SG11202100725YA - Biosynthetic platform for the production of cannabinoids and other prenylated compounds - Google Patents

Biosynthetic platform for the production of cannabinoids and other prenylated compounds

Info

Publication number
SG11202100725YA
SG11202100725YA SG11202100725YA SG11202100725YA SG11202100725YA SG 11202100725Y A SG11202100725Y A SG 11202100725YA SG 11202100725Y A SG11202100725Y A SG 11202100725YA SG 11202100725Y A SG11202100725Y A SG 11202100725YA SG 11202100725Y A SG11202100725Y A SG 11202100725YA
Authority
SG
Singapore
Prior art keywords
cannabinoids
production
prenylated compounds
biosynthetic
platform
Prior art date
Application number
SG11202100725YA
Other languages
English (en)
Inventor
James Bowie
Meaghan Valliere
Tyler Korman
Nicholas Woodall
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Publication of SG11202100725YA publication Critical patent/SG11202100725YA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P9/00—Preparation of organic compounds containing a metal or atom other than H, N, C, O, S or halogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/03—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with oxygen as acceptor (1.2.3)
    • C12Y102/03003—Pyruvate oxidase (1.2.3.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01008—Phosphate acetyltransferase (2.3.1.8)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C12Y205/01039—4-Hydroxybenzoate polyprenyltransferase (2.5.1.39)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
SG11202100725YA 2018-08-01 2019-08-01 Biosynthetic platform for the production of cannabinoids and other prenylated compounds SG11202100725YA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862713348P 2018-08-01 2018-08-01
PCT/US2019/044752 WO2020028722A1 (en) 2018-08-01 2019-08-01 Biosynthetic platform for the production of cannabinoids and other prenylated compounds

Publications (1)

Publication Number Publication Date
SG11202100725YA true SG11202100725YA (en) 2021-02-25

Family

ID=69232031

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202100725YA SG11202100725YA (en) 2018-08-01 2019-08-01 Biosynthetic platform for the production of cannabinoids and other prenylated compounds

Country Status (12)

Country Link
US (2) US11479760B2 (zh)
EP (1) EP3830581A4 (zh)
JP (1) JP2021532747A (zh)
KR (1) KR20210049805A (zh)
CN (1) CN112789505B (zh)
AU (1) AU2019314484A1 (zh)
BR (1) BR112021001450A2 (zh)
CA (1) CA3107544A1 (zh)
IL (1) IL280442A (zh)
MX (1) MX2021001065A (zh)
SG (1) SG11202100725YA (zh)
WO (1) WO2020028722A1 (zh)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11479760B2 (en) * 2018-08-01 2022-10-25 The Regents Of The University Of California Biosynthetic platform for the production of cannabinoids and other prenylated compounds
WO2020176547A1 (en) 2019-02-25 2020-09-03 Ginkgo Bioworks, Inc. Biosynthesis of cannabinoids and cannabinoid precursors
US20220315969A1 (en) * 2019-06-06 2022-10-06 Genomatica Inc. Olivetolic acid cyclase variants and methods for their use
WO2021067748A1 (en) * 2019-10-03 2021-04-08 Renew Biopharma, Inc. Compositions and methods for using genetically modified orthologous enzymes
CN111286509B (zh) * 2020-03-20 2021-02-26 天津法莫西生物医药科技有限公司 一种烯还原酶突变体及其编码基因和应用
EP3901256A1 (en) * 2020-04-21 2021-10-27 Synbionik GmbH Optimized production of cbga from olivetol acid and geranyl pyrophosphate via synnphb
CN113355300B (zh) * 2020-08-05 2022-04-01 深圳蓝晶生物科技有限公司 芳香族异戊烯基转移酶突变体、用于其表达的重组菌的构建方法及由其构建的重组菌
WO2022133223A1 (en) * 2020-12-18 2022-06-23 Debut Biotechnology, Inc. A versatile continuous manufacturing platform for cell-free chemical production
US11518983B1 (en) 2021-05-26 2022-12-06 Invizyne Technologies, Inc. Prenyltransferase variants with increased thermostability
CN113584089B (zh) * 2021-07-01 2023-11-24 嘉兴欣贝莱生物科技有限公司 异戊烯基转移酶催化合成大麻萜酚或大麻萜酚酸的用途
CN114621982B (zh) * 2022-03-16 2023-11-07 嘉兴欣贝莱生物科技有限公司 香叶基二磷酸酯的生物合成方法及其在制备大麻类化合物中的应用
CN116024111A (zh) * 2022-12-03 2023-04-28 中国科学院深圳先进技术研究院 一种产大麻萜酚的微生物细胞及其构建方法与应用
CN116622784B (zh) * 2023-02-14 2024-03-01 黑龙江八一农垦大学 一种大麻二酚酸合成酶的应用
CN117363593B (zh) * 2023-11-14 2024-07-09 北京大学深圳研究生院 多酶级联催化体系及其在对映-贝壳杉烯合成中的应用
CN117512033B (zh) * 2023-12-21 2024-04-19 山东三元生物科技股份有限公司 一种由葡萄糖同时生产d-塔格糖和d-阿洛酮糖的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2204300B1 (es) * 2002-07-18 2005-05-01 J. URIACH & CIA S.A. Nuevos derivados del acido 2,4-dihidroxibenzoico.
WO2006081537A2 (en) * 2005-01-28 2006-08-03 The Salk Institute For Biological Studies Novel aromatic prenyltransferases, nucleic acids encoding same and uses therefor
DE102010011601A1 (de) * 2010-03-16 2011-09-22 Eberhard-Karls-Universität Tübingen Prenyltransferasen aus Pilzen und ihre Verwendung zur Herstellung prenylierter Verbindungen
JP7181082B2 (ja) * 2015-07-21 2022-11-30 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 分子パージバルブを有するグルコース代謝
ES2898272T3 (es) * 2017-04-27 2022-03-04 Univ California Microorganismos y métodos para producir cannabinoides y derivados de cannabinoides
AU2019231994A1 (en) 2018-03-08 2020-09-10 Genomatica, Inc. Prenyltransferase variants and methods for production of prenylated aromatic compounds
WO2019183152A1 (en) * 2018-03-19 2019-09-26 Renew Biopharma, Inc. Compositions and methods for using genetically modified enzymes
US11479760B2 (en) * 2018-08-01 2022-10-25 The Regents Of The University Of California Biosynthetic platform for the production of cannabinoids and other prenylated compounds
CA3136629A1 (en) 2019-04-12 2020-10-15 Renew Biopharma, Inc. Compositions and methods for using genetically modified enzymes
CN113355300B (zh) 2020-08-05 2022-04-01 深圳蓝晶生物科技有限公司 芳香族异戊烯基转移酶突变体、用于其表达的重组菌的构建方法及由其构建的重组菌

Also Published As

Publication number Publication date
EP3830581A1 (en) 2021-06-09
US20230193221A1 (en) 2023-06-22
KR20210049805A (ko) 2021-05-06
CN112789505A (zh) 2021-05-11
CN112789505B (zh) 2024-04-09
MX2021001065A (es) 2021-06-23
IL280442A (en) 2021-03-01
US20210309975A1 (en) 2021-10-07
CA3107544A1 (en) 2020-02-06
AU2019314484A1 (en) 2021-02-25
WO2020028722A9 (en) 2020-04-09
BR112021001450A2 (pt) 2021-04-27
US11479760B2 (en) 2022-10-25
JP2021532747A (ja) 2021-12-02
EP3830581A4 (en) 2022-07-27
WO2020028722A1 (en) 2020-02-06

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