SG11202003360QA - Fermentative production of n-acetylneuraminic acid - Google Patents
Fermentative production of n-acetylneuraminic acidInfo
- Publication number
- SG11202003360QA SG11202003360QA SG11202003360QA SG11202003360QA SG11202003360QA SG 11202003360Q A SG11202003360Q A SG 11202003360QA SG 11202003360Q A SG11202003360Q A SG 11202003360QA SG 11202003360Q A SG11202003360Q A SG 11202003360QA SG 11202003360Q A SG11202003360Q A SG 11202003360QA
- Authority
- SG
- Singapore
- Prior art keywords
- acetylneuraminic acid
- fermentative production
- fermentative
- production
- acetylneuraminic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Pediatric Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17196925.6A EP3473644A1 (en) | 2017-10-17 | 2017-10-17 | Fermentative production of n-acetylneuraminic acid |
| PCT/EP2018/078318 WO2019076941A1 (en) | 2017-10-17 | 2018-10-17 | Fermentative production of n-acetylneuraminic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202003360QA true SG11202003360QA (en) | 2020-05-28 |
Family
ID=60268177
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202003360QA SG11202003360QA (en) | 2017-10-17 | 2018-10-17 | Fermentative production of n-acetylneuraminic acid |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US11920173B2 (en) |
| EP (2) | EP3473644A1 (en) |
| JP (1) | JP7305630B2 (en) |
| KR (1) | KR20200067176A (en) |
| CN (1) | CN111556873A (en) |
| AU (1) | AU2018350754A1 (en) |
| BR (1) | BR112020007532A2 (en) |
| MX (1) | MX2020003629A (en) |
| PH (1) | PH12020550441A1 (en) |
| SG (1) | SG11202003360QA (en) |
| WO (1) | WO2019076941A1 (en) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11926858B2 (en) | 2014-06-27 | 2024-03-12 | Glycom A/S | Oligosaccharide production |
| CN113684233A (en) | 2014-06-27 | 2021-11-23 | 格礼卡姆股份公司 | Preparation of oligosaccharides |
| EP3486326A1 (en) * | 2017-11-21 | 2019-05-22 | Jennewein Biotechnologie GmbH | Method for the purification of n-acetylneuraminic acid from a fermentation broth |
| EP3702468A1 (en) | 2019-03-01 | 2020-09-02 | Jennewein Biotechnologie GmbH | Fermentative production of carbohydrates by microbial cells utilizing a mixed feedstock |
| US20220153884A1 (en) * | 2019-04-15 | 2022-05-19 | Nof Corporation | Phosphoryl-choline-group-containing vinyl monomer |
| KR102283626B1 (en) * | 2019-10-31 | 2021-08-02 | 대상 주식회사 | Strain with Improved Aromatic Amino Acid Production Capacity by glsB Gene Inactivation |
| CN111411065B (en) * | 2020-03-30 | 2022-07-05 | 江南大学 | Recombinant bacterium for producing N-acetylneuraminic acid based on artificial double carbon sources |
| CN111411066B (en) * | 2020-03-30 | 2022-08-23 | 江南大学 | Double-way composite neuraminic acid-producing bacillus subtilis and construction method thereof |
| CN111394292B (en) * | 2020-03-30 | 2022-08-09 | 江南大学 | Multi-way composite neuraminic acid-producing bacillus subtilis and application thereof |
| EP4179102A1 (en) | 2020-07-13 | 2023-05-17 | Glycom A/S | Oligosaccharide production |
| EP4192945A1 (en) | 2020-08-10 | 2023-06-14 | Inbiose N.V. | Cellular production of sialylated di- and/or oligosaccharides |
| CN112175893B (en) * | 2020-09-04 | 2022-06-17 | 清华大学 | Recombinant microorganism for producing sialic acid and application thereof |
| CN113122491B (en) * | 2021-03-26 | 2022-08-02 | 清华大学 | Recombinant microorganism for producing N-acetylneuraminic acid and application thereof |
| KR20230172003A (en) | 2021-04-16 | 2023-12-21 | 인바이오스 엔.브이. | Cellular production of bioproducts |
| KR20230170961A (en) | 2021-04-16 | 2023-12-19 | 인바이오스 엔.브이. | Cellular production of sialylated disaccharides and/or oligosaccharides |
| CN113817658B (en) * | 2021-08-24 | 2023-06-16 | 天津科技大学 | Genetically engineered bacterium for producing N-acetylneuraminic acid and construction and application thereof |
| CN114196693B (en) * | 2021-10-25 | 2023-11-24 | 福州一诺维生物科技有限公司 | Preparation method of N-acetylneuraminic acid |
| CN116200316B (en) * | 2021-11-30 | 2024-08-06 | 虹摹生物科技(上海)有限公司 | Genetically engineered bacterium and application thereof in preparation of sialyllactose |
| CN114874967B (en) * | 2022-06-17 | 2024-06-25 | 江南大学 | Recombinant escherichia coli for producing N-acetylneuraminic acid and construction method thereof |
| CN116496330B (en) * | 2023-06-28 | 2023-09-19 | 山东福洋生物制造工程研究院 | Sialic acid extraction method and sialic acid extracted by same |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3131655B2 (en) | 1992-02-03 | 2001-02-05 | マルキン忠勇株式会社 | Method for producing N-acetylneuraminic acid |
| GB9311873D0 (en) | 1993-06-09 | 1993-07-28 | Glaxo Group Ltd | Process |
| JP3501415B2 (en) | 1994-03-30 | 2004-03-02 | 雪印乳業株式会社 | Bifidobacterium and lactic acid bacteria growth promoter |
| US6372457B1 (en) | 1997-01-14 | 2002-04-16 | Arkion Life Sciences Llc | Process and materials for production of glucosamine |
| US6846656B1 (en) | 1999-08-30 | 2005-01-25 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing N-acetylneuraminic acid |
| EP2348121A1 (en) | 2002-02-20 | 2011-07-27 | University Of Georgia Research Foundation, Inc. | Microbial production of pyruvate |
| AU2003220850A1 (en) | 2002-02-28 | 2003-09-09 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing n-acetylneuraminic acid |
| US7332304B2 (en) | 2002-07-01 | 2008-02-19 | Arkion Life Sciences Llc | Process and materials for production of glucosamine and N-acetylglucosamine |
| US7867541B2 (en) | 2003-04-14 | 2011-01-11 | Mead Johnson Nutrition Company | Compositions and methods of formulation for enteral formulas containing sialic acid |
| US7951410B2 (en) | 2003-04-14 | 2011-05-31 | Mead Johnson Nutrition Company | Enteral compositions containing caseinoglycomacropeptide having an enhanced concentration of sialic acid |
| WO2008097366A2 (en) | 2006-09-26 | 2008-08-14 | Syracuse University | Metabolically engineered escherichia coli for enchanced production of sialic acid |
| CA2665332A1 (en) | 2006-10-03 | 2008-04-10 | Centre National De La Recherche Scientifique (Cnrs) | High yield production of sialic acid (neu5ac) by fermentation |
| AT510299B1 (en) | 2010-12-22 | 2012-03-15 | Univ Wien Tech | METHOD AND AGENT FOR PRODUCING N-ACETYLNEURAMIC ACID (NEUNAC) |
| MX2013008500A (en) * | 2011-02-04 | 2014-03-05 | Univ California | Disialyllacto-n-tetraose (dslnt) or variants, isomers, analogs and derivatives thereof to prevent or inhibit bowel disease. |
| CN103361283B (en) | 2012-04-01 | 2015-06-03 | 中国科学院微生物研究所 | Method for producing poly-N-acetylneuraminic acid by microbial fermentation and purification method thereof |
| KR101481782B1 (en) | 2012-12-28 | 2015-01-13 | 대상 주식회사 | Mutant Strain with improved Amino acid production by inactivating GOGAT |
| WO2014153253A1 (en) * | 2013-03-14 | 2014-09-25 | Glycosyn LLC | Microorganisms and methods for producing sialylated and n-acetylglucosamine-containing oligosaccharides |
| WO2018122225A1 (en) | 2016-12-27 | 2018-07-05 | Inbiose N.V. | In vivo synthesis of sialylated compounds |
| CN106929461B (en) | 2017-04-25 | 2020-11-03 | 江南大学 | Recombinant bacillus subtilis for increasing yield of N-acetylneuraminic acid |
| EP3450443A1 (en) | 2017-08-29 | 2019-03-06 | Jennewein Biotechnologie GmbH | Process for purifying sialylated oligosaccharides |
-
2017
- 2017-10-17 EP EP17196925.6A patent/EP3473644A1/en not_active Ceased
-
2018
- 2018-10-17 CN CN201880081537.1A patent/CN111556873A/en active Pending
- 2018-10-17 KR KR1020207013007A patent/KR20200067176A/en active IP Right Grant
- 2018-10-17 BR BR112020007532-9A patent/BR112020007532A2/en unknown
- 2018-10-17 SG SG11202003360QA patent/SG11202003360QA/en unknown
- 2018-10-17 EP EP18785382.5A patent/EP3697805A1/en active Pending
- 2018-10-17 AU AU2018350754A patent/AU2018350754A1/en active Pending
- 2018-10-17 US US16/756,279 patent/US11920173B2/en active Active
- 2018-10-17 WO PCT/EP2018/078318 patent/WO2019076941A1/en unknown
- 2018-10-17 JP JP2020521610A patent/JP7305630B2/en active Active
- 2018-10-17 MX MX2020003629A patent/MX2020003629A/en unknown
-
2020
- 2020-04-17 PH PH12020550441A patent/PH12020550441A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2020115025A3 (en) | 2022-03-02 |
| WO2019076941A1 (en) | 2019-04-25 |
| PH12020550441A1 (en) | 2021-04-26 |
| US11920173B2 (en) | 2024-03-05 |
| BR112020007532A2 (en) | 2020-10-06 |
| KR20200067176A (en) | 2020-06-11 |
| EP3697805A1 (en) | 2020-08-26 |
| JP7305630B2 (en) | 2023-07-10 |
| US20200332331A1 (en) | 2020-10-22 |
| RU2020115025A (en) | 2021-11-18 |
| AU2018350754A1 (en) | 2020-05-07 |
| CN111556873A (en) | 2020-08-18 |
| JP2020537530A (en) | 2020-12-24 |
| EP3473644A1 (en) | 2019-04-24 |
| MX2020003629A (en) | 2020-07-29 |
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