SG11202011332QA - Coupling of ion mobility spectrometer with mass spectrometer - Google Patents

Coupling of ion mobility spectrometer with mass spectrometer

Info

Publication number
SG11202011332QA
SG11202011332QA SG11202011332QA SG11202011332QA SG11202011332QA SG 11202011332Q A SG11202011332Q A SG 11202011332QA SG 11202011332Q A SG11202011332Q A SG 11202011332QA SG 11202011332Q A SG11202011332Q A SG 11202011332QA SG 11202011332Q A SG11202011332Q A SG 11202011332QA
Authority
SG
Singapore
Prior art keywords
spectrometer
coupling
ion mobility
mass spectrometer
mass
Prior art date
Application number
SG11202011332QA
Inventor
Ahmed M Hamid
Gordon Anderson
John Daniel Debord
Original Assignee
Mobilion Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mobilion Systems Inc filed Critical Mobilion Systems Inc
Publication of SG11202011332QA publication Critical patent/SG11202011332QA/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • G01N27/622—Ion mobility spectrometry
    • G01N27/623—Ion mobility spectrometry combined with mass spectrometry
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/06—Electron- or ion-optical arrangements
    • H01J49/061—Ion deflecting means, e.g. ion gates
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/06—Electron- or ion-optical arrangements
    • H01J49/062—Ion guides
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/107—Arrangements for using several ion sources
SG11202011332QA 2018-05-14 2019-05-14 Coupling of ion mobility spectrometer with mass spectrometer SG11202011332QA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862671126P 2018-05-14 2018-05-14
PCT/US2019/032297 WO2019222274A1 (en) 2018-05-14 2019-05-14 Coupling of ion mobility spectrometer with mass spectrometer

Publications (1)

Publication Number Publication Date
SG11202011332QA true SG11202011332QA (en) 2020-12-30

Family

ID=68463308

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202011332QA SG11202011332QA (en) 2018-05-14 2019-05-14 Coupling of ion mobility spectrometer with mass spectrometer

Country Status (8)

Country Link
US (2) US10741375B2 (en)
EP (1) EP3794630A4 (en)
JP (1) JP2021524991A (en)
CN (1) CN112840434A (en)
AU (1) AU2019269449A1 (en)
CA (1) CA3100350A1 (en)
SG (1) SG11202011332QA (en)
WO (1) WO2019222274A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10741375B2 (en) 2018-05-14 2020-08-11 MOBILion Systems, Inc. Coupling of ion mobility spectrometer with mass spectrometer
WO2020237037A1 (en) 2019-05-21 2020-11-26 MOBILion Systems, Inc. Voltage control for ion mobility separation
WO2021102406A1 (en) * 2019-11-22 2021-05-27 MOBILion Systems, Inc. Mobility based filtering of ions
US11662333B2 (en) 2020-04-06 2023-05-30 MOBILion Systems, Inc. Systems and methods for two-dimensional mobility based filtering of ions
CN115885176A (en) * 2020-05-22 2023-03-31 莫比莱昂系统有限公司 Method and apparatus for trapping and accumulating ions
EP4161683A1 (en) 2020-06-05 2023-04-12 Mobilion Systems, Inc. Apparatus and methods for ion manipulation having improved duty cycle
WO2022108942A1 (en) * 2020-11-17 2022-05-27 MOBILion Systems, Inc. Systems and methods for image and/or video processing of mass spectrometry data

Family Cites Families (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5789745A (en) 1997-10-28 1998-08-04 Sandia Corporation Ion mobility spectrometer using frequency-domain separation
EP1268041B1 (en) * 2000-02-29 2012-09-05 Ionwerks, Inc. Improved mobility spectrometer
CA2391060C (en) 2001-06-21 2011-08-09 Micromass Limited Mass spectrometer
CA2391140C (en) 2001-06-25 2008-10-07 Micromass Limited Mass spectrometer
US6872939B2 (en) 2002-05-17 2005-03-29 Micromass Uk Limited Mass spectrometer
US6794641B2 (en) 2002-05-30 2004-09-21 Micromass Uk Limited Mass spectrometer
US7095013B2 (en) 2002-05-30 2006-08-22 Micromass Uk Limited Mass spectrometer
US6800846B2 (en) 2002-05-30 2004-10-05 Micromass Uk Limited Mass spectrometer
US6791078B2 (en) 2002-06-27 2004-09-14 Micromass Uk Limited Mass spectrometer
US6884995B2 (en) 2002-07-03 2005-04-26 Micromass Uk Limited Mass spectrometer
US7071467B2 (en) 2002-08-05 2006-07-04 Micromass Uk Limited Mass spectrometer
GB2449760B (en) 2003-03-19 2009-01-14 Thermo Finnigan Llc Obtaining tandem mass spectrometry data for multiple parent lons in an ion population
GB0514964D0 (en) * 2005-07-21 2005-08-24 Ms Horizons Ltd Mass spectrometer devices & methods of performing mass spectrometry
US7405401B2 (en) 2004-01-09 2008-07-29 Micromass Uk Limited Ion extraction devices, mass spectrometer devices, and methods of selectively extracting ions and performing mass spectrometry
CA2554997A1 (en) 2004-02-02 2005-08-18 Sionex Corporation Compact sample analysis systems and related methods using combined chromatography and mobility spectrometry techniques
GB0408751D0 (en) 2004-04-20 2004-05-26 Micromass Ltd Mass spectrometer
WO2006014984A1 (en) * 2004-07-27 2006-02-09 Ionwerks, Inc. Multiplex data acquisition modes for ion mobility-mass spectrometry
CA2575913A1 (en) 2004-08-02 2006-02-09 Owlstone Ltd Ion mobility spectrometer
US7154088B1 (en) 2004-09-16 2006-12-26 Sandia Corporation Microfabricated ion trap array
GB0424426D0 (en) 2004-11-04 2004-12-08 Micromass Ltd Mass spectrometer
WO2006130474A2 (en) * 2005-05-27 2006-12-07 Ionwerks, Inc. Multi-beam ion mobility time-of-flight mass spectrometer with bipolar ion extraction and zwitterion detection
GB0808344D0 (en) 2008-05-08 2008-06-18 Owlstone Ltd Sensor
CA2628922C (en) * 2005-11-10 2016-01-26 Micromass Uk Limited Mass spectrometer
GB0524972D0 (en) * 2005-12-07 2006-01-18 Micromass Ltd Mass spectrometer
EP2038913B1 (en) 2006-07-10 2015-07-08 Micromass UK Limited Mass spectrometer
US8362420B2 (en) * 2006-09-01 2013-01-29 Indiana University Research And Technology Corporation Apparatus and methods for analyzing ions
US7491930B2 (en) 2006-12-29 2009-02-17 Battelle Memorial Institute Hooked differential mobility spectrometry apparatus and method therefore
GB2457769B (en) 2007-09-14 2010-07-14 Micromass Ltd Method of ion mobility separation
US7888635B2 (en) 2008-05-30 2011-02-15 Battelle Memorial Institute Ion funnel ion trap and process
US7838826B1 (en) * 2008-08-07 2010-11-23 Bruker Daltonics, Inc. Apparatus and method for parallel flow ion mobility spectrometry combined with mass spectrometry
GB2476964A (en) 2010-01-15 2011-07-20 Anatoly Verenchikov Electrostatic trap mass spectrometer
WO2012016330A1 (en) * 2010-08-04 2012-02-09 Dh Technologies Development Pte. Ltd. A linear ion trap for radial amplitude assisted transfer
JP5686566B2 (en) 2010-10-08 2015-03-18 株式会社日立ハイテクノロジーズ Mass spectrometer
GB201021360D0 (en) * 2010-12-16 2011-01-26 Thermo Fisher Scient Bremen Gmbh Apparatus and methods for ion mobility spectrometry
GB201103255D0 (en) 2011-02-25 2011-04-13 Micromass Ltd Curved ion guide with non mass to charge ratio dependent confinement
GB201103858D0 (en) * 2011-03-07 2011-04-20 Micromass Ltd DC ion guide for analytical filtering/separation
US8581177B2 (en) 2011-04-11 2013-11-12 Thermo Finnigan Llc High duty cycle ion storage/ion mobility separation mass spectrometer
US8941055B2 (en) 2011-04-26 2015-01-27 Bruker Daltonik Gmbh Selective ion mobility filter
US8941054B2 (en) 2011-04-26 2015-01-27 Bruker Daltonik Gmbh Selective ion mobility spectrometer formed from two consecutive mass selective filters
GB201114734D0 (en) 2011-08-25 2011-10-12 Micromass Ltd Mass spectrometer
GB201114735D0 (en) 2011-08-25 2011-10-12 Micromass Ltd Mass spectrometer
US8921772B2 (en) 2011-11-02 2014-12-30 Leco Corporation Ion mobility spectrometer
US8809769B2 (en) 2012-11-29 2014-08-19 Bruker Daltonics, Inc. Apparatus and method for cross-flow ion mobility spectrometry
CN103871820B (en) * 2012-12-10 2017-05-17 株式会社岛津制作所 Ion mobility analyzer and combination unit thereof and ion mobility analysis method
EP2965075B2 (en) 2013-03-06 2022-09-21 Micromass UK Limited Optimised ion mobility separation timescales for targeted ions
JP6495192B2 (en) * 2013-03-13 2019-04-03 マイクロマス ユーケー リミテッド Pulse ion source with toroidal trap structure
US9812311B2 (en) 2013-04-08 2017-11-07 Battelle Memorial Institute Ion manipulation method and device
US8835839B1 (en) * 2013-04-08 2014-09-16 Battelle Memorial Institute Ion manipulation device
US9455132B2 (en) 2013-05-30 2016-09-27 Agilent Technologies, Inc. Ion mobility spectrometry-mass spectrometry (IMS-MS) with improved ion transmission and IMS resolution
US9939408B2 (en) 2013-12-24 2018-04-10 Micromass Uk Limited Travelling wave IMS with counterflow of gas
US10497551B2 (en) * 2013-12-24 2019-12-03 Micromass Uk Limited Storage ring for fast processes
US10043644B2 (en) * 2014-05-14 2018-08-07 Micromass Uk Limited De-convolution of overlapping ion mobility spectrometer or separator data
GB2541795B (en) 2014-05-23 2018-04-11 Thermo Fisher Scient Bremen Gmbh Method and apparatus for mass spectrometry of macromolecular complexes
US9613788B2 (en) 2014-06-13 2017-04-04 Perkinelmer Health Sciences, Inc. RF ion guide with axial fields
WO2016020678A1 (en) 2014-08-05 2016-02-11 Micromass Uk Limited Method of introducing ions into a vacuum region of a mass spectrometer
US9683964B2 (en) 2015-02-05 2017-06-20 Bruker Daltonik Gmbh Trapping ion mobility spectrometer with parallel accumulation
US10861687B2 (en) 2015-04-23 2020-12-08 Micromass Uk Limited Separating ions in an ion trap
CN109154583B (en) 2015-10-07 2021-06-18 巴特尔纪念研究院 Method and apparatus for ion mobility separation using alternating current waveforms
US9741552B2 (en) 2015-12-22 2017-08-22 Bruker Daltonics, Inc. Triple quadrupole mass spectrometry coupled to trapped ion mobility separation
US10727041B2 (en) 2016-01-28 2020-07-28 Purdue Research Foundation Systems and methods for separating ions at about or above atmospheric pressure
US10060879B2 (en) 2016-04-28 2018-08-28 Bruker Daltonics, Inc. Ion storage for a mobility separator of a mass spectrometric system
US10018592B2 (en) 2016-05-17 2018-07-10 Battelle Memorial Institute Method and apparatus for spatial compression and increased mobility resolution of ions
GB201608653D0 (en) 2016-05-17 2016-06-29 Micromass Ltd Ion mobility seperator
DE102017111067B4 (en) 2016-06-02 2021-09-23 Bruker Daltonics GmbH & Co. KG Isomer analysis in TIMS-Q-q-TOF mass spectrometers
US9939409B2 (en) 2016-08-03 2018-04-10 Battelle Memorial Institute Systems and methods for integrating ion mobility and ion trap mass spectrometers
US10241079B2 (en) 2017-05-24 2019-03-26 Bruker Daltonik Gmbh Mass spectrometer with tandem ion mobility analyzers
GB201711795D0 (en) 2017-07-21 2017-09-06 Micromass Ltd Mobility and mass measurement using time - varying electric fields
GB2579314A (en) 2017-08-16 2020-06-17 Battelle Memorial Institute Methods and systems for ion manipulation
US10692710B2 (en) 2017-08-16 2020-06-23 Battelle Memorial Institute Frequency modulated radio frequency electric field for ion manipulation
WO2019070324A1 (en) 2017-10-04 2019-04-11 Battelle Memorial Institute Methods and systems for integrating ion manipulation devices
US10522337B2 (en) 2017-12-08 2019-12-31 Ecole Polytechnique Federale De Lausanne (Efpl) High-throughput cryogenic spectroscopy for glycan analysis
US10332723B1 (en) 2017-12-20 2019-06-25 Battelle Memorial Institute Ion focusing device
GB201802917D0 (en) 2018-02-22 2018-04-11 Micromass Ltd Charge detection mass spectrometry
US10741375B2 (en) 2018-05-14 2020-08-11 MOBILion Systems, Inc. Coupling of ion mobility spectrometer with mass spectrometer
EP3578966A1 (en) 2018-06-04 2019-12-11 Bruker Scientific LLC Separation of ions according to ion mobility with enhanced resolving power for mass spectrometric analysis
US10720315B2 (en) 2018-06-05 2020-07-21 Trace Matters Scientific Llc Reconfigurable sequentially-packed ion (SPION) transfer device
US10840077B2 (en) 2018-06-05 2020-11-17 Trace Matters Scientific Llc Reconfigureable sequentially-packed ion (SPION) transfer device
US10460920B1 (en) 2018-06-26 2019-10-29 Battelle Memorial Institute Flexible ion conduit
GB201904425D0 (en) 2019-03-29 2019-05-15 Micromass Ltd Method of selecting ions
US11119069B2 (en) 2019-05-28 2021-09-14 Battelle Memorial Institute Device and method to manipulate ions in multi level system
GB2586321B (en) 2019-05-31 2023-12-13 Bruker Daltonics Gmbh & Co Kg Hybrid mass spectrometric system
GB201907787D0 (en) 2019-05-31 2019-07-17 Micromass Ltd Ion guide
US11460439B2 (en) 2019-09-16 2022-10-04 MOBILion Systems, Inc. Voltage control for traveling wave characteristic variation

Also Published As

Publication number Publication date
CA3100350A1 (en) 2019-11-21
JP2021524991A (en) 2021-09-16
US20190348268A1 (en) 2019-11-14
CN112840434A (en) 2021-05-25
US11322340B2 (en) 2022-05-03
EP3794630A1 (en) 2021-03-24
AU2019269449A1 (en) 2020-12-10
EP3794630A4 (en) 2022-01-26
US20200373140A1 (en) 2020-11-26
WO2019222274A1 (en) 2019-11-21
US10741375B2 (en) 2020-08-11

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