SG11202006024UA - Dosage forms with desired release profiles and methods of designing and making thereof - Google Patents

Dosage forms with desired release profiles and methods of designing and making thereof

Info

Publication number
SG11202006024UA
SG11202006024UA SG11202006024UA SG11202006024UA SG11202006024UA SG 11202006024U A SG11202006024U A SG 11202006024UA SG 11202006024U A SG11202006024U A SG 11202006024UA SG 11202006024U A SG11202006024U A SG 11202006024UA SG 11202006024U A SG11202006024U A SG 11202006024UA
Authority
SG
Singapore
Prior art keywords
designing
making
methods
dosage forms
release profiles
Prior art date
Application number
SG11202006024UA
Inventor
Feihuang Deng
Xiaoling Li
Senping Cheng
Original Assignee
Triastek Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Triastek Inc filed Critical Triastek Inc
Publication of SG11202006024UA publication Critical patent/SG11202006024UA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
    • B29C64/10—Processes of additive manufacturing
    • B29C64/106—Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material
    • B29C64/118—Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using filamentary material being melted, e.g. fused deposition modelling [FDM]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
    • B29C64/20—Apparatus for additive manufacturing; Details thereof or accessories therefor
    • B29C64/205—Means for applying layers
    • B29C64/209—Heads; Nozzles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
    • B29C64/30—Auxiliary operations or equipment
    • B29C64/307—Handling of material to be used in additive manufacturing
    • B29C64/321—Feeding
    • B29C64/336—Feeding of two or more materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
    • B29C64/30—Auxiliary operations or equipment
    • B29C64/386—Data acquisition or data processing for additive manufacturing
    • B29C64/393—Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y10/00—Processes of additive manufacturing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y30/00—Apparatus for additive manufacturing; Details thereof or accessories therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y40/00—Auxiliary operations or equipment, e.g. for material handling
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y50/00—Data acquisition or data processing for additive manufacturing
    • B33Y50/02—Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y70/00—Materials specially adapted for additive manufacturing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y80/00—Products made by additive manufacturing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4458—Non condensed piperidines, e.g. piperocaine only substituted in position 2, e.g. methylphenidate
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2105/00—Condition, form or state of moulded material or of the material to be shaped
    • B29K2105/0005—Condition, form or state of moulded material or of the material to be shaped containing compounding ingredients
    • B29K2105/0035—Medical or pharmaceutical agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Manufacturing & Machinery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Mechanical Engineering (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SG11202006024UA 2018-01-09 2018-12-25 Dosage forms with desired release profiles and methods of designing and making thereof SG11202006024UA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2018071967 2018-01-09
US16/049,713 US10350822B1 (en) 2018-01-09 2018-07-30 Dosage forms with desired release profiles and methods of designing and making thereof
PCT/CN2018/123399 WO2019137199A1 (en) 2018-01-09 2018-12-25 Dosage forms with desired release profiles and methods of designing and making thereof

Publications (1)

Publication Number Publication Date
SG11202006024UA true SG11202006024UA (en) 2020-07-29

Family

ID=67140337

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202006024UA SG11202006024UA (en) 2018-01-09 2018-12-25 Dosage forms with desired release profiles and methods of designing and making thereof

Country Status (9)

Country Link
US (2) US10350822B1 (en)
EP (1) EP3737358A4 (en)
JP (1) JP7300743B2 (en)
KR (2) KR102701478B1 (en)
CN (1) CN111655240B (en)
AU (1) AU2018401078B2 (en)
CA (1) CA3087723A1 (en)
SG (1) SG11202006024UA (en)
WO (1) WO2019137199A1 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10363220B2 (en) 2015-06-03 2019-07-30 Triastek, Inc. Compartmented pharmaceutical dosage forms
KR20190107712A (en) 2017-01-26 2019-09-20 트리아스텍 인코포레이티드 Dosage forms of controlled release at specific gastrointestinal sites
CN114311659A (en) 2017-05-16 2022-04-12 南京三迭纪医药科技有限公司 3D printing apparatus and method
US10201503B1 (en) 2018-01-09 2019-02-12 Triastek, Inc. Precision pharmaceutical 3D printing device
CN116270513A (en) 2018-01-09 2023-06-23 南京三迭纪医药科技有限公司 A compound oral pharmaceutical dosage form containing fixed dose of ADHD non-agonist and ADHD agonist
US11458684B2 (en) 2020-07-30 2022-10-04 Triastek, Inc. High-throughput and high-precision pharmaceutical additive manufacturing system
CN112638619B (en) 2019-08-20 2023-10-03 南京三迭纪医药科技有限公司 High throughput and high precision pharmaceutical additive manufacturing system
WO2021042865A1 (en) * 2019-09-06 2021-03-11 Triastek, Inc. Oral drug dosage forms having a desired pk profile and methods of designing and producing thereof
CA3183295A1 (en) 2020-06-26 2021-12-30 Jaedeok Yoo Rapidly-orodispersible tablets having an interior cavity
EP4178783A4 (en) 2020-07-10 2024-09-25 Triastek Inc High-precision additive manufacturing device and high-throughput additive manufacturing system
TW202224672A (en) 2020-10-30 2022-07-01 大陸商南京三迭紀醫藥科技有限公司 Gastroretentive pharmaceutical dosage form
EP4236924A4 (en) * 2020-10-30 2024-10-09 Triastek Inc Drug dosage forms for stomach retention
US20220168551A1 (en) * 2020-11-30 2022-06-02 International Business Machines Corporation Time controlled medication
US20240041779A1 (en) * 2020-12-08 2024-02-08 Triastek, Inc. Delayed sustained-release oral drug dosage forms of a janus kinase (jak) inhibitor and methods of use
EP4159202A1 (en) 2021-09-29 2023-04-05 Biomind Labs Inc Pharmaceutical formulation containing a psychedelic substance obtained by 3d printing by selective laser sintering (sls)
CN114248434B (en) * 2021-12-22 2023-07-21 广东药科大学 3D printing pharmaceutical method with controllable release time
CN115068408B (en) * 2022-06-13 2024-01-26 吉林大学 PH response 3D printing drug controlled release hydrogel and preparation method and application thereof
WO2024199448A1 (en) * 2023-03-31 2024-10-03 Triastek, Inc. Oral drug dosage forms for colon delivery and methods of use and making thereof

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5204055A (en) 1989-12-08 1993-04-20 Massachusetts Institute Of Technology Three-dimensional printing techniques
US5387380A (en) 1989-12-08 1995-02-07 Massachusetts Institute Of Technology Three-dimensional printing techniques
CA2060230C (en) 1991-01-31 2001-04-10 Steven M. Penn System, method, and process for computer-controlled manufacture of three-dimensional objects from computer data
US5370839A (en) 1991-07-05 1994-12-06 Nippon Steel Corporation Tial-based intermetallic compound alloys having superplasticity
US6280771B1 (en) 1997-02-20 2001-08-28 Therics, Inc. Dosage forms exhibiting multi-phasic release kinetics and methods of manufacture thereof
US5490962A (en) 1993-10-18 1996-02-13 Massachusetts Institute Of Technology Preparation of medical devices by solid free-form fabrication methods
US5503785A (en) 1994-06-02 1996-04-02 Stratasys, Inc. Process of support removal for fused deposition modeling
US5633021A (en) 1994-10-19 1997-05-27 Bpm Technology, Inc. Apparatus for making a three-dimensional article
AU736912B2 (en) 1997-02-20 2001-08-02 Therics, Inc. Dosage form exhibiting rapid disperse properties, methods of use and process for the manufacture of same
ES2257412T3 (en) 2000-05-18 2006-08-01 Therics, Inc. ENCAPSULATION OF A TOXIC NUCLEUS IN A NON-TOXIC REGION IN AN ORAL DOSAGE FORM.
AU2001273687A1 (en) 2000-07-10 2002-01-21 Massachusetts Institute Of Technology Method and materials for controlling migration of binder liquid in a powder
WO2003017745A2 (en) 2001-08-23 2003-03-06 Sciperio, Inc. Architecture tool and methods of use
ATE322972T1 (en) 2001-10-29 2006-04-15 Therics Inc SYSTEM AND METHOD FOR UNIAXIALLY PRESSING AN OBJECT SUCH AS A THREE-DIMENSIONALLY PRINTED DOSAGE FORM
CA2464653C (en) 2001-10-29 2011-10-18 Therics, Inc. System for manufacturing controlled release dosage forms, such as a zero-order release profile dosage form manufactured by three-dimensional printing
WO2003092633A2 (en) 2002-05-06 2003-11-13 Massachusetts Institute Of Technology Diffusion-controlled dosage form and method of fabrication including three dimensional printing
WO2006058247A2 (en) 2004-11-26 2006-06-01 Aprecia Pharmaceuticals Co. Dosage forms and methods of use thereof
CN1709222A (en) * 2005-06-03 2005-12-21 华中科技大学 Gastric floating slow-release administrating system and its three-dimensional printing forming preparation method
CN101244045B (en) * 2007-12-21 2010-06-30 东华大学 Zero level drug administration oral controlled-release tablet and preparation thereof
CA2742680C (en) * 2008-11-07 2013-12-31 Samyang Corporation Pharmaceutical compositions for release control of methylphenidate
US9381154B2 (en) 2011-06-09 2016-07-05 Xerox Corporation Direct inkjet fabrication of drug delivery devices
PL3007882T3 (en) * 2013-06-13 2020-06-01 Aspect Biosystems Ltd. System for additive manufacturing of three-dimensional structures and method for same
CN111037913B (en) * 2014-09-08 2022-04-01 中央兰开夏大学 Production of solid dosage forms
GB201420300D0 (en) 2014-11-14 2014-12-31 Bio Images Drug Delivery Ltd Tablet
US10363220B2 (en) 2015-06-03 2019-07-30 Triastek, Inc. Compartmented pharmaceutical dosage forms
CN113081991B (en) * 2015-06-03 2022-07-15 南京三迭纪医药科技有限公司 Pharmaceutical dosage forms and uses thereof
US20180214383A1 (en) 2015-07-16 2018-08-02 National University Of Singapore Printing drug tablets with fully customizable release profiles for personalized medicine
WO2017075096A1 (en) * 2015-10-26 2017-05-04 Blaesi Aron H Solid dosage form immediate drug release and apparatus and method for manufacture thereof
CN105690762A (en) 2016-01-26 2016-06-22 南京三迭纪医药科技有限公司 Printing head for 3D printing of powder material
CN205343831U (en) 2016-01-26 2016-06-29 南京三迭纪医药科技有限公司 3D prints powder material with beating printer head
CN107019676B (en) 2016-01-29 2020-08-04 南京三迭纪医药科技有限公司 Preparation method of anticoagulant medicine
CN105687153A (en) 2016-03-22 2016-06-22 西北工业大学 3D-printing preparation method for tablet medicines through spraying medicaments on matrix material
CA3023278C (en) 2016-05-05 2019-04-30 Triastek, Inc. Controlled release dosage form
CN106491551A (en) 2016-11-17 2017-03-15 暨南大学 A kind of 3D printing multilamellar controlled-release pharmaceutical tablet and preparation method thereof
CN108215154B (en) 2017-12-29 2020-01-14 南京三迭纪医药科技有限公司 Platform device of 3D printing equipment
CN108215153B (en) 2017-12-29 2019-08-23 南京三迭纪医药科技有限公司 It is a kind of measurement 3D printing equipment multiple print head between deviant system

Also Published As

Publication number Publication date
KR20200105871A (en) 2020-09-09
JP2021509870A (en) 2021-04-08
KR102701478B1 (en) 2024-09-04
US20210078244A1 (en) 2021-03-18
CN111655240B (en) 2023-02-03
AU2018401078A1 (en) 2020-07-16
EP3737358A4 (en) 2021-11-24
JP7300743B2 (en) 2023-06-30
AU2018401078B2 (en) 2023-05-11
CN111655240A (en) 2020-09-11
EP3737358A1 (en) 2020-11-18
US10350822B1 (en) 2019-07-16
KR20240134241A (en) 2024-09-06
US20190209468A1 (en) 2019-07-11
WO2019137199A1 (en) 2019-07-18
CA3087723A1 (en) 2019-07-18

Similar Documents

Publication Publication Date Title
SG11202006024UA (en) Dosage forms with desired release profiles and methods of designing and making thereof
IL259713A (en) Anti-dr5 antibodies and methods of use thereof
ZA201905677B (en) Glycan-interacting compounds and methods of use
IL283387A (en) Diarylhydantoin compounds and methods of use thereof
IL274045A (en) Dantrolene prodrugs and methods of their use
HK1244512A1 (en) Mutant smoothened and methods of using the same
IL283782A (en) Anellosomes and methods of use
GB2568907B (en) Gears and methods of manufacturing gears
EP3849664C0 (en) Phenoxy-pyridyl-pyrimidine compounds and methods of use
GB201717885D0 (en) Prothesis and method of manufacture
GB2574294B (en) Security elements and methods of manufacture thereof
EP3448375C0 (en) Benzoylglycine derivatives and methods of making and using same
IL276053A (en) Therapeutic-gard and method of use thereof
GB2559482B (en) Superhard constructions and methods of making same
IL274433A (en) Fulvestrant formulations and methods of their use
GB2555458B (en) Biscuit and manufacture thereof
GB2575196B (en) Thieno pyridimine compounds and manufacture of the same
EP3624865A4 (en) Agaroid structures and related methods of use and manufacture
GB2559481B (en) Superhard constructions and methods of making same
GB201705270D0 (en) Electronic structures and their methods of manufacture
GB201820842D0 (en) Sercurity documents and methods of manufacture thereof
IL281763A (en) Documents and methods of manufacture thereof
EP3849663C0 (en) Pyrimidinyl-heteroaryloxy-naphthyl compounds and methods of use
IL246493A0 (en) Utensil and method of manufacture thereof
EP3341322A4 (en) Sparse truss structures and methods of making the same