SG11202009234QA - Modified a1-a2 domains of non-natural nkg2d ligands that bind non-natural nkg2d receptors - Google Patents

Modified a1-a2 domains of non-natural nkg2d ligands that bind non-natural nkg2d receptors

Info

Publication number
SG11202009234QA
SG11202009234QA SG11202009234QA SG11202009234QA SG11202009234QA SG 11202009234Q A SG11202009234Q A SG 11202009234QA SG 11202009234Q A SG11202009234Q A SG 11202009234QA SG 11202009234Q A SG11202009234Q A SG 11202009234QA SG 11202009234Q A SG11202009234Q A SG 11202009234QA
Authority
SG
Singapore
Prior art keywords
natural nkg2d
domains
modified
receptors
natural
Prior art date
Application number
SG11202009234QA
Inventor
Kaman C Kim
Kyle E Landgraf
Original Assignee
Xyphos Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xyphos Biosciences Inc filed Critical Xyphos Biosciences Inc
Publication of SG11202009234QA publication Critical patent/SG11202009234QA/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/7056—Lectin superfamily, e.g. CD23, CD72
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/463—Cellular immunotherapy characterised by recombinant expression
    • A61K39/4631—Chimeric Antigen Receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464402—Receptors, cell surface antigens or cell surface determinants
    • A61K39/464429—Molecules with a "CD" designation not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biotechnology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SG11202009234QA 2018-03-27 2019-03-27 Modified a1-a2 domains of non-natural nkg2d ligands that bind non-natural nkg2d receptors SG11202009234QA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862648636P 2018-03-27 2018-03-27
PCT/US2019/024298 WO2019191243A1 (en) 2018-03-27 2019-03-27 Modified a1-a2 domains of non-natural nkg2d ligands that bind non-natural nkg2d receptors

Publications (1)

Publication Number Publication Date
SG11202009234QA true SG11202009234QA (en) 2020-10-29

Family

ID=66286967

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202009234QA SG11202009234QA (en) 2018-03-27 2019-03-27 Modified a1-a2 domains of non-natural nkg2d ligands that bind non-natural nkg2d receptors

Country Status (16)

Country Link
US (1) US20190300594A1 (en)
EP (1) EP3774873A1 (en)
JP (2) JP7443240B2 (en)
KR (1) KR20200138311A (en)
CN (1) CN112074532A (en)
AU (1) AU2019243703A1 (en)
BR (1) BR112020019336A2 (en)
CA (1) CA3093967A1 (en)
CO (1) CO2020013140A2 (en)
IL (1) IL277339A (en)
JO (1) JOP20200234A1 (en)
MA (1) MA52206A (en)
MX (1) MX2020010003A (en)
PH (1) PH12020551554A1 (en)
SG (1) SG11202009234QA (en)
WO (1) WO2019191243A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230126689A1 (en) 2020-03-06 2023-04-27 Go Therapeutics, Inc. Anti-glyco-cd44 antibodies and their uses
CN111471099B (en) * 2020-03-31 2022-04-12 长沙学院 MICA extracellular domain mutant and screening method thereof, scFv-MICA fusion antibody and preparation method and application thereof
WO2022187591A1 (en) 2021-03-05 2022-09-09 Go Therapeutics, Inc. Anti-glyco-cd44 antibodies and their uses
CA3220872A1 (en) 2021-06-08 2022-12-15 Kyle LANDGRAF Antibody-nkg2d ligand domain fusion protein
WO2022260659A1 (en) 2021-06-08 2022-12-15 Xyphos Biosciences Inc. Antibody-nkg2d ligand domain fusion protein
CA3228178A1 (en) 2021-08-05 2023-02-09 Go Therapeutics, Inc. Anti-glyco-muc4 antibodies and their uses
TW202328188A (en) 2021-09-03 2023-07-16 美商Ｇｏ治療公司 Anti-glyco-cmet antibodies and their uses
AU2022339819A1 (en) 2021-09-03 2024-04-11 Go Therapeutics, Inc. Anti-glyco-lamp1 antibodies and their uses

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7435596B2 (en) 2004-11-04 2008-10-14 St. Jude Children's Research Hospital, Inc. Modified cell line and method for expansion of NK cell
US10259858B2 (en) * 2015-08-04 2019-04-16 Xyphos Biosciences Inc. Insertable variable fragments of antibodies and modified α1-α2 domains of NKG2D ligands, and non-natural NKG2D ligands that bind non-natural NKG2D receptors
EP3917946A4 (en) * 2019-01-28 2022-10-26 Xyphos Biosciences Inc. Modified non-natural nkg2d ligands that selectively deliver attached heterologous molecules to non-natural nkg2d receptors on car-cells

Also Published As

Publication number Publication date
WO2019191243A1 (en) 2019-10-03
US20190300594A1 (en) 2019-10-03
JP2021519287A (en) 2021-08-10
IL277339A (en) 2020-10-29
CO2020013140A2 (en) 2021-01-18
MX2020010003A (en) 2021-01-15
MA52206A (en) 2021-02-17
EP3774873A1 (en) 2021-02-17
PH12020551554A1 (en) 2021-06-07
KR20200138311A (en) 2020-12-09
JP7443240B2 (en) 2024-03-05
JP2024023230A (en) 2024-02-21
CA3093967A1 (en) 2019-10-03
RU2020134984A (en) 2022-04-27
JOP20200234A1 (en) 2020-09-15
AU2019243703A1 (en) 2020-10-08
CN112074532A (en) 2020-12-11
BR112020019336A2 (en) 2021-01-05

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