SG11202103293UA - Azithromycin and roxithromycin derivatives as senolytic drugs - Google Patents
Azithromycin and roxithromycin derivatives as senolytic drugsInfo
- Publication number
- SG11202103293UA SG11202103293UA SG11202103293UA SG11202103293UA SG11202103293UA SG 11202103293U A SG11202103293U A SG 11202103293UA SG 11202103293U A SG11202103293U A SG 11202103293UA SG 11202103293U A SG11202103293U A SG 11202103293UA SG 11202103293U A SG11202103293U A SG 11202103293UA
- Authority
- SG
- Singapore
- Prior art keywords
- roxithromycin
- azithromycin
- derivatives
- senolytic drugs
- senolytic
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862740137P | 2018-10-02 | 2018-10-02 | |
| US201862750559P | 2018-10-25 | 2018-10-25 | |
| US201962788187P | 2019-01-04 | 2019-01-04 | |
| PCT/US2019/054231 WO2020072598A1 (en) | 2018-10-02 | 2019-10-02 | Azithromycin and roxithromycin derivatives as senolytic drugs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202103293UA true SG11202103293UA (en) | 2021-04-29 |
Family
ID=70054763
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202103293UA SG11202103293UA (en) | 2018-10-02 | 2019-10-02 | Azithromycin and roxithromycin derivatives as senolytic drugs |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US11957700B2 (en) |
| EP (1) | EP3860616A4 (en) |
| JP (1) | JP2022504204A (en) |
| KR (1) | KR20210072026A (en) |
| CN (1) | CN113164504A (en) |
| AU (1) | AU2019353002A1 (en) |
| BR (1) | BR112021006423A2 (en) |
| CA (1) | CA3114888A1 (en) |
| CL (1) | CL2021000825A1 (en) |
| CO (1) | CO2021004427A2 (en) |
| CR (1) | CR20210221A (en) |
| CU (1) | CU20210024A7 (en) |
| DO (1) | DOP2021000056A (en) |
| EC (1) | ECSP21029576A (en) |
| IL (1) | IL281879A (en) |
| MX (1) | MX2021003808A (en) |
| PE (1) | PE20211006A1 (en) |
| PH (1) | PH12021550719A1 (en) |
| SG (1) | SG11202103293UA (en) |
| WO (1) | WO2020072598A1 (en) |
| ZA (1) | ZA202102157B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11202004729QA (en) * | 2017-11-24 | 2020-06-29 | Lunella Biotech Inc | Triphenylphosphonium-derivative compounds for eradicating cancer stem cells |
| WO2023085787A1 (en) * | 2021-11-10 | 2023-05-19 | 주식회사 라이프신약 | Compositions for removing senescent cells and uses thereof |
| WO2023090901A1 (en) * | 2021-11-18 | 2023-05-25 | 의료법인 성광의료재단 | Method for selecting marker of cellular senescence using machine learning, biomarker for cellular senescence, and method for screening senolytic agent using same |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20022292A1 (en) | 2002-10-29 | 2004-04-30 | Zambon Spa | 9A-AZALIDS WITH ANTI-INFLAMMATORY ACTIVITY. |
| CN102816194A (en) | 2004-02-27 | 2012-12-12 | 瑞伯-X医药品有限公司 | Macrocyclic compounds and methods of making and using the same |
| WO2008072034A1 (en) * | 2006-12-12 | 2008-06-19 | Zambon S.P.A. | Macrolide compounds endowed with antiinflammatory activity |
| GB0912584D0 (en) * | 2009-07-20 | 2009-08-26 | Ucl Business Plc | Cyclosporin conjugates |
| US9180134B2 (en) | 2011-08-18 | 2015-11-10 | Ecole Polytechnique Federale De Lausanne (Epel) | Mitochondrial ribosomal proteins as aging regulators |
| US9775855B2 (en) * | 2011-09-14 | 2017-10-03 | Thomas J. Lewis | Compositions comprising macrolide and tetracycline and their uses |
| KR101435717B1 (en) * | 2012-09-06 | 2014-09-01 | 영남대학교 산학협력단 | Composition for inhibiting cellular senescence comprising quercetin-3-O-β-D-glucuronide |
| WO2016118859A1 (en) * | 2015-01-22 | 2016-07-28 | Board Of Trustees Of The University Of Arkansas | Compositions and methods for selectively depleting senescent cells comprising flip |
| JP2020511951A (en) * | 2017-01-03 | 2020-04-23 | バイオアトラ、エルエルシー | Protein therapy for the treatment of senescent cells |
| JP7104134B2 (en) | 2017-03-15 | 2022-07-20 | ルネラ・バイオテック・インコーポレーテッド | Mitribocin: a mitochondrial-based therapeutic agent targeting cancer cells, bacteria, and pathogenic yeast |
| US11427606B2 (en) * | 2017-04-20 | 2022-08-30 | Rising Tide Foundation | Azithromycin derivatives containing a phosphonium ion as anticancer agents |
| WO2018195434A1 (en) | 2017-04-21 | 2018-10-25 | Lisanti Michael P | Vitamin c and doxycycline: a synthetic lethal combination therapy for eradicating cancer stem cells (cscs) |
| CN111315400A (en) | 2017-05-19 | 2020-06-19 | 卢内拉生物技术有限公司 | Antinitosicin: targeted inhibitors of mitochondrial biogenesis for eradication of cancer stem cells |
| CA3063450A1 (en) | 2017-05-19 | 2018-11-22 | Lunella Biotech, Inc. | Companion diagnostics for mitochondrial inhibitors |
| RU2020102908A (en) | 2017-06-26 | 2021-07-27 | Лунелла Байотек, Инк. | MITOCETOSCINS: MITOCHONDRIAL THERAPY TARGETING KETONE METABOLISM IN CANCER CELLS |
| CU20200039A7 (en) | 2017-10-24 | 2021-03-11 | Lunella Biotech Inc | MITOFLAVOSCINS: TARGETING BINDING OF ENZYMES CONTAINING FLAVIN KILLS CANCER STEM CELLS (CSCS) BY INHIBITING MITOCHRONDRIAL RESPIRATION |
| SG11202004729QA (en) | 2017-11-24 | 2020-06-29 | Lunella Biotech Inc | Triphenylphosphonium-derivative compounds for eradicating cancer stem cells |
| WO2019108729A1 (en) | 2017-12-01 | 2019-06-06 | Lunella Biotech, Inc. | Repurposcins: targeted inhibitors of mitochondrial biogenesis for eradicating cancer stem cells |
| US11559527B2 (en) | 2017-12-20 | 2023-01-24 | Lunella Biotech, Inc. | Targeting mitochondrial fission through mDIVI-1 derivatives |
| EP3897659A4 (en) | 2018-12-17 | 2022-09-07 | Lunella Biotech, Inc. | Triple combination therapies for anti-aging |
-
2019
- 2019-10-02 KR KR1020217012994A patent/KR20210072026A/en unknown
- 2019-10-02 EP EP19869744.3A patent/EP3860616A4/en active Pending
- 2019-10-02 CA CA3114888A patent/CA3114888A1/en active Pending
- 2019-10-02 MX MX2021003808A patent/MX2021003808A/en unknown
- 2019-10-02 CN CN201980079188.4A patent/CN113164504A/en active Pending
- 2019-10-02 WO PCT/US2019/054231 patent/WO2020072598A1/en active Application Filing
- 2019-10-02 CR CR20210221A patent/CR20210221A/en unknown
- 2019-10-02 SG SG11202103293UA patent/SG11202103293UA/en unknown
- 2019-10-02 AU AU2019353002A patent/AU2019353002A1/en active Pending
- 2019-10-02 PE PE2021000425A patent/PE20211006A1/en unknown
- 2019-10-02 US US17/282,212 patent/US11957700B2/en active Active
- 2019-10-02 CU CU2021000024A patent/CU20210024A7/en unknown
- 2019-10-02 BR BR112021006423A patent/BR112021006423A2/en unknown
- 2019-10-02 JP JP2021518508A patent/JP2022504204A/en active Pending
-
2021
- 2021-03-29 IL IL281879A patent/IL281879A/en unknown
- 2021-03-30 ZA ZA2021/02157A patent/ZA202102157B/en unknown
- 2021-03-31 CL CL2021000825A patent/CL2021000825A1/en unknown
- 2021-03-31 PH PH12021550719A patent/PH12021550719A1/en unknown
- 2021-03-31 DO DO2021000056A patent/DOP2021000056A/en unknown
- 2021-04-09 CO CONC2021/0004427A patent/CO2021004427A2/en unknown
- 2021-04-26 EC ECSENADI202129576A patent/ECSP21029576A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DOP2021000056A (en) | 2021-06-30 |
| KR20210072026A (en) | 2021-06-16 |
| JP2022504204A (en) | 2022-01-13 |
| CO2021004427A2 (en) | 2021-04-30 |
| US20210275560A1 (en) | 2021-09-09 |
| IL281879A (en) | 2021-05-31 |
| CL2021000825A1 (en) | 2021-10-22 |
| CR20210221A (en) | 2021-06-24 |
| BR112021006423A2 (en) | 2021-07-06 |
| EP3860616A4 (en) | 2022-07-06 |
| AU2019353002A1 (en) | 2021-05-06 |
| CA3114888A1 (en) | 2020-04-09 |
| PE20211006A1 (en) | 2021-06-01 |
| US11957700B2 (en) | 2024-04-16 |
| WO2020072598A1 (en) | 2020-04-09 |
| ZA202102157B (en) | 2022-09-28 |
| PH12021550719A1 (en) | 2021-12-06 |
| ECSP21029576A (en) | 2021-05-31 |
| EP3860616A1 (en) | 2021-08-11 |
| CU20210024A7 (en) | 2021-11-04 |
| CN113164504A (en) | 2021-07-23 |
| MX2021003808A (en) | 2021-05-27 |
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