SG11202004336VA - Creatine prodrugs, compositions and methods of use thereof - Google Patents
Creatine prodrugs, compositions and methods of use thereofInfo
- Publication number
- SG11202004336VA SG11202004336VA SG11202004336VA SG11202004336VA SG11202004336VA SG 11202004336V A SG11202004336V A SG 11202004336VA SG 11202004336V A SG11202004336V A SG 11202004336VA SG 11202004336V A SG11202004336V A SG 11202004336VA SG 11202004336V A SG11202004336V A SG 11202004336VA
- Authority
- SG
- Singapore
- Prior art keywords
- compositions
- methods
- creatine prodrugs
- creatine
- prodrugs
- Prior art date
Links
- CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 title 2
- 229960003624 creatine Drugs 0.000 title 1
- 239000006046 creatine Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 229940002612 prodrug Drugs 0.000 title 1
- 239000000651 prodrug Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/001—Acyclic or carbocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
- C07D273/02—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and only one oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D317/34—Oxygen atoms
- C07D317/40—Vinylene carbonate; Substituted vinylene carbonates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762593731P | 2017-12-01 | 2017-12-01 | |
| PCT/US2018/063580 WO2019109067A2 (en) | 2017-12-01 | 2018-12-03 | Creatine prodrugs, compositions and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202004336VA true SG11202004336VA (en) | 2020-06-29 |
Family
ID=66665277
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202004336VA SG11202004336VA (en) | 2017-12-01 | 2018-12-03 | Creatine prodrugs, compositions and methods of use thereof |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US11332438B2 (en) |
| EP (1) | EP3717453A4 (en) |
| JP (2) | JP7433226B2 (en) |
| KR (1) | KR20200105833A (en) |
| CN (1) | CN111417620B (en) |
| AR (1) | AR118403A1 (en) |
| AU (1) | AU2018375199B2 (en) |
| BR (1) | BR112020010805B1 (en) |
| CA (1) | CA3082184A1 (en) |
| CO (1) | CO2020006542A2 (en) |
| IL (1) | IL274701B1 (en) |
| MX (1) | MX2020005707A (en) |
| SG (1) | SG11202004336VA (en) |
| TW (1) | TWI815832B (en) |
| WO (1) | WO2019109067A2 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019109067A2 (en) | 2017-12-01 | 2019-06-06 | Ultragenyx Pharmaceutical Inc. | Creatine prodrugs, compositions and methods of use thereof |
| US11597399B1 (en) | 2021-08-13 | 2023-03-07 | Oshkosh Defense, Llc | Electrified military vehicle |
Family Cites Families (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0718000B2 (en) | 1985-05-15 | 1995-03-01 | 日本真空技術株式会社 | Method for forming synthetic resin film |
| US4767627A (en) | 1985-05-29 | 1988-08-30 | Merck & Co., Inc. | Drug delivery device which can be retained in the stomach for a controlled period of time |
| US4915952A (en) | 1987-02-27 | 1990-04-10 | Alza Corporation | Composition comprising drug, HPC, HPMC and PEO |
| US4786503A (en) | 1987-04-06 | 1988-11-22 | Alza Corporation | Dosage form comprising parallel lamine |
| US5002772A (en) | 1988-05-31 | 1991-03-26 | Pfizer Inc. | Gastric retention system for controlled drug release |
| CA1340821C (en) | 1988-10-06 | 1999-11-16 | Nobuyuki Fukazawa | Heterocyclic compounds and anticancer-drug reinforcing agents containing them as effective components |
| US5007790A (en) | 1989-04-11 | 1991-04-16 | Depomed Systems, Inc. | Sustained-release oral drug dosage form |
| DE69206993T2 (en) | 1991-07-19 | 1996-05-30 | Uniroyal Chem Co Inc | COMPOSITIONS FOR USING FILMS ON SEED |
| US6235313B1 (en) | 1992-04-24 | 2001-05-22 | Brown University Research Foundation | Bioadhesive microspheres and their use as drug delivery and imaging systems |
| US5643909A (en) | 1993-04-19 | 1997-07-01 | Syntex (U.S.A.) Inc. | 10,11-Methanodibenzosuberane derivatives |
| JPH0718000A (en) * | 1993-06-18 | 1995-01-20 | Takeda Chem Ind Ltd | Novel peptide |
| US5451409A (en) | 1993-11-22 | 1995-09-19 | Rencher; William F. | Sustained release matrix system using hydroxyethyl cellulose and hydroxypropyl cellulose polymer blends |
| ATE332127T1 (en) | 1994-11-08 | 2006-07-15 | Avicena Group Inc | USE OF CREATINE OR CREATINENOLOGIST TO TREAT HUNTINGTON CHOREA, PARKINSON'S DISEASE AND AMYOTROPHIC LATERAL SCLERosis |
| US5945125A (en) | 1995-02-28 | 1999-08-31 | Temple University | Controlled release tablet |
| MY113429A (en) | 1995-02-28 | 2002-02-28 | Univ Temple | Controlled release tablet containing swellable polyethylene oxide |
| US5824638A (en) | 1995-05-22 | 1998-10-20 | Shire Laboratories, Inc. | Oral insulin delivery |
| JPH11513671A (en) | 1995-10-11 | 1999-11-24 | アヴィセナ グループ，インク． | Use of creatine analogs for the treatment of glucose metabolism disorders |
| US5783212A (en) | 1996-02-02 | 1998-07-21 | Temple University--of the Commonwealth System of Higher Education | Controlled release drug delivery system |
| IT1282650B1 (en) | 1996-02-19 | 1998-03-31 | Jagotec Ag | PHARMACEUTICAL TABLET, CHARACTERIZED BY A HIGH INCREASE IN VOLUME IN CONTACT WITH BIOLOGICAL LIQUIDS |
| US6008252A (en) | 1996-07-26 | 1999-12-28 | Beale; Paxton K. | Method for increasing muscle mass in a mammal |
| US6210710B1 (en) | 1997-04-28 | 2001-04-03 | Hercules Incorporated | Sustained release polymer blend for pharmaceutical applications |
| GB9710699D0 (en) | 1997-05-24 | 1997-07-16 | Danbiosyst Uk | Gastro-retentive controlled release system |
| US6635280B2 (en) | 1997-06-06 | 2003-10-21 | Depomed, Inc. | Extending the duration of drug release within the stomach during the fed mode |
| ES2234139T3 (en) | 1997-08-11 | 2005-06-16 | Alza Corporation | DOSAGE FORM OF AN ACTIVE PROLONGED RELEASE AGENT ADAPTED FOR GASTRIC RETENTION. |
| US6090411A (en) | 1998-03-09 | 2000-07-18 | Temple University | Monolithic tablet for controlled drug release |
| US6797283B1 (en) | 1998-12-23 | 2004-09-28 | Alza Corporation | Gastric retention dosage form having multiple layers |
| US6476006B2 (en) | 2000-06-23 | 2002-11-05 | Teva Pharmaceutical Industries, Ltd. | Composition and dosage form for delayed gastric release of alendronate and/or other bis-phosphonates |
| US20030008007A1 (en) | 2001-04-23 | 2003-01-09 | Jose Gutierrez-Rocca | Release pharmaceutical construct for gastric retention |
| US20030013767A1 (en) | 2001-07-13 | 2003-01-16 | Samuel Bessman | Method of treating weight loss using creatine |
| US20040219186A1 (en) | 2001-08-16 | 2004-11-04 | Ayres James W. | Expandable gastric retention device |
| US7125568B2 (en) | 2001-08-23 | 2006-10-24 | Sung Michael T | Lipophilic drug compositions |
| US6723340B2 (en) | 2001-10-25 | 2004-04-20 | Depomed, Inc. | Optimal polymer mixtures for gastric retentive tablets |
| JP2005513057A (en) | 2001-12-15 | 2005-05-12 | スフェリックス， インコーポレイテッド | Bioadhesive drug delivery system with increased gastric retention |
| US20050202090A1 (en) | 2002-01-03 | 2005-09-15 | Clarke Allan J. | Novel pharmaceutical dosage forms and method for producing same |
| DE10221344A1 (en) | 2002-05-14 | 2003-12-04 | Hannover Med Hochschule | Transgenic rats and their use in animal models for human Huntington's disease as well as nucleic acid constructs, vectors and cells for their generation |
| BR0310100A (en) | 2002-05-17 | 2007-04-27 | Esperion Therapeutics Inc | methods to treat, prevent or reduce ischemic reperfusion injury in a tissue or organ, and to prevent or treat a condition associated with oxygen deprivation, followed by increased oxygen supply to a tissue or organ in need of it |
| US20040102525A1 (en) | 2002-05-22 | 2004-05-27 | Kozachuk Walter E. | Compositions and methods of treating neurological disease and providing neuroprotection |
| EP2567705A3 (en) | 2002-06-04 | 2013-07-03 | Avicena Group, Inc. | Methods of treating cognitive dysfunction by modulating brain energy metabolism |
| GB0214013D0 (en) | 2002-06-18 | 2002-07-31 | Euro Celtique Sa | Pharmaceutical product |
| WO2004002445A2 (en) | 2002-06-26 | 2004-01-08 | Cadila Healthcare Limited | Novel floating dosage form |
| US20040120983A1 (en) | 2002-12-23 | 2004-06-24 | Philip Connolly | Nutritional supplement |
| JPWO2005108370A1 (en) | 2004-04-16 | 2008-03-21 | 味の素株式会社 | Benzene compounds |
| MX2007000304A (en) | 2004-07-02 | 2007-06-15 | Baylor Res Inst | Glycogen or polysaccharide storage disease treatment method. |
| US20060046962A1 (en) | 2004-08-25 | 2006-03-02 | Aegis Therapeutics Llc | Absorption enhancers for drug administration |
| US20060045865A1 (en) | 2004-08-27 | 2006-03-02 | Spherics, Inc. | Controlled regional oral delivery |
| US20080103202A1 (en) | 2004-11-08 | 2008-05-01 | Chris Ferguson | Method of preparing creatine ester salts and uses thereof. |
| US20070012105A1 (en) | 2005-07-13 | 2007-01-18 | Barnes-Jewish Hospital | Method and apparatus for resistive characteristic assessment |
| US20070032750A1 (en) | 2005-07-15 | 2007-02-08 | Jeffrey Oster | Muscle strength assessment system |
| US20070281995A1 (en) | 2006-06-06 | 2007-12-06 | Xenoport, Inc. | Creatine analog prodrugs, compositions and uses thereof |
| US7683043B2 (en) | 2006-06-06 | 2010-03-23 | Xenoport, Inc. | Creatine phosphate analog prodrugs, compositions and uses thereof |
| WO2007146085A2 (en) | 2006-06-06 | 2007-12-21 | Xenoport, Inc. | Creatine phosphate prodrugs, compositions and uses thereof |
| US20080206170A1 (en) | 2006-12-07 | 2008-08-28 | Belinda Tsao Nivaggioli | Creatine compositions for skin treatment |
| WO2008101310A1 (en) | 2007-02-20 | 2008-08-28 | Multi Formulations Ltd. | Creatine-fatty acids |
| US7319157B1 (en) | 2007-02-20 | 2008-01-15 | Multi Formulations Ltd. | Creatine-fatty acids |
| WO2008101309A1 (en) | 2007-02-20 | 2008-08-28 | Multi Formulations Ltd. | Creatine-fatty acids |
| US8426395B2 (en) | 2008-05-30 | 2013-04-23 | Northern Northern Innovations Holding Corp | Preparations containing creatine and imino sugars |
| WO2010005692A2 (en) | 2008-06-16 | 2010-01-14 | E. I. Du Pont De Nemours And Company | Insecticidal cyclic carbonyl amidines |
| US8350077B2 (en) | 2008-12-24 | 2013-01-08 | Vertex Closed Joint Stock Company | Amides of creatine, method of their preparation, and remedy possessing a neuroprotective activity |
| CA2785714C (en) | 2009-12-30 | 2016-01-26 | Baylor Research Institute | Anaplerotic therapy for alzheimer's disease and the aging brain |
| CN103079555A (en) | 2010-06-14 | 2013-05-01 | 贝勒研究院 | Triheptanoin diet for adult polyglucosan body disease (APBD) treatment |
| JP5702248B2 (en) * | 2011-07-28 | 2015-04-15 | 三菱製紙株式会社 | Nanofiber, method for forming nanofiber, and method for forming nanofiber aggregate |
| WO2013043580A2 (en) | 2011-09-19 | 2013-03-28 | Gencia Corporation | Modified creatine compounds |
| US9233099B2 (en) | 2012-01-11 | 2016-01-12 | University Of Cincinnati | Methods of treating cognitive dysfunction by modulating brain energy metabolism |
| AR091857A1 (en) | 2012-07-25 | 2015-03-04 | Sova Pharmaceuticals Inc | CISTATIONIN-g-LIASA INHIBITORS (CSE) |
| DK2692719T3 (en) | 2012-07-30 | 2016-09-12 | Commissariat L Energie Atomique Et Aux Energies Alternatives | A process for the preparation of kreatinfedtestere, thus prepared and to their use kreatinfedtestere |
| ITTO20121098A1 (en) | 2012-12-18 | 2014-06-19 | Univ Degli Studi Genova | PROCEDURE FOR SYNTHESIZING CREATINE DERIVATIVES |
| US9914809B2 (en) * | 2013-08-30 | 2018-03-13 | Momentive Performance Materials Inc. | Moisture curable composition with amino acids |
| CA2929538A1 (en) | 2013-11-05 | 2015-05-14 | Ultragenyx Pharmaceutical Inc. | Creatine analogs and the use thereof |
| ITTO20131070A1 (en) | 2013-12-24 | 2015-06-25 | Univ Degli Studi Genova | THERAPEUTIC APPLICATION OF A CREATINE DERIVATIVE |
| US9642825B2 (en) * | 2014-02-27 | 2017-05-09 | 4141 Holdings, Llc | Bio-available N-acetyl creatine species and compositions thereof |
| AU2015312159B2 (en) | 2014-09-03 | 2019-03-07 | Lumos Pharma, Inc. | Synthesis of cyclocreatine and analogs thereof |
| US9617230B2 (en) | 2014-12-22 | 2017-04-11 | Farmington Pharma Development | Creatine prodrugs, compositions and methods of use thereof |
| WO2016110822A1 (en) * | 2015-01-09 | 2016-07-14 | Universita' Degli Studi Di Genova | Carboxylic biacyl creatine derivative, uses and method of synthesis thereof |
| AR104144A1 (en) | 2015-03-30 | 2017-06-28 | Farmington Pharma Dev | PROPHARMS OF CREATINE PHOSPHATE ANALOGS, THEIR COMPOSITIONS AND THEIR USES |
| WO2019109067A2 (en) | 2017-12-01 | 2019-06-06 | Ultragenyx Pharmaceutical Inc. | Creatine prodrugs, compositions and methods of use thereof |
-
2018
- 2018-12-03 WO PCT/US2018/063580 patent/WO2019109067A2/en unknown
- 2018-12-03 US US16/764,969 patent/US11332438B2/en active Active
- 2018-12-03 MX MX2020005707A patent/MX2020005707A/en unknown
- 2018-12-03 CN CN201880077165.5A patent/CN111417620B/en active Active
- 2018-12-03 BR BR112020010805-7A patent/BR112020010805B1/en active IP Right Grant
- 2018-12-03 TW TW107143208A patent/TWI815832B/en active
- 2018-12-03 CA CA3082184A patent/CA3082184A1/en active Pending
- 2018-12-03 KR KR1020207018932A patent/KR20200105833A/en not_active Application Discontinuation
- 2018-12-03 AU AU2018375199A patent/AU2018375199B2/en active Active
- 2018-12-03 EP EP18883842.9A patent/EP3717453A4/en active Pending
- 2018-12-03 JP JP2020527818A patent/JP7433226B2/en active Active
- 2018-12-03 SG SG11202004336VA patent/SG11202004336VA/en unknown
- 2018-12-03 AR ARP180103527A patent/AR118403A1/en unknown
- 2018-12-03 IL IL274701A patent/IL274701B1/en unknown
-
2020
- 2020-05-28 CO CONC2020/0006542A patent/CO2020006542A2/en unknown
-
2022
- 2022-03-28 US US17/706,283 patent/US11753369B2/en active Active
-
2023
- 2023-07-14 US US18/352,959 patent/US20240092731A1/en active Pending
- 2023-09-20 JP JP2023152930A patent/JP2024009811A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA3082184A1 (en) | 2019-06-06 |
| MX2020005707A (en) | 2020-08-20 |
| US20220227703A1 (en) | 2022-07-21 |
| CO2020006542A2 (en) | 2020-06-09 |
| CN111417620A (en) | 2020-07-14 |
| IL274701A (en) | 2020-06-30 |
| TW201927368A (en) | 2019-07-16 |
| AU2018375199A1 (en) | 2020-05-28 |
| WO2019109067A3 (en) | 2020-03-26 |
| US11332438B2 (en) | 2022-05-17 |
| JP2021505537A (en) | 2021-02-18 |
| EP3717453A2 (en) | 2020-10-07 |
| AR118403A1 (en) | 2021-10-06 |
| US20240092731A1 (en) | 2024-03-21 |
| CN111417620B (en) | 2023-08-25 |
| JP7433226B2 (en) | 2024-02-19 |
| KR20200105833A (en) | 2020-09-09 |
| TWI815832B (en) | 2023-09-21 |
| BR112020010805B1 (en) | 2024-01-30 |
| JP2024009811A (en) | 2024-01-23 |
| US11753369B2 (en) | 2023-09-12 |
| US20210002211A1 (en) | 2021-01-07 |
| IL274701B1 (en) | 2024-03-01 |
| EP3717453A4 (en) | 2021-07-28 |
| WO2019109067A2 (en) | 2019-06-06 |
| BR112020010805A2 (en) | 2020-11-10 |
| AU2018375199B2 (en) | 2023-03-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL272089B1 (en) | Compounds, compositions and methods | |
| SG11202001783YA (en) | Oligonucleotide compositions and methods thereof | |
| HK1256997A1 (en) | Tyk2 inhibitors and uses thereof | |
| HK1248690A1 (en) | Tyk2 inhibitors and uses thereof | |
| PL3676297T3 (en) | Compounds, compositions and methods | |
| IL268970A (en) | Novel compositions and methods | |
| GB2546350B (en) | Compositions and methods | |
| ZA201703507B (en) | Compositions and methods of treatment with prodrugs of tizoxanide, an analogue or salt thereof | |
| IL268684A (en) | Compositions and methods for immunooncology | |
| GB201718876D0 (en) | Antithrombin-heparin compositions and methods | |
| GB201807325D0 (en) | Compositions and methods | |
| ZA202104969B (en) | Compositions comprising 15-hepe and methods of using the same | |
| GB202201859D0 (en) | Novel methods and compositions | |
| PT3552017T (en) | Compounds, compositions and methods | |
| IL274524A (en) | Compositions and methods for aquaculturing | |
| ZA201903928B (en) | Compositions comprising methylphenidate-prodrugs, processes of making and using the same | |
| EP3237391A4 (en) | Creatine prodrugs, compositions and methods of use thereof | |
| PL2998311T3 (en) | Mixture of alkylglycosides, manufacture and use thereof | |
| HK1247136A1 (en) | Compositions comprising 15-hepe and methods of using the same | |
| IL274701A (en) | Creatine prodrugs, compositions and methods of use thereof | |
| ZA202004533B (en) | Skin-brightening compositions and methods | |
| IL270505B1 (en) | Compounds, compositions and methods | |
| GB201512996D0 (en) | Compositions and methods | |
| SG11201706369PA (en) | Compositions and methods for the treatment of mucositis | |
| GB201522814D0 (en) | Compositions and uses thereof |