SG11202000817SA - Carbamoyl phenylalaninol analogs and uses thereof - Google Patents
Carbamoyl phenylalaninol analogs and uses thereofInfo
- Publication number
- SG11202000817SA SG11202000817SA SG11202000817SA SG11202000817SA SG11202000817SA SG 11202000817S A SG11202000817S A SG 11202000817SA SG 11202000817S A SG11202000817S A SG 11202000817SA SG 11202000817S A SG11202000817S A SG 11202000817SA SG 11202000817S A SG11202000817S A SG 11202000817SA
- Authority
- SG
- Singapore
- Prior art keywords
- analogs
- phenylalaninol
- carbamoyl
- carbamoyl phenylalaninol
- phenylalaninol analogs
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/11—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
- C07C275/18—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of a saturated carbon skeleton containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
- C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C307/02—Monoamides of sulfuric acids or esters thereof, e.g. sulfamic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C333/02—Monothiocarbamic acids; Derivatives thereof
- C07C333/04—Monothiocarbamic acids; Derivatives thereof having nitrogen atoms of thiocarbamic groups bound to hydrogen atoms or to acyclic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762539088P | 2017-07-31 | 2017-07-31 | |
PCT/US2018/044465 WO2019027941A1 (en) | 2017-07-31 | 2018-07-31 | Carbamoyl phenylalaninol analogs and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202000817SA true SG11202000817SA (en) | 2020-02-27 |
Family
ID=65233074
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202000817SA SG11202000817SA (en) | 2017-07-31 | 2018-07-31 | Carbamoyl phenylalaninol analogs and uses thereof |
Country Status (11)
Country | Link |
---|---|
US (2) | US11413264B2 (en) |
EP (1) | EP3661911A4 (en) |
JP (2) | JP7366002B2 (en) |
KR (1) | KR102643275B1 (en) |
CN (1) | CN111094238B (en) |
AU (1) | AU2018312328B2 (en) |
CA (1) | CA3071779A1 (en) |
MX (2) | MX2020001146A (en) |
RU (1) | RU2020108634A (en) |
SG (1) | SG11202000817SA (en) |
WO (1) | WO2019027941A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11400065B2 (en) | 2019-03-01 | 2022-08-02 | Flamel Ireland Limited | Gamma-hydroxybutyrate compositions having improved pharmacokinetics in the fed state |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11504347B1 (en) | 2016-07-22 | 2022-11-22 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
US11986451B1 (en) | 2016-07-22 | 2024-05-21 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
US11602513B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
UY37341A (en) | 2016-07-22 | 2017-11-30 | Flamel Ireland Ltd | FORMULATIONS OF GAMMA-MODIFIED RELEASE HYDROXIBUTIRATE WITH IMPROVED PHARMACOCINETICS |
US11602512B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
US11583510B1 (en) | 2022-02-07 | 2023-02-21 | Flamel Ireland Limited | Methods of administering gamma hydroxybutyrate formulations after a high-fat meal |
US11779557B1 (en) | 2022-02-07 | 2023-10-10 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
WO2023235844A2 (en) * | 2022-06-03 | 2023-12-07 | Axsome Therapeutics | Carbamoyl phenylalaninol compounds as taar1 agonists |
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FR2604434B1 (en) | 1986-09-29 | 1989-05-19 | Inst Nat Sante Rech Med | 2-AMINO ETHANETHIOL DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
KR100197892B1 (en) | 1994-09-09 | 1999-06-15 | 남창우 | Novel phenylalkylaminoalcohol carbamates and process for preparing the same |
KR0173862B1 (en) | 1995-02-11 | 1999-04-01 | 조규향 | O-carbamoyl- (D) -phenylalaninol compounds and their pharmaceutically useful salts and methods for their preparation |
US5756817C1 (en) | 1995-02-11 | 2001-04-17 | Sk Corp | O-carbamoyl-phenylananinol compounds their pharmaceutically useful salts and process for preparing the same |
KR0173863B1 (en) | 1995-04-10 | 1999-04-01 | 조규향 | O-carbamoyl-phenylalanineol compounds having substituents on phenyl, pharmaceutically useful salts thereof, and preparation methods thereof |
ES2170878T3 (en) * | 1996-10-10 | 2002-08-16 | Sk Corp | O-CARBAMOIL-PHENYLALANINOL COMPOUNDS AND ITS PHARMACEUTICALLY USEFUL SALTS. |
WO1998017636A1 (en) * | 1996-10-22 | 1998-04-30 | Ortho Pharmaceutical Corporation | Phenylalaninol derivatives for the treatment of central nervous system disorders |
US5935997A (en) | 1998-01-13 | 1999-08-10 | Yukong Limited | O-thiocarbamoyl-aminoalkanol compounds, their pharmaceutically useful salts and process for preparing the same |
CA2355293C (en) | 1998-12-23 | 2005-08-16 | Orphan Medical, Inc. | Microbiologically sound and stable solutions of gamma-hydroxybutyrate salt for the treatment of narcolepsy |
EP1149843A4 (en) * | 1999-01-28 | 2012-06-06 | Chugai Pharmaceutical Co Ltd | Substituted phenethylamine derivatives |
JP4443771B2 (en) | 1999-02-05 | 2010-03-31 | エスケー ホルディングス カンパニー リミテッド | O-thiocarbamoyl-aminoalkanol compound, pharmaceutically acceptable salts thereof, and production method thereof |
AU4403000A (en) | 1999-04-23 | 2000-11-10 | Solvay Pharmaceuticals B.V. | Monomers and oligourea peptidomimetics and process for the prepa ration thereof |
US6680322B2 (en) | 1999-12-02 | 2004-01-20 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A1 receptors and uses thereof |
US6680324B2 (en) | 2000-12-01 | 2004-01-20 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A1 receptors and uses thereof |
EP1264814A1 (en) | 2001-06-08 | 2002-12-11 | Avantium International B.V. | Resolving agents based on amines |
US6680299B2 (en) | 2001-07-27 | 2004-01-20 | Enanta Pharmaceuticals, Inc. | 4'-substituted leucomycins |
KR100576372B1 (en) * | 2001-08-03 | 2006-05-03 | 에스케이 주식회사 | O-thiocarbamoyl-aminoalkanol compounds, their pharmaceutically acceptable salts and process for preparing the same |
ITFI20030113A1 (en) | 2003-04-24 | 2004-10-25 | Menarini Ricerche Spa | LINEAR COMPOUNDS NK-2 ANTAGONISTS WITH BASIC CHARACTERISTICS AND FORMULATIONS THAT CONTAIN THEM. |
MX2007005172A (en) | 2004-10-28 | 2007-06-22 | Sk Corp | Shaving razors, and blade subassemblies therefor and methods of manufacture. |
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EP1893291B1 (en) | 2005-06-22 | 2010-03-03 | SK Holdings Co., Ltd. | Treatment of sexual dysfunction |
CN101823987B (en) * | 2009-03-06 | 2014-06-04 | 中国科学院上海药物研究所 | New DPP-IV inhibitors and preparation method and application thereof |
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US9050302B2 (en) | 2013-03-01 | 2015-06-09 | Jazz Pharmaceuticals Ireland Limited | Method of administration of gamma hydroxybutyrate with monocarboxylate transporters |
JP6530741B2 (en) | 2013-03-13 | 2019-06-12 | エアリアル,バイオファーマ,エルエルシー | Treatment of cataplexy |
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KR102616545B1 (en) | 2016-10-06 | 2023-12-26 | 재즈 파마슈티칼즈 아일랜드 리미티드 | Carbamoyl phenylalaninol compounds and uses thereof |
-
2018
- 2018-07-31 CA CA3071779A patent/CA3071779A1/en active Pending
- 2018-07-31 AU AU2018312328A patent/AU2018312328B2/en active Active
- 2018-07-31 CN CN201880059970.5A patent/CN111094238B/en active Active
- 2018-07-31 RU RU2020108634A patent/RU2020108634A/en unknown
- 2018-07-31 WO PCT/US2018/044465 patent/WO2019027941A1/en active Application Filing
- 2018-07-31 JP JP2020505344A patent/JP7366002B2/en active Active
- 2018-07-31 MX MX2020001146A patent/MX2020001146A/en unknown
- 2018-07-31 EP EP18840981.7A patent/EP3661911A4/en active Pending
- 2018-07-31 KR KR1020207005652A patent/KR102643275B1/en active IP Right Grant
- 2018-07-31 US US16/634,935 patent/US11413264B2/en active Active
- 2018-07-31 SG SG11202000817SA patent/SG11202000817SA/en unknown
-
2020
- 2020-01-29 MX MX2023005484A patent/MX2023005484A/en unknown
-
2022
- 2022-06-16 US US17/841,976 patent/US20220401401A1/en active Pending
-
2023
- 2023-04-26 JP JP2023072520A patent/JP2023100758A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11400065B2 (en) | 2019-03-01 | 2022-08-02 | Flamel Ireland Limited | Gamma-hydroxybutyrate compositions having improved pharmacokinetics in the fed state |
Also Published As
Publication number | Publication date |
---|---|
CN111094238B (en) | 2023-06-09 |
JP2023100758A (en) | 2023-07-19 |
US11413264B2 (en) | 2022-08-16 |
CA3071779A1 (en) | 2019-02-07 |
EP3661911A4 (en) | 2021-04-14 |
AU2018312328A1 (en) | 2020-03-19 |
US20220401401A1 (en) | 2022-12-22 |
RU2020108634A3 (en) | 2021-11-30 |
RU2020108634A (en) | 2021-09-02 |
US20210093603A1 (en) | 2021-04-01 |
KR102643275B1 (en) | 2024-03-04 |
JP2020530837A (en) | 2020-10-29 |
JP7366002B2 (en) | 2023-10-20 |
KR20200045489A (en) | 2020-05-04 |
CN111094238A (en) | 2020-05-01 |
MX2020001146A (en) | 2020-08-20 |
MX2023005484A (en) | 2023-05-18 |
EP3661911A1 (en) | 2020-06-10 |
AU2018312328B2 (en) | 2022-12-15 |
WO2019027941A1 (en) | 2019-02-07 |
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