SG11202103025PA - Methods and compositions for the expansion and use of allogeneic gamma/delta-t cells - Google Patents
Methods and compositions for the expansion and use of allogeneic gamma/delta-t cellsInfo
- Publication number
- SG11202103025PA SG11202103025PA SG11202103025PA SG11202103025PA SG11202103025PA SG 11202103025P A SG11202103025P A SG 11202103025PA SG 11202103025P A SG11202103025P A SG 11202103025PA SG 11202103025P A SG11202103025P A SG 11202103025PA SG 11202103025P A SG11202103025P A SG 11202103025PA
- Authority
- SG
- Singapore
- Prior art keywords
- delta
- compositions
- expansion
- cells
- methods
- Prior art date
Links
- 230000000735 allogeneic effect Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/26—Universal/off- the- shelf cellular immunotherapy; Allogenic cells or means to avoid rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2302—Interleukin-2 (IL-2)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862737378P | 2018-09-27 | 2018-09-27 | |
PCT/IB2019/058188 WO2020065584A1 (en) | 2018-09-27 | 2019-09-26 | Methods and compositions for the expansion and use of allogeneic gamma/delta-t cells |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202103025PA true SG11202103025PA (en) | 2021-04-29 |
Family
ID=68211140
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202103025PA SG11202103025PA (en) | 2018-09-27 | 2019-09-26 | Methods and compositions for the expansion and use of allogeneic gamma/delta-t cells |
Country Status (9)
Country | Link |
---|---|
US (1) | US20210338728A1 (en) |
EP (1) | EP3856206A1 (en) |
JP (1) | JP2022513328A (en) |
KR (1) | KR20210069665A (en) |
CN (1) | CN112930187A (en) |
AU (1) | AU2019349956A1 (en) |
CA (1) | CA3114292A1 (en) |
SG (1) | SG11202103025PA (en) |
WO (1) | WO2020065584A1 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102648375B1 (en) | 2020-10-20 | 2024-03-14 | 강승찬 | Preparaion of plant fermentation product using plant fermented liquid |
WO2022214887A1 (en) | 2021-04-08 | 2022-10-13 | Phosphogam, Llc | Methods and compositions for enhancing the cytotoxicity of gamma/delta-t cells |
WO2022221439A1 (en) * | 2021-04-14 | 2022-10-20 | The Trustees Of The University Of Pennsylvania | Methods to determine treatment efficacy with gamma-delta t cells |
CN114645022B (en) * | 2022-05-13 | 2022-09-02 | 首都医科大学宣武医院 | CD 5-targeted CAR-gamma delta T cell and preparation method and application thereof |
CN115678846B (en) * | 2022-09-01 | 2023-06-16 | 广东龄值生物科技有限公司 | Tumor specific gamma delta T cell and preparation method thereof |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
AU610083B2 (en) | 1986-08-18 | 1991-05-16 | Clinical Technologies Associates, Inc. | Delivery systems for pharmacological agents |
US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
US5756096A (en) | 1991-07-25 | 1998-05-26 | Idec Pharmaceuticals Corporation | Recombinant antibodies for human therapy |
IE922437A1 (en) | 1991-07-25 | 1993-01-27 | Idec Pharma Corp | Recombinant antibodies for human therapy |
DE614989T1 (en) | 1993-02-17 | 1995-09-28 | Morphosys Proteinoptimierung | Method for in vivo selection of ligand binding proteins. |
CA2323080A1 (en) | 1998-03-12 | 1999-09-16 | Emory University | Methods and compositions for the selective expansion of gamma/delta t-cells |
FR2782721B1 (en) | 1998-09-01 | 2000-11-03 | Inst Nat Sante Rech Med | NOVEL PHOSPHOHALOHYDRIN COMPOUNDS, MANUFACTURING METHOD AND APPLICATIONS |
US7399756B2 (en) | 2001-07-20 | 2008-07-15 | Bioagency Ag | Organo-phosphorous compounds for activating gamma/delta T cells |
FR2833266B1 (en) | 2001-12-11 | 2004-10-22 | Mayoly Spindler Lab | NOVEL PHOSPHONATE DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR USE AS MODULATORS OF THE ACTIVITY OF TGAMMA9 DELTA2 LYMPHOCYTES |
FR2836483B1 (en) | 2002-02-22 | 2006-09-15 | Innate Pharma | METHODS FOR PRODUCING GAMMA DELTA T LYMPHOCYTES |
EP1878440A1 (en) * | 2006-07-13 | 2008-01-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for increasing the efficiency of therapeutic antibodies using gamma delta cell activator compounds |
CN102137925B (en) | 2008-07-01 | 2014-12-10 | 迈世耐特股份公司 | Method for simultaneous induction of CTL and [gamma][delta]t cell |
US8735624B2 (en) | 2008-09-10 | 2014-05-27 | Innate Pharma | Polymorphic form of CHDMAPP, method of preparation thereof, and pharmaceutical composition comprising same |
US20150353643A1 (en) | 2013-09-24 | 2015-12-10 | Universite De La Mediterranee - Aix-Marseille Ii | Anti-cd277 antibodies and uses thereof |
WO2014072446A1 (en) * | 2012-11-08 | 2014-05-15 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method for inducing il-2-free proliferation of gamma delta t cells |
CN107075480A (en) * | 2014-07-09 | 2017-08-18 | Tc生物制药有限公司 | Gamma delta T cells and application thereof |
GB201421716D0 (en) * | 2014-12-05 | 2015-01-21 | King S College London | Cell expansion procedure |
IL257678B2 (en) * | 2015-08-25 | 2024-04-01 | Uab Res Found | Methods for stem cell transplantation |
-
2019
- 2019-09-26 AU AU2019349956A patent/AU2019349956A1/en active Pending
- 2019-09-26 CN CN201980071044.4A patent/CN112930187A/en active Pending
- 2019-09-26 CA CA3114292A patent/CA3114292A1/en active Pending
- 2019-09-26 EP EP19786671.8A patent/EP3856206A1/en active Pending
- 2019-09-26 WO PCT/IB2019/058188 patent/WO2020065584A1/en unknown
- 2019-09-26 JP JP2021542292A patent/JP2022513328A/en active Pending
- 2019-09-26 US US17/279,938 patent/US20210338728A1/en active Pending
- 2019-09-26 SG SG11202103025PA patent/SG11202103025PA/en unknown
- 2019-09-26 KR KR1020217012506A patent/KR20210069665A/en unknown
Also Published As
Publication number | Publication date |
---|---|
KR20210069665A (en) | 2021-06-11 |
US20210338728A1 (en) | 2021-11-04 |
WO2020065584A1 (en) | 2020-04-02 |
CN112930187A (en) | 2021-06-08 |
EP3856206A1 (en) | 2021-08-04 |
JP2022513328A (en) | 2022-02-07 |
CA3114292A1 (en) | 2020-04-02 |
AU2019349956A1 (en) | 2021-04-29 |
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