SG11202012109UA - Engineered phosphopentomutase variant enzymes - Google Patents

Engineered phosphopentomutase variant enzymes

Info

Publication number
SG11202012109UA
SG11202012109UA SG11202012109UA SG11202012109UA SG11202012109UA SG 11202012109U A SG11202012109U A SG 11202012109UA SG 11202012109U A SG11202012109U A SG 11202012109UA SG 11202012109U A SG11202012109U A SG 11202012109UA SG 11202012109U A SG11202012109U A SG 11202012109UA
Authority
SG
Singapore
Prior art keywords
variant enzymes
engineered phosphopentomutase
phosphopentomutase variant
engineered
enzymes
Prior art date
Application number
SG11202012109UA
Inventor
Scott Novick
Xiang Yi
Nikki Dellas
Oscar Alvizo
Jovana Nazor
Da Duan
Vesna Mitchell
Jonathan Vroom
Santhosh Sivaramakrishnan
Nandhitha Subramanian
Jeffrey Moore
Mark Huffman
Agustina Rodriguez-Granillo
Deeptak Verma
Grant Murphy
Nicholas Marshall
Jay Russell
Keith Canada
Original Assignee
Codexis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Codexis Inc filed Critical Codexis Inc
Publication of SG11202012109UA publication Critical patent/SG11202012109UA/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90Isomerases (5.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70Vectors or expression systems specially adapted for E. coli
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y504/00Intramolecular transferases (5.4)
    • C12Y504/02Phosphotransferases (phosphomutases) (5.4.2)
    • C12Y504/02007Phosphopentomutase (5.4.2.7)

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SG11202012109UA 2018-07-09 2019-07-02 Engineered phosphopentomutase variant enzymes SG11202012109UA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862695491P 2018-07-09 2018-07-09
PCT/US2019/040353 WO2020014046A1 (en) 2018-07-09 2019-07-02 Engineered phosphopentomutase variant enzymes

Publications (1)

Publication Number Publication Date
SG11202012109UA true SG11202012109UA (en) 2021-01-28

Family

ID=69101520

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202012109UA SG11202012109UA (en) 2018-07-09 2019-07-02 Engineered phosphopentomutase variant enzymes

Country Status (11)

Country Link
US (3) US11034948B2 (en)
EP (1) EP3821026A4 (en)
JP (2) JP7493248B2 (en)
KR (1) KR20210031933A (en)
CN (1) CN112601821A (en)
AU (1) AU2019302422B2 (en)
CA (1) CA3108728A1 (en)
IL (1) IL279880A (en)
MX (1) MX2021000322A (en)
SG (1) SG11202012109UA (en)
WO (1) WO2020014046A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3108728A1 (en) 2018-07-09 2020-01-16 Codexis, Inc. Engineered phosphopentomutase variant enzymes
CN112996511B (en) 2018-07-09 2024-08-09 默沙东有限责任公司 Enzymatic synthesis of 4' -ethynyl nucleoside analogues
CN114072165A (en) * 2019-07-02 2022-02-18 科德克希思公司 Engineered sucrose phosphorylase variant enzymes
EP4225909A1 (en) * 2020-10-07 2023-08-16 Codexis, Inc. Engineered phosphopentomutase variant enzymes
WO2022133289A2 (en) * 2020-12-18 2022-06-23 Codexis, Inc. Engineered uridine phosphorylase variant enzymes
CN116855471B (en) * 2023-09-04 2023-11-28 江苏申基生物科技有限公司 Purine nucleoside phosphorylase mutant and application thereof

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Also Published As

Publication number Publication date
CA3108728A1 (en) 2020-01-16
US20240060064A1 (en) 2024-02-22
KR20210031933A (en) 2021-03-23
US20200010823A1 (en) 2020-01-09
US11795445B2 (en) 2023-10-24
EP3821026A4 (en) 2022-06-01
JP2021530981A (en) 2021-11-18
WO2020014046A1 (en) 2020-01-16
JP2024040366A (en) 2024-03-25
US20210261940A1 (en) 2021-08-26
MX2021000322A (en) 2021-03-25
AU2019302422B2 (en) 2022-08-04
AU2019302422A1 (en) 2021-01-07
EP3821026A1 (en) 2021-05-19
IL279880A (en) 2021-03-01
JP7493248B2 (en) 2024-05-31
CN112601821A (en) 2021-04-02
US11034948B2 (en) 2021-06-15

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