SG11202100025QA - Methods for gene modification of hematopoietic cells - Google Patents

Methods for gene modification of hematopoietic cells

Info

Publication number
SG11202100025QA
SG11202100025QA SG11202100025QA SG11202100025QA SG11202100025QA SG 11202100025Q A SG11202100025Q A SG 11202100025QA SG 11202100025Q A SG11202100025Q A SG 11202100025QA SG 11202100025Q A SG11202100025Q A SG 11202100025QA SG 11202100025Q A SG11202100025Q A SG 11202100025QA
Authority
SG
Singapore
Prior art keywords
methods
hematopoietic cells
gene modification
gene
modification
Prior art date
Application number
SG11202100025QA
Inventor
Brian Beard
Gaurav D Shah
Roncero Juan Antonio Bueren
Sanz Jose Carlos Segovia
Galdo Paula Rio
Ordonez Susana Navarro
Novoa Elena Almarza
Bustamante Oscar Quintana
Nunez Cristina Mesa
Kenneth Law
Kinnari Patel
Original Assignee
Centro De Investigaciones Energeticas Medioambientales Y Tecnologicas
Consorcio Centro De Investigacion Biomedica En Red M P
Fundacion Instituto De Investig Sanitaria Fundacion Jimenez Diaz
Rocket Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centro De Investigaciones Energeticas Medioambientales Y Tecnologicas, Consorcio Centro De Investigacion Biomedica En Red M P, Fundacion Instituto De Investig Sanitaria Fundacion Jimenez Diaz, Rocket Pharmaceuticals Ltd filed Critical Centro De Investigaciones Energeticas Medioambientales Y Tecnologicas
Publication of SG11202100025QA publication Critical patent/SG11202100025QA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/50—Soluble polymers, e.g. polyethyleneglycol [PEG]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SG11202100025QA 2018-07-30 2019-07-30 Methods for gene modification of hematopoietic cells SG11202100025QA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862712146P 2018-07-30 2018-07-30
PCT/US2019/044237 WO2020028430A1 (en) 2018-07-30 2019-07-30 Methods for gene modification of hematopoietic cells

Publications (1)

Publication Number Publication Date
SG11202100025QA true SG11202100025QA (en) 2021-01-28

Family

ID=69232048

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202100025QA SG11202100025QA (en) 2018-07-30 2019-07-30 Methods for gene modification of hematopoietic cells

Country Status (12)

Country Link
US (1) US20210290685A1 (en)
EP (1) EP3830248A4 (en)
JP (1) JP2021532776A (en)
KR (1) KR20210046004A (en)
CN (1) CN112888777A (en)
AU (1) AU2019315438A1 (en)
BR (1) BR112021001757A2 (en)
CA (1) CA3106241A1 (en)
IL (1) IL280465A (en)
MX (1) MX2021001292A (en)
SG (1) SG11202100025QA (en)
WO (1) WO2020028430A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112022021862A2 (en) * 2020-05-27 2023-02-28 Univ Zuerich INNOVATIVE TRANSDUCTION IMPROVEERS AND THEIR USES
CN116194154A (en) 2020-08-07 2023-05-30 太空飞船七有限责任公司 PLAKOPHILIN-2 (PKP 2) gene therapy using AAV vectors
CN114763563B (en) * 2021-01-12 2024-04-30 深圳华大临床检验中心 Method for improving slow virus infection efficiency

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2744603C2 (en) * 2016-02-12 2021-03-11 Блубёрд Био, Инк. Compositions increasing the number of copies of the vector (vcn), and methods of using
US20190284533A1 (en) * 2016-02-12 2019-09-19 Bluebird Bio, Inc. Vcn enhancer compositions and methods of using the same
WO2017218519A1 (en) * 2016-06-13 2017-12-21 Bluebird Bio, Inc. Gene therapy of neuronal ceroid lipofuscinoses
US20200071721A1 (en) * 2016-12-06 2020-03-05 Bluebird Bio, Inc. Gene therapy for mucopolysaccharidosis, type ii
CN110214182A (en) * 2016-12-06 2019-09-06 蓝鸟生物公司 Gene therapy for I type mucopolysaccharidosis

Also Published As

Publication number Publication date
IL280465A (en) 2021-03-25
AU2019315438A1 (en) 2021-01-28
EP3830248A4 (en) 2022-05-04
EP3830248A1 (en) 2021-06-09
BR112021001757A2 (en) 2021-05-11
WO2020028430A1 (en) 2020-02-06
MX2021001292A (en) 2021-07-15
CN112888777A (en) 2021-06-01
CA3106241A1 (en) 2020-02-06
US20210290685A1 (en) 2021-09-23
KR20210046004A (en) 2021-04-27
JP2021532776A (en) 2021-12-02

Similar Documents

Publication Publication Date Title
HK1247245A1 (en) Methods and compositions for inducing hematopoietic cell differentiation
IL287553A (en) Modified pluripotent cells
EP3371301A4 (en) Methods and compositions for inducing hematopoietic cell differentiation
IL274351A (en) Primary cell gene editing
IL276131A (en) Methods of use for car t cells
EP3472173A4 (en) Coatings for components of electrochemical cells
IL280465A (en) Methods for gene modification of hematopoietic cells
EP3824080A4 (en) Methods of analyzing cells
EP3234109A4 (en) Suspension culturing of pluripotent stem cells
IL279172A (en) Methods for generating hematopoietic stem cells
IL290590A (en) Cell culture methods
EP3475412A4 (en) Vessel for culturing cells
EP3702444A4 (en) Method for inducing differentiation of pluripotent stem cells into hepatocytes
IL274746A (en) Method for culture of cells
GB201608060D0 (en) Method of culturing T cells
PL3436568T3 (en) Culture medium for pluripotent stem cells
IL294152A (en) Method for culturing hematopoietic stem cells
GB201911958D0 (en) Methods of t cell production
EP3862428A4 (en) Method for extending telomere of cell
IL281231A (en) Methods of continuous cell culture
EP3540049A4 (en) Method for inducing differentiation of pluripotent stem cells into somatic cells
CA185441S (en) Cell culture insert
EP3570852A4 (en) Methods of treating multiple sclerosis using autologous t cells
CA185442S (en) Cell culture insert
SG11202010878QA (en) Cell culture medium