SG11202002366VA - Agonistic cd40 antibodies - Google Patents

Agonistic cd40 antibodies

Info

Publication number
SG11202002366VA
SG11202002366VA SG11202002366VA SG11202002366VA SG11202002366VA SG 11202002366V A SG11202002366V A SG 11202002366VA SG 11202002366V A SG11202002366V A SG 11202002366VA SG 11202002366V A SG11202002366V A SG 11202002366VA SG 11202002366V A SG11202002366V A SG 11202002366VA
Authority
SG
Singapore
Prior art keywords
agonistic
antibodies
Prior art date
Application number
SG11202002366VA
Inventor
Stephan Fischer
Karsten Beckmann
Original Assignee
Mab Discovery Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mab Discovery Gmbh filed Critical Mab Discovery Gmbh
Publication of SG11202002366VA publication Critical patent/SG11202002366VA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SG11202002366VA 2017-09-19 2018-09-19 Agonistic cd40 antibodies SG11202002366VA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17191974 2017-09-19
PCT/EP2018/075388 WO2019057792A1 (en) 2017-09-19 2018-09-19 Agonistic cd40 antibodies

Publications (1)

Publication Number Publication Date
SG11202002366VA true SG11202002366VA (en) 2020-04-29

Family

ID=59914405

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202002366VA SG11202002366VA (en) 2017-09-19 2018-09-19 Agonistic cd40 antibodies

Country Status (14)

Country Link
US (2) US11702478B2 (en)
EP (1) EP3684813A1 (en)
JP (2) JP7346390B2 (en)
KR (1) KR20200063139A (en)
CN (2) CN111225924B (en)
AU (1) AU2018335828A1 (en)
BR (1) BR112020003988A2 (en)
CA (1) CA3075221A1 (en)
EA (1) EA202090791A1 (en)
IL (1) IL272770A (en)
MX (1) MX2020002984A (en)
SG (1) SG11202002366VA (en)
WO (1) WO2019057792A1 (en)
ZA (1) ZA202001066B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116057070A (en) * 2019-10-23 2023-05-02 礼进生物医药科技（上海）有限公司 anti-CD 40 binding molecules and bispecific antibodies comprising same
KR20230020521A (en) * 2020-06-04 2023-02-10 셀벡스 피티와이 리미티드 Agonist anti-CD40 antibody
CN113861292A (en) * 2020-06-30 2021-12-31 百奥泰生物制药股份有限公司 anti-CD 40 antibody or antigen binding fragment and application thereof
WO2023052581A1 (en) * 2021-10-01 2023-04-06 Mab Discovery Gmbh Agonistic cd40 antibodies as immune stimulatory agents
WO2024005423A1 (en) * 2022-06-29 2024-01-04 고려대학교 산학협력단 Glycosylated fc variants of which binding affinity for human fcγrs is removed

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2009027B1 (en) * 2001-04-27 2014-05-21 Kyowa Hakko Kirin Co., Ltd. Anti-CD40 monoclonal antibody
AR039067A1 (en) * 2001-11-09 2005-02-09 Pfizer Prod Inc ANTIBODIES FOR CD40
US7563443B2 (en) * 2004-09-17 2009-07-21 Domantis Limited Monovalent anti-CD40L antibody polypeptides and compositions thereof
TWI461211B (en) 2009-03-20 2014-11-21 Genentech Inc Anti-her antibodies
AR083847A1 (en) 2010-11-15 2013-03-27 Novartis Ag FC VARIANTS (CONSTANT FRAGMENT) SILENCERS OF ANTI-CD40 ANTIBODIES
CN113461819B (en) 2011-04-29 2024-01-02 埃派斯进有限公司 anti-CD 40 antibodies and methods of use thereof
GB201115280D0 (en) 2011-09-05 2011-10-19 Alligator Bioscience Ab Antibodies, uses and methods
CA2943167A1 (en) 2014-03-24 2015-10-01 University Of Southampton Modified antibodies containing modified igg2 domains which elicit agonist or antagonistic properties and use thereof
JP2018526977A (en) 2015-06-29 2018-09-20 ザ ロックフェラー ユニヴァーシティ Antibody against CD40 with enhanced agonist activity
GB201601073D0 (en) 2016-01-20 2016-03-02 Ucb Biopharma Sprl Antibodies
ES2906823T3 (en) 2015-09-30 2022-04-20 Janssen Biotech Inc Agonist antibodies that specifically bind to human CD40 and methods of use
EA201892362A1 (en) 2016-04-18 2019-04-30 Селлдекс Терапьютикс, Инк. AGONISTIC ANTIBODIES THAT ARE BINDING HUMAN CD40, AND THEIR OPTIONS
BR112019000512A2 (en) * 2016-07-14 2019-04-24 Genmab A/S antibody, nucleic acid, expression vector, host cell, composition, methods of treating a disease, to produce a bispecific antibody and to detect if cross-linking between cd40 and cd137 expressing cells occurs in a sample, use of a multispecific antibody and kit
EP3401332A1 (en) 2017-05-08 2018-11-14 MAB Discovery GmbH Anti-il-1r3 antibodies for use in inflammatory conditions

Also Published As

Publication number Publication date
CA3075221A1 (en) 2019-03-28
JP7346390B2 (en) 2023-09-19
AU2018335828A1 (en) 2020-03-05
EA202090791A1 (en) 2020-06-17
CN111225924B (en) 2023-10-10
EP3684813A1 (en) 2020-07-29
ZA202001066B (en) 2021-09-29
JP2023182583A (en) 2023-12-26
WO2019057792A1 (en) 2019-03-28
JP2020534292A (en) 2020-11-26
US11702478B2 (en) 2023-07-18
KR20200063139A (en) 2020-06-04
US20200239583A1 (en) 2020-07-30
BR112020003988A2 (en) 2020-09-01
MX2020002984A (en) 2020-07-22
CN117551197A (en) 2024-02-13
IL272770A (en) 2020-04-30
CN111225924A (en) 2020-06-02
US20240010741A1 (en) 2024-01-11

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