SG11202005081QA - Sulphonyl urea derivatives as nlrp3 inflammasome modulators - Google Patents

Sulphonyl urea derivatives as nlrp3 inflammasome modulators

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Publication number
SG11202005081QA
SG11202005081QA SG11202005081QA SG11202005081QA SG11202005081QA SG 11202005081Q A SG11202005081Q A SG 11202005081QA SG 11202005081Q A SG11202005081Q A SG 11202005081QA SG 11202005081Q A SG11202005081Q A SG 11202005081QA SG 11202005081Q A SG11202005081Q A SG 11202005081QA
Authority
SG
Singapore
Prior art keywords
modulators
urea derivatives
nlrp3 inflammasome
sulphonyl urea
sulphonyl
Prior art date
Application number
SG11202005081QA
Inventor
David Harrison
Alan Paul Watt
Mark G Bock
Original Assignee
Nodthera Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nodthera Ltd filed Critical Nodthera Ltd
Publication of SG11202005081QA publication Critical patent/SG11202005081QA/en

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
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    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
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    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/14—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
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    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/50—Nitrogen atoms bound to hetero atoms
    • C07D277/52—Nitrogen atoms bound to hetero atoms to sulfur atoms, e.g. sulfonamides
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    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
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    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
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    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SG11202005081QA 2017-12-18 2018-12-18 Sulphonyl urea derivatives as nlrp3 inflammasome modulators SG11202005081QA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1721185.5A GB201721185D0 (en) 2017-12-18 2017-12-18 Sulphonyl urea derivatives
PCT/EP2018/085511 WO2019121691A1 (en) 2017-12-18 2018-12-18 Sulphonyl urea derivatives as nlrp3 inflammasome modulators

Publications (1)

Publication Number Publication Date
SG11202005081QA true SG11202005081QA (en) 2020-06-29

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US (2) US11518757B2 (en)
EP (1) EP3728238A1 (en)
JP (1) JP7339959B2 (en)
KR (1) KR20200101423A (en)
CN (1) CN111954670A (en)
AR (1) AR114941A1 (en)
AU (1) AU2018391675B2 (en)
BR (1) BR112020011779A2 (en)
CA (1) CA3084694A1 (en)
EA (1) EA202091512A1 (en)
GB (1) GB201721185D0 (en)
IL (1) IL275058A (en)
MX (1) MX2020006399A (en)
SG (1) SG11202005081QA (en)
TW (1) TWI813610B (en)
WO (1) WO2019121691A1 (en)
ZA (1) ZA202003409B (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA47308A (en) 2017-01-23 2019-11-27 Genentech Inc CHEMICAL COMPOUNDS AS INHIBITORS OF INTERLEUKIN-1 ACTIVITY
GB201721185D0 (en) 2017-12-18 2018-01-31 Nodthera Ltd Sulphonyl urea derivatives
AU2019305095A1 (en) 2018-07-20 2020-12-17 F. Hoffmann-La Roche Ag Sulfonylurea compounds as inhibitors of interleukin-1 activity
KR20210053910A (en) * 2018-08-15 2021-05-12 인플라좀 리미티드 Novel Sulfonamide Urea Compound
US20220267300A1 (en) * 2019-06-12 2022-08-25 NodThera Limited Sulfonamide derivatives and uses thereof
CN114222739A (en) * 2019-06-12 2022-03-22 诺瑟拉有限公司 Sulfonylurea derivatives and use thereof
JP2022535956A (en) * 2019-06-12 2022-08-10 ノッドセラ リミテッド Sulfonylurea derivatives and uses thereof
WO2021188450A1 (en) 2020-03-16 2021-09-23 Zomagen Biosciences Ltd Nlrp3 modulators
EP4135842A1 (en) 2020-04-15 2023-02-22 JANSSEN Pharmaceutica NV Pyrrolo[1,2-d][1,2,4]triazine-2-yl-acetamides as inhibitors of the nlrp3 inflammasome pathway
WO2021209552A1 (en) 2020-04-15 2021-10-21 Janssen Pharmaceutica Nv Pyrazolo[1,5-d][1,2,4]triazine-5(4h)-acetamides as inhibitors of the nlrp3 inflammasome pathway
US20230203064A1 (en) 2020-04-23 2023-06-29 Janssen Pharmaceutica Nv Tricyclic compounds as inhibitors of nlrp3
CN115485280A (en) 2020-04-30 2022-12-16 詹森药业有限公司 Novel triazinoindole compounds
KR20230016658A (en) 2020-05-28 2023-02-02 얀센 파마슈티카 엔.브이. compound
CN115768749B (en) 2020-06-11 2024-04-19 辰欣药业股份有限公司 Dimethyl sulfimide derivative
JP2023540733A (en) * 2020-09-04 2023-09-26 ノッドセラ リミテッド Sulfamoyl urea derivatives containing alkyloxacycloalkyl moieties and uses thereof
CN112079729A (en) * 2020-09-22 2020-12-15 海南梵圣生物科技有限公司 Preparation method of 3-alkyl-5-trifluoromethylaniline
US20240043450A1 (en) 2020-09-24 2024-02-08 Janssen Pharmaceutica Nv New compound
EP3974415A1 (en) 2020-09-24 2022-03-30 Janssen Pharmaceutica NV Nlrp3 modulators
WO2022187804A1 (en) * 2021-03-02 2022-09-09 Icahn School Of Medicine At Mount Sinai Benzoxazolone inhibitors of inflammasomes
MX2023010223A (en) 2021-03-04 2023-09-11 Janssen Pharmaceutica Nv 4-amino-6-oxo-pyridazine derivatives modulating nlrp3.
JP2024508017A (en) 2021-03-04 2024-02-21 ヤンセン ファーマシューティカ エヌ．ベー． 4-Alkoxy-6-oxo-pyridazine derivatives that modulate NLRP3
CA3212725A1 (en) 2021-04-29 2022-11-03 Daniel Oehlrich Phthalazinone derivatives as nlrp3 inflammasome inhibitors
KR20240029027A (en) 2021-07-01 2024-03-05 얀센 파마슈티카 엔브이 5-oxo-pyrido[2,3-d]pyridazin-6(5H)-yl acetamide
US20230193469A1 (en) * 2021-12-20 2023-06-22 Indian Institute Of Science Education And Research Process for graphene-like carbon coating on substrates
US20240124451A1 (en) 2022-09-23 2024-04-18 Merck Sharp & Dohme Llc Phthalazine derivatives useful as inhibitors of nod-like receptor protein 3

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2110689A (en) 1981-12-03 1983-06-22 Sandoz Ltd Herbicidal heterocyclic aminosulfonyl ureas and isoureas
CH649081A5 (en) 1982-01-12 1985-04-30 Ciba Geigy Ag TRIAZA CONNECTIONS.
JPS60214785A (en) 1984-03-27 1985-10-28 Nissan Chem Ind Ltd Pyrazolesulfonyl urea derivative and plant growth regulator or herbicide
US5214206A (en) * 1990-11-07 1993-05-25 Warner-Lambert Company Aminosulfonyl urea acat inhibitors
CA2115990A1 (en) 1991-08-19 1993-03-04 George Albert Boswell Angiotensin ii receptor blocking imidazolinone derivatives
AU2496492A (en) 1991-08-19 1993-03-16 E.I. Du Pont De Nemours And Company Angiotensin ii receptor blocking imidazolinone derivatives
NZ247440A (en) 1992-05-06 1995-04-27 Squibb & Sons Inc Phenyl sulphonamide derivatives, preparation and pharmaceutical compositions thereof
DE4217719A1 (en) 1992-05-29 1993-12-02 Bayer Ag Double heterocyclically substituted sulfonylamino (thio) carbonyl compounds
DE4302701A1 (en) 1993-02-01 1994-08-04 Bayer Ag Arylaminosulfonylureas
DE4302702A1 (en) 1993-02-01 1994-08-04 Bayer Ag Arylaminosulfonylureas
JP3355237B2 (en) 1993-10-15 2002-12-09 呉羽化学工業株式会社 N- (substituted amino) pyrrole derivatives, production method thereof and herbicides
JPH0827147A (en) 1994-07-20 1996-01-30 Kureha Chem Ind Co Ltd N-(substituted amino)imide derivative, its production and herbicide
JPH09132574A (en) 1995-11-09 1997-05-20 Nissan Chem Ind Ltd Production of fluoropropylthiazoline derivative
US6028201A (en) 1996-01-30 2000-02-22 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
AU3440597A (en) 1996-07-02 1998-01-21 Novartis Ag N-phenylimino heterocyclic derivatives and their use as herbicides
JPH1029990A (en) 1996-07-12 1998-02-03 Kureha Chem Ind Co Ltd 1-(substituted amino)imidazole derivative, its production and herbicide
DE19651037A1 (en) 1996-12-09 1998-06-10 Bayer Ag Substituted thienyl (amino) sulfonyl (thio) ureas
SK283679B6 (en) 1997-01-29 2003-11-04 Pfizer Inc. Sulfonyl urea derivatives
IT1290062B1 (en) 1997-03-13 1998-10-19 Isagro Ricerca Srl HERBICIDE ACTIVITY AMMINOSOLFONILUREE
DE19937118A1 (en) 1999-08-06 2001-02-08 Bayer Ag Substituted thienyl (amino) sulfonylureas
JP4112127B2 (en) 1999-08-31 2008-07-02 株式会社リコー Thermal recording material
AU7447500A (en) 1999-09-30 2001-04-30 Mitsubishi Chemical Corporation Acylsulfonamide derivatives
US6593356B2 (en) 1999-10-20 2003-07-15 Bristol-Myers Squibb Pharma Company Acylsemicarbazides as cyclin dependent kinase inhibitors useful as anti-cancer and anti-proliferative agents
EP1281399A3 (en) 2001-08-01 2004-02-11 Warner-Lambert Company Dual inhibitors of wax ester and cholesteryl ester synthesis for inhibiting sebum production
WO2003029226A1 (en) 2001-09-26 2003-04-10 Basf Aktiengesellschaft Heterocyclyl substituted phenoxyalkyl-, phenylthioalkyl-, phenylaminoalkyl- and phenylalkyl-sulfamoylcarboxamides
US7202257B2 (en) 2003-12-24 2007-04-10 Deciphera Pharmaceuticals, Llc Anti-inflammatory medicaments
US7279576B2 (en) 2002-12-31 2007-10-09 Deciphera Pharmaceuticals, Llc Anti-cancer medicaments
US7144911B2 (en) 2002-12-31 2006-12-05 Deciphera Pharmaceuticals Llc Anti-inflammatory medicaments
US20070191336A1 (en) 2003-12-24 2007-08-16 Flynn Daniel L Anti-inflammatory medicaments
WO2006081034A2 (en) 2004-12-23 2006-08-03 Deciphera Pharmaceuticals, Llc Anti-inflammatory medicaments
EP2219646A4 (en) 2007-12-21 2010-12-22 Univ Rochester Method for altering the lifespan of eukaryotic organisms
WO2013119040A1 (en) 2012-02-07 2013-08-15 Kainos Medicine, Inc. Compounds as inhibitors of diacylglycerol o-acyltransferase type 1 enzyme
CN103288750A (en) 2013-03-04 2013-09-11 盐城工学院 Novel amino sulfonylurea compounds
US9410217B2 (en) 2014-02-18 2016-08-09 Renmatix, Inc. Method of reducing a fermentation and/or enzyme inhibitor in a saccharide-containing composition
MA41553B1 (en) * 2015-02-16 2020-04-30 The Provost Fellows Found Scholars And The Other Members Of Board Of The College Of The Holy & Undiv Sulfonylureas, Related Compounds, and Their Use
SG11201806745RA (en) * 2016-02-16 2018-09-27 Univ Queensland Sulfonylureas and related compounds and use of same
WO2017189663A1 (en) 2016-04-26 2017-11-02 Enanta Pharmaceuticals, Inc. Isoxazole derivatives as fxr agonists and methods of use thereof
WO2017189652A1 (en) 2016-04-26 2017-11-02 Enanta Pharmaceuticals, Inc. Isoxazole derivatives as fxr agonists and methods of use thereof
US10080742B2 (en) 2016-04-26 2018-09-25 Enanta Pharmaceuticals, Inc. Isoxazole derivatives as FXR agonists and methods of use thereof
WO2017201152A1 (en) 2016-05-18 2017-11-23 Enanta Pharmaceuticals, Inc. Isoxazole derivatives as fxr agonists and methods of use thereof
WO2017201155A1 (en) 2016-05-18 2017-11-23 Enanta Pharmaceuticals, Inc. lSOXAZOLE DERIVATIVES AS FXR AGONISTS AND METHODS OF USE THEREOF
US10144729B2 (en) 2016-05-18 2018-12-04 Enanta Pharmaceuticals, Inc. Isoxazole analogs as FXR agonists and methods of use thereof
EP3272739A1 (en) 2016-07-20 2018-01-24 NodThera Limited Sulfonyl urea derivatives and their use in the control of interleukin-1 activity
CR20200037A (en) 2017-07-24 2020-05-24 Novartis Inflammasome Res Inc COMPOUNDS AND COMPOSITIONS TO TREAT CONDITIONS ASSOCIATED WITH NLRP ACTIVITY
TW201910317A (en) 2017-08-15 2019-03-16 愛爾蘭商英弗雷佐姆有限公司 Novel compound
WO2019034697A1 (en) 2017-08-15 2019-02-21 Inflazome Limited Novel sulfonamide carboxamide compounds
TW201910314A (en) 2017-08-15 2019-03-16 愛爾蘭商英弗雷佐姆有限公司 Novel compound
RU2020110219A (en) 2017-08-15 2021-09-17 Инфлазоум Лимитед SULFONYLUREAS AND SULFONYLTHIUREAS AS NLRP3 INHIBITORS
US20210122739A1 (en) 2017-08-15 2021-04-29 Inflazome Limited Novel sulfonamide carboxamide compounds
EP3668843A1 (en) 2017-08-15 2020-06-24 Inflazome Limited Sulfonylureas and sulfonylthioureas as nlrp3 inhibitors
EP3668601A1 (en) 2017-08-15 2020-06-24 Inflazome Limited Novel sulfonamide carboxamide compounds
GB201721185D0 (en) * 2017-12-18 2018-01-31 Nodthera Ltd Sulphonyl urea derivatives
KR20210053910A (en) 2018-08-15 2021-05-12 인플라좀 리미티드 Novel Sulfonamide Urea Compound
GB201902327D0 (en) 2019-02-20 2019-04-03 Inflazome Ltd Novel compounds
JP2022535956A (en) 2019-06-12 2022-08-10 ノッドセラ リミテッド Sulfonylurea derivatives and uses thereof
US20220267300A1 (en) 2019-06-12 2022-08-25 NodThera Limited Sulfonamide derivatives and uses thereof
CN114222739A (en) 2019-06-12 2022-03-22 诺瑟拉有限公司 Sulfonylurea derivatives and use thereof
JP2023540733A (en) 2020-09-04 2023-09-26 ノッドセラ リミテッド Sulfamoyl urea derivatives containing alkyloxacycloalkyl moieties and uses thereof

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