SG11201912827TA - 7-substituted pyrrolotriazine compounds or pharmaceutically acceptable salts thereof, and preparation methods and uses thereof - Google Patents
7-substituted pyrrolotriazine compounds or pharmaceutically acceptable salts thereof, and preparation methods and uses thereofInfo
- Publication number
- SG11201912827TA SG11201912827TA SG11201912827TA SG11201912827TA SG11201912827TA SG 11201912827T A SG11201912827T A SG 11201912827TA SG 11201912827T A SG11201912827T A SG 11201912827TA SG 11201912827T A SG11201912827T A SG 11201912827TA SG 11201912827T A SG11201912827T A SG 11201912827TA
- Authority
- SG
- Singapore
- Prior art keywords
- pharmaceutically acceptable
- acceptable salts
- preparation methods
- pyrrolotriazine compounds
- substituted pyrrolotriazine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201710493411.2A CN109111447A (en) | 2017-06-23 | 2017-06-23 | 7- substituted azole triazin compounds or its pharmaceutically available salt, and its preparation method and application |
PCT/CN2018/092419 WO2018233684A1 (en) | 2017-06-23 | 2018-06-22 | 7-site substituted pyrrole triazine compounds or pharmaceutically acceptable salts thereof, and preparation method therefor and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201912827TA true SG11201912827TA (en) | 2020-01-30 |
Family
ID=64733772
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201912827TA SG11201912827TA (en) | 2017-06-23 | 2018-06-22 | 7-substituted pyrrolotriazine compounds or pharmaceutically acceptable salts thereof, and preparation methods and uses thereof |
Country Status (13)
Country | Link |
---|---|
US (1) | US11214572B2 (en) |
EP (1) | EP3643717B1 (en) |
JP (1) | JP6852199B2 (en) |
KR (1) | KR102413943B1 (en) |
CN (2) | CN109111447A (en) |
AU (1) | AU2018287971B9 (en) |
BR (1) | BR112019027545A2 (en) |
CA (1) | CA3068114C (en) |
ES (1) | ES2887629T3 (en) |
PT (1) | PT3643717T (en) |
RU (1) | RU2745548C1 (en) |
SG (1) | SG11201912827TA (en) |
WO (1) | WO2018233684A1 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3154079A1 (en) * | 2019-09-19 | 2021-03-25 | Totus Medicines Inc. | Therapeutic conjugates |
CN111909153B (en) * | 2020-04-16 | 2021-11-19 | 山东鲁西药业有限公司 | Synthesis process of 7-iodopyrrolo [2,1-F ] [1,2,4] triazin-4-amine |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2005245875C1 (en) | 2004-05-13 | 2017-08-31 | Icos Corporation | Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta |
EP2435438A1 (en) | 2009-05-27 | 2012-04-04 | Genentech, Inc. | Bicyclic pyrimidine pi3k inhibitor compounds selective for p110 delta, and methods of use |
KR20140036269A (en) * | 2011-07-01 | 2014-03-25 | 바이엘 인텔렉쳐 프로퍼티 게엠베하 | Hydroxymethylaryl-substituted pyrrolotriazines as alk1 inhibitors |
TW201350474A (en) | 2012-03-06 | 2013-12-16 | Boehringer Ingelheim Int | Benzodioxane inhibitors of leukotriene production |
CN103450204B (en) * | 2012-05-31 | 2016-08-17 | 中国科学院上海药物研究所 | Pyrroles [2,1-f] [1,2,4] triazin compound, Preparation Method And The Use |
CN102675323B (en) | 2012-06-01 | 2014-04-09 | 南京药石药物研发有限公司 | Pyrrole-[2, 1-f] [1, 2 and 4] triazine derivative and antitumor effect thereof |
JOP20130273B1 (en) | 2012-09-11 | 2021-08-17 | Genzyme Corp | Glucosylceramide synthase inhibitors |
JP6441910B2 (en) * | 2013-09-30 | 2018-12-19 | シャンハイ インリ ファーマシューティカル カンパニー リミティド | Fused pyrimidine compounds, intermediates, methods for their preparation, compositions and uses |
JP6858252B2 (en) * | 2016-06-25 | 2021-04-14 | スーチョウ キンター ファーマシューティカルズ インコーポレイテッド | Mechanism of rapamycin signaling pathway inhibitors Targets and their therapeutic applications |
-
2017
- 2017-06-23 CN CN201710493411.2A patent/CN109111447A/en active Pending
-
2018
- 2018-06-22 CN CN201880042091.1A patent/CN110869371B/en active Active
- 2018-06-22 KR KR1020207002152A patent/KR102413943B1/en active IP Right Grant
- 2018-06-22 EP EP18820615.5A patent/EP3643717B1/en active Active
- 2018-06-22 JP JP2019571243A patent/JP6852199B2/en active Active
- 2018-06-22 RU RU2020101594A patent/RU2745548C1/en active
- 2018-06-22 ES ES18820615T patent/ES2887629T3/en active Active
- 2018-06-22 BR BR112019027545-2A patent/BR112019027545A2/en active Search and Examination
- 2018-06-22 US US16/626,254 patent/US11214572B2/en active Active
- 2018-06-22 PT PT188206155T patent/PT3643717T/en unknown
- 2018-06-22 CA CA3068114A patent/CA3068114C/en active Active
- 2018-06-22 AU AU2018287971A patent/AU2018287971B9/en active Active
- 2018-06-22 SG SG11201912827TA patent/SG11201912827TA/en unknown
- 2018-06-22 WO PCT/CN2018/092419 patent/WO2018233684A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP3643717A1 (en) | 2020-04-29 |
PT3643717T (en) | 2021-08-31 |
CA3068114A1 (en) | 2018-12-27 |
AU2018287971B9 (en) | 2021-02-11 |
JP6852199B2 (en) | 2021-03-31 |
US11214572B2 (en) | 2022-01-04 |
CN110869371B (en) | 2022-04-15 |
RU2745548C1 (en) | 2021-03-26 |
US20200157110A1 (en) | 2020-05-21 |
KR102413943B1 (en) | 2022-06-27 |
AU2018287971B2 (en) | 2020-12-24 |
CN109111447A (en) | 2019-01-01 |
KR20200015786A (en) | 2020-02-12 |
AU2018287971A8 (en) | 2021-02-04 |
BR112019027545A2 (en) | 2020-07-07 |
AU2018287971A1 (en) | 2020-02-13 |
WO2018233684A1 (en) | 2018-12-27 |
AU2018287971B8 (en) | 2021-02-04 |
EP3643717A4 (en) | 2020-04-29 |
ES2887629T3 (en) | 2021-12-23 |
JP2020527541A (en) | 2020-09-10 |
CA3068114C (en) | 2022-05-10 |
EP3643717B1 (en) | 2021-06-02 |
CN110869371A (en) | 2020-03-06 |
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