SG11202102421PA - Cell-free dna hydroxymethylation profiles in the evaluation of pancreatic lesions - Google Patents

Cell-free dna hydroxymethylation profiles in the evaluation of pancreatic lesions

Info

Publication number
SG11202102421PA
SG11202102421PA SG11202102421PA SG11202102421PA SG11202102421PA SG 11202102421P A SG11202102421P A SG 11202102421PA SG 11202102421P A SG11202102421P A SG 11202102421PA SG 11202102421P A SG11202102421P A SG 11202102421PA SG 11202102421P A SG11202102421P A SG 11202102421PA
Authority
SG
Singapore
Prior art keywords
evaluation
cell
free dna
pancreatic lesions
hydroxymethylation profiles
Prior art date
Application number
SG11202102421PA
Inventor
Samuel Levy
Patrick A Arensdorf
Chin-Jen Ku
Francois Collin
Original Assignee
Bluestar Genomics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bluestar Genomics Inc filed Critical Bluestar Genomics Inc
Publication of SG11202102421PA publication Critical patent/SG11202102421PA/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06FELECTRIC DIGITAL DATA PROCESSING
    • G06F17/00Digital computing or data processing equipment or methods, specially adapted for specific functions
    • G06F17/10Complex mathematical operations
    • G06F17/18Complex mathematical operations for evaluating statistical data, e.g. average values, frequency distributions, probability functions, regression analysis
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/30ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indices; for individual health risk assessment
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2537/00Reactions characterised by the reaction format or use of a specific feature
    • C12Q2537/10Reactions characterised by the reaction format or use of a specific feature the purpose or use of
    • C12Q2537/164Methylation detection other then bisulfite or methylation sensitive restriction endonucleases
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/154Methylation markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/60Complex ways of combining multiple protein biomarkers for diagnosis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/70Mechanisms involved in disease identification
    • G01N2800/7023(Hyper)proliferation
    • G01N2800/7028Cancer
SG11202102421PA 2018-09-19 2019-09-19 Cell-free dna hydroxymethylation profiles in the evaluation of pancreatic lesions SG11202102421PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862733566P 2018-09-19 2018-09-19
PCT/US2019/052026 WO2020061380A1 (en) 2018-09-19 2019-09-19 Cell-free dna hydroxymethylation profiles in the evaluation of pancreatic lesions

Publications (1)

Publication Number Publication Date
SG11202102421PA true SG11202102421PA (en) 2021-04-29

Family

ID=68343435

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202102421PA SG11202102421PA (en) 2018-09-19 2019-09-19 Cell-free dna hydroxymethylation profiles in the evaluation of pancreatic lesions

Country Status (9)

Country Link
US (2) US20200123616A1 (en)
EP (1) EP3853383A1 (en)
JP (1) JP2022501033A (en)
CN (1) CN113508181A (en)
AU (1) AU2019343931A1 (en)
CA (1) CA3112880A1 (en)
MX (1) MX2021003164A (en)
SG (1) SG11202102421PA (en)
WO (1) WO2020061380A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112626210A (en) * 2020-12-22 2021-04-09 上海市第一人民医院 Application of diagnosis marker GATA4 in pancreatic inflammation-cancer transformation
WO2022271857A1 (en) * 2021-06-23 2022-12-29 Accuragen Holdings Limited Gene expression and cell-free dna methods and systems for disease detection

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5712126A (en) 1995-08-01 1998-01-27 Yale University Analysis of gene expression by display of 3-end restriction fragments of CDNA
US6287825B1 (en) 1998-09-18 2001-09-11 Molecular Staging Inc. Methods for reducing the complexity of DNA sequences
EP2322547A1 (en) 2003-06-25 2011-05-18 Crucell Holland B.V. Myeloid cell-specific lectin
US7537897B2 (en) 2006-01-23 2009-05-26 Population Genetics Technologies, Ltd. Molecular counting
CA2689356A1 (en) 2007-06-01 2008-12-11 454 Life Sciences Corporation System and meth0d for identification of individual samples from a multiplex mixture
WO2009032167A1 (en) 2007-08-29 2009-03-12 Illumina Cambridge Method for sequencing a polynucleotide template
US9115386B2 (en) 2008-09-26 2015-08-25 Children's Medical Center Corporation Selective oxidation of 5-methylcytosine by TET-family proteins
US20100323348A1 (en) 2009-01-31 2010-12-23 The Regents Of The University Of Colorado, A Body Corporate Methods and Compositions for Using Error-Detecting and/or Error-Correcting Barcodes in Nucleic Acid Amplification Process
US8835358B2 (en) 2009-12-15 2014-09-16 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse labels
WO2011127136A1 (en) * 2010-04-06 2011-10-13 University Of Chicago Composition and methods related to modification of 5-hydroxymethylcytosine (5-hmc)
SG2014007454A (en) * 2010-08-13 2014-07-30 Somalogic Inc Pancreatic cancer biomarkers and uses thereof
US9476095B2 (en) 2011-04-15 2016-10-25 The Johns Hopkins University Safe sequencing system
US9976184B2 (en) * 2011-06-23 2018-05-22 The Johns Hopkins University Mutations in pancreatic neoplasms
PL3363901T3 (en) 2012-02-17 2021-07-05 Fred Hutchinson Cancer Research Center Compositions and methods for accurately identifying mutations
WO2013142389A1 (en) 2012-03-20 2013-09-26 University Of Washington Through Its Center For Commercialization Methods of lowering the error rate of massively parallel dna sequencing using duplex consensus sequencing
ES2882329T3 (en) * 2016-04-07 2021-12-01 Univ Leland Stanford Junior Non-invasive diagnosis by DNA sequencing outside of 5-hydroxymethylated cells
US20170298422A1 (en) 2016-04-18 2017-10-19 The Board Of Trustees Of The Leland Stanford Junior University Simultaneous single-molecule epigenetic imaging of dna methylation and hydroxymethylation
CN107385050A (en) * 2017-08-04 2017-11-24 上海易毕恩生物技术有限公司 For detecting the gene marker, kit and cancer of pancreas detection method of cancer of pancreas
CN112105626A (en) 2018-02-14 2020-12-18 蓝星基因组股份有限公司 Method for epigenetic analysis of DNA, in particular cell-free DNA

Also Published As

Publication number Publication date
WO2020061380A9 (en) 2020-05-28
WO2020061380A1 (en) 2020-03-26
CN113508181A (en) 2021-10-15
AU2019343931A1 (en) 2021-05-13
US20200123616A1 (en) 2020-04-23
CA3112880A1 (en) 2020-03-26
EP3853383A1 (en) 2021-07-28
MX2021003164A (en) 2021-06-23
US20240026459A1 (en) 2024-01-25
JP2022501033A (en) 2022-01-06

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