SG11202003096UA - Methods of treating immunotherapy-related toxicity using a gm-csf antagonist - Google Patents
Methods of treating immunotherapy-related toxicity using a gm-csf antagonistInfo
- Publication number
- SG11202003096UA SG11202003096UA SG11202003096UA SG11202003096UA SG11202003096UA SG 11202003096U A SG11202003096U A SG 11202003096UA SG 11202003096U A SG11202003096U A SG 11202003096UA SG 11202003096U A SG11202003096U A SG 11202003096UA SG 11202003096U A SG11202003096U A SG 11202003096UA
- Authority
- SG
- Singapore
- Prior art keywords
- methods
- related toxicity
- csf antagonist
- immunotherapy
- treating
- Prior art date
Links
- 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 title 1
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 238000009169 immunotherapy Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 230000001988 toxicity Effects 0.000 title 1
- 231100000419 toxicity Toxicity 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2893—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD52
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/463—Cellular immunotherapy characterised by recombinant expression
- A61K39/4631—Chimeric Antigen Receptors [CAR]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464402—Receptors, cell surface antigens or cell surface determinants
- A61K39/464411—Immunoglobulin superfamily
- A61K39/464412—CD19 or B4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464402—Receptors, cell surface antigens or cell surface determinants
- A61K39/464416—Receptors for cytokines
- A61K39/464419—Receptors for interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/243—Colony Stimulating Factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/48—Blood cells, e.g. leukemia or lymphoma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/626—Diabody or triabody
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762567187P | 2017-10-02 | 2017-10-02 | |
US201862729043P | 2018-09-10 | 2018-09-10 | |
PCT/US2018/053933 WO2019070680A2 (en) | 2017-10-02 | 2018-10-02 | Methods of treating immunotherapy-related toxicity using a gm-csf antagonist |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202003096UA true SG11202003096UA (en) | 2020-05-28 |
Family
ID=65994983
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202003096UA SG11202003096UA (en) | 2017-10-02 | 2018-10-02 | Methods of treating immunotherapy-related toxicity using a gm-csf antagonist |
Country Status (8)
Country | Link |
---|---|
US (3) | US10870703B2 (en) |
EP (1) | EP3691663A4 (en) |
JP (1) | JP7320498B2 (en) |
CN (1) | CN111757744A (en) |
AU (1) | AU2018345751A1 (en) |
CA (1) | CA3078349A1 (en) |
SG (1) | SG11202003096UA (en) |
WO (1) | WO2019070680A2 (en) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3691663A4 (en) | 2017-10-02 | 2021-08-18 | Humanigen, Inc. | Methods of treating immunotherapy-related toxicity using a gm-csf antagonist |
US11130805B2 (en) | 2017-10-02 | 2021-09-28 | Humanigen, Inc. | Methods of treating CART-T cell therapy-induced neuroinflammation using a GM-CSF antagonist |
JP2021525530A (en) * | 2018-06-01 | 2021-09-27 | ワシントン・ユニバーシティWashington University | Suppression of cytokine release syndrome using chimeric antigen receptor cell therapy |
BR112021004489A2 (en) * | 2018-09-10 | 2021-07-20 | Humanigen, Inc. | methods of treating immunotherapy-related toxicity using a gm-csf antagonist |
JP2022532865A (en) * | 2019-05-03 | 2022-07-20 | カイト ファーマ インコーポレイテッド | Administration method of chimeric antigen receptor immunotherapy |
AU2020287327A1 (en) | 2019-06-03 | 2022-03-10 | Kiniksa Pharmaceuticals, Ltd. | Treatment of cancers with GM-CSF antagonists |
MX2022011111A (en) * | 2020-03-08 | 2023-03-02 | Humanigen Inc | Methods for treating coronavirus infection and resulting inflammation-induced lung injury. |
US20210284744A1 (en) | 2020-03-15 | 2021-09-16 | Kiniksa Pharmaceuticals, Ltd. | Treatment of cytokine release syndrome with gm-csf antagonists |
WO2021204649A1 (en) * | 2020-04-06 | 2021-10-14 | Glaxosmithkline Intellectual Property Development Limited | Gm-csf antagonists for use in the treatment of severe pulmonary covid-19, cytokine release syndrome and/or acute respiratory distress syndrome |
AU2021372454A1 (en) * | 2020-10-26 | 2023-06-22 | Kiniksa Pharmaceuticals, Ltd. | Treatment of cancers with gm-csf antagonists |
WO2022177815A1 (en) * | 2021-02-19 | 2022-08-25 | Edifice Health, Inc. | MUCOSAL DELIVERY OF COMPOUNDS FOR MODIFYING iAGE |
CU20210021A7 (en) | 2021-03-30 | 2022-11-07 | Ct Inmunologia Molecular | VACCINE COMPOSITIONS DEPLETING HEMATOPOIETIC GROWTH FACTORS FOR THE TREATMENT OF INFLAMMATORY DISEASES |
CN113945723B (en) * | 2021-10-28 | 2024-03-12 | 复旦大学附属中山医院 | System for predicting risk of occurrence of immune checkpoint inhibitor treatment-related pneumonia, storage medium and application thereof |
WO2023138499A1 (en) * | 2022-01-20 | 2023-07-27 | 舒泰神(北京)生物制药股份有限公司 | Antibody preparation for specifically recognizing granulocyte-macrophage colony-stimulating factor receptor and use thereof |
Family Cites Families (30)
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DE60329489D1 (en) | 2002-02-13 | 2009-11-12 | Ludwig Inst Cancer Res | FUSION PROTEINS HUMANIZED G250-SPECIFIC ANTIBODY AND USES THEREOF |
PL3540062T3 (en) | 2004-11-16 | 2021-12-27 | Humanigen, Inc. | Immunoglobulin variable region cassette exchange |
WO2006111353A2 (en) | 2005-04-18 | 2006-10-26 | Micromet Ag | Antibody neutralizers of human granulocyte macrophage colony stimulating factor |
WO2006122797A2 (en) | 2005-05-18 | 2006-11-23 | Morphosys Ag | Anti-gm-csf antibodies and uses therefor |
EP1981909B1 (en) | 2006-02-08 | 2016-10-12 | Morphotek, Inc. | Antigenic gm-csf peptides and antibodies to gm-csf |
WO2007120842A2 (en) | 2006-04-13 | 2007-10-25 | Cornell Research Foundation, Inc. | Methods and compositions for targeting c-rel |
EP2402013A1 (en) | 2006-11-21 | 2012-01-04 | Kalobios Pharmaceuticals, Inc. | Methods of Treating Chronic Inflammatory Diseases using a GM-CSF Antagonist |
US8398972B2 (en) | 2006-11-21 | 2013-03-19 | Kalobios Pharmaceuticals, Inc. | Methods of treating dementia using a GM-CSF antagonist |
US8075885B2 (en) | 2008-04-07 | 2011-12-13 | Kalobios Pharmaceuticals, Inc. | Methods of treating heart failure using an anti-GM-CSF antibody |
EP3449941A1 (en) * | 2008-04-28 | 2019-03-06 | Humanigen, Inc. | Antibodies to granulocyte-macrophage colony-stimulating factor |
US20140127814A1 (en) | 2010-08-10 | 2014-05-08 | Srinivasan Chandrasegaran | Generation and use of pluripotent stem cells |
AU2012280267B2 (en) | 2011-07-06 | 2016-04-21 | Morphosys Ag | Therapeutic combinations of anti-cd20 and anti-gm-csf antibodies and uses thereof |
BR112015000660A8 (en) | 2012-07-13 | 2022-03-15 | Childrens Hospital Philadelphia | use of a first-line therapy and a second-line therapy for treating a patient having a disease, disorder or condition associated with elevated tumor antigen expression, and a composition for reducing or preventing an adverse effect associated with administering a genetically modified cell to express a car. |
US20160186208A1 (en) | 2013-04-16 | 2016-06-30 | Whitehead Institute For Biomedical Research | Methods of Mutating, Modifying or Modulating Nucleic Acid in a Cell or Nonhuman Mammal |
WO2015066262A1 (en) | 2013-11-04 | 2015-05-07 | Trustees Of Dartmouth College | Methods for preventing toxicity of adoptive cell therapy |
ES2876263T3 (en) | 2014-04-07 | 2021-11-12 | Novartis Ag | Cancer treatment using anti-cd19 chimeric antigen receptor |
CN117427091A (en) | 2014-10-20 | 2024-01-23 | 朱诺治疗学股份有限公司 | Compositions and methods for administration in adoptive cell therapy |
US10688166B2 (en) | 2014-11-03 | 2020-06-23 | Cerus Corporation | Compositions and methods for improved car-T cell therapies |
EP3322439A4 (en) * | 2015-07-16 | 2019-03-20 | Prospect Chartercare RWMC LLC D/B/A Roger Williams Medical Center | Compositions and methods for treating peritoneal cancers |
WO2017040930A2 (en) | 2015-09-03 | 2017-03-09 | The Trustees Of The University Of Pennsylvania | Biomarkers predictive of cytokine release syndrome |
US11667911B2 (en) | 2015-09-24 | 2023-06-06 | Editas Medicine, Inc. | Use of exonucleases to improve CRISPR/CAS-mediated genome editing |
ES2901795T3 (en) | 2015-12-04 | 2022-03-23 | Juno Therapeutics Inc | Methods and compositions related to toxicity associated with cell therapy |
EP3416661A4 (en) | 2016-02-18 | 2020-03-04 | Enlivex Therapeutics Ltd. | Combination immune therapy and cytokine control therapy for cancer treatment |
WO2018093591A1 (en) | 2016-11-03 | 2018-05-24 | Juno Therapeutics, Inc. | Combination therapy of a cell based therapy and a microglia inhibitor |
CN110382532B (en) | 2017-02-07 | 2023-04-14 | Me医疗公司 | anti-G-CSF antibodies and uses thereof |
US11130805B2 (en) | 2017-10-02 | 2021-09-28 | Humanigen, Inc. | Methods of treating CART-T cell therapy-induced neuroinflammation using a GM-CSF antagonist |
US10927168B2 (en) | 2017-10-02 | 2021-02-23 | Humanicen, Inc. | Method of reducing tumor relapse rate in immunotherapy by administration of lenzilumab |
US10899831B2 (en) | 2017-10-02 | 2021-01-26 | Humanigen, Inc. | Method of reducing the level of non-GM-CSF cytokines/chemokines in immunotherapy-related toxicity |
EP3691663A4 (en) | 2017-10-02 | 2021-08-18 | Humanigen, Inc. | Methods of treating immunotherapy-related toxicity using a gm-csf antagonist |
WO2019232370A1 (en) | 2018-06-01 | 2019-12-05 | Mayo Foundation For Medical Education And Research | Materials and methods for treating cancer |
-
2018
- 2018-10-02 EP EP18865158.2A patent/EP3691663A4/en active Pending
- 2018-10-02 SG SG11202003096UA patent/SG11202003096UA/en unknown
- 2018-10-02 CA CA3078349A patent/CA3078349A1/en active Pending
- 2018-10-02 JP JP2020520060A patent/JP7320498B2/en active Active
- 2018-10-02 CN CN201880073017.6A patent/CN111757744A/en active Pending
- 2018-10-02 WO PCT/US2018/053933 patent/WO2019070680A2/en unknown
- 2018-10-02 US US16/149,346 patent/US10870703B2/en active Active
- 2018-10-02 US US16/652,977 patent/US11673962B2/en active Active
- 2018-10-02 AU AU2018345751A patent/AU2018345751A1/en active Pending
-
2020
- 2020-11-13 US US17/097,303 patent/US20210130488A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20200354443A1 (en) | 2020-11-12 |
US20210130488A1 (en) | 2021-05-06 |
CN111757744A (en) | 2020-10-09 |
WO2019070680A3 (en) | 2019-05-23 |
AU2018345751A1 (en) | 2020-05-07 |
JP2020536118A (en) | 2020-12-10 |
CA3078349A1 (en) | 2019-04-11 |
WO2019070680A2 (en) | 2019-04-11 |
US11673962B2 (en) | 2023-06-13 |
EP3691663A4 (en) | 2021-08-18 |
EP3691663A2 (en) | 2020-08-12 |
US20190194343A1 (en) | 2019-06-27 |
JP7320498B2 (en) | 2023-08-03 |
US10870703B2 (en) | 2020-12-22 |
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