SG11202102497SA - Method of manufacturing a solid form of a bet bromodomain inhibitor - Google Patents

Method of manufacturing a solid form of a bet bromodomain inhibitor

Info

Publication number
SG11202102497SA
SG11202102497SA SG11202102497SA SG11202102497SA SG11202102497SA SG 11202102497S A SG11202102497S A SG 11202102497SA SG 11202102497S A SG11202102497S A SG 11202102497SA SG 11202102497S A SG11202102497S A SG 11202102497SA SG 11202102497S A SG11202102497S A SG 11202102497SA
Authority
SG
Singapore
Prior art keywords
manufacturing
solid form
bromodomain inhibitor
bet bromodomain
bet
Prior art date
Application number
SG11202102497SA
Inventor
Feng Wen
Jiahui Chen
Xianghui Wen
Mark Edgar
Henrik Hansen
Original Assignee
Zenith Epigenetics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zenith Epigenetics Ltd filed Critical Zenith Epigenetics Ltd
Publication of SG11202102497SA publication Critical patent/SG11202102497SA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/38Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
    • B01J23/40Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals
    • B01J23/44Palladium
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Materials Engineering (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SG11202102497SA 2018-09-13 2019-09-13 Method of manufacturing a solid form of a bet bromodomain inhibitor SG11202102497SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862730849P 2018-09-13 2018-09-13
PCT/IB2019/001011 WO2020053657A1 (en) 2018-09-13 2019-09-13 Method of manufacturing a solid form of a bet bromodomain inhibitor

Publications (1)

Publication Number Publication Date
SG11202102497SA true SG11202102497SA (en) 2021-04-29

Family

ID=69777480

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202102497SA SG11202102497SA (en) 2018-09-13 2019-09-13 Method of manufacturing a solid form of a bet bromodomain inhibitor

Country Status (13)

Country Link
US (1) US20220048905A1 (en)
EP (1) EP3849980A4 (en)
JP (1) JP2022500433A (en)
KR (1) KR20210080373A (en)
CN (1) CN112955449A (en)
AU (1) AU2019338059A1 (en)
CA (1) CA3111527A1 (en)
EA (1) EA202190598A1 (en)
IL (1) IL281258A (en)
MX (1) MX2021002885A (en)
SG (1) SG11202102497SA (en)
TW (1) TW202024078A (en)
WO (1) WO2020053657A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202327594A (en) 2021-09-23 2023-07-16 大陸商恒翼生物醫藥(上海)股份有限公司 Methods for treating triple-negative breast cancer in pre-selected patient populations with a combination of a bet bromodomain inhibitor and a parp inhibitor
KR102619332B1 (en) * 2021-11-30 2024-01-02 주식회사 베노바이오 Novel carboxamide redox derivative of inhibiting BET protein and composition for preventing and treating ophthalmic diseases using the same

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015002754A2 (en) * 2013-06-21 2015-01-08 Zenith Epigenetics Corp. Novel bicyclic bromodomain inhibitors
US20170121347A1 (en) * 2015-10-29 2017-05-04 Incyte Corporation Amorphous solid form of a bet protein inhibitor
EP3472157B1 (en) * 2016-06-20 2023-04-12 Incyte Corporation Crystalline solid forms of a bet inhibitor

Also Published As

Publication number Publication date
US20220048905A1 (en) 2022-02-17
IL281258A (en) 2021-04-29
AU2019338059A1 (en) 2021-04-01
MX2021002885A (en) 2021-07-15
EP3849980A4 (en) 2022-06-01
CA3111527A1 (en) 2020-03-19
JP2022500433A (en) 2022-01-04
EA202190598A1 (en) 2021-08-02
EP3849980A1 (en) 2021-07-21
TW202024078A (en) 2020-07-01
KR20210080373A (en) 2021-06-30
CN112955449A (en) 2021-06-11
WO2020053657A1 (en) 2020-03-19

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