SG11202003483SA - MODIFICATION OF D AND T ARMS OF TRNA ENHANCING D-AMINO ACID AND ß-AMINO ACID UPTAKE - Google Patents

MODIFICATION OF D AND T ARMS OF TRNA ENHANCING D-AMINO ACID AND ß-AMINO ACID UPTAKE

Info

Publication number
SG11202003483SA
SG11202003483SA SG11202003483SA SG11202003483SA SG11202003483SA SG 11202003483S A SG11202003483S A SG 11202003483SA SG 11202003483S A SG11202003483S A SG 11202003483SA SG 11202003483S A SG11202003483S A SG 11202003483SA SG 11202003483S A SG11202003483S A SG 11202003483SA
Authority
SG
Singapore
Prior art keywords
amino acid
trna
enhancing
arms
modification
Prior art date
Application number
SG11202003483SA
Inventor
Hiroaki Suga
Takayuki Katoh
Original Assignee
Univ Tokyo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Tokyo filed Critical Univ Tokyo
Publication of SG11202003483SA publication Critical patent/SG11202003483SA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1062—Isolating an individual clone by screening libraries mRNA-Display, e.g. polypeptide and encoding template are connected covalently
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/06—Biochemical methods, e.g. using enzymes or whole viable microorganisms
SG11202003483SA 2017-10-16 2018-08-28 MODIFICATION OF D AND T ARMS OF TRNA ENHANCING D-AMINO ACID AND ß-AMINO ACID UPTAKE SG11202003483SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2017200356 2017-10-16
PCT/JP2018/031814 WO2019077887A1 (en) 2017-10-16 2018-08-28 MODIFICATION OF D AND T ARMS OF TRNA ENHANCING D-AMINO ACID AND β-AMINO ACID UPTAKE

Publications (1)

Publication Number Publication Date
SG11202003483SA true SG11202003483SA (en) 2020-07-29

Family

ID=66173315

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202003483SA SG11202003483SA (en) 2017-10-16 2018-08-28 MODIFICATION OF D AND T ARMS OF TRNA ENHANCING D-AMINO ACID AND ß-AMINO ACID UPTAKE

Country Status (5)

Country Link
US (1) US11946042B2 (en)
EP (1) EP3699276A4 (en)
JP (1) JP7079018B6 (en)
SG (1) SG11202003483SA (en)
WO (1) WO2019077887A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021078428A (en) 2019-11-19 2021-05-27 国立大学法人 東京大学 MODIFICATION OF T STEM OF tRNA FOR ENHANCING UPTAKE OF N-METHYL AMINO ACIDS
US20230108274A1 (en) * 2019-12-26 2023-04-06 Chugai Seiyaku Kabushiki Kaisha Composition for translation, and method for producing peptide
EP4101929A1 (en) 2019-12-27 2022-12-14 The University of Tokyo Library construction method, cyclic peptide, fxiia binder and ifngr1 binder

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060200878A1 (en) * 2004-12-21 2006-09-07 Linda Lutfiyya Recombinant DNA constructs and methods for controlling gene expression
JP5200241B2 (en) * 2006-11-17 2013-06-05 国立大学法人 東京大学 Translational synthesis of polypeptides with non-natural backbone at the N-terminus and their applications
JP5605602B2 (en) 2007-03-26 2014-10-15 国立大学法人 東京大学 Method for synthesizing cyclic peptide compound
WO2011049157A1 (en) 2009-10-22 2011-04-28 ペプチドリーム株式会社 Rapid display method in translational synthesis of peptide
JP5818237B2 (en) * 2010-09-09 2015-11-18 国立大学法人 東京大学 Translational construction and search for active species of special peptide compound library containing N-methylamino acid and other special amino acids
US9657289B2 (en) 2010-12-03 2017-05-23 The University Of Tokyo Peptide with safer secondary structure, peptide library, and production methods for same
US10195578B2 (en) 2010-12-03 2019-02-05 The University Of Tokyo Peptide library production method, peptide library, and screening method
JP6440055B2 (en) * 2013-05-10 2018-12-19 国立大学法人 東京大学 Method for producing peptide library, peptide library, and screening method
US20160115487A1 (en) * 2013-05-29 2016-04-28 Bradley C. Bundy Cell-free synthetic incorporation of non-natural amino acids into proteins
JP6754997B2 (en) 2013-08-26 2020-09-16 国立大学法人 東京大学 A large cyclic peptide, a method for producing the same, and a screening method using a large cyclic peptide library.

Also Published As

Publication number Publication date
JP7079018B2 (en) 2022-06-01
EP3699276A4 (en) 2021-07-28
WO2019077887A1 (en) 2019-04-25
EP3699276A1 (en) 2020-08-26
US11946042B2 (en) 2024-04-02
JP7079018B6 (en) 2024-01-31
US20200308572A1 (en) 2020-10-01
JPWO2019077887A1 (en) 2021-01-14

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