SG11202001087RA - A label-free method and system for measuring drug response kinetics of three-dimensional cellular structures - Google Patents

A label-free method and system for measuring drug response kinetics of three-dimensional cellular structures

Info

Publication number
SG11202001087RA
SG11202001087RA SG11202001087RA SG11202001087RA SG11202001087RA SG 11202001087R A SG11202001087R A SG 11202001087RA SG 11202001087R A SG11202001087R A SG 11202001087RA SG 11202001087R A SG11202001087R A SG 11202001087RA SG 11202001087R A SG11202001087R A SG 11202001087RA
Authority
SG
Singapore
Prior art keywords
label
drug response
cellular structures
free method
dimensional cellular
Prior art date
Application number
SG11202001087RA
Inventor
Lie Yong Judice Koh
Ramanuj Dasgupta
Giridharan Periyasamy
Original Assignee
Agency Science Tech & Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agency Science Tech & Res filed Critical Agency Science Tech & Res
Publication of SG11202001087RA publication Critical patent/SG11202001087RA/en

Links

Classifications

    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00Image analysis
    • G06T7/0002Inspection of images, e.g. flaw detection
    • G06T7/0012Biomedical image inspection
    • G06T7/0014Biomedical image inspection using an image reference approach
    • G06T7/0016Biomedical image inspection using an image reference approach involving temporal comparison
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0693Tumour cells; Cancer cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06FELECTRIC DIGITAL DATA PROCESSING
    • G06F18/00Pattern recognition
    • G06F18/20Analysing
    • G06F18/21Design or setup of recognition systems or techniques; Extraction of features in feature space; Blind source separation
    • G06F18/214Generating training patterns; Bootstrap methods, e.g. bagging or boosting
    • G06F18/2155Generating training patterns; Bootstrap methods, e.g. bagging or boosting characterised by the incorporation of unlabelled data, e.g. multiple instance learning [MIL], semi-supervised techniques using expectation-maximisation [EM] or naïve labelling
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06FELECTRIC DIGITAL DATA PROCESSING
    • G06F18/00Pattern recognition
    • G06F18/20Analysing
    • G06F18/24Classification techniques
    • G06F18/241Classification techniques relating to the classification model, e.g. parametric or non-parametric approaches
    • G06F18/2411Classification techniques relating to the classification model, e.g. parametric or non-parametric approaches based on the proximity to a decision surface, e.g. support vector machines
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06NCOMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N20/00Machine learning
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06NCOMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N5/00Computing arrangements using knowledge-based models
    • G06N5/04Inference or reasoning models
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06VIMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00Scenes; Scene-specific elements
    • G06V20/60Type of objects
    • G06V20/64Three-dimensional objects
    • G06V20/653Three-dimensional objects by matching three-dimensional models, e.g. conformal mapping of Riemann surfaces
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06VIMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00Scenes; Scene-specific elements
    • G06V20/60Type of objects
    • G06V20/69Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/695Preprocessing, e.g. image segmentation
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00Use of cells in diagnostics
    • C12N2503/02Drug screening
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/10Screening for compounds of potential therapeutic value involving cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/10Image acquisition modality
    • G06T2207/10016Video; Image sequence
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/10Image acquisition modality
    • G06T2207/10028Range image; Depth image; 3D point clouds
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/10Image acquisition modality
    • G06T2207/10056Microscopic image
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/20Special algorithmic details
    • G06T2207/20081Training; Learning
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/20Special algorithmic details
    • G06T2207/20084Artificial neural networks [ANN]
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/30Subject of image; Context of image processing
    • G06T2207/30004Biomedical image processing
    • G06T2207/30024Cell structures in vitro; Tissue sections in vitro
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06VIMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V2201/00Indexing scheme relating to image or video recognition or understanding
    • G06V2201/03Recognition of patterns in medical or anatomical images
SG11202001087RA 2017-08-14 2018-08-14 A label-free method and system for measuring drug response kinetics of three-dimensional cellular structures SG11202001087RA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SG10201706639T 2017-08-14
PCT/SG2018/050412 WO2019035766A1 (en) 2017-08-14 2018-08-14 A label-free method and system for measuring drug response kinetics of three-dimensional cellular structures

Publications (1)

Publication Number Publication Date
SG11202001087RA true SG11202001087RA (en) 2020-03-30

Family

ID=65362592

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202001087RA SG11202001087RA (en) 2017-08-14 2018-08-14 A label-free method and system for measuring drug response kinetics of three-dimensional cellular structures

Country Status (4)

Country Link
US (1) US20200218874A1 (en)
CN (1) CN111194407A (en)
SG (1) SG11202001087RA (en)
WO (1) WO2019035766A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021113821A1 (en) * 2019-12-05 2021-06-10 Tempus Labs, Inc. Systems and methods for high throughput drug screening
US11561178B2 (en) 2020-04-20 2023-01-24 Tempus Labs, Inc. Artificial fluorescent image systems and methods
KR102343594B1 (en) * 2021-03-23 2021-12-27 엠비디 주식회사 Method and system for predicting sensitivity to anti-cancer agent based on cell growth factor
US20240062365A1 (en) * 2022-08-17 2024-02-22 Xilis, Inc. Imaging-based microorganosphere drug assays
EP4361944A1 (en) * 2022-10-31 2024-05-01 Sartorius Stedim Data Analytics AB Monitoring of biofabrication processes
CN116912825B (en) * 2023-09-14 2023-11-24 生态环境部华南环境科学研究所(生态环境部生态环境应急研究所) High content chemical pulmonary toxicity screening method by utilizing artificial intelligence and machine learning
CN117625541B (en) * 2024-01-26 2024-04-02 零壹人工智能科技研究院(南京)有限公司 Brain glioma organoid construction method and drug sensitivity detection method

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7235353B2 (en) * 2003-07-18 2007-06-26 Cytokinetics, Inc. Predicting hepatotoxicity using cell based assays
GB2435923A (en) * 2006-03-09 2007-09-12 Cytokinetics Inc Cellular predictive models for toxicities

Also Published As

Publication number Publication date
WO2019035766A1 (en) 2019-02-21
US20200218874A1 (en) 2020-07-09
CN111194407A (en) 2020-05-22

Similar Documents

Publication Publication Date Title
SG11202001087RA (en) A label-free method and system for measuring drug response kinetics of three-dimensional cellular structures
SG10202007724SA (en) Method and system for distributed acoustic sensing
PL3312633T3 (en) Method and system for determining a position of a mobile device
IL244025A0 (en) System and method for determining movements and oscillations of moving structures
EP3211987C0 (en) Method for providing a three-dimensional assessment of water movement through soil and across a field and associated system
EP3399143A4 (en) Method and device for determining dissolution degree of karst reservoir
GB201905435D0 (en) Appartus and method for providing reminders
HUE057712T2 (en) Sensor system and method for manufacturing thereof
GB201510036D0 (en) Method of forming a chemical sensor device and device
ZA201701963B (en) Method and system for determining postural balance of a person
EP3384265C0 (en) A method and system for measuring deformation of a surface
GB201519397D0 (en) Systems and methods for forming models of a three-dimensional objects
ZA201901158B (en) Method to radiographically determine geometrical parameters and/or substance state of an object under study
EP3155369A4 (en) System and method for measuring a displacement of a mobile platform
IL262955B (en) A system and method for identifying success of a physiological measurement
GB201718238D0 (en) Method and system for determining the disease status of a subject
GB2544935B (en) Method for optically measuring three-dimensional coordinates and calibration of a three-dimensional measuring device
IL266484B (en) Measurement system, lithographic system, and method of measuring a target
FI3488059T3 (en) Device and method for construction of a self-supporting three-dimensional prestressed structure
IL267092B1 (en) Metrology apparatus, lithographic system, and method of measuring a structure
HUE045623T2 (en) Sensor device and method for surface inspection of a cylindrical cavity
EP3293481A4 (en) Multi-measurement-mode three-dimensional measurement system and measurement method
HUE061545T2 (en) Electrochemical sensor and method for producing thereof
GB201521503D0 (en) A temperature measuring appartus and a method of measuring tempurature
PL429602A1 (en) Measurement system and method for measuring displacements of structure elements