SG11201907892VA - Composition comprising avelumab - Google Patents

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 13 September 2018 (13.09.2018) WIP0 I PCT omit VIII °nolo VIII VIII olo mil no Elio ois (10) International Publication Number WO 2018/162430 Al (51) International Patent Classification: CO7K 16/28 (2006.01) (21) International Application Number: PCT/EP2018/055379 (22) International Filing Date: 05 March 2018 (05.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 17159470.8 06 March 2017 (06.03.2017) EP (71) Applicant: MERCK PATENT GMBH [DE/DE]; Frank- furter Strasse 250, 64293 Darmstadt (DE). (72) Inventors: TERLIZZESE, Maria Grazia; Via Erminio Macario 24, 00125 Roma RM (IT). CAVALIERE, Francesca; Via Roberto Sanseverino 2, 00177 Roma RM (IT). PEZZOTTI, Anna R; Via Luciano Conti, 50, 00132 Roma RM (IT). DE ROSSI, Elio; Via Le Cese, 20, 00060 Capena RM (IT). (74) Agent: MERCK SERONO S.A.; Intellectual Property, Terre Bonne Business Park A2, Route de Crassier 15, 1162 Eysins (CH). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a)) O 00 O C Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) of inventorship (Rule 4.17(iv)) (54) Title: COMPOSITION COMPRISING AVELUMAB (57) : The present invention relates to avelumab antibody compositions with an elevated deamidation level, as well as methods for using such compositions to treat a disorder, e.g., a disorder in which the interaction between PD-1 and PD-L1 is detrimental.