SG11202002903XA - Bispecific 2+1 contorsbodies - Google Patents
Bispecific 2+1 contorsbodiesInfo
- Publication number
- SG11202002903XA SG11202002903XA SG11202002903XA SG11202002903XA SG11202002903XA SG 11202002903X A SG11202002903X A SG 11202002903XA SG 11202002903X A SG11202002903X A SG 11202002903XA SG 11202002903X A SG11202002903X A SG 11202002903XA SG 11202002903X A SG11202002903X A SG 11202002903XA
- Authority
- SG
- Singapore
- Prior art keywords
- contorsbodies
- bispecific
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP17199537 | 2017-11-01 | ||
PCT/EP2018/079785 WO2019086500A2 (en) | 2017-11-01 | 2018-10-31 | Bispecific 2+1 contorsbodies |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202002903XA true SG11202002903XA (en) | 2020-04-29 |
Family
ID=60201893
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202002903XA SG11202002903XA (en) | 2017-11-01 | 2018-10-31 | Bispecific 2+1 contorsbodies |
Country Status (18)
Country | Link |
---|---|
US (1) | US20210324108A1 (en) |
EP (1) | EP3703821A2 (en) |
JP (1) | JP7098725B2 (en) |
KR (1) | KR20200079492A (en) |
CN (1) | CN111182944B (en) |
AU (1) | AU2018357923A1 (en) |
BR (1) | BR112020006443A2 (en) |
CA (1) | CA3076027A1 (en) |
CL (1) | CL2020000662A1 (en) |
CR (1) | CR20200171A (en) |
IL (1) | IL272747A (en) |
MA (1) | MA50505A (en) |
MX (1) | MX2020004571A (en) |
PE (1) | PE20210844A1 (en) |
SG (1) | SG11202002903XA (en) |
TW (1) | TWI829658B (en) |
WO (1) | WO2019086500A2 (en) |
ZA (1) | ZA202001139B (en) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3224275B1 (en) | 2014-11-14 | 2020-03-04 | F.Hoffmann-La Roche Ag | Antigen binding molecules comprising a tnf family ligand trimer |
UA123323C2 (en) * | 2016-05-02 | 2021-03-17 | Ф. Хоффманн-Ля Рош Аг | The contorsbody - a single chain target binder |
EP3559034B1 (en) | 2016-12-20 | 2020-12-02 | H. Hoffnabb-La Roche Ag | Combination therapy of anti-cd20/anti-cd3 bispecific antibodies and 4-1bb (cd137) agonists |
BR112019013189A2 (en) | 2017-01-03 | 2019-12-10 | Hoffmann La Roche | bispecific antigen binding molecules, polynucleotide, host cell, bispecific antigen binding molecule production method, pharmaceutical composition, use, methods for inhibiting tumor cell growth in an individual and for treating cancer or an infectious disease |
CN110573528B (en) * | 2017-03-29 | 2023-06-09 | 豪夫迈·罗氏有限公司 | Bispecific antigen binding molecules to costimulatory TNF receptors |
CN110382542B (en) | 2017-03-29 | 2023-06-09 | 豪夫迈·罗氏有限公司 | Bispecific antigen binding molecules to costimulatory TNF receptors |
JP7221379B2 (en) | 2018-10-01 | 2023-02-13 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | Bispecific antigen-binding molecule comprising anti-FAP clone 212 |
MY198034A (en) | 2018-12-21 | 2023-07-27 | Hoffmann La Roche | Tumor-targeted agonistic cd28 antigen binding molecules |
BR112021020843A2 (en) * | 2019-04-25 | 2022-02-01 | Hoffmann La Roche | Set of heterodimeric precursor polypeptides, heterodimeric polypeptides, methods for generating a heterodimeric polypeptide and for identifying a multispecific heterodimeric polypeptide, multispecific heterodimeric polypeptide, first and second heterodimeric precursor polypeptides |
EP3959237A1 (en) * | 2019-04-25 | 2022-03-02 | F. Hoffmann-La Roche AG | Therapeutic multispecific polypeptides activated by polypeptide chain exchange |
EP3959238A1 (en) * | 2019-04-25 | 2022-03-02 | F. Hoffmann-La Roche AG | Activatable therapeutic multispecific polypeptides with extended half-life |
JPWO2020230899A1 (en) * | 2019-05-15 | 2020-11-19 | ||
WO2020260326A1 (en) * | 2019-06-27 | 2020-12-30 | F. Hoffmann-La Roche Ag | Novel icos antibodies and tumor-targeted antigen binding molecules comprising them |
AR121706A1 (en) * | 2020-04-01 | 2022-06-29 | Hoffmann La Roche | OX40 AND FAP-TARGETED BSPECIFIC ANTIGEN-BINDING MOLECULES |
BR112022021447A2 (en) * | 2020-05-19 | 2022-12-13 | Boehringer Ingelheim Int | BINDING MOLECULES FOR THE TREATMENT OF CANCER |
WO2023245022A2 (en) * | 2022-06-14 | 2023-12-21 | Invenra Inc. | Multispecific binding agents that target b7h3 and gd2 and uses thereof |
WO2024038183A1 (en) * | 2022-08-18 | 2024-02-22 | Immunocore Limited | Multi-domain binding molecules |
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CA2859667C (en) | 2011-12-20 | 2022-05-24 | Medimmune, Llc | Modified polypeptides for bispecific antibody scaffolds |
MX360109B (en) | 2012-04-20 | 2018-10-23 | Merus Nv | Methods and means for the production of ig-like molecules. |
EP2948475A2 (en) * | 2013-01-23 | 2015-12-02 | AbbVie Inc. | Methods and compositions for modulating an immune response |
BR112018002570A2 (en) | 2015-10-02 | 2018-10-16 | Hoffmann La Roche | bispecific antigen binding molecule, bispecific antibody, polynucleotides, ox40-specific binding antibody, pharmaceutical composition and method for inhibiting tumor cell growth in an individual |
AU2016334623A1 (en) * | 2015-10-07 | 2018-02-15 | F. Hoffmann-La Roche Ag | Bispecific antibodies with tetravalency for a costimulatory TNF receptor |
SG11201808911SA (en) * | 2016-04-13 | 2018-11-29 | Sanofi Sa | Trispecific and/or trivalent binding proteins |
UA123323C2 (en) * | 2016-05-02 | 2021-03-17 | Ф. Хоффманн-Ля Рош Аг | The contorsbody - a single chain target binder |
BR112019013189A2 (en) * | 2017-01-03 | 2019-12-10 | Hoffmann La Roche | bispecific antigen binding molecules, polynucleotide, host cell, bispecific antigen binding molecule production method, pharmaceutical composition, use, methods for inhibiting tumor cell growth in an individual and for treating cancer or an infectious disease |
BR112019017753A2 (en) * | 2017-04-04 | 2020-04-07 | Hoffmann La Roche | bispecific molecule, polynucleotide, vector, cell, methods for the production of a molecule and for the treatment of an individual, composition and use of the bispecific molecule |
-
2018
- 2018-10-31 EP EP18800546.6A patent/EP3703821A2/en active Pending
- 2018-10-31 AU AU2018357923A patent/AU2018357923A1/en active Pending
- 2018-10-31 MA MA050505A patent/MA50505A/en unknown
- 2018-10-31 US US16/760,820 patent/US20210324108A1/en active Pending
- 2018-10-31 TW TW107138691A patent/TWI829658B/en active
- 2018-10-31 PE PE2020000390A patent/PE20210844A1/en unknown
- 2018-10-31 CA CA3076027A patent/CA3076027A1/en active Pending
- 2018-10-31 MX MX2020004571A patent/MX2020004571A/en unknown
- 2018-10-31 SG SG11202002903XA patent/SG11202002903XA/en unknown
- 2018-10-31 KR KR1020207011913A patent/KR20200079492A/en not_active Application Discontinuation
- 2018-10-31 CN CN201880063441.2A patent/CN111182944B/en active Active
- 2018-10-31 BR BR112020006443-2A patent/BR112020006443A2/en unknown
- 2018-10-31 JP JP2020523704A patent/JP7098725B2/en active Active
- 2018-10-31 CR CR20200171A patent/CR20200171A/en unknown
- 2018-10-31 WO PCT/EP2018/079785 patent/WO2019086500A2/en unknown
-
2020
- 2020-02-18 IL IL272747A patent/IL272747A/en unknown
- 2020-02-24 ZA ZA2020/01139A patent/ZA202001139B/en unknown
- 2020-03-13 CL CL2020000662A patent/CL2020000662A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
MX2020004571A (en) | 2020-08-24 |
TW201922791A (en) | 2019-06-16 |
WO2019086500A2 (en) | 2019-05-09 |
US20210324108A1 (en) | 2021-10-21 |
CR20200171A (en) | 2020-06-14 |
JP2021500898A (en) | 2021-01-14 |
MA50505A (en) | 2020-09-09 |
PE20210844A1 (en) | 2021-05-10 |
WO2019086500A3 (en) | 2019-08-29 |
AU2018357923A1 (en) | 2020-03-05 |
CN111182944A (en) | 2020-05-19 |
CA3076027A1 (en) | 2019-05-09 |
CL2020000662A1 (en) | 2020-10-02 |
BR112020006443A2 (en) | 2020-09-29 |
CN111182944B (en) | 2022-11-22 |
JP7098725B2 (en) | 2022-07-11 |
EP3703821A2 (en) | 2020-09-09 |
RU2020117441A3 (en) | 2022-04-01 |
TWI829658B (en) | 2024-01-21 |
IL272747A (en) | 2020-04-30 |
ZA202001139B (en) | 2021-03-31 |
RU2020117441A (en) | 2021-12-01 |
KR20200079492A (en) | 2020-07-03 |
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GB201718324D0 (en) | Zenaura 1 | |
GB201717162D0 (en) | Lightpack 2 | |
GB201717202D0 (en) | 11 | |
AU2017293V (en) | HANSOTI 13 Zamioculcas zamiifolia | |
GB201710030D0 (en) | Busuu 3 | |
AU2017130V (en) | Bonsca 1160 Scaevola aemula | |
AU2017135V (en) | Bonsca 1203 Scaevola aemula | |
GB201705299D0 (en) | 360 | |
GB201720220D0 (en) | Concept 162 | |
GB201720046D0 (en) | Concept 160 | |
GB201718058D0 (en) | Concept 39 | |
GB201718057D0 (en) | Concept 38 | |
GB201718023D0 (en) | Concept 30 | |
GB201718050D0 (en) | Concept 33 | |
GB201718060D0 (en) | Concept 42 | |
GB201718065D0 (en) | Concept 54 | |
GB201718059D0 (en) | Concept 40 | |
GB201718064D0 (en) | Concept 53 | |
GB201718061D0 (en) | Concept 43 | |
GB201718062D0 (en) | Concept 44 | |
GB201718056D0 (en) | Concept 37 | |
GB201718052D0 (en) | Concept 36 | |
GB201718049D0 (en) | Concept 32 | |
GB201718063D0 (en) | Concept 51 |