SG11202007982VA - Three-dimensional cell and tissue image analysis for cellular and sub-cellular morphological modeling and classification - Google Patents

Three-dimensional cell and tissue image analysis for cellular and sub-cellular morphological modeling and classification

Info

Publication number
SG11202007982VA
SG11202007982VA SG11202007982VA SG11202007982VA SG11202007982VA SG 11202007982V A SG11202007982V A SG 11202007982VA SG 11202007982V A SG11202007982V A SG 11202007982VA SG 11202007982V A SG11202007982V A SG 11202007982VA SG 11202007982V A SG11202007982V A SG 11202007982VA
Authority
SG
Singapore
Prior art keywords
cellular
classification
sub
image analysis
tissue image
Prior art date
Application number
SG11202007982VA
Inventor
Ivaylo Dinov
Brian D Athey
David S Dilworth
Ari Allyn-Feuer
Alexandr Kalinin
Alex S Ade
Original Assignee
Univ Michigan Regents
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Michigan Regents filed Critical Univ Michigan Regents
Publication of SG11202007982VA publication Critical patent/SG11202007982VA/en

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Classifications

    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/10—Segmentation; Edge detection
    • G06T7/12—Edge-based segmentation
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F18/00—Pattern recognition
    • G06F18/20—Analysing
    • G06F18/24—Classification techniques
    • G06F18/24765—Rule-based classification
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/10—Segmentation; Edge detection
    • G06T7/143—Segmentation; Edge detection involving probabilistic approaches, e.g. Markov random field [MRF] modelling
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/64—Three-dimensional objects
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/695—Preprocessing, e.g. image segmentation
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/698—Matching; Classification
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F18/00—Pattern recognition
    • G06F18/20—Analysing
    • G06F18/24—Classification techniques
    • G06F18/241—Classification techniques relating to the classification model, e.g. parametric or non-parametric approaches
    • G06F18/2411—Classification techniques relating to the classification model, e.g. parametric or non-parametric approaches based on the proximity to a decision surface, e.g. support vector machines
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F18/00—Pattern recognition
    • G06F18/20—Analysing
    • G06F18/24—Classification techniques
    • G06F18/241—Classification techniques relating to the classification model, e.g. parametric or non-parametric approaches
    • G06F18/2413—Classification techniques relating to the classification model, e.g. parametric or non-parametric approaches based on distances to training or reference patterns
    • G06F18/24147—Distances to closest patterns, e.g. nearest neighbour classification
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F18/00—Pattern recognition
    • G06F18/20—Analysing
    • G06F18/24—Classification techniques
    • G06F18/241—Classification techniques relating to the classification model, e.g. parametric or non-parametric approaches
    • G06F18/2415—Classification techniques relating to the classification model, e.g. parametric or non-parametric approaches based on parametric or probabilistic models, e.g. based on likelihood ratio or false acceptance rate versus a false rejection rate
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F18/00—Pattern recognition
    • G06F18/20—Analysing
    • G06F18/24—Classification techniques
    • G06F18/245—Classification techniques relating to the decision surface
    • G06F18/2451—Classification techniques relating to the decision surface linear, e.g. hyperplane
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10056—Microscopic image
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10064—Fluorescence image
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10072—Tomographic images
    • G06T2207/10101—Optical tomography; Optical coherence tomography [OCT]
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/20—Special algorithmic details
    • G06T2207/20036—Morphological image processing
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/20—Special algorithmic details
    • G06T2207/20072—Graph-based image processing
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/20—Special algorithmic details
    • G06T2207/20081—Training; Learning
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/20—Special algorithmic details
    • G06T2207/20084—Artificial neural networks [ANN]
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30024—Cell structures in vitro; Tissue sections in vitro
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30242—Counting objects in image
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/50—Depth or shape recovery
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/60—Analysis of geometric attributes
    • G06T7/62—Analysis of geometric attributes of area, perimeter, diameter or volume

Landscapes

  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Theoretical Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Multimedia (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Data Mining & Analysis (AREA)
  • Chemical & Material Sciences (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Evolutionary Computation (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Evolutionary Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Artificial Intelligence (AREA)
  • Probability & Statistics with Applications (AREA)
  • Software Systems (AREA)
  • Medical Informatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Radiology & Medical Imaging (AREA)
  • Quality & Reliability (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Image Generation (AREA)
  • Image Analysis (AREA)
  • Medical Treatment And Welfare Office Work (AREA)
  • Image Processing (AREA)
SG11202007982VA 2018-02-20 2019-02-19 Three-dimensional cell and tissue image analysis for cellular and sub-cellular morphological modeling and classification SG11202007982VA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862632663P 2018-02-20 2018-02-20
US16/277,128 US10915729B2 (en) 2018-02-20 2019-02-15 Three-dimensional cell and tissue image analysis for cellular and sub-cellular morphological modeling and classification
PCT/US2019/018617 WO2019164850A1 (en) 2018-02-20 2019-02-19 Three-dimensional cell and tissue image analysis for cellular and sub-cellular morphological modeling and classification

Publications (1)

Publication Number Publication Date
SG11202007982VA true SG11202007982VA (en) 2020-09-29

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Family Applications (1)

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SG11202007982VA SG11202007982VA (en) 2018-02-20 2019-02-19 Three-dimensional cell and tissue image analysis for cellular and sub-cellular morphological modeling and classification

Country Status (8)

Country Link
US (1) US10915729B2 (en)
EP (1) EP3756167A4 (en)
JP (1) JP7336806B2 (en)
CN (1) CN111886630A (en)
AU (1) AU2019223959B2 (en)
CA (1) CA3091935A1 (en)
SG (1) SG11202007982VA (en)
WO (1) WO2019164850A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020092590A1 (en) * 2018-10-30 2020-05-07 Allen Institute Segmenting 3d intracellular structures in microscopy images using an iterative deep learning workflow that incorporates human contributions
CN115359056B (en) * 2022-10-19 2023-03-24 浙江华诺康科技有限公司 Method and device for detecting dividing cells and computer equipment
CN116665210B (en) * 2023-07-28 2023-10-17 珠海横琴圣澳云智科技有限公司 Cell classification method and device based on multichannel information fusion
CN116704503B (en) * 2023-08-01 2023-10-13 昕传生物科技(北京)有限公司 Machine learning-based three-dimensional lung slice cell classification and protein quantification method

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US20070071755A1 (en) * 2005-09-27 2007-03-29 David Balasundaram Novel nucleolar GTPases and method for controlling proliferation of cells
JP6161146B2 (en) 2013-01-11 2017-07-12 国立大学法人東京工業大学 Pathological tissue image analysis method, pathological tissue image analysis apparatus, and pathological tissue image analysis program
EP2772882A1 (en) 2013-03-01 2014-09-03 Universite D'angers Automatic measurement of lesions on medical images
WO2015127183A2 (en) 2014-02-21 2015-08-27 Massachusetts Institute Of Technology Expansion microscopy
US9784666B2 (en) * 2014-09-11 2017-10-10 3D Signatures Holdings Inc. Methods for assessing cancer cells using granulometry
JP6628969B2 (en) 2015-03-06 2020-01-15 シスメックス株式会社 Cell analyzer, method for controlling cell analyzer, and program
US10059990B2 (en) 2015-04-14 2018-08-28 Massachusetts Institute Of Technology In situ nucleic acid sequencing of expanded biological samples
US10545145B2 (en) 2015-04-14 2020-01-28 Massachusetts Institute Of Technology Stochastic arrangement of reagents in clusters—STARC
US11408890B2 (en) 2015-04-14 2022-08-09 Massachusetts Institute Of Technology Iterative expansion microscopy
US10839509B2 (en) 2015-07-10 2020-11-17 3Scan Inc. Spatial multiplexing of histological stains
CA2994957A1 (en) 2015-08-07 2017-02-16 Massachusetts Institute Of Technology Protein retention expansion microscopy
US11214661B2 (en) 2015-09-17 2022-01-04 Massachusetts Institute Of Technology Three-dimensional nanofabrication by patterning of hydrogels
JP6597316B2 (en) * 2016-01-06 2019-10-30 コニカミノルタ株式会社 Image processing apparatus and program
ES2959835T3 (en) * 2016-05-03 2024-02-28 Univ Bruxelles Evaluation and manipulation of nucleolar structure
US10360434B2 (en) 2016-07-25 2019-07-23 Case Western Reserve University Multi-pass adaptive voting for nuclei detection in histopathological images

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Publication number Publication date
JP7336806B2 (en) 2023-09-01
AU2019223959B2 (en) 2024-03-14
CN111886630A (en) 2020-11-03
US20190258846A1 (en) 2019-08-22
EP3756167A4 (en) 2022-07-06
WO2019164850A1 (en) 2019-08-29
CA3091935A1 (en) 2019-08-29
US10915729B2 (en) 2021-02-09
JP2021514468A (en) 2021-06-10
AU2019223959A1 (en) 2020-09-17
EP3756167A1 (en) 2020-12-30

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