SG11202103062UA - Inhibitors of vap-1 - Google Patents
Inhibitors of vap-1Info
- Publication number
- SG11202103062UA SG11202103062UA SG11202103062UA SG11202103062UA SG11202103062UA SG 11202103062U A SG11202103062U A SG 11202103062UA SG 11202103062U A SG11202103062U A SG 11202103062UA SG 11202103062U A SG11202103062U A SG 11202103062UA SG 11202103062U A SG11202103062U A SG 11202103062UA
- Authority
- SG
- Singapore
- Prior art keywords
- vap
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D249/18—Benzotriazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862738924P | 2018-09-28 | 2018-09-28 | |
| PCT/US2019/053481 WO2020069330A2 (en) | 2018-09-28 | 2019-09-27 | Inhibitors of vap-1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202103062UA true SG11202103062UA (en) | 2021-04-29 |
Family
ID=69952172
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202103062UA SG11202103062UA (en) | 2018-09-28 | 2019-09-27 | Inhibitors of vap-1 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US11787791B2 (en) |
| EP (1) | EP3856176A4 (en) |
| JP (1) | JP2022511374A (en) |
| CN (1) | CN113164454A (en) |
| AU (1) | AU2019351122A1 (en) |
| BR (1) | BR112021005903A2 (en) |
| CA (1) | CA3114208A1 (en) |
| IL (1) | IL281939A (en) |
| MX (1) | MX2021003559A (en) |
| SG (1) | SG11202103062UA (en) |
| WO (1) | WO2020069330A2 (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109988106B (en) * | 2017-12-29 | 2023-03-31 | 广东东阳光药业有限公司 | Amine compound for inhibiting SSAO/VAP-1 and application thereof in medicine |
| CN109988109B (en) * | 2017-12-29 | 2020-12-29 | 广东东阳光药业有限公司 | Amine compound for inhibiting SSAO/VAP-1 and application thereof |
| KR20190110736A (en) | 2018-03-21 | 2019-10-01 | 주식회사유한양행 | Novel triazolone derivatives or its salt and pharmaceutical compositions comprising the same |
| KR20190110740A (en) | 2018-03-21 | 2019-10-01 | 주식회사유한양행 | Novel aryl or heteroaryl triazolone derivatives or its salt and pharmaceutical compositions comprising the same |
| AU2019351122A1 (en) | 2018-09-28 | 2021-05-20 | Acucela Inc. | Inhibitors of VAP-1 |
| AU2019351124A1 (en) * | 2018-09-28 | 2021-05-20 | Acucela Inc. | Inhibitors of VAP-1 |
| PL3860998T3 (en) | 2018-10-05 | 2024-06-17 | Annapurna Bio Inc. | Compounds and compositions for treating conditions associated with apj receptor activity |
| TW202039486A (en) | 2018-12-14 | 2020-11-01 | 南韓商柳韓洋行股份有限公司 | Triazolopyridin-3-ones or their salts and pharmaceutical compositions comprising the same |
| TWI835945B (en) | 2018-12-14 | 2024-03-21 | 南韓商柳韓洋行股份有限公司 | 3,3-difluoroallylamines or salts thereof and pharmaceutical compositions comprising the same |
| IL293592A (en) | 2019-12-06 | 2022-08-01 | Vertex Pharma | Substituted tetrahydrofurans as modulators of sodium channels |
| AU2022284886A1 (en) | 2021-06-04 | 2023-11-30 | Vertex Pharmaceuticals Incorporated | N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamides as modulators of sodium channels |
| CN114644539B (en) * | 2022-04-01 | 2023-07-14 | 安徽农业大学 | Synthesis method of difluoro aryloxy ether containing olefin and application of difluoro aryloxy ether in pesticide |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5505953A (en) | 1992-05-06 | 1996-04-09 | Alcon Laboratories, Inc. | Use of borate-polyol complexes in ophthalmic compositions |
| FR2742357B1 (en) | 1995-12-19 | 1998-01-09 | Rhone Poulenc Rorer Sa | STABILIZED AND FILTRABLE NANOPARTICLES UNDER STERILE CONDITIONS |
| JP2007523955A (en) * | 2004-02-25 | 2007-08-23 | ラ ホヤ ファーマシューティカル カンパニー | Amines and amides for the treatment of diseases |
| TW200612918A (en) * | 2004-07-29 | 2006-05-01 | Threshold Pharmaceuticals Inc | Lonidamine analogs |
| WO2007120528A2 (en) * | 2006-03-31 | 2007-10-25 | La Jolla Pharmaceutical Company | Inhibitors of semicarbazide-sensitive amine oxidase (ssao) and vap-1 mediated adhesion useful for treatment and prevention of diseases |
| CA2706465A1 (en) | 2007-11-21 | 2009-05-28 | Pharmaxis Ltd. | Haloallylamine inhibitors of ssao/vap-1 and uses therefor |
| EP2387568A1 (en) * | 2009-01-19 | 2011-11-23 | NeuroSearch A/S | Novel benzotriazole derivatives useful for the treatment of cns disorders |
| WO2013163675A1 (en) | 2012-05-02 | 2013-11-07 | Pharmaxis Ltd. | Substituted 3-haloallylamine inhibitors of ssao and uses thereof |
| HUE042032T2 (en) * | 2013-02-25 | 2019-06-28 | Aurigene Discovery Tech Ltd | Trisubstituted benzotriazole derivatives as dihydroorotate oxygenase inhibitors |
| GB201321740D0 (en) * | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
| CA3041169A1 (en) * | 2016-10-19 | 2018-04-26 | Boehringer Ingelheim International Gmbh | Combinations comprising an ssao/vap-1 inhibitor and a sglt2 inhibitor, uses thereof |
| CN109810041B (en) * | 2017-11-21 | 2023-08-15 | 药捷安康(南京)科技股份有限公司 | Halogenated allylamine SSAO/VAP-1 inhibitor and application thereof |
| CN109988106B (en) | 2017-12-29 | 2023-03-31 | 广东东阳光药业有限公司 | Amine compound for inhibiting SSAO/VAP-1 and application thereof in medicine |
| AU2019351122A1 (en) | 2018-09-28 | 2021-05-20 | Acucela Inc. | Inhibitors of VAP-1 |
-
2019
- 2019-09-27 AU AU2019351122A patent/AU2019351122A1/en active Pending
- 2019-09-27 US US17/279,382 patent/US11787791B2/en active Active
- 2019-09-27 WO PCT/US2019/053481 patent/WO2020069330A2/en unknown
- 2019-09-27 MX MX2021003559A patent/MX2021003559A/en unknown
- 2019-09-27 SG SG11202103062UA patent/SG11202103062UA/en unknown
- 2019-09-27 BR BR112021005903-2A patent/BR112021005903A2/en unknown
- 2019-09-27 EP EP19867564.7A patent/EP3856176A4/en active Pending
- 2019-09-27 CN CN201980078999.2A patent/CN113164454A/en active Pending
- 2019-09-27 JP JP2021517603A patent/JP2022511374A/en active Pending
- 2019-09-27 CA CA3114208A patent/CA3114208A1/en active Pending
-
2021
- 2021-03-31 IL IL281939A patent/IL281939A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2020069330A3 (en) | 2020-07-23 |
| JP2022511374A (en) | 2022-01-31 |
| EP3856176A2 (en) | 2021-08-04 |
| WO2020069330A2 (en) | 2020-04-02 |
| CN113164454A (en) | 2021-07-23 |
| MX2021003559A (en) | 2021-08-24 |
| US20210387975A1 (en) | 2021-12-16 |
| US11787791B2 (en) | 2023-10-17 |
| BR112021005903A2 (en) | 2021-07-27 |
| EP3856176A4 (en) | 2022-05-04 |
| IL281939A (en) | 2021-05-31 |
| AU2019351122A1 (en) | 2021-05-20 |
| CA3114208A1 (en) | 2020-04-02 |
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