SG11202004105TA - Anticancer agents - Google Patents

Anticancer agents

Info

Publication number
SG11202004105TA
SG11202004105TA SG11202004105TA SG11202004105TA SG11202004105TA SG 11202004105T A SG11202004105T A SG 11202004105TA SG 11202004105T A SG11202004105T A SG 11202004105TA SG 11202004105T A SG11202004105T A SG 11202004105TA SG 11202004105T A SG11202004105T A SG 11202004105TA
Authority
SG
Singapore
Prior art keywords
anticancer agents
anticancer
agents
Prior art date
Application number
SG11202004105TA
Inventor
Gene Cutler
William Ho
Paul Kassner
Silpa Suthram
Brian Wong
Original Assignee
Rapt Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rapt Therapeutics Inc filed Critical Rapt Therapeutics Inc
Publication of SG11202004105TA publication Critical patent/SG11202004105TA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965Non-condensed pyrazines
    • A61K31/497Non-condensed pyrazines containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
SG11202004105TA 2017-11-06 2018-11-05 Anticancer agents SG11202004105TA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762582284P 2017-11-06 2017-11-06
US201862723415P 2018-08-27 2018-08-27
PCT/US2018/059284 WO2019090272A1 (en) 2017-11-06 2018-11-05 Chemokine receptor modulators for treatment of epstein barr virus positive cancer

Publications (1)

Publication Number Publication Date
SG11202004105TA true SG11202004105TA (en) 2020-06-29

Family

ID=64572480

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202004105TA SG11202004105TA (en) 2017-11-06 2018-11-05 Anticancer agents

Country Status (15)

Country Link
US (1) US11730736B2 (en)
EP (1) EP3706750A1 (en)
JP (1) JP2021502345A (en)
KR (1) KR20200104291A (en)
CN (1) CN111918652A (en)
AU (1) AU2018360766A1 (en)
BR (1) BR112020009055A2 (en)
CA (1) CA3081750A1 (en)
IL (1) IL274444B2 (en)
MX (1) MX2020004836A (en)
RU (1) RU2020118594A (en)
SG (1) SG11202004105TA (en)
TW (1) TWI838350B (en)
WO (1) WO2019090272A1 (en)
ZA (1) ZA202002898B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2020118594A (en) 2017-11-06 2021-12-09 Рапт Терапьютикс, Инк. ANTI-CANCER AGENTS
SG11202007072RA (en) 2018-01-26 2020-08-28 Rapt Therapeutics Inc Chemokine receptor modulators and uses thereof
AU2020383625A1 (en) * 2019-11-13 2022-05-05 Rapt Therapeutics, Inc. Crystalline forms of C-C chemokine receptor type 4 antagonist and uses thereof
WO2023196432A1 (en) * 2022-04-06 2023-10-12 Rapt Therapeutics, Inc. Chemokine receptor modulators and uses thereof
TW202411219A (en) * 2022-06-02 2024-03-16 大陸商西藏海思科製藥有限公司 Heterocyclic compound CCR4 inhibitor and user thereof
CN118084873A (en) * 2022-11-28 2024-05-28 上海美悦生物科技发展有限公司 Spiro heterocycle substituted pyrimidine compound and preparation method and application thereof
WO2024114568A1 (en) * 2022-11-28 2024-06-06 上海美悦生物科技发展有限公司 Heterocyclic substituted pyrimidine compound, preparation method therefor, and use thereof

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4911920A (en) 1986-07-30 1990-03-27 Alcon Laboratories, Inc. Sustained release, comfort formulation for glaucoma therapy
US5391485A (en) 1985-08-06 1995-02-21 Immunex Corporation DNAs encoding analog GM-CSF molecules displaying resistance to proteases which cleave at adjacent dibasic residues
US4810643A (en) 1985-08-23 1989-03-07 Kirin- Amgen Inc. Production of pluripotent granulocyte colony-stimulating factor
JPS63500636A (en) 1985-08-23 1988-03-10 麒麟麦酒株式会社 DNA encoding multipotent granulocyte colony stimulating factor
FR2588189B1 (en) 1985-10-03 1988-12-02 Merck Sharp & Dohme LIQUID-GEL PHASE TRANSITION PHARMACEUTICAL COMPOSITION
DK0495421T3 (en) 1991-01-15 1996-12-09 Alcon Lab Inc Use of carrageenans in topical ophthalmic compositions
US5212162A (en) 1991-03-27 1993-05-18 Alcon Laboratories, Inc. Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions
US5360352A (en) 1992-12-24 1994-11-01 The Whitaker Corporation Wire retainer for current mode coupler
US6537579B1 (en) 1993-02-22 2003-03-25 American Bioscience, Inc. Compositions and methods for administration of pharmacologically active compounds
US6096331A (en) 1993-02-22 2000-08-01 Vivorx Pharmaceuticals, Inc. Methods and compositions useful for administration of chemotherapeutic agents
US6749868B1 (en) 1993-02-22 2004-06-15 American Bioscience, Inc. Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
US5916596A (en) 1993-02-22 1999-06-29 Vivorx Pharmaceuticals, Inc. Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
US5300498A (en) 1993-06-04 1994-04-05 Hoechst-Roussel Pharmaceuticals Incorporated 6-piperazinyl-1H-pyrazolo[3,4-b]pyridine-3-carboxylic acids, esters, amides and related compounds
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
SK285141B6 (en) 1996-02-13 2006-07-07 Astrazeneca Uk Limited Use of quinazoline derivative, quinazoline derivative, process for preparation thereof and pharmaceutical composition containing thereof
EP0885198B1 (en) 1996-03-05 2001-12-19 AstraZeneca AB 4-anilinoquinazoline derivatives
AP1147A (en) 1996-05-03 2003-02-25 Pfizer Substituted indazole derivatives and related compounds.
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
GB9714249D0 (en) 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
US6488930B1 (en) 1999-01-15 2002-12-03 Millennium Pharmaceuticals, Inc. Anti-CCR4 antibodies and methods of use therefor
GB9900752D0 (en) 1999-01-15 1999-03-03 Angiogene Pharm Ltd Benzimidazole vascular damaging agents
CA2378047A1 (en) 1999-07-15 2001-01-25 Methvin Isaac Heterocyclic compounds for the treatment of migraine
MXPA02011770A (en) 2000-05-31 2003-04-10 Astrazeneca Ab Indole derivatives with vascular damaging activity.
IL153484A0 (en) 2000-07-07 2003-07-06 Angiogene Pharm Ltd Colchinol derivatives as angiogenesis inhibitors
WO2002008213A1 (en) 2000-07-07 2002-01-31 Angiogene Pharmaceuticals Limited Colchinol derivatives as angiogenesis inhibitors
US20020132836A1 (en) 2000-10-11 2002-09-19 Chemocentryx Inc. Compounds and methods for modulating CCR4 function
AU2002213467A1 (en) 2000-10-11 2002-04-22 Chemocentryx, Inc. Modulation of ccr4 function
TW593278B (en) 2001-01-23 2004-06-21 Wyeth Corp 1-aryl-or 1-alkylsulfonylbenzazole derivatives as 5-hydroxytryptamine-6 ligands
WO2002094264A1 (en) 2001-05-23 2002-11-28 Tularik Inc. Ccr4 antagonists
AU2002354476A1 (en) 2001-12-14 2003-06-30 Japan Tobacco Inc. Pyrazolopyridine derivatives and medicinal use thereof
US20060004010A1 (en) 2002-07-10 2006-01-05 Hiromu Habashita Ccr4 antagonist and medical use thereof
AU2003299590B8 (en) 2002-12-09 2010-04-08 Abraxis Bioscience, Llc Compositions and methods of delivery of pharmacological agents
SE0301650D0 (en) 2003-06-04 2003-06-04 Astrazeneca Ab Novel compounds
SE0301653D0 (en) 2003-06-05 2003-06-05 Astrazeneca Ab Novel compounds
SE0301654D0 (en) * 2003-06-05 2003-06-05 Astrazeneca Ab Novel compounds
US20050287138A1 (en) 2003-10-08 2005-12-29 Kyowa Hakko Kogyo Co., Ltd. CCR4-specific antibody composition
EP1702625B1 (en) 2003-12-04 2010-11-03 Kyowa Hakko Kirin Co., Ltd. Medicine containing genetically modified antibody against chemokine receptor ccr4
US20070166388A1 (en) 2005-02-18 2007-07-19 Desai Neil P Combinations and modes of administration of therapeutic agents and combination therapy
PL3248600T3 (en) 2005-02-18 2020-09-07 Abraxis Bioscience, Llc Combinations and modes of administration of therapeutic agents and combination therapy
WO2006101456A1 (en) 2005-03-21 2006-09-28 S*Bio Pte Ltd Bicyclic heterocycles hydroxamate compounds useful as histone deacetylase (hdac) inhibitors
BRPI0615265A8 (en) 2005-08-31 2018-03-06 Abraxis Bioscience Llc compositions comprising low water soluble pharmaceutical agents and antimicrobial agents
JP5368093B2 (en) 2005-08-31 2013-12-18 アブラクシス バイオサイエンス, エルエルシー Compositions and methods of preparation of poorly water-soluble drugs with increased stability
GB0525143D0 (en) 2005-12-09 2006-01-18 Novartis Ag Organic compounds
GB0525144D0 (en) 2005-12-09 2006-01-18 Novartis Ag Organic compounds
TW200730512A (en) 2005-12-12 2007-08-16 Astrazeneca Ab Novel compounds
US7807704B2 (en) 2006-03-30 2010-10-05 Chemocentryx, Inc. Bicyclic, nitrogen-containing compounds modulating CXCR4 and/or CCXCKR2
WO2008045529A1 (en) 2006-10-12 2008-04-17 Serenex, Inc. Purine and pyrimidine derivatives for treatment of cancer and inflammatory diseases
ES2700074T3 (en) 2006-12-14 2019-02-13 Abraxis Bioscience Llc Therapy for breast cancer based on the status of the hormone receptors with nanoparticles that comprise taxane
AU2008211172A1 (en) 2007-01-30 2008-08-07 Biogen Idec Ma Inc. 1-H-pyrazolo(3,4B)pyrimidine derivatives and their use as modulators of mitotic kinases
PE20091104A1 (en) * 2007-12-21 2009-07-18 Wyeth Corp GENETICALLY MODIFIED ATTENUATED VESICULAR STOMATITIS VIRUS, COMPOSITIONS AND METHODS OF USE OF THE SAME
KR20150136137A (en) 2008-04-10 2015-12-04 아브락시스 바이오사이언스, 엘엘씨 Compositions of hydrophobic taxane derivatives and uses thereof
WO2009126401A1 (en) 2008-04-10 2009-10-15 Abraxis Bioscience, Llc Compositions of hydrophobic taxane derivatives and uses thereof
DK2401270T3 (en) 2009-02-26 2014-01-13 Glaxo Group Ltd Pyrazole derivatives used as CCR4 receptor antagonists.
WO2010118367A2 (en) 2009-04-10 2010-10-14 Progenics Pharmaceuticals, Inc. Antiviral pyrimidines
AU2010293383B2 (en) 2009-09-10 2014-12-18 Kyowa Kirin Co., Ltd. Medicament including antibody composition specifically bound to human CC chemokine receptor 4 (CCR4)
EP2785710B1 (en) * 2011-12-01 2017-09-20 ChemoCentryx, Inc. Substituted benzimidazoles and benzopyrazoles as ccr(4) antagonists
AU2013256010B2 (en) 2012-05-04 2018-01-04 Dana-Farber Cancer Institute, Inc. Affinity matured anti-CCR4 humanized monoclonal antibodies and methods of use
JP2017517506A (en) 2014-05-21 2017-06-29 ファイザー・インコーポレイテッド Combination of anti-CCR4 antibody and 4-1BB agonist for treating cancer
WO2016057488A1 (en) 2014-10-06 2016-04-14 Dana-Farber Cancer Institute, Inc. Humanized cc chemokine receptor 4 (ccr4) antibodies and methods of use thereof
WO2018022992A1 (en) * 2016-07-29 2018-02-01 Flx Bio, Inc. Chemokine receptor modulators and uses thereof
WO2018049271A1 (en) * 2016-09-09 2018-03-15 Flx Bio, Inc. Chemokine receptor modulators and uses thereof
WO2018187509A1 (en) * 2017-04-04 2018-10-11 Flx Bio, Inc. Heterocyclic compounds as chemokine receptor modulators
RU2020118594A (en) 2017-11-06 2021-12-09 Рапт Терапьютикс, Инк. ANTI-CANCER AGENTS

Also Published As

Publication number Publication date
US11730736B2 (en) 2023-08-22
WO2019090272A1 (en) 2019-05-09
KR20200104291A (en) 2020-09-03
RU2020118594A (en) 2021-12-09
CA3081750A1 (en) 2019-05-09
CN111918652A (en) 2020-11-10
RU2020118594A3 (en) 2021-12-29
ZA202002898B (en) 2022-12-21
IL274444A (en) 2020-06-30
AU2018360766A1 (en) 2020-05-21
MX2020004836A (en) 2020-10-16
IL274444B2 (en) 2024-06-01
BR112020009055A2 (en) 2020-11-03
JP2021502345A (en) 2021-01-28
US20190134031A1 (en) 2019-05-09
TWI838350B (en) 2024-04-11
EP3706750A1 (en) 2020-09-16
IL274444B1 (en) 2024-02-01
TW201922251A (en) 2019-06-16

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