021-04-01 |
| AR116797A1 (en) | 2021-06-16 |
| TW202033525A (en) | 2020-09-16 |
| MX2021003241A (en) | 2021-05-12 |
| KR20210080468A (en) | 2021-06-30 |
| EP3870584A1 (en) | 2021-09-01 |
| WO2020084435A1 (en) | 2020-04-30 |
| CA3059000A1 (en) | 2020-04-22 |
| AU2019363840B2 (en) | 2021-12-09 |
| BR112021007568A2 (en) | 2021-07-27 |
| KR102629132B1 (en) | 2024-01-29 |
| TWI729530B (en) | 2021-06-01 |
| IL282446A (en) | 2021-06-30 |
| CN112888691B (en) | 2023-10-31 |
| US20210387989A1 (en) | 2021-12-16 |
| IL282446B1 (en) | 2024-02-01 |
| JP2020066629A (en) | 2020-04-30 |
| CN112888691A (en) | 2021-06-01 |
| ZA202101735B (en) | 2022-07-27 |
| JP6944496B2 (en) | 2021-10-06 |
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