SG11202010675UA - Device and method for determining depth and concentration of a subsurface fluorescent object - Google Patents

Device and method for determining depth and concentration of a subsurface fluorescent object

Info

Publication number
SG11202010675UA
SG11202010675UA SG11202010675UA SG11202010675UA SG11202010675UA SG 11202010675U A SG11202010675U A SG 11202010675UA SG 11202010675U A SG11202010675U A SG 11202010675UA SG 11202010675U A SG11202010675U A SG 11202010675UA SG 11202010675U A SG11202010675U A SG 11202010675UA
Authority
SG
Singapore
Prior art keywords
subsurface
concentration
determining depth
fluorescent object
fluorescent
Prior art date
Application number
SG11202010675UA
Inventor
Keith D Paulsen
David W Roberts
Dennis Wirth
Brian C Wilson
Mira Sibai
Original Assignee
Dartmouth College
Univ Health Network
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dartmouth College, Univ Health Network filed Critical Dartmouth College
Publication of SG11202010675UA publication Critical patent/SG11202010675UA/en

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N21/6456Spatial resolved fluorescence measurements; Imaging
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0077Devices for viewing the surface of the body, e.g. camera, magnifying lens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/48Other medical applications
    • A61B5/4887Locating particular structures in or on the body
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01BMEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B11/00Measuring arrangements characterised by the use of optical techniques
    • G01B11/22Measuring arrangements characterised by the use of optical techniques for measuring depth
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47Scattering, i.e. diffuse reflection
    • G01N21/4795Scattering, i.e. diffuse reflection spatially resolved investigating of object in scattering medium
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • G01N33/4833Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2505/00Evaluating, monitoring or diagnosing in the context of a particular type of medical care
    • A61B2505/05Surgical care
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2576/00Medical imaging apparatus involving image processing or analysis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/41Refractivity; Phase-affecting properties, e.g. optical path length
    • G01N2021/4173Phase distribution
    • G01N2021/418Frequency/phase diagrams
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00Features of devices classified in G01N21/00
    • G01N2201/06Illumination; Optics
    • G01N2201/062LED's
SG11202010675UA 2018-04-26 2019-04-26 Device and method for determining depth and concentration of a subsurface fluorescent object SG11202010675UA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862663158P 2018-04-26 2018-04-26
PCT/US2019/029421 WO2019210218A1 (en) 2018-04-26 2019-04-26 Device and method for determining depth and concentration of a subsurface fluorescent object

Publications (1)

Publication Number Publication Date
SG11202010675UA true SG11202010675UA (en) 2020-11-27

Family

ID=68294701

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202010675UA SG11202010675UA (en) 2018-04-26 2019-04-26 Device and method for determining depth and concentration of a subsurface fluorescent object

Country Status (9)

Country Link
US (3) US11162900B2 (en)
EP (1) EP3785019B1 (en)
KR (1) KR102521793B1 (en)
CN (1) CN112449683A (en)
AU (1) AU2019260756B2 (en)
BR (1) BR112020021901B1 (en)
CA (1) CA3098446A1 (en)
SG (1) SG11202010675UA (en)
WO (1) WO2019210218A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112020021901B1 (en) * 2018-04-26 2023-03-07 The Trustees Of Dartmouth College METHOD FOR DETERMINING A DEPTH OF A FLUOROPHOR CONCENTRATION AND DEVICE FOR QUANTIFYING AND DETERMINING THE DEPTH OF FLUOROPHOR CONCENTRATIONS
CN114866766A (en) * 2022-07-04 2022-08-05 广东欧谱曼迪科技有限公司 Sensitivity evaluation method, sensitivity test device, electronic device, and storage medium

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5919140A (en) * 1995-02-21 1999-07-06 Massachusetts Institute Of Technology Optical imaging using time gated scattered light
AU1130797A (en) * 1995-08-24 1997-03-19 Purdue Research Foundation Fluorescence lifetime-based imaging and spectroscopy in tissues and other random media
EP1682878A1 (en) * 2003-10-31 2006-07-26 Art Advanced Research Technologies Inc. A time-domain method and apparatus for determining the depth and concentration of a fluorophore in a turbid medium
US7729750B2 (en) * 2005-01-20 2010-06-01 The Regents Of The University Of California Method and apparatus for high resolution spatially modulated fluorescence imaging and tomography
GB0601961D0 (en) * 2006-01-31 2006-03-15 Bp Exploration Operating Method
CA2662893A1 (en) * 2006-09-06 2008-03-13 University Health Network Fluorescence quantification and image acquisition in highly turbid media
WO2011072401A1 (en) * 2009-12-18 2011-06-23 University Health Network System and method for sub-surface fluorescence imaging
CA2788018C (en) * 2010-01-25 2020-12-29 University Health Network Device, system and method for quantifying fluorescence and optical properties
US9066657B2 (en) * 2010-11-23 2015-06-30 General Electric Company Methods and systems of optical imaging for target detection in a scattering medium
US11510600B2 (en) * 2012-01-04 2022-11-29 The Trustees Of Dartmouth College Method and apparatus for quantitative and depth resolved hyperspectral fluorescence and reflectance imaging for surgical guidance
WO2015023990A1 (en) * 2013-08-15 2015-02-19 The Trustees Of Dartmouth College Method and apparatus for quantitative and depth resolved hyperspectral fluorescence and reflectance imaging for surgical guidance
WO2015103566A2 (en) 2014-01-06 2015-07-09 The Regents Of The University Of California Spatial frequency domain imaging using custom patterns
US10785393B2 (en) * 2015-05-22 2020-09-22 Facebook, Inc. Methods and devices for selective flash illumination
BR112020021901B1 (en) * 2018-04-26 2023-03-07 The Trustees Of Dartmouth College METHOD FOR DETERMINING A DEPTH OF A FLUOROPHOR CONCENTRATION AND DEVICE FOR QUANTIFYING AND DETERMINING THE DEPTH OF FLUOROPHOR CONCENTRATIONS

Also Published As

Publication number Publication date
US20230324301A1 (en) 2023-10-12
CN112449683A (en) 2021-03-05
AU2019260756B2 (en) 2023-06-08
BR112020021901A2 (en) 2021-03-02
EP3785019B1 (en) 2024-05-01
CA3098446A1 (en) 2019-10-31
WO2019210218A1 (en) 2019-10-31
EP3785019A1 (en) 2021-03-03
BR112020021901B1 (en) 2023-03-07
US11162900B2 (en) 2021-11-02
US20210239617A1 (en) 2021-08-05
KR102521793B1 (en) 2023-04-14
US20220057328A1 (en) 2022-02-24
US11662315B2 (en) 2023-05-30
EP3785019A4 (en) 2022-01-12
KR20210027255A (en) 2021-03-10
AU2019260756A1 (en) 2020-12-03

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