SG11201912864SA - Multi-specific antibodies and methods of making and using thereof - Google Patents

Multi-specific antibodies and methods of making and using thereof

Info

Publication number
SG11201912864SA
SG11201912864SA SG11201912864SA SG11201912864SA SG11201912864SA SG 11201912864S A SG11201912864S A SG 11201912864SA SG 11201912864S A SG11201912864S A SG 11201912864SA SG 11201912864S A SG11201912864S A SG 11201912864SA SG 11201912864S A SG11201912864S A SG 11201912864SA
Authority
SG
Singapore
Prior art keywords
making
methods
specific antibodies
antibodies
specific
Prior art date
Application number
SG11201912864SA
Inventor
Yi Zhu
Ole Olsen
Dong Xia
David Jellyman
Katrina Bykova
Anne-Marie Rousseau
Bill Brady
Blair Renshaw
Brian Kovacevich
Yu Liang
Zeren Gao
Original Assignee
Systimmune Inc
Sichuan Baili Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Systimmune Inc, Sichuan Baili Pharmaceutical Co Ltd filed Critical Systimmune Inc
Publication of SG11201912864SA publication Critical patent/SG11201912864SA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
SG11201912864SA 2017-06-25 2018-06-22 Multi-specific antibodies and methods of making and using thereof SG11201912864SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762524557P 2017-06-25 2017-06-25
PCT/US2018/039156 WO2019005639A2 (en) 2017-06-25 2018-06-22 Multi-specific antibodies and methods of making and using thereof

Publications (1)

Publication Number Publication Date
SG11201912864SA true SG11201912864SA (en) 2020-01-30

Family

ID=64742644

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201912864SA SG11201912864SA (en) 2017-06-25 2018-06-22 Multi-specific antibodies and methods of making and using thereof

Country Status (11)

Country Link
US (1) US11787863B2 (en)
EP (1) EP3645049A4 (en)
JP (1) JP7399852B2 (en)
KR (1) KR20200092301A (en)
CN (4) CN116948035A (en)
AU (1) AU2018295118A1 (en)
CA (1) CA3068045A1 (en)
IL (1) IL271257A (en)
RU (1) RU2020102662A (en)
SG (1) SG11201912864SA (en)
WO (1) WO2019005639A2 (en)

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JP7474193B2 (en) * 2017-06-25 2024-04-24 システィミューン， インク． Multispecific antibodies and methods for making and using same
WO2019005642A1 (en) * 2017-06-25 2019-01-03 Systimmune, Inc. Methods of making and using guidance and navigation control proteins
CN116535508A (en) * 2017-06-25 2023-08-04 西雅图免疫公司 anti-PD-L1 antibodies and methods of making and using the same
JP2021519072A (en) * 2018-03-27 2021-08-10 システィミューン， インク．Ｓｙｓｔｉｍｍｕｎｅ， Ｉｎｃ． Guidance and navigation control proteins and their production and usage
TW202132352A (en) * 2019-11-06 2021-09-01 美商西雅圖免疫公司 Guidance and navigation control proteins and method of making and using thereof
EP3988568A1 (en) * 2020-10-21 2022-04-27 Numab Therapeutics AG Combination treatment
WO2023198635A1 (en) * 2022-04-11 2023-10-19 Astrazeneca Ab T cell binding proteins
CN116143934B (en) * 2023-03-21 2023-07-25 诺赛联合(北京)生物医学科技有限公司 Stem cell exosome extraction kit and application thereof

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WO2002092771A2 (en) 2001-05-11 2002-11-21 Ludwig Institute For Cancer Research Specific binding proteins and uses thereof
EP3150630A1 (en) * 2002-09-27 2017-04-05 Xencor Inc. Optimized fc variants and methods for their generation
AU2006262232A1 (en) 2005-06-20 2007-01-04 Medarex, Inc. CD19 antibodies and their uses
CA2705539A1 (en) * 2007-11-13 2009-05-22 Evec Inc. Monoclonal antibodies that bind to hgm-csf and medical compositions comprising same
US9365644B2 (en) 2008-04-23 2016-06-14 Epitomics, Inc. Anti-TNFα antibody
CA2756244A1 (en) 2009-04-02 2010-10-07 Roche Glycart Ag Multispecific antibodies comprising full length antibodies and single chain fab fragments
BRPI1007602A2 (en) * 2009-05-27 2016-02-16 Hoffmann La Roche "tri or tetraspecific antibody, method for preparing a trispecific or tetraspecific antibody, host cell, composition, pharmaceutical composition and method for treating a patient in need of therapy"
GB201020995D0 (en) * 2010-12-10 2011-01-26 Bioinvent Int Ab Biological materials and uses thereof
WO2013070565A1 (en) * 2011-11-07 2013-05-16 Medimmune, Llc Multispecific and multivalent binding proteins and uses thereof
KR102134088B1 (en) * 2012-08-24 2020-07-14 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 Antibodies and vaccines for use in treating ror1 cancers and inhibiting metastasis
US9732150B2 (en) * 2013-03-14 2017-08-15 Alderbio Holdings Llc Therapeutic use of antibodies to HGF
CA2914829A1 (en) 2013-06-26 2014-12-31 Numab Ag Novel antibody frameworks
EP3406633B1 (en) * 2013-07-25 2022-03-02 Cytomx Therapeutics Inc. Multispecific antibodies, multispecific activatable antibodies and methods of using the same
US20160368987A1 (en) * 2013-10-25 2016-12-22 Numab Ag Bispecific constructs and their use in the treatment of various diseases
EP3107569A4 (en) 2014-02-20 2018-02-21 Alder Biopharmaceuticals, Inc. Anti-acth antibodies and use thereof
UA117289C2 (en) * 2014-04-02 2018-07-10 Ф. Хоффманн-Ля Рош Аг Multispecific antibodies
EP3237449A2 (en) 2014-12-22 2017-11-01 Xencor, Inc. Trispecific antibodies
JP6640232B2 (en) * 2015-02-06 2020-02-05 ユニバーシティ オブ メリーランド，ボルチモア Quadruple-specific octameric binders and antibodies to Clostridium difficile against toxin A and toxin B for the treatment of Clostridium difficile infection
CN104829733B (en) * 2015-05-25 2018-06-05 广州百暨基因科技有限公司 The Chimeric antigen receptor and preparation method and application that antigen-binding unit is stablized
MA42821A (en) * 2015-09-15 2018-07-25 Amgen Inc TETRAVALENT TETRASPECIFIC AND BISPECIFIC BISPECIFIC ANTIGEN BINDING PROTEINS AND USES THEREOF
JP7474193B2 (en) 2017-06-25 2024-04-24 システィミューン， インク． Multispecific antibodies and methods for making and using same
WO2019005642A1 (en) * 2017-06-25 2019-01-03 Systimmune, Inc. Methods of making and using guidance and navigation control proteins
JP2021519072A (en) * 2018-03-27 2021-08-10 システィミューン， インク．Ｓｙｓｔｉｍｍｕｎｅ， Ｉｎｃ． Guidance and navigation control proteins and their production and usage

Also Published As

Publication number Publication date
CN116041530A (en) 2023-05-02
CN116199785A (en) 2023-06-02
JP2020530777A (en) 2020-10-29
CN110831973B (en) 2023-08-15
KR20200092301A (en) 2020-08-03
EP3645049A2 (en) 2020-05-06
JP7399852B2 (en) 2023-12-18
EP3645049A4 (en) 2021-06-30
WO2019005639A3 (en) 2019-02-07
CN116948035A (en) 2023-10-27
CA3068045A1 (en) 2019-01-03
AU2018295118A1 (en) 2020-02-06
IL271257A (en) 2020-01-30
US20220002406A1 (en) 2022-01-06
WO2019005639A2 (en) 2019-01-03
RU2020102662A (en) 2021-07-27
US11787863B2 (en) 2023-10-17
CN110831973A (en) 2020-02-21

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