SG11201909590XA - Dementia therapeutic agent combining pyrazoloquinoline derivative and memantine - Google Patents

Dementia therapeutic agent combining pyrazoloquinoline derivative and memantine

Info

Publication number
SG11201909590XA
SG11201909590XA SG11201909590XA SG11201909590XA SG 11201909590X A SG11201909590X A SG 11201909590XA SG 11201909590X A SG11201909590X A SG 11201909590XA SG 11201909590X A SG11201909590X A SG 11201909590XA
Authority
SG
Singapore
Prior art keywords
therapeutic agent
memantine
agent combining
dementia therapeutic
pyrazoloquinoline derivative
Prior art date
Application number
Inventor
Mai MIYAMOTO
Sadaharu Kotani
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of SG11201909590XA publication Critical patent/SG11201909590XA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

ABSfRACT There is provided a therapeutic agent for Alzheimer's disease for combined use of (S)-(2-methoxy-3,5-dimethylpyridin-4-y1)-1-(telmhydrofuran-3-y1)-1H-pyrazolo[4,3-c]qui noline-4(5H)-one represented by formula (1): 0 or a pharmaceutically acceptable salt thereof, and meniantine represented by formula (II): NH 2 ( H ) or a pharmaceutically acceptable salt thereof. 19
SG11201909590X 2017-06-01 2018-05-30 Dementia therapeutic agent combining pyrazoloquinoline derivative and memantine SG11201909590XA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762513754P 2017-06-01 2017-06-01
PCT/JP2018/020649 WO2018221550A1 (en) 2017-06-01 2018-05-30 Dementia therapeutic agent combining pyrazoloquinoline derivative and memantine

Publications (1)

Publication Number Publication Date
SG11201909590XA true SG11201909590XA (en) 2019-11-28

Family

ID=64454745

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201909590X SG11201909590XA (en) 2017-06-01 2018-05-30 Dementia therapeutic agent combining pyrazoloquinoline derivative and memantine
SG10202113199RA SG10202113199RA (en) 2017-06-01 2018-05-30 Dementia therapeutic agent combining pyrazoloquinoline derivative and memantine

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG10202113199RA SG10202113199RA (en) 2017-06-01 2018-05-30 Dementia therapeutic agent combining pyrazoloquinoline derivative and memantine

Country Status (12)

Country Link
US (1) US11147803B2 (en)
EP (1) EP3632437B1 (en)
JP (1) JP7177772B2 (en)
KR (1) KR102627790B1 (en)
CN (1) CN110603039B (en)
AU (1) AU2018276568A1 (en)
BR (1) BR112019023595A2 (en)
CA (1) CA3060183A1 (en)
IL (1) IL270394B (en)
MX (1) MX2019013383A (en)
SG (2) SG11201909590XA (en)
WO (1) WO2018221550A1 (en)

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RU2019135261A (en) 2017-06-01 2021-07-09 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. PHARMACEUTICAL COMPOSITION CONTAINING PDE9 INHIBITOR
AU2018278422B2 (en) 2017-06-01 2022-03-17 Eisai R&D Management Co., Ltd. Lewy body disease therapeutic agent containing pyrazoloquinoline derivative
JP7079777B2 (en) 2017-06-01 2022-06-02 エーザイ・アール・アンド・ディー・マネジメント株式会社 Dementia treatment agent by combined use of pyrazoloquinoline derivative and donepezil
AU2022367432A1 (en) 2021-10-14 2024-05-02 Incyte Corporation Quinoline compounds as inhibitors of kras
CN114524828B (en) * 2022-02-22 2024-07-09 深圳市儿童医院 Thiazole derivative for treating severe neurosis and application thereof
CN114524827B (en) * 2022-02-22 2024-07-09 深圳市儿童医院 Pyrazole derivative for treating severe neurosis and application thereof

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Also Published As

Publication number Publication date
CA3060183A1 (en) 2018-12-06
RU2019135838A3 (en) 2021-09-29
BR112019023595A2 (en) 2020-05-26
JPWO2018221550A1 (en) 2020-04-02
IL270394B (en) 2022-08-01
KR20200010219A (en) 2020-01-30
IL270394A (en) 2020-02-27
SG10202113199RA (en) 2021-12-30
AU2018276568A1 (en) 2019-11-07
US20200129488A1 (en) 2020-04-30
US11147803B2 (en) 2021-10-19
KR102627790B1 (en) 2024-01-23
CN110603039B (en) 2023-02-28
EP3632437A1 (en) 2020-04-08
EP3632437A4 (en) 2021-03-17
EP3632437B1 (en) 2024-03-13
CN110603039A (en) 2019-12-20
RU2019135838A (en) 2021-07-13
MX2019013383A (en) 2020-02-20
WO2018221550A1 (en) 2018-12-06
JP7177772B2 (en) 2022-11-24

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